Inhibitory actions of ceramide upon PKC-ε/ERK interactions

American Journal of Physiology - Cell Physiology

Volumn 280, Issue 6 49-6, 2001, Pages

  Bourbon, Nicole A ^a   Yun, Jong ^a   Berkey, Danielle ^a   Wang, Yizheng ^b   Kester, Mark ^a,c  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Ceramide; Extracelular signal regulated kinase; Mitogen activated protein kinase; Protein kinase C; Raf 1

Indexed keywords

CERAMIDE; ENZYME ACTIVATOR; GROWTH FACTOR; INTERLEUKIN 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; RAF PROTEIN; RECOMBINANT ENZYME; SOMATOMEDIN;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; EMBRYO CELL; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MITOGENESIS; PERICYTE; PRIORITY JOURNAL; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

EID: 0034979181     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2001.280.6.c1403     Document Type: Article

References (35)

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4. PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase
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9. Routing MAP kinase cascades
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15. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation
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18. Opioid peptides activate phospholipase D and protein kinase C-epsilon in chicken embryo neuron cultures
19. Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta
20. Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity
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22. Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling
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24. Identification of ceramide targets in interleukin-1 and tumor necrosis factor-alpha signaling in mesangial cells
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26. Ceramide- induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis
27. MPI: A MEK binding partner that enhances enzymatic activation of the MAP kinase cascade
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29. Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization
30. The synergistic effect of PDGF-AA and IGF-1 on VSMC proliferation might be explained by the differential activation of their intracellular signaling pathways
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33. A mammalian scaffold complex that selectively mediates MAP kinase activation
34. Phosphorylation of Raf by ceramide-activated protein kinase
35. Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK