Inhibition of interleukin-4 production in activated T cells via the downregulation of AP-1/NF-AT activation by N-lauroyl-D-erythro-sphingosine and N-lauroyl-D-erythro-C20-sphingosine

Biochemical Pharmacology

Volumn 71, Issue 8, 2006, Pages 1229-1239

  Park, Jin ^a   Kim, Seung Hyun ^a   Li, Qian ^b   Chang, Young Tae ^b   Kim, Tae Sung ^a  

^a Korea University   (South Korea)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

Activating protein 1; Allergy; Ceramide; Interleukin 4; Nuclear factor of activated T cell; T cells

Indexed keywords

CERAMIDE DERIVATIVE; DNA; INTERLEUKIN 4; N LAUROYL DEXTRO ERYTHRO C 20 SPHINGOSINE; N LAUROYL DEXTRO ERYTHROSPHINGOSINE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; SPHINGOSINE DERIVATIVE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NF AT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; GENE ACTIVITY; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN TARGETING; T LYMPHOCYTE ACTIVATION; THYMOMA;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CERAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; NFATC TRANSCRIPTION FACTORS; STEREOISOMERISM; TRANSCRIPTION FACTOR AP-1;

EID: 33644823225     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.12.036     Document Type: Article

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