Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells

Journal of Experimental Medicine

Volumn 197, Issue 8, 2003, Pages 1059-1063

  Gilliet, Michel ^a   Soumelis, Vassili ^a,c   Watanabe, Norihiko ^a   Hanabuchi, Shino ^a   Antonenko, Svetlana ^a   De Waal Malefyt, Rene ^a   Liu, Yong Jun ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Allergy; CD11c+ DC; CD8+ T lymphocyte; Cytotoxicity; TSLP

Indexed keywords

CD4 ANTIGEN; CD40 LIGAND; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; THYMIC STROMAL LYMPHOPOIETIN; UNCLASSIFIED DRUG;

ALLERGY; ARTICLE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DENDRITIC CELL; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD11C; CD40 LIGAND; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; HUMANS; HYPERSENSITIVITY; INFLAMMATION; INTERFERON TYPE II; INTERLEUKIN-13; INTERLEUKIN-5; LYMPHOCYTE ACTIVATION;

EID: 0037460072     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030240     Document Type: Article

References (30)

1. Sims, J.E., D.E. Williams, P.J. Morrissey, K. Garka, D. Foxworthe, V. Price, S.L. Friend, A. Farr, M.A. Bedell, N.A. Jenkins, et al. 2000. Molecular cloning and biological characterization of a novel murine lymphoid growth factor. J. Exp. Med. 192:671-680.
2. Reche, P.A., V. Soumelis, D.M. Gorman, T. Clifford, M. Liu, M. Travis, S.M. Zurawski, J. Johnston, Y.J. Liu, H. Spits, et al. 2001. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J. Immunol. 167:336-343.
3. Soumelis, V., P.A. Reche, H. Kanzler, W. Yuan, G. Edward, B. Homey, M. Gilliet, S. Ho, S. Antonenko, A. Lauerma, et al. 2002. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol. 3:673-680.
4. Kay, A.B. 2001. Allergy and allergic diseases. First of two parts. N. Engl. J. Med. 344:30-37.
5. Renauld, J.C. 2001. New insights into the role of cytokines in asthma. J. Clin. Pathol. 54:577-589.
6. van Reijsen, F.C., C.A. Bruijnzeel-Koomen, F.S. Kalthoff, E. Maggi, S. Romagnani, J.K. Westland, and G.C. Mudde, 1992. Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dematitis. J. Allergy Clin. Immunol. 90:184-193.
7. Robinson, D.S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A.M. Bentley, C. Corrigan, S.R. Durham, and A.B. Kay. 1992. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326: 298-304.
8. Salgame, P., J.S. Abrams, C. Clayberger, H. Goldstein, J, Convit, R.L. Modlin, and B.R. Bloom. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science. 254:279-282.
9. Croft, M., L. Carter, S.L. Swain, and R.W. Dutton. 1994. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J. Exp. Med. 180:1715-1728.
10. Kemeny, D.M., A. Noble, B.J. Holmes, and D. DiazSanchez. 1994. Immune regulation: a new role for the CD8+ T cell. Immunol. Today. 15:107-110.
11. Wahlstrom, J., B. Dahlen, E. Ihre, H. Wigzell, J. Grunewald, and A. Eklund. 1998. Selective CD8+ T cells accumulate in the lungs of patients with allergic asthma after allergen bronchoprovocation. Clin. Exp. Immunol. 112:1-9.
12. Akdis, M., H.U. Simon, L. Weigl, O. Kreyden, K. Blaser, and C.A. Akdis. 1999. Skin homing (cutaneous lymphocyteassociated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis. J. Immunol. 163:466-475.
13. Mosmann, T.R., and R.L. Coffman. 1989, TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145-173.
14. Seneviratne, S.L., L. Jones, A.S. King, A. Black, S. Pwell, A.J. McMichael, and G.S. Ogg. 2002. Allergen-specific CD8+ T cells and atopic disease. J. Clin. Invest, 110:1283-1291.
15. Shiota, Y., H. Arikita, N. Horita, J. Hiyama, T. Ono, and M. Yamakido. 2002. Intracellular IL-5 and T-lymphocyte subsets in atopic and nonatopic bronchial asthma. J. Allergy Clin. Immunol. 109:294-298.
16. Mauri-Hellweg, D., F. Bettens, D. Mauri, C. Brander, T. Hunziker, and W.J. Pichler. 1995. Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine. J. Immunol. 155: 462-472.
17. Coyle, A.J., F. Erard, C. Bertrand, S. Walti, H. Pircher, and G. Le Gros, 1995. Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia. J. Exp. Med. 181:1229-1233.
18. Borish, L., A. Aarons, J. Rumbyrt, P. Cvietusa, J. Negri, and S. Wenzel. 1996. Interleukin-10 regulation in normal subjects and patients with asthma. J. Allergy Clin. Immunol. 97: 1288-1296.
19. Grunig, G., D.B. Corry, M.W. Leach, B,W. Seymore, V.P. Kurup, and D.M. Rennick. 1997. Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J. Exp. Med. 185:1089-1099.
20. Akbari, O., G.J. Freeman, E.H. Meyer, E.A. Greenfield, T.T. Chang, A.H. Sharpe, G. Berry, R.H. DeKruyff, and D.T. Umetsu. 2002. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat. Med. 8:1024-1032.
21. Werfel, T., A. Morita, M. Grewe, H. Renz, U. Wahn, J. Krutmann, and A. Kapp. 1996. Allergen specificity of skininfiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis. J. Invest. Dermatol. 107:871-876.
22. Grewe, M., C.A. Bruijnzeel-Koomen, E. Schopf, T. Thepen, A.G. Langeveld-Wildschut, T. Ruzicka, and J. Krutmann, 1998. A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol. Today. 19:359-361.
23. Thepen, T., E.G. Langeveld-Wildschut, I.C. Bihari, D.F. van Wichen, F.C. van Reijsen, G.C. Mudde, and C.A. Bruijnzeel-Koomen. 1996. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: an immunocytochemical study, J. Allergy Clin. Immunol. 97:828-837.
24. Carroll, J.M., T. Crompton, J.P. Seery, and F.M. Watt. 1997. Transgenic mice expressing IFN-gamma in the epidermis have eczema, hair hypopigmentation, and hair loss. J. Invest. Dermatol. 108:412-422.
25. Yawalkar, N., S. Schmid, L.R. Braathen, and W.J. Pichler. 2001. Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasis. Br. J. Dermatol. 144:1133-1139.
26. Hessel, E.M., A.J. Van Oosterhout, I. Van Ark, B. Van Esch, G. Hofman, H. Van Loveren, H.F. Savelkoul, and F.P. Nijkamp. 1997. Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration. Am. J. Respir. Cell Mol. Biol. 16:325-334.
27. Hamelmann, E., A. Oshiba, J. Paluh, K. Bradley, J. Loader, T.A. Potter, G.L. Larsen, and E.W. Gelfand. 1996. Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a murine model of airway sensitization. J. Exp. Med. 183:1719-1729.
28. O'Sullivan, S., L. Cormican, J.L. Faul, S. Ichinohe, S.L. Johnston, C.M. Burke, and L.W. Poulter. Activated, cytotoxic CD8+ T lymphocytes contribute to the pathology of asthma death. Am. J. Respir. Crit. Care Med. 164:560-564.
29. Banchereau, J., and R.M. Steinman. 1998. Dendritic cells and the control of immunity. Nature. 392:245-252.
30. Van Kooten, C., and J. Banchereau, 2000, CD40-CD40 ligand. J. Leukoc. Biol. 67:2-17.