Recent advances in the immunobiology of ceramide

Experimental and Molecular Pathology

Volumn 82, Issue 3, 2007, Pages 298-309

  Pandey, Saumya ^a   Murphy, Richard F ^a   Agrawal, Devendra K ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Atherosclerosis; Cancer; Cardiovascular diseases; Ceramide; Ion channels; Neurodegeneration; Raft; Sphingomyelinase

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR; AMINOTRANSFERASE; CALCIMYCIN; CELL SURFACE RECEPTOR; CERAMIDE; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DAUNORUBICIN; DESIPRAMINE; ENZYME INHIBITOR; ION CHANNEL; PACLITAXEL; PROTEIN KINASE; SPHINGOSINE; STRESS ACTIVATED PROTEIN KINASE; TAMOXIFEN; VINBLASTINE; VINCA ALKALOID; VINCRISTINE;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; ATHEROGENESIS; CANCER CELL; CARDIOVASCULAR DISEASE; CELL DIFFERENTIATION; CELL MEMBRANE; CELL PROLIFERATION; CELLULAR STRESS RESPONSE; ENZYME ACTIVITY; IMMUNOBIOLOGY; LIPID HYDROLYSIS; LIPID METABOLISM; LIPID TRANSPORT; LIPOGENESIS; NERVE DEGENERATION; PATHOPHYSIOLOGY; PROTEIN BINDING; SENESCENCE; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CERAMIDES; HUMANS; MEMBRANE MICRODOMAINS; SIGNAL TRANSDUCTION;

EID: 34247648058     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2006.07.009     Document Type: Article

References (132)

1. Abdel Shakor A.B., Kwiatkowska K., and Sobota A. Cell surface ceramide generation precedes and controls Fas clustering and phosphorylation in rafts. J. Biol. Chem. 279 (2004) 36778-36787
2. Albi E., Cataldi S., Bartoccini E., Magni M.V., Marini F., Mazzoni F., Rainaldi G., Evangelista M., and Garcia-Gil M. Nuclear sphingomyelin pathway in serum deprivation-induced apoptosis of embryonic hippocampal cells. J. Cell. Physiol. 206 (2006) 189-195
3. Auge N., Andrieu N., Negre-Salvayre A., Thiers J.C., Levade T., and Salvayre R. The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation. J. Biol. Chem. 271 (1996) 19251-19255
4. Auge N., Nikolova-Karakashian M., Carpentier S., Parthasarathy S., Negre-Salvayre A., Salvayre R., Merril Jr. A.H., and Levade T. Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase. J. Biol. Chem. 274 (1999) 21533-21538
5. Barsacchi R., Perrotta C., Bulotta S., Moncada S., Borgese N., and Clementi E. Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3′ kinase, and Akt. Mol. Pharmacol. 63 (2003) 886-895
6. Basu S., Bayoumy S., Zhang Y., Lozano J., and Kolesnick R. BAD enables ceramide to signal apoptosis via Ras and Raf-1. J. Biol. Chem. 273 (1998) 30419-30426
7. Bhunia A.K., Han H., Snowden A., and Chatterjee S. Lactosylceramide stimulates Ras-GTP loading kinases (MEK, Raf), p44-mitogen activated protein kinase and c-fos expression in human aortic smooth muscles. J. Biol. Chem. 27 (1996) 10660-10666
8. Bhunia A.K., Han H., Snowden A., and Chatterjee S. Redox-regulated signaling by lactosylceramide in the proliferation of human aortic smooth muscle cells. J. Biol. Chem. 272 (1997) 15642-15649
9. Bielawska A.E., Shapiro J.P., Jiang L., Melkonyan H.S., Piot C., Wolfe C.L., Tomei L.D., Hannun Y.A., and Umansky S.R. Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. Am. J. Pathol. 151 (1997) 1257-1263
10. Birbes H., Luberto C., Hsu Y.T., El Bawab S., Hannun Y.A., and Obeid L.M. A mitochondrial pool of sphingomyelin is involved in TNF-alpha-induced Bax translocation to mitochondria. Biochem. J. 386 (2005) 445-451
11. Bose R., Verheij M., Haimovitz-Friedman A., Scotto K., Fuks Z., and Kolesnick R. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82 (1995) 405-414
12. Bourbon N.A., Yun J., and Kester M. Ceramide directly activates protein kinase C ζ to regulate a stress-activated protein signaling complex. J. Biol. Chem. 267 (1992) 5048-5051
13. Bourbon N.A., Yun J., Berkey D., Wang Y., and Kester M. Inhibitory actions of ceramide upon PKC-epsilon/ERK interactions. Am. J. Physiol. Cell. Physiol. 280 (2001) c1403-c1411
14. Brenner B., Koppenhoefer U., Weinstock C., Lindercamp O., Lang F., and Gulbins E. Fas- or ceramide-induced apoptosis is mediated by a Rac-1 regulated activation of Jun N-terminal kinase/p38 kinases and GADD 153. J. Biol. Chem. 272 (1997) 22173-22181
15. Bulotta S., Barsacchi R., Rotiroti D., Borgese N., and Clementi E. Activation of the endothelial nitric-oxide synthase by tumor necrosis factor-alpha. A novel feedback mechanism regulating cell death. J. Biol. Chem. 276 (2001) 6529-66536
16. Cabot M.C., Guiliano A.E., Volner A., and Han T.Y. Tamoxifen retards glycosphingolipid metabolism in human cancer cells. FEBS Lett. 394 (1996) 129-131
17. Chalfant C.E., Kishikawa K., Mumby M.C., Kamibaya C., Bielawska A., and Hannun Y.A. Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A: activation is stereospecific and regulated by phosphatidic acid. J. Biol. Chem. 274 (1999) 20313-20317
18. Charles R., Sandirasegarane L., Yun J., Bourbon N., Wilson R., Rothstein R.P., Levison S.W., and Kester M. Ceramide-coated balloon catheters limit neointimal hyperplasia after stretch injury in carotid arteries. Circ. Res. 87 (2000) 282-288
19. Charruyer A., Grazide S., Benzombes C., Muller S., Laurent G., and Jaffrezou J.P. UV-C induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal. J. Biol. Chem. 280 (2005) 19196-19204
20. Chatterjee S.B., Dey S., Shi W.Y., Thomas K., and Hutchins G.M. Accumulation of glycosphingolipids in human atherosclerotic plaque and unaffected aorta tissues. Glycobiology 7 (1997) 57-65
21. Chatterjee S. Sphingolipids in atherosclerosis and vascular biology. Arterioscler. Thromb. 18 (1998) 1523-1533
22. Chatterjee S. Neutral sphingomyelinase: past, present and future. Chem. Phys. Lipids 102 (1999) 79-96
23. Cuvillier O., Pirianov G., Kleuser B., Vanek P.G., Coso O.A., Gutkind S., and Spiegel S. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381 (1996) 800-803
24. De Stefanis D., Reffo P., Bonelli G., Baccino F.M., Sala G., Ghidoni R., Codogno P., and Isidoro C. Increase in ceramide level alters the lysosomal targeting of Cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells. Biol. Chem. 383 (2002) 989-999
25. Dumitru C.A., and Gulbins E. TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis. Oncogene (2006) 1-14
26. Durham J.P., and Mawhinns M.G. Downregulation of neutral sphingomyelinase in androgen-dependent smooth muscle. J. Surg. Res. 130 (2006) 136-139
27. El Btaouri H., Rath G., Morjani H., Schneider C., Petitfrere E., Antonicelli F., and Martiny L. Interleukin-1-beta-induced apoptosis through adenylyl cyclase and ERK1/2 inhibition in primary cultured thyroid cells. Biochem. Biophys. Res. Commun. 339 (2006) 469-476
28. Erdreich-Epstein A., Tran L.B., Cox O.T., Huang E.Y., Laug W.E., Shimada H., and Millard M. Endothelial apoptosis induced by inhibition of integrins αVβ3 and αVβ5 involves ceramide metabolic pathways. Blood 105 (2005) 4353-4361
29. Fanani M.L., Harte S., Olivera R.G., and Maggio B. Bidirectional control of sphingomyelinase activity and surface topography in lipid monolayers. Biophys. J. 83 (2002) 3416-3424
30. Florio T., Arena S., Pattarozzi A., Thellung S., Corsaro A., Villa V., Massa A., Diana F., Spoto G., Forcella S., Damonte G., Filocamo M., Benatti U., and Schettini G. Basic fibroblast growth factor activates endothelial nitric oxide synthase in CHO-CK1 cells via the activation of ceramide synthesis. Mol. Pharmacol. 63 (2003) 297-310
31. Fukasawa M., Nishijima M., and Hanada K. Genetic evidence for ATP-dependent endoplasmic reticulum-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in Chinese hamster ovary cells. J. Cell Biol. 144 (1999) 673-685
32. Futerman A.H., Stieger B., Hubbard A.L., and Pagano R.E. Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus. J. Biol. Chem. 265 (1990) 8650-8657
33. Galle J., Mulsch A., Busse R., and Bassenge E. Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium derived relaxing factor. Arterioscler. Thromb. 11 (1991) 198-203
34. Garcia-Ruiz C., Collel A., Mari M., Morales A., and Fernandez-Checa J.C. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species: role of mitochondrial glutathione. J. Biol. Chem. 272 (1997) 11369-11377
35. Gentil B., Grimot F., and Riva C. Commitment to apoptosis by ceramides depends on mitochondrial respiratory function, cytochrome c release and caspase-3 activation in Hep-G2 cells. Mol. Cell. Biochem. 254 (2003) 203-210
36. German O.L., Miranda G.E., Abraham C.E., and Rotstein N.P. Ceramide is a mediator of apoptosis in retina photoreceptors. Invest. Opthalmol. Visual Sci. 47 (2006) 1658-1668
37. Ghosh N., Sabbadini R., and Chatterjee S. Identification, partial purification, and localization of a neutral sphingomyelinase in rabbit skeletal muscle: neutral sphingomyelinase in skeletal muscle. Mol. Cell. Biochem. 189 (1998) 161-168
38. 2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells. J. Cell Sci. 111 (1998) 3209-3220
39. Grassme H., Jekle A., Riehle A., Schwarz H., Berger J., Sandhoff K., Kolesnick R., and Gulbins E. CD95-signaling via ceramide-rich membrane rafts. J. Biol. Chem. 276 (2001) 20589-20596
40. Grassme H., Jendrossek V., Bock J., Riehle A., and Gulbins E. Ceramide-rich membrane rafts mediate CD40 clustering. J. Immunol. 168 (2002) 298-307
41. Grassme H., Cremesti A., Kolesnick R.N., and Gulbins E. Ceramide mediated clustering is required for CD95-DISC formation. Oncogene 22 (2003) 5457-5470
42. Grassme H., Jendrossek V., Riehle A., von Kurthy G., Berger J., Schwarz H., Weller M., Kolesnick R., and Gulbins E. Host defence against Pseudomonas aeruginosa requires ceramide-rich membrane rafts. Nat. Med. 9 (2003) 322-330
43. Grassme H., Riehle A., Wilker B., and Gulbins E. Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms. J. Biol. Chem. 80 (2005) 26256-26262
44. Gudz T.I., Tseng K.Y., and Hoppel C.L. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. J. Biol. Chem. 272 (1997) 24154-24158
45. Gulbins E., and Kolesnick R. Raft ceramide in molecular medicine. Oncogene 22 (2003) 7070-7077
46. Gulbins E., Coggeshall K.M., Baier G., Telford D., Langlet C., Baier-Bitterlich G., Bonnefoy-Berard N., Burn P., Wittinghofer A., and Altman A. Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides. Mol. Cell. Biol. 14 (1994) 4749-4758
47. Gulbins E., Szabo I., Baltzer K., and Lang F. Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 7661-7666
48. Hanada K., Kumagai K., Yasuda S., Miura Y., Kawano M., Fukasawa M., and Nishijima M. Molecular machinery for non-vesicular trafficking of ceramide. Nature 426 (2003) 803-809
49. Hannun Y.A. The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem. 26 (1994) 3125-3128
50. Hannun Y.A., and Luberto C. Ceramide in the eukaryotic stress response. Trends Cell Biol. 10 (2000) 73-80
51. Hannun Y.A., Luberto C., and Argraves K.M. Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry 40 (2001) 4893-4903
52. Hannun Y.A., and Obeid L.M. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem. 277 (2002) 25847-25850
53. Hartel S., Fanani M.L., and Maggio B. Shape transitions and lattice structuring of ceramide-enriched domains generated by sphingomyelinase in lipid monolayers. Biophys. J. 88 (2005) 287-304
54. + currents via a Ras- and Raf-1-dependent pathway in cultured oligodendrocytes. J. Neurosci. 18 (1998) 8712-8719
55. Hirschberg K., Rodger J., and Futerman A.H. The long chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. Biochem. J. 290 (1993) 751-757
56. Hojjati M.R., Li Z., Zhou H., Tang S., Huan C., Ooi E., Lu S., and Jiang X.C. Effect of Myriocin on plasma sphingolipid metabolism and atherosclerosis in apo-E-deficient mice. J. Biol. Chem. 280 (2005) 10284-10289
57. Huwiler A., Brunner J., Hummel R., Vervoordeldonk M., Stabel S., van den Bosch H., and Pfeilschifter J. Ceramide binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 6959-6963
58. Huwiler A., Pfeilschifter J., and van den Bosch H. Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells. J. Biol. Chem. 274 (1999) 7190-7195
59. Huwiler A., Johansen B., Skarstad A., and Pfeilschifter J. Ceramide binds to the CaLB domain of phospholipase A2 and facilitates its membrane docking and arachidonic acid release. FASEB J. 15 (2001) 7-9
60. Ito Y., Sato S., Ohashi T., Nakayama S., Shimokata K., and Kume H. Reduction of airway anion secretion via CFTR in sphingomyelin pathway. Biochem. Biophys. Res. Commun. 324 (2004) 901-908
61. 2+ signalling in cultured glioma cells. Brain Res. 597 (1992) 108-113
62. Kashkar H., Wiegmann K., Yazdanpanah B., Haubert D., and Kronke M. Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane. J. Biol. Chem. 280 (2005) 20804-20813
63. Kim H.J., Mun J.Y., Chun Y.J., Choi K.H., and Kim M.Y. Bax-dependent apoptosis is induced by ceramide in HL-60 cells. FEBS Lett. 505 (2001) 264-268
64. Kim J.W., Inagaki Y., and Mitsutake S. Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509 A olefin isomer K1. Biochim. Biophys. Acta 1738 (2005) 82-90
65. 95-mediated apoptosis in vivo involves acid sphingomyelinase. J. Biol. Chem. 275 (2000) 27316-27323
66. Kishikawa K., Chalfant C.E., Perry D.K., Bielawska A., and Hannun Y.A. Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses. J. Biol. Chem. 274 (1999) 21335-21341
67. Kolesnick R.N., Goni F.M., and Alonso A. Compartmentalization of ceramide signaling: physical foundations and biological effects. J. Cell. Physiol. 184 (2000) 285-300
68. Kong J.Y., Klassen S.S., and Rabkin S.W. Ceramide activates a mitochondrial p38-mitogen activated protein kinase: a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis. Mol. Cell. Biochem. 278 (2005) 39-51
69. Krueger K.D., Mitra A.K., Del Core M.D., Hunter W.J., and Agrawal D.K. A comparison of stent-induced stenosis in coronary and peripheral arteries. J. Clin. Pathol. 59 (2006) 575-579
70. Kumagai K., Ysuda S., Okemoto K., Nishimija M., Kobayashi S., and Hanada K. CERT mediates intermembrane transfer of various molecular species of ceramides. J. Biol. Chem. 280 (2005) 6488-6495
71. Lacour S., Hammann A., Grazide S., Lagadic-Gossmann D., Athias A., Sergent O., Laurent G., Gambert P., Solary E., and Dimanche-Boitrel M.J. Cisplatin-induced CD 95 redistribution into membrane lipid rafts of HT 29 human colon cancer cells. Cancer Res. 64 (2004) 3593-3598
72. Lavie Y., Cao H.T., Volner A., Lucci A., Han T.Y., Geffen V., Giuliano A.E., and Cabot M.C. Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells. J. Biol. Chem. 272 (1997) 1682-1687
73. Levade T., and Jaffrezou J.P. Signaling sphingomyelinases: which, where, how, and why?. Biochim. Biophys. Acta 1438 (1999) 1-17
74. Leventhal A.R., Chen W., Tall A.R., and Tabas I. Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux. J. Biol. Chem. 276 (2001) 44976-44983
75. Lew B.L., Cho Y., Kim J., Sim W.Y., and Kim N.I. Ceramides and cell signaling molecules in psoriatic epidermis: reduced levels of ceramides, PKC-alpha and JNK. J. Korean Med. Sci. 21 (2006) 95-99
76. Li P.L., Zhang D.X., Zou A.P., and Campbell W.B. Effect of ceramide on KCa channel activity and vascular tone in coronary arteries. Hypertension 33 (1999) 1441-1446
77. Loewen C.J., and Levine T.P. A highly conserved binding site in VAP for the FFAT motif of lipid binding proteins. J. Biol. Chem. 280 (2005) 14097-14104
78. Lozano J., Berra E., and Municio M.M. Protein kinase C zeta isoform is critical for kappaB dependent promoter activation by sphingomyelinase. J. Biol. Chem. 269 (1994) 19200-19202
79. Lucci A., Han T.Y., Liu Y.Y., Giuliano A.E., and Cabot M.C. Modification of ceramide metabolism increases sensitivity to cytotoxics. Int. J. Oncol. 15 (1999) 541-546
80. Malaplate-Armand C., Florent-Bechard S., Youssef I., Koziel V., Sponne I., Kriem B., Leininqer-Muller B., Olivier J.L., Oster T., and Pillot T. Soluble oligomers of amyloid-β peptide induce neuronal apoptosis by activating a cPLA-dependent sphingomyelinase-ceramide pathway. Neurobiol. Dis. 23 (2006) 178-189
81. Mallat Z., and Tedgui A. Current perspective on the role of apoptosis in atherothrombotic disease. Circ. Res. 88 (2001) 998-1003
82. Mandon E.C., Ehses I., Rother J., van Echten G., and Sandhoff K. Subcellular localization and membrane topology of serine palmitoyltransferase 3-dehydrosphinganine reductase and sphinganine N-acyltransferase in mouse liver. J. Biol. Chem. 267 (1992) 11144-111448
83. Mathias S., Pena L.A., and Kolesnick R.N. Signal transduction of stress via ceramide. Biochem. J. 335 (1998) 465-480
84. Maurer B.J., Metelitsa L.S., Seeger R.C., Cabot M.C., and Reynolds C.P. Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)-retinamide in neuroblastoma cell lines. J. Natl. Cancer Inst. 91 (1999) 1138-1146
85. Mc Closkey D.E., Kaufmann S.H., Prestigiacomo L.J., and Davidson N.E. Paclitaxel induces programmed cell death in MDA-MB-468 human breast cancer cells. Clin. Cancer Res. 2 (1996) 847-854
86. Mehta S., Blackinton D., Omar I., Kouttab N., Myrick D., Klostergaard J., and Wanebo H. Combined cytotoxic action of paclitaxel and ceramide against the human Tu138 head and neck squamous carcinoma cell line. Cancer Chemother. Pharmacol. 48 (2000) 85-92
87. Michael C., and van Echten Deckert G. Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum. FEBS Lett. 416 (1997) 153-155
88. Mitra A.K., and Agrawal D.K. In stent restenosis: bane of the stent era. J. Clin. Pathol. 59 (2006) 232-239
89. Morita Y., Perez G.I., Paris F., Miranda S.R., Ehleiter D., and Haimovitz-Friedman A. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate pathway. Nat. Med. 6 (2000) 1109-1114
90. Nilsson A., and Duan R.D. Alkaline sphingomyelinases and ceramidases of the gastrointestinal tract. Chem. Phys. Lipids 102 (1999) 97-105
91. Park J., Kim S.H., Li Q., Chang Y.T., and Kim T.S. Inhibition of interleukin-4 production in activated T cells via the downregulation of AP-1/NF-AT activation by N-lauroyl-d-erythro-sphingosine and N-lauroyl-d-erythro-C20-sphingosine. Biochem. Pharmacol. 71 (2006) 1229-1239
92. Pelled D., Raveh T., Riebeling C., Fridkin M., Berissi H., Futerman A.H., and Kimchi A. Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons. J. Biol. Chem. 277 (2002) 1957-1961
93. Perez G.I., Jurisicova A., Matikainen T., Moriyama T., Kim M.R., Takai Y., Pru J.K., Kolesnick R.N., and Tilly J.L. A central role for ceramide in the age-related acceleration of apoptosis in the female germline. FASEB J. 19 (2005) 860-862
94. Perry R.J., and Ridgway N.D. Molecular mechanisms and regulation of ceramide transport. Biochim. Biophys. Acta 1734 (2005) 220-234
95. Quillet-Mary A., Jaffrezou J.P., Mansat V., Bordier C., Naval J., and Laurent G. Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J. Biol. Chem. 272 (1997) 21388-21395
96. Raya A., Revert F., Navarro S., and Saus J. Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human good pasture antigen. J. Biol. Chem. 274 (1999) 12642-12649
97. Raymond M.N., and Le Stunff H. Involvement of de novo ceramide biosynthesis in macrophage death induced by activation of ATP-sensitive P2X7 receptor. FEBS Lett. 580 (2006) 131-136
98. Riboni L., Viani P., Bassi R., Prinetti A., and Tettamanti G. The role of sphingolipids in the process of signal transduction. Prog. Lipid Res. 36 (1997) 153-195
99. Ruvolo P.P., Gao F.G., Blalock W.L., Deng X., and Stratford May W. Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX. J. Biol. Chem. 276 (2001) 11754-11765
100. Samet D., and Barenholz Y. Characterization of acid and neutral sphingomyelinase activities in crude extracts of HL-60 cells. Chem. Phys. Lipids 102 (1999) 65-77
101. Scheel-Toellner D., Wang K., Craddock R., Webb P.R., Mc Gettrick H.M., Assi L.K., Parkes N., Clough L.E., Gulbins E., Salmon M., and Lord J.M. Reactive oxygen species limit neutrophil life span by activating death receptor signaling. Blood 104 (2004) 2557-2564
102. Scheid M.P., Foltz I.N., Young P.R., Schrader J.W., and Duronio V. Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival. Blood 93 (1999) 217-225
103. Schissel S.L., Jiang X., Tweedie-Hardman J., Jeong T., Camejo E.H., Najib J., Rapp J.H., Williams K.J., and Tabas I. Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. J. Biol. Chem. 273 (1998) 2738-2746
104. Sciorati C., Rovere P., Ferrarini M., Paulucci C., Heltai S., Vaiani R., Clementi E., and Manfredi M. Generation of nitric oxide by the inducible nitric oxide synthase protects gamma delta T cells from Mycobacterium tuberculosis-induced apoptosis. J. Immunol. 163 (1999) 1570-1576
105. Selzner M., Bielawska A., Morse M.A., Rudiger H.A., Sindram D., Hannun Y.A., and Clavien P.A. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res. 61 (2001) 1233-1240
106. Senchenkov A., Litvak D.A., and Cabot M.C. Targeting ceramide metabolism-A strategy overcoming drug resistance. J. Natl. Cancer Inst. 93 (2001) 347-357
107. Shimazawa M., Kondo K., Hara H., Nakashima M., and Umemura K. Sulfatides, L- and P-selectin ligands, exacerbate the intimal hyperplasia occurring after endothelial injury. Eur. J. Pharmacol. 520 (2005) 118-126
108. Shirakabe K., Yamaguchi K., Shibuya H., Irie K., Matsuda S., Moriguchi T., Gotoh Y., Matsumoto K., and Nishida E. TAK 1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase. J. Biol. Chem. 272 (1997) 8141-8144
109. Soeda S., Honda O., Shimeno H., and Nagamatsu A. Sphingomyelinase and cell-permeable ceramide analogs increase the release of plasminogen activator inhibitor-1 from cultured endothelial cells. Thromb. Res. 80 (1995) 509-518
110. Soreghan B., Thomas S.N., and Yang A.J. Aberrant sphingomyelin/ceramide metabolic-induced neuronal endosomal/lysosomal dysfunction: potential pathological consequences in age-related neurodegeneration. Adv. Drug Delivery Rev. 55 (2003) 1515-1524
111. Spiegel S., and Milstein S. Sphingosine 1-phosphate, a key cell signaling molecule. J. Biol. Chem. 277 (2002) 25851-25854
112. Tabas I. Secretory sphingomyelinase. Chem. Phys. Lipids 102 (1999) 123-130
113. Taha T.A., Kitatani K., El-Alwani M., Bielawski J., Hannun Y.A., and Obeid L.M. Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J. 20 (2006) 482-484
114. Takeda Y., Tashima M., Takahashi A., Uchiyama T., and Ukazaki T. Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3. J. Biol. Chem. 274 (1999) 10654-10660
115. Takeda S., Mitsutake S., Tsuji K., and Igarashi Y. Apoptosis occurs via the ceramide recycling pathway in human HaCaT keratinocytes. J. Biochem. 139 (2006) 255-262
116. Tsujishita Y., and Hurley J.H. Structure and lipid transport mechanism of a StAR-related domain. Nat. Struct. Biol. 7 (2000) 408-414
117. Turnbull K.J., Brown B.L., and Dobson P.R. Caspase-3-like activity is necessary but not sufficient for daunorubicin-induced apoptosis in Jurkat human lymphoblastic leukemia cells. Leukemia 13 (1999) 1056-1061
118. Vallee B., and Riezman H. Lip 1p: a novel subunit of Acyl-Co A ceramide synthase. EMBO J. 24 (2005) 730-741
119. Vazquez-Boland J.A., Kuhn M., Berche P., Chakraborty T., Dominguez-Bernal G., Goebel W., Gonzalez-Zorn B., Wehland J., and Kreft J. Listeria pathogenesis and molecular virulence determinants. Clin. Microbiol. Rev. 14 (2001) 584-640
120. Verheij M., Bose R., Lin X.H., Yao B., Jarvis W.D., Grant S., Birrer M.J., Szabo E., Zon L.I., Kyriakis J.M., Haimovitz-Friedman A., Fuks Z., and Kolesnick R. Requirement for ceramide-initiated SAPK/JNK signaling in stress-induced apoptosis. Nature 380 (1996) 75-79
121. Voelkel Johnson C., Hannan Y.A., and El-Zawahry A. Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. Mol. Cancer Ther. 4 (2005) 1320-1327
122. Wang E., Norred W.P., Bacon C.W., and Riley R.T. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J. Biol. Chem. 266 (1991) 14486-14490
123. Wu S.N., Lo Y.K., Kuo B.I., and Chiang H.T. Ceramide inhibits the inwardly rectifying potassium current in GH(3) lactotrophs. Endocrinology 142 (2001) 4785-4794
124. Wyles J.P., Mc Master C.R., and Ridgway N.D. Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with oxysterol-binding protein to modify export from the endoplasmic reticulum. J. Biol. Chem. 277 (2002) 29908-29918
125. Yan F., and Polk D.B. Kinase suppressor of ras is necessary for tumor necrosis factor alpha activation of extracellular ligand-regulated kinase/mitogen-activated protein kinase in intestinal epithelial cells. Cancer Res. 61 (2001) 963-969
126. Yeh L.H., Kiney A.M., Chatterjee S., and Alevriadou B.R. Lactosylceramide mediates shear-induced endothelial superoxide production and intercellular adhesion molecule-1 expression. J. Vasc. Res. 38 (2001) 551-559
127. Yi F., Zhang A.Y., Janscha J.L., Li P.L., and Zou A.P. Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cells. Kidney Int. 66 (2004) 1977-1987
128. Zhang J., Alter N., Reed J.C., Borner C., Obeid L.M., and Hannun Y.A. Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 5325-5328
129. Zhang Y., Yao B., Delikat S., Bayoumy S., Lin X.H., Basu S., Mc Ginley M., Chan-Hui P.Y., Linchenstein H., and Kolesnick R. Kinase suppressor of Ras is ceramide-activated protein kinase. Cell 89 (1997) 63-72
130. Zhang D.X., Yi F.X., Zou A.P., and Li P.L. Role of ceramide in TNF-alpha-induced impairment of endothelium-dependent vasorelaxation in coronary arteries. Am. J. Physiol.: Heart Circ. Physiol. 283 (2002) H1785-H1794
131. Zhang D.X., Zou A.P., and Li P.L. Ceramide-induced activation of NADPH oxidase and endothelial dysfunction in small coronary arteries. Am. J. Physiol. Heart Circ. Physiol. 284 (2003) H605-H612
132. 2* production in intact coronary endothelium. Am. J. Physiol.: Heart Circ. Physiol. 288 (2005) H686-H694