Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors

EMBO Journal

Volumn 18, Issue 4, 1999, Pages 968-976

  Yates, Paula R ^a   Atherton, Graham T ^a   Deed, Richard W ^b   Norton, John D ^b   Sharrocks, Andrew D ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

ETS domain proteins; Helix loop helix proteins; Ids; TCFs; Transcription factor

Indexed keywords

DNA BINDING PROTEIN; HELIX LOOP HELIX PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NUCLEOPROTEIN; SERUM RESPONSE FACTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL CYCLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DNA BINDING; DNA PROTEIN COMPLEX; DOWN REGULATION; GENETIC TRANSCRIPTION; MITOGENESIS; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; DNA-BINDING PROTEINS; ETS-DOMAIN PROTEIN ELK-1; ETS-DOMAIN PROTEIN ELK-4; GENE EXPRESSION REGULATION; GENES, FOS; HELIX-LOOP-HELIX MOTIFS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; INHIBITOR OF DIFFERENTIATION PROTEIN 2; INHIBITOR OF DIFFERENTIATION PROTEINS; MICE; NEOPLASM PROTEINS; NUCLEAR PROTEINS; OLIGODEOXYRIBONUCLEOTIDES; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; RNA, MESSENGER; SERUM RESPONSE FACTOR; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0033558030     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.4.968     Document Type: Article

References (52)

1. Barone, M.V., Pepperkok, R., Peverali, F.A. and Philipson, L. (1994) Id proteins control growth induction in mammalian cells. Proc. Natl Acad. Sci. USA, 91, 4985-4988.
2. Benezra, R., Davis, R.L., Lockshon, D., Turner, D.L. and Weintraub, H. (1990) The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell. 61, 49-59.
3. Biggs, J.R., Murphy, E.V. and Israel, M.A. (1992) A human Id-like HLH protein expressed during early development. Proc. Natl Acad. Sci. USA, 89, 1512-1516.
4. Cahill, M.A., Janknecht, R. and Nordheim, A. (1996) Signalling pathways: Jack of all cascades. Curr. Biol., 6, 16-19.
5. Christy, B.A., Sanders, L.K., Lau, L.F., Copeland, N.G., Jenkins, N.A. and Nathans, D. (1991) An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proc. Natl Acad. Sci. USA, 88, 1815-1819.
6. Dalton, S. and Treisman, R. (1992) Characterisation of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. Cell, 68, 597-612.
7. Dang, W., Sun, X.-H. and Sen, R. (1998) ETS-mediated cooperation between basic helix-loop-helix molifs of the immunoglobulin μ heavychain gene enhancer. Mol. Cell. Biol., 18, 1477-1488.
8. Deed, R.W., Bianchi, S.M., Atherton, G.T., Johnston, D., Santibanez-Akaref, M., Murphy, J.J. and Norton, J.D. (1993) An immediate early gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types. Oncogene, 8, 599-607.
9. Deed, R.W., Hara, E., Atherton, G.T., Peters, G. and Norton, J.D. (1997) Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation. Mol. Cell. Biol., 12, 6815-6821.
10. Florio, M., Hernandez, M., Yang, H., Shu, H-K., Cleveland, J.L. and Israel, M.A. (1998) Id2 promotes apoptosis by a novel mechanism independent of dimerisation to basic helix-loop-helix factors. Mol. Cell. Biol., 18, 5435-5444.
11. Gersten, D.M. and Marchalonis, J.J. (1978) A rapid and novel method for the solid-phase derivatization of IgG antibodies for immune-affinity chromatography. J. Immunol. Methods, 24, 305-309.
12. TCF by MAP kinase stimulates ternary complex formation at the c-fos promoter. Nature, 358, 415-417.
13. Gille, H., Kortenjann, M., Thomae, O., Moomaw, C. Slaughter, C., Cobb, M.H. and Shaw, P.E. (1995a) ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J., 14, 951-962.
14. Gille, H., Strahl, T. and Shaw, P.E. (1995b) Activation of ternary complex factor Elk-1 by stress-activated protein kinases. Curr. Biol., 5, 1191-1200.
15. Giovane, A., Pintzas, A., Maira, S.-M. Sobieszcuk, P. and Wasylyk, B. (1994) Net, a new ets transcription factor that is activated by Ras. Genes Dev., 8, 1502-1513.
16. Giovane, A., Sobieszczuk, P., Ayadi, A., Maira, S.-M. and Wasylyk, B. (1997) Net-b, a Ras-inscnsitive factor that forms ternary complexes with the serum response element of the fos promoter. Mol. Cell. Biol., 17, 5667-5678.
17. Goldfarb, A.N., Lewandowska, K. and Pennell, C.A. (1998) Identification of a highly conserved module in E proteins required for in vivo helix-loop-helix dimerization. J. Biol. Chem., 273, 2866-2873.
18. Guan, K. and Dixon, J.E. (1991) Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal. Biochem., 192, 262-267.
19. 1 progression and are repressed in senescent human fibroblasts. J. Biol. Chem., 269, 2139-2145.
20. Herrera, R.E., Shaw, P.E. and Nordheim, A. (1989) Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction. Nature, 340, 68-70.
21. Herschmann, H.R. (1991) Primary response genes induced by growth factors and tumour promoters. Annu. Rev. Biochem., 60, 281-319.
22. Iavarone, A., Garg, P. Lasorella, A. Hsu, J. and Israel, M.A. (1994) The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Genes Dev., 8, 1270-1284.
23. Janknecht, R. and Nordheim, A. (1992) Elk-1 protein domains required for direct and SRF-assisted DNA-binding. Nucleic Acids Res., 20, 3317-3324.
24. Janknecht, R., Zinck, R., Ernst, W.H. and Nordheim, A. (1994) Functional dissection of the transcription factor Elk-1. Oncogene, 9, 1273-1278.
25. Ling, Y., Lakey, J., Roberts, E.C. and Sharrocks, A.D. (1997) Molecular characterisation of the B-box protein-protein interaction motif of the ETS-domain transcription factors Elk-1. EMBO J., 16, 2431-2440.
26. Ling, Y., West, A.G., Roberts, E.C., Lakey, J.H. and Sharrocks, A.D. (1998) Interaction of transcription factors with SRF: identification of the Elk-1 binding surface. J. Biol. Chem., 273, 10506-10514.
27. Lopez, M., Oettgen, P., Akbarali, Y., Dendorfer, U. and Liberman, T.A. (1994) ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization and differential expression during B-lymphocyte development. Mol. Cell. Biol., 14, 3292-3309.
28. Maira, S.-M., Wurtz, J.-M. and Wasylyk, B. (1996) Net (ERP/SAP2), one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif. EMBO J., 15, 5849-5865.
29. Mansour, S.J., Matten, W.T., Hermann, A.S., Candia, J.M., Rong, S., Fukasawa, K., Vande-Woude, G.F. and Ahn, N.G. (1994) Transformation of mammalian cells by constitutively active MAPkinase kinase. Science, 265, 966-970.
30. Marais, R., Wynne, J. and Treisman, R. (1993) The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell, 73, 381-393.
31. Mo, Y., Vaessen, B., Johnston, K. and Marmorstein, R. (1998) Structures of SAP-1 bound to DNA sequences from the E74 and c-fos promoters provide insights into how ETS proteins discriminate between related DNA targets. Mol. Cell. 2, 201-212.
32. Murphy, J.J., Newton, J.S. and Norton, J.D. (1997) Early response genes and B cell activation. In Harnett, M.M. and Righley, K.P. (eds), Lymphocyte Signalling: Mechanisms, Subversion and Manipulation. John Wiley and Sons Ltd, New York, NY, pp. 183-202.
33. Norton, J.D. and Atherton, G.T. (1998) Coupling of cell growth control and apoptosis functions of Id proteins. Mol. Cell. Biol., 18, 2371-2381.
34. Norton, J.D., Deed, R.W., Craggs, G. and Sablitzky, F. (1998) Id helix-loop-helix proteins in cell growth and differentiation. Trends Cell Biol., 8, 58-65.
35. Price, M.A., Rogers, A.E. and Treisman, R. (1995) Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). EMBO J., 14, 2589-2601.
36. Rao, V.N., Huebner, K., Isobe, M., Ab-Rushidi, A., Croce, C.M. and Reddy, E.S.P. (1989) Elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. Science, 244, 66-70.
37. Riechmann, V., van Crüchten, I. and Sablitzky, F. (1994) The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3. Nucleic Acids Res., 22, 749-755.
38. Seth, A., Gonzalez, F.A., Gupta, S., Raden, D.L. and Davis, R.J. (1992) Signal transduction within the nucleus by mitogen-activated protein kinase. J. Biol. Chem., 267, 24796-24804.
39. Sharrocks, A.D., von Hesler, F. and Shaw, P.E. (1993a) The identification of elements determining the different DNA-binding specificities of the MADS box proteins p67SRF and RSRFC4. Nucleic Acids Res., 21, 215-221.
40. SRF: implications for a novel DNA-binding motif. Mol. Cell. Biol., 13, 123-132.
41. Shoji, W., Inoue, T., Yamamoto, T. and Obinata, M. (1995) MIDA1, a protein associated with Id, regulates cell growth. J. Biol. Chem., 270, 24818-24825.
42. Shore, P. and Sharrocks, A.D. (1994) The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1. Mol. Cell. Biol., 14, 3283-3291.
43. Shore, P. and Sharrocks, A.D. (1995) The ETS-domain transcription factors Elk-1 and SAP-1 exhibit differential DNA binding specificities. Nucleic Acids Res., 23, 4698-4706.
44. Shore, P. Whitmarsh, A.J., Bhaskaran, R., Waltho, J., Davis, R.J. and Sharrocks, A.D. (1996) Determinants of DNA binding specificity of ETS-domain transcription factors. Mol. Cell. Biol., 16, 3338-3349.
45. Sieweke, M.H., Tekotte, H., Jarosch, U. and Graf, T. (1998) Cooperative interaction of ETS-1 with USF-1 required for HIV-1 enhancer activity in T cells. EMBO J., 17, 1728-1739.
46. Sun, X.-H., Copeland, N.G., Jenkins, N.A. and Baltimore, D. (1991) Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol. Cell. Biol., 11, 5603-5611.
47. Tournay, O. and Benezra, R. (1996) Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early gene Egr-l. Mol. Cell. Biol., 16, 2418-2430.
48. Treisman, R. (1985) Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences. Cell, 42, 889-902.
49. Treisman, R. (1994) Ternary complex factors: growth regulated transcriptional activators. Curr. Opin. Gen. Dev., 4, 96-101.
50. Watson, D.K., Robinson, L., Hodge, D.R., Kola, I., Papas, T.K. and Seth, A. (1997) FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr 1 promoter serum response elements. Oncogene, 14, 213-221.
51. Yang, S.-H., Whitmarsh, A.J., Davis, R.J. and Sharrocks, A.D. (1998a) The Elk-1ETS-domain transcription factor contains a MAP kinase targeting motif. Mol. Cell. Biol., 18, 710-720.
52. Yang, S.-H., Whitmarsh, A.J., Davis, R.J. and Sharrocks, A.D. (1998b) Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1. EMBO J., 17, 1740-1749.