Structure and function of latency-associated nuclear antigen

Current Topics in Microbiology and Immunology

Volumn 312, Issue , 2007, Pages 101-136

  Verma, S C ^a   Lan, K ^a   Robertson, E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; BETA CATENIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; INHIBITOR OF DIFFERENTIATION PROTEIN; LATENCY ASSOCIATED NUCLEAR ANTIGEN; LYMPHOID ENHANCER FACTOR; MESSENGER RNA; NUCLEAR PROTEIN; PROTEIN P300; PROTEIN P53; RETINOBLASTOMA PROTEIN; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN; WNT PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HISTONE ACETYLTRANSFERASE PCAF; LATENCY-ASSOCIATED NUCLEAR ANTIGEN; VIRUS ANTIGEN;

AMINO TERMINAL SEQUENCE; ANTIGEN FUNCTION; ANTIGEN STRUCTURE; CANCER INHIBITION; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL DIVISION; CELL GROWTH; CELL NUCLEUS; CELL TRANSFORMATION; CHROMOSOME; DEREGULATION; DNA BINDING; DNA REPLICATION; DNA SEQUENCE; EPISOME; FIBROBLAST; GENE CONTROL; GENE FUNCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; GENOME; HUMAN; HUMAN HERPESVIRUS 8; LATENT PERIOD; MOLECULAR WEIGHT; NONHUMAN; NUCLEOSOME; ONCOGENE; OPEN READING FRAME; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; UPREGULATION; VIRUS LATENCY; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; PATHOGENICITY; PHYSIOLOGY; PLASMID; VIRUS REPLICATION;

HUMAN HERPESVIRUS 8; RATTUS;

ANIMALS; ANTIGENS, VIRAL; BETA CATENIN; CELL CYCLE; CELL DIFFERENTIATION; DNA REPLICATION; GLYCOGEN SYNTHASE KINASE 3; HERPESVIRUS 8, HUMAN; HUMANS; NUCLEAR PROTEINS; P300-CBP TRANSCRIPTION FACTORS; PLASMIDS; RETINOBLASTOMA PROTEIN; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53; VIRUS LATENCY; VIRUS REPLICATION;

EID: 34247618075     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-540-34344-8_4     Document Type: Review

References (168)

1. Alani RM, Young AZ, Shifflett CB (2001) Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a. Proc Natl Acad Sci USA 98:7812-7816
2. Albrecht JC, Nicholas J, Biller D, Cameron KR, Biesinger B, Newman C, Wittmann S, Craxton MA, Coleman H, Fleckenstein B, et al. (1992) Primary structure of the herpesvirus saimiri genome. J Virol 66:5047-5058
3. Ambros V (2004) The functions of animal microRNAs. Nature 431:350-355
4. An FQ, Compitello N, Horwitz E, Sramkoski M, Knudsen ES, Renne R (2005) The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrest. J Biol Chem 280:3862-3874
5. An J, Lichtenstein AK, Brent G, Rettig MB (2002) The Kaposi sarcoma-associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response element. Blood 99:649-654
6. Apone LM, Virbasius CM, Reese JC, Green MR (1996) Yeast TAF(II)90 is required for cell-cycle progression through G2/M but not for general transcription activation. Genes Dev 10:2368-2380
7. Ballestas ME, Chatis PA, Kaye KM (1999a) Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science 284:641-644
8. Ballestas ME, Chatis PA, Kaye KM (1999b) Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science 284:641-644
9. Ballestas ME, Kaye KM (2001) Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA. J Virol 75:3250-3258
10. Barbera AJ, Ballestas ME, Kaye KM (2004) The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 N terminus is essential for chromosome association, DNA replication, and episome persistence. J Virol 78:294-301
11. Barker N, Morin PJ, Clevers H (2000) The Yin-Yang of TCF/β-catenin signaling. Adv Cancer Res 77:1-24
12. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281-297
13. Bechtel JT, Liang Y, Hvidding J, Ganem D (2003) Host range of Kaposi's sarcoma-associated herpesvirus in cultured cells. J Virol 77:6474-6481
14. Bechtel JT, Winant RC, Ganem D (2005) Host and viral proteins in the virion of Kaposi's sarcoma-associated herpesvirus. J Virol 79:4952-4964
15. Beck S, Hanson I, Kelly A, Pappin DJ, Trowsdale J (1992) A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC. DNA Seq 2:203-210
16. Benezra R, Davis RL, Lockshon D, Turner DL, Weintraub H (1990) The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61:49-59
17. Borah S, Verma SC, Robertson ES (2004) ORF73 of herpesvirus saimiri, a viral homolog of Kaposi's sarcoma-associated herpesvirus, modulates the two cellular tumor suppressor proteins p53 and pRb. J Virol 78:10336-10347
18. Boshoff C (2003) Kaposi virus scores cancer coup. Nat Med 9:261-262
19. Boshoff C, Schulz TF, Kennedy MM, Graham AK, Fisher C, Thomas A, McGee JO, Weiss RA, O'Leary JJ (1995) Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med 1:1274-1278
20. Boulikas T (1993) Nuclear localization signals (NLS). Crit Rev Eukaryot Gene Expr 3:193-227
21. Cannon M, Philpott NJ, Cesarman E (2003) The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor has broad signaling effects in primary effusion lymphoma cells. J Virol 77:57-67
22. Cesarman E, Nador RG, Bai F, Bohenzky RA, Russo JJ, Moore PS, Chang Y, Knowles DM (1996) Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma. J Virol 70:8218-8223
23. Chang J, Renne R, Dittmer D, Ganem D (2000) Inflammatory cytokines and the reactivation of Kaposi's sarcoma-associated herpesvirus lytic replication. Virology 266:17-25
24. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266:1865-1869
25. Chen X, Ko LJ, Jayaraman L, Prives C (1996) p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev 10:2438-2451
26. Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365:855-859
27. Cloutier N, Gravel A, Flamand L (2004) Multiplex detection and quantitation of latent and lytic transcripts of human herpesvirus-8 using RNase protection assay. J Virol Methods 122:1-7
28. Cotter MA 2nd, Robertson ES (1999) The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells. Virology 264:254-264
29. Cotter MA 2nd, Subramanian C, Robertson ES (2001) The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen binds to specific sequences at the left end of the viral genome through its carboxy-terminus. Virology 291:241-259
30. Couty JP, Geras-Raaka E, Weksler BB, Gershengorn MC (2001) Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor signals through multiple pathways in endothelial cells. J Biol Chem 276:33805-33811
31. Deng H, Young A, Sun R (2000) Auto-activation of the rta gene of human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus. J Gen Virol 81:3043-3048
32. Denis GV, Green MR (1996) A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator. Genes Dev 10:261-271
33. Denis GV, Vaziri C, Guo N, Faller DV (2000) RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. Cell Growth Differ 11:417-424
34. DeWire SM, Damania B (2005) The latency-associated nuclear antigen of rhesus monkey rhadinovirus inhibits viral replication through repression of Orf50/Rta transcriptional activation. J Virol 79:3127-3138
35. Dhar SK, Yoshida K, Machida Y, Khaira P, Chaudhuri B, Wohlschlegel JA, Leffak M, Yates J, Dutta A (2001) Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin. Cell 106:287-296
36. Dittmer D, Lagunoff M, Renne R, Staskus K, Haase A, Ganem D (1998) A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus. J Virol 72:8309-8315
37. Dittmer D, Stoddart C, Renne R, Linquist-Stepps V, Moreno ME, Bare C, McCune JM, Ganem D (1999) Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice. J Exp Med 190:1857-1868
38. Dittmer DP (2003) Transcription profile of Kaposi's sarcoma-associated herpesvirus in primary Kaposi's sarcoma lesions as determined by real-time PCR arrays. Cancer Res 63:2010-2015
39. Dupin N, Fisher C, Kellam P, Ariad S, Tulliez M, Franck N, vanMarck E, Salmon D, Gorin I, Escande JP, Weiss RA, Alitalo K, Boshoff C (1999) Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma. Proc Natl Acad Sci USA 96:4546-4551
40. Dyson N(1998) The regulation of E2F by pRB-family proteins. Genes Dev 12:2245-2262
41. Ensser A, Pflanz R, Fleckenstein B (1997) Primary structure of the alcelaphine herpesvirus 1 genome. J Virol 71:6517-6525
42. Fakhari FD, Dittmer DP (2002) Charting latency transcripts in Kaposi's sarcoma-associated herpesvirus by whole-genome real-time quantitative PCR. J Virol 76:6213-6223
43. Flore O, Rafii S, Ely S, O'Leary JJ, Hyjek EM, Cesarman E (1998) Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus. Nature 394:588-592
44. Friborg J, Jr., Kong W, Hottiger MO, Nabel GJ (1999) p53 inhibition by the LANA protein of KSHV protects against cell death. Nature 402:889-894
45. Friend S (1994) p53: a glimpse at the puppet behind the shadow play. Science 265:334-335
46. Fujimuro M, Hayward SD (2003) The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus manipulates the activity of glycogen synthase kinase-3β. J Virol 77:8019-8030
47. Fujimuro M, Hayward SD (2004) Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers. J Mol Med 82:223-231
48. Fujimuro M, Wu FY, ApRhys C, Kajumbula H, Young DB, Hayward GS, Hayward SD (2003) A novel viral mechanism for dysregulation of β-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nat Med 9:300-306
49. Fukushi M, Higuchi M, Oie M, Tetsuka T, Kasolo F, Ichiyama K, Yamamoto N, Katano H, Sata T, Fujii M (2003) Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon α. Virus Genes 27: 237-247
50. Gao SJ, Kingsley L, Li M, Zheng W, Parravicini C, Ziegler J, Newton R, Rinaldo CR, Saah A, Phair J, Detels R, Chang Y, Moore PS (1996) KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med 2:925-928
51. Gao SJ, Zhang YJ, Deng JH, Rabkin CS, Flore O, Jenson HB (1999) Molecular polymorphism of Kaposi's sarcoma-associated herpesvirus (Human herpesvirus 8) latent nuclear antigen: evidence for a large repertoire of viral genotypes and dual infection with different viral genotypes. J Infect Dis 180:1466-1476
52. Glaunsinger B, Ganem D (2004) Lytic KSHV infection inhibits host gene expression by accelerating global mRNA turnover. Mol Cell 13:713-723
53. Glenn M, Rainbow L, Aurade F, Davison A, Schulz TF (1999) Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus. J Virol 73:6953-6963
54. Godfrey A, Anderson J, Papanastasiou A, Takeuchi Y, Boshoff C (2005) Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA. Blood 105:2510-2518
55. Greider CW (1991a) Chromosome first aid. Cell 67:645-647
56. Greider CW (1991b) Telomerase is processive. Mol Cell Biol 11:4572-4580
57. Groves AK, Cotter MA, Subramanian C, Robertson ES (2001) The latency-associated nuclear antigen encoded by Kaposi's sarcoma-associated herpesvirus activates two major essential Epstein-Barr virus latent promoters. J Virol 75:9446-9457
58. Grundhoff A, Ganem D (2001) Mechanisms governing expression of the v-FLIP gene of Kaposi's sarcoma-associated herpesvirus. J Virol 75:1857-1863
59. Grundhoff A, Ganem D (2003) The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus permits replication of terminal repeat-containing plasmids. J Virol 77:2779-2783
60. Guo N, Faller DV, Denis GV (2000) Activation-induced nuclear translocation of RING3. J Cell Sci 113 (Pt 17): 3085-3091
61. Gwack Y, Byun H, Hwang S, Lim C, Choe J (2001) CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50. J Virol 75:1909-1917
62. Harrington LA, Greider CW (1991) Telomerase primer specificity and chromosome healing. Nature 353:451-454
63. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, daCosta LT, Morin PJ, Vogelstein B, Kinzler KW (1998) Identification of c-MYC as a target of the APC pathway. Science 281:1509-1512
64. Hollnagel A, Oehlmann V, Heymer J, Ruther U, Nordheim A (1999) Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J Biol Chem 274:19838-19845
65. Hollstein M, Sidransky D, Vogelstein B, Harris CC (1991) p53 mutations in human cancers. Science 253:49-53
66. Hu J, Garber AC, Renne R (2002) The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells. J Virol 76:11677-11687
67. Hu J, Renne R (2005) Characterization of the minimal replicator of Kaposi's sarcoma-associated herpesvirus latent origin. J Virol 79:2637-2642
68. Hyun TS, Subramanian C, Cotter MA, 2nd, Thomas RA, Robertson ES (2001) Latency-associated nuclear antigen encoded by Kaposi's sarcoma-associated herpesvirus interacts with Tat and activates the long terminal repeat of human immunodeficiency virus type 1 in human cells. J Virol 75:8761-8771
69. Iyer NG, Ozdag H, Caldas C (2004) p300/CBP and cancer. Oncogene 23:4225-4231
70. Jay G, Khoury G, DeLeo AB, Dippold WG, Old LJ (1981) p53 transformation-related protein: detection of an associated phosphotransferase activity. Proc Natl Acad Sci USA 78:2932-2936
71. Jenner RG, Alba MM, Boshoff C, Kellam P (2001) Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arrays. JVirol 75:891-902
72. Jeong J, Papin J, Dittmer D (2001) Differential regulation of the overlapping Kaposi's sarcoma-associated herpesvirus vGCR (orf74) and LANA (orf73) promoters. J Virol 75:1798-1807
73. Jeong JH, Hines-Boykin R, Ash JD, Dittmer DP (2002) Tissue specificity of the Kaposi's sarcoma-associated herpesvirus latent nuclear antigen (LANA/orf73) promoter in transgenic mice. J Virol 76:11024-11032
74. Jeong JH, Orvis J, Kim JW, McMurtrey CP, Renne R, Dittmer DP (2004) Regulation and autoregulation of the promoter for the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Biol Chem 279:16822-16831
75. Johnstone RW, Trapani JA (1999) Transcription and growth regulatory functions of the HIN-200 family of proteins. Mol Cell Biol 19:5833-5838
76. Jones MH, Numata M, Shimane M (1997) Identification and characterization of BRDT: a testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh. Genomics 45:529-534
77. Katano H, Sato Y, Kurata T, Mori S, Sata T (1999) High expression of HHV-8-encoded ORF73 protein in spindle-shaped cells of Kaposi's sarcoma. Am J Pathol 155:47-52
78. Katano H, Sato Y, Kurata T, Mori S, Sata T (2000) Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease. Virology 269:335-344
79. Kedes DH, Lagunoff M, Renne R, Ganem D (1997) Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. J Clin Invest 100:2606-2610
80. Kellam P, Boshoff C, Whitby D, Matthews S, Weiss RA, Talbot SJ (1997) Identification of a major latent nuclear antigen, LNA-1, in the human herpesvirus 8 genome. J Hum Virol 1:19-29
81. Kiess M, Gill RM, Hamel PA (1995) Expression and activity of the retinoblastoma protein (pRB)-family proteins, p107 and p130, during L6myoblast differentiation. Cell Growth Differ 6:1287-1298
82. Kitagawa M, Hatakeyama S, Shirane M, Matsumoto M, Ishida N, Hattori K, Nakamichi I, Kikuchi A, Nakayama K, Nakayama K (1999) An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin. EMBO J 18:2401-2410
83. Knight JS, Cotter MA, 2nd, Robertson ES (2001) The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus transactivates the telomerase reverse transcriptase promoter. J Biol Chem 276:22971-22978
84. Ko LJ, Prives C (1996) p53: puzzle and paradigm. Genes Dev 10:1054-1072
85. Komatsu T, Ballestas ME, Barbera AJ, Kelley-Clarke B, Kaye KM (2004) KSHV LANA1 binds DNA as an oligomer and residues N-terminal to the oligomerization domain are essential for DNA binding, replication, and episome persistence. Virology 319:225-236
86. Krishnan HH, Naranatt PP, Smith MS, Zeng L, Bloomer C, Chandran B (2004) Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. J Virol 78:3601-3620
87. Krithivas A, Fujimuro M, Weidner M, Young DB, Hayward SD (2002) Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes. J Virol 76:11596-11604
88. Krithivas A, Young DB, Liao G, Greene D, Hayward SD (2000) Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. J Virol 74:9637-9645
89. Lagunoff M, Bechtel J, Venetsanakos E, Roy AM, Abbey N, Herndier B, McMahon M, Ganem D (2002) De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells. J Virol 76:2440-2448
90. Lan K, Kuppers DA, Robertson ES (2005a) Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jκ, the major downstream effector of the Notch signaling pathway. J Virol 79:3468-3478
91. Lan K, Kuppers DA, Verma SC, Robertson ES (2004) Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latency. J Virol 78:6585-6594
92. Lan K, Kuppers DA, Verma SC, Sharma N, Murakami M, Robertson ES (2005b) Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: a novel mechanism for establishment of latency. J Virol 79:7453-7465
93. Langlands K, Down GA, Kealey T (2000) Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma. Cancer Res 60:5929-5933
94. Lee H, Veazey R, Williams K, Li M, Guo J, Neipel F, Fleckenstein B, Lackner A, Desrosiers RC, Jung JU (1998) Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus. Nat Med 4:435-440
95. Lennette ET, Blackbourn DJ, Levy JA (1996) Antibodies to human herpesvirus type 8 in the general population and in Kaposi's sarcoma patients. Lancet 348:858-861
96. Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88:323-331
97. Liang Y, Chang J, Lynch SJ, Lukac DM, Ganem D (2002) The lytic switch protein of KSHVactivates gene expression via functional interaction with RBP-Jκ (CSL), the target of the Notch signaling pathway. Genes Dev 16:1977-1989
98. Liang Y, Ganem D (2003) Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling. Proc Natl Acad Sci USA 100:8490-8495
99. Lim C, Gwack Y, Hwang S, Kim S, Choe J (2001) The transcriptional activity of cAMP response element-binding protein-binding protein is modulated by the latency associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Biol Chem 276:31016-31022
100. Lim C, Sohn H, Gwack Y, Choe J (2000) Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity. J Gen Virol 81:2645-2652
101. Lim C, Sohn H, Lee D, Gwack Y, Choe J (2002) Functional dissection of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated herpesvirus involved in latent DNA replication and transcription of terminal repeats of the viral genome. J Virol 76:10320-10331
102. Lin CQ, Singh J, Murata K, Itahana Y, Parrinello S, Liang SH, Gillett CE, Campisi J, Desprez PY (2000) A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells. Cancer Res 60:1332-1340
103. Low W, Harries M, Ye H, Du MQ, Boshoff C, Collins M (2001) Internal ribosome entry site regulates translation of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein. J Virol 75:2938-2945
104. Lukac DM, Kirshner JR, Ganem D (1999) Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J Virol 73:9348-9361
105. Lukac DM, Renne R, Kirshner JR, Ganem D (1998) Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology 252:304-312
106. Mattsson K, Kiss C, Platt GM, Simpson GR, Kashuba E, Klein G, Schulz TF, Szekely L (2002) Latent nuclear antigen of Kaposi's sarcoma herpesvirus/human herpesvirus-8 induces and relocates RING3 to nuclear heterochromatin regions. J Gen Virol 83:179-188
107. Mesri EA, Cesarman E, Arvanitakis L, Rafii S, Moore MA, Posnett DN, Knowles DM, Asch AS (1996) Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells. J Exp Med 183:2385-2390
108. Nador RG, Milligan LL, Flore O, Wang X, Arvanitakis L, Knowles DM, Cesarman E (2001) Expression of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor monocistronic and bicistronic transcripts in primary effusion lymphomas. Virology 287:62-70
109. Nakamura H, Lu M, Gwack Y, Souvlis J, Zeichner SL, Jung JU (2003) Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivator. J Virol 77:4205-4220
110. Neipel F, Albrecht JC, Fleckenstein B (1997) Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity? J Virol 71:4187-4192
111. Nickoloff BJ, Chaturvedi V, Bacon P, Qin JZ, Denning MF, Diaz MO (2000) Id-1 delays senescence but does not immortalize keratinocytes. J Biol Chem 275:27501-27504
112. Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994) Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res 1:223-229
113. Norton JD (2000) ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci 113 (Pt 22): 3897-3905
114. Parravicini C, Chandran B, Corbellino M, Berti E, Paulli M, Moore PS, Chang Y (2000) Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Am J Pathol 156:743-749
115. Paulose-Murphy M, Ha NK, Xiang C, Chen Y, Gillim L, Yarchoan R, Meltzer P, Bittner M, Trent J, Zeichner S (2001) Transcription program of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). J Virol 75:4843-4853
116. Pearce M, Matsumura S, Wilson AC (2005) Transcripts encoding K12, v-FLIP, v-cyclin, and the microRNA cluster of Kaposi's sarcoma-associated herpesvirus originate from a common promoter. J Virol 79:14457-14464
117. Piolot T, Tramier M, Coppey M, Nicolas JC, Marechal V (2001) Closebut distinct regions of human herpesvirus 8 latency-associated nuclear antigen 1 are responsible for nuclear targeting and binding to human mitotic chromosomes. J Virol 75:3948-3959.
118. Platt GM, Cannell E, Cuomo ME, Singh S, Mittnacht S (2000) Detection of the human herpesvirus 8-encoded cyclin protein in primary effusion lymphoma-derived cell lines. Virology 272:257-266
119. Platt GM, Simpson GR, Mittnacht S, Schulz TF (1999) Latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with RING3, a homolog of the Drosophila female sterile homeotic (fsh) gene. J Virol 73:9789-9795
120. Polakis P (2000) Wnt signaling and cancer. Genes Dev 14:1837-1851
121. Qiu Y, Sharma A, Stein R (1998) p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. Mol Cell Biol 18:2957-2964
122. Radkov SA, Kellam P, Boshoff C (2000) The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nat Med 6:1121-1127
123. Rainbow L, Platt GM, Simpson GR, Sarid R, Gao SJ, Stoiber H, Herrington CS, Moore PS, Schulz TF (1997) The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. J Virol 71:5915-5921
124. Renne R, Barry C, Dittmer D, Compitello N, Brown PO, Ganem D (2001) Modulation of cellular and viral gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Virol 75:458-468
125. Renne R, Blackbourn D, Whitby D, Levy J, Ganem D (1998) Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells. J Virol 72:5182-5188
126. Renne R, Lagunoff M, Zhong W, Ganem D (1996) The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions. J Virol 70:8151-8154
127. Ritzi M, Tillack K, Gerhardt J, Ott E, Humme S, Kremmer E, Hammerschmidt W, Schepers A (2003) Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virus. J Cell Sci 116:3971-3984
128. Russo JJ, Bohenzky RA, Chien MC, Chen J, Yan M, Maddalena D, Parry JP, Peruzzi D, Edelman IS, Chang Y, Moore PS (1996) Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci USA 93:14862-14867
129. Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT (1999) Casein kinase iepsilon in the wnt pathway: regulation of β-catenin function. Proc Natl Acad Sci USA 96:12548-12552
130. Samols MA, Hu J, Skalsky RL, Renne R (2005) Cloning and identificationof a microRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus. J Virol 79:9301-9305
131. Sarid R, Flore O, Bohenzky RA, Chang Y, Moore PS (1998) Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1). J Virol 72:1005-1012
132. Sarid R, Wiezorek JS, Moore PS, Chang Y(1999) Characterization and cell cycle regulation of the major Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) latent genes and their promoter. J Virol 73:1438-1446
133. Schafer A, Lengenfelder D, Grillhosl C, Wieser C, Fleckenstein B, Ensser A (2003) The latency-associated nuclear antigen homolog of herpesvirus saimiri inhibits lytic virus replication. J Virol 77:5911-5925
134. Schalling M, Ekman M, Kaaya EE, Linde A, Biberfeld P (1995) A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma. Nat Med 1:707-708
135. Schiller M, Verrecchia F, Mauviel A (2003) Cyclic adenosine 3′,5′-monophosphate-elevating agents inhibit transforming growth factor-β-induced SMAD3/4-dependent transcription via a protein kinase A-dependent mechanism. Oncogene 22:8881-8890
136. Schindl M, Oberhuber G, Obermair A, Schoppmann SF, Karner B, Birner P (2001) Overexpression of Id-1 protein is a marker for unfavorable prognosis in early-stage cervical cancer. Cancer Res 61:5703-5706
137. Schneider TD (2001) Strong minor groove base conservation in sequence logos implies DNA distortion or base flipping during replication and transcription initiation. Nucleic Acids Res 29:4881-4891
138. Schulz TF (1999) Epidemiology of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. Adv Cancer Res 76:121-160
139. Schwam DR, Luciano RL, Mahajan SS, Wong L, Wilson AC (2000) Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies. J Virol 74:8532-8540
140. Searles RP, Bergquam EP, Axthelm MK, Wong SW (1999) Sequence and genomic analysis of a Rhesus macaque rhadinovirus with similarity to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. J Virol 73:3040-3053
141. Sherr CJ, McCormick F (2002) The RB and p53 pathways in cancer. Cancer Cell 2:103-112
142. Shinohara H, Fukushi M, Higuchi M, Oie M, Hoshi O, Ushiki T, Hayashi J, Fujii M (2002) Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1. J Virol 76:12917-12924
143. Si H, Robertson ES (2006) Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen induces chromosomal instability through inhibition of p53 function. J Virol 80:697-709
144. Srinivasan V, Komatsu T, Ballestas ME, Kaye KM (2004) Definition of sequence requirements for latency-associated nuclear antigen 1 binding to Kaposi's sarcoma-associated herpesvirus DNA. J Virol 78:14033-14038
145. Staskus KA, Zhong W, Gebhard K, Herndier B, Wang H, Renne R, Beneke J, Pudney J, Anderson DJ, Ganem D, Haase AT (1997) Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol 71:715-719
146. Stedman W, Deng Z, Lu F, Lieberman PM (2004) ORC, MCM, and histone hyperacetylation at the Kaposi's sarcoma-associated herpesvirus latent replication origin. J Virol 78:12566-12575
147. Sturzl M, Wunderlich A, Ascherl G, Hohenadl C, Monini P, Zietz C, Browning PJ, Neipel F, Biberfeld P, Ensoli B (1999) Human herpesvirus-8 (HHV-8) gene expression in Kaposi's sarcoma (KS) primary lesions: an in situ hybridization study. Leukemia 13 Suppl 1: S110-112
148. Sun R, Lin SF, Staskus K, Gradoville L, Grogan E, Haase A, Miller G (1999) Kinetics of Kaposi's sarcoma-associated herpesvirus gene expression. J Virol 73:2232-2242
149. Szekely L, Chen F, Teramoto N, Ehlin-Henriksson B, Pokrovskaja K, Szeles A, Manneborg-Sandlund A, Lowbeer M, Lennette ET, Klein G (1998) Restricted expression of Epstein-Barr virus (EBV)-encoded, growth transformation-associated antigens in an EBV- and human herpesvirus type 8-carrying body cavity lymphoma line. J Gen Virol 79 (Pt 6): 1445-1452
150. Szekely L, Kiss C, Mattsson K, Kashuba E, Pokrovskaja K, Juhasz A, Holmvall P, Klein G (1999) Human herpesvirus-8-encoded LNA-1 accumulates in heterochromatin-associated nuclear bodies. J Gen Virol 80 (Pt 11): 2889-2900
151. Talbot SJ, Weiss RA, Kellam P, Boshoff C (1999) Transcriptional analysis of human herpesvirus-8 open reading frames 71, 72, 73, K14, and 74 in a primary effusion lymphoma cell line. Virology 257:84-94
152. Tang J, Gordon GM, Muller MG, Dahiya M, Foreman KE (2003) Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induces expression of the helix-loop-helix protein Id-1 in human endothelial cells. J Virol 77:5975-5984
153. Tomescu C, Law WK, Kedes DH (2003) Surface downregulation of major histocompatibility complex class I, PE-CAM, and ICAM-1 following de novo infection of endothelial cells with Kaposi's sarcoma-associated herpesvirus. J Virol 77:9669-9684
154. Verma SC, Borah S, Robertson ES (2004) Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1. J Virol 78:10348-10359
155. Verma SC, Choudhuri, T., Kaul, R., and Robertson, ES (2006) Latency associated nuclear antigen of Kaposi's sarcoma associated herpesvirus interacts with origin recognition complexes at the LANA binding sequence within the terminal repeats. J Virology 80: In Press
156. Verma SC, Robertson ES (2003) Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus. FEMS Microbiol Lett 222:155-163
157. Viejo-Borbolla A, Ottinger M, Bruning E, Burger A, Konig R, Kati E, Sheldon JA, Schulz TF (2005) Brd2/RING3 interacts with a chromatin-binding domain in the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (LANA-1) that is required for multiple functions of LANA-1. J Virol 79:13618-13629
158. Virgin HW, Latreille P, Wamsley P, Hallsworth K, Weck KE, Dal Canto AJ, Speck SH (1997) Complete sequence and genomic analysis of murine gammaherpesvirus 68. J Virol 71:5894-5904
159. Waltzer L, Bienz M (1998) Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling. Nature 395:521-525
160. Weninger W, Partanen TA, Breiteneder-Geleff S, Mayer C, Kowalski H, Mildner M, Pammer J, Sturzl M, Kerjaschki D, Alitalo K, Tschachler E (1999) Expression of vascular endothelial growth factor receptor-3 and podoplanin
161. Werness BA, Levine AJ, Howley PM (1990)Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248:76-79
162. Willert K, Brink M, Wodarz A, Varmus H, Nusse R (1997) Casein kinase 2 associates with and phosphorylates dishevelled. EMBO J 16:3089-3096
163. Wu WS, Xu ZX, Ran R, Meng F, Chang KS (2002) Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions. Oncogene 21:3925-3933
164. Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD (1999) Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. Embo J 18:968-976
165. Ye FC, Zhou FC, Yoo SM, Xie JP, Browning PJ, Gao SJ (2004) Disruption of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen leads to abortive episome persistence. J Virol 78:11121-11129
166. Zhang YJ, Deng JH, Rabkin C, Gao SJ (2000) Hot-spot variations of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen and application in genotyping by PCR-RFLP. J Gen Virol 81:2049-2058
167. Zhong W, Ganem D (1997) Characterization of ribonucleoprotein complexes containing an abundant polyadenylated nuclear RNA encoded by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8). J Virol 71:1207-1212
168. Zhong W, Wang H, Herndier B, Ganem D (1996) Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci USA 93:6641-6646