Perforin-dependent neurologic injury in a viral model of multiple sclerosis

Journal of Neuroscience

Volumn 18, Issue 18, 1998, Pages 7306-7314

  Murray, Paul D ^a   McGavern, Dorian B ^a   Lin, Xiaoqi ^a   Njenga, M Kariuki ^a   Leibowitz, Julian ^b   Pease, Larry R ^a   Rodriguez, Moses ^a  

^a MAYO CLINIC   (United States)

^b TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

Cytotoxic T lymphocyte; Granule exocytosis; MHC class I; Perforin; Picornavirus; Theiler's murine encephalomyelitis virus

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PERFORIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DEMYELINATION; EXOCYTOSIS; IMMUNOPATHOGENESIS; MOUSE; MULTIPLE SCLEROSIS; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL;

EID: 0032530698     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-18-07306.1998     Document Type: Article

References (22)

1. Adachi M, Watanabe-Fukunaga R, Nagata S (1993) Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of Ipr mice. Proc Natl Acad Sci USA 90:1756-1760.
2. Adams RD, Victor M, Ropper AH (1998) Multiple sclerosis and allied demyelinative diseases. In: Principles of neurology (Wonsiewicz MJ, Navrozov M, eds), pp 902-927. New York: McGraw-Hill.
3. Bonetti B, Raine CS (1997) Multiple sclerosis: oligodendrocytes display cell death-related molecules in situ but do not undergo apoptosis. Ann Neurol 42:74-84.
4. Bregman BS, Kunkel-Bagden E, Schnell L, Dai HN, Gao D, Schwab ME (1995) Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. Nature 378:498-501.
5. Clatch RJ, Melvold RW, Miller SD, Lipton HL (1985) Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: correlation with TMEV-specific delayed-type hypersensitivity. J Immunol 135:1408-1414.
6. D'Souza SD, Bonetti B, Balasingam V, Cashman NR, Barker PA, Troutt AB, Raine CS, Antel JP (1996) Multiple sclerosis: Fas signaling in oligodendrocyte cell death. J Exp Med 184:2361-2370.
7. de Medinaceli L, Freed WJ, Wyatt RJ (1982) An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks. Exp Neurol 77:634-643.
8. Dowling P, Shang G, Raval S, Menonna J, Cook S, Husar W (1996) Involvement of the CD95 (APO-1/Fas) receptor/ligand system in multiple sclerosis brain. J Exp Med 184:1513-1518.
9. Foster RE, Whalen CC, Waxman SG (1980) Reorganization of the axon membrane in demyelinated peripheral nerve fibers: morphological evidence. Science 210:661-663.
10. Gasque P, Jones J, Singhrao SK, Morgan B (1998) Identification of an astrocyte cell population from human brain that expresses perforin, a cytotoxic protein implicated in immune defense. J Exp Med 187:451-460.
11. Gosgrove D, Gray D, Dierich A, Kaufman J, Lemeur M, Benoist C, Mathis D (1991) Mice lacking MHC class II molecules. Cell 66:1051-1066.
12. Isaaz S, Baetz K, Olsen K, Podack E, Griffiths GM (1995) Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway. Eur J Immunol 25:1071-1079.
13. 2+ changes in individual oligodendrocytes attacked by T-cell perform. Immunology 74:572-577.
14. Kagi D, Ledermann B, Burki K, Seiler P, Odermatt B, Olsen KJ, Podack ER, Zinkernagel RM, Hengartner H (1994) Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31-37.
15. Kagi D, Seiler P, Pavlovic J, Ledermann B, Burki K, Zinkernagel RM, Hengartner H (1995) The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses. Eur J Immunol 25:3256-3262.
16. Kagi D, Ledermann B, Burki K, Zinkernagel RM, Hengartner H (1996) Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol 14:207-232.
17. Klapdor K, Dulfer BG, Hammann A, Van der Staay FJ (1997) A lowcost method to analyze footprint patterns. J Neurosci Methods 75:49-54.
18. Lehrich JR, Arnason BG, Hochberg FH (1976) Demyelinative myelopathy in mice induced by the DA virus. J Neurol Sci 29:149-160.
19. Lin X, Thiemann R, Pease LR, Rodriguez M (1995) VP1 and VP2 capsid proteins of Theiler's virus are targets of H-2D-restricted cytotoxic lymphocytes in the central nervous system of BIO mice. Virology 214:91-99.
20. Lindsay MD, Rodriguez M (1989) Characterization of the inflammatory response in the central nervous system of mice susceptible or resistant to demyelination by Theiler's virus. J Immunol 142:2677-2682.
21. Miller DJ, Rivera-Quinones C, Njenga MK, Leibowitz J, Rodriguez M (1995) Spontaneous CNS remyelination in Beta(2) microglobulin-deficient mice following virus-induced demyelination. J Neurosci 15:8345-8352.
22. Njenga MK, Pavelko KD, Baisch J, Lin X, David C, Leibowitz J, Rodriguez M (1996) Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice. J Virol 70:1729-1737.