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Volumn , Issue , 2006, Pages 143-182

The Overview of Studies on Huperzine A: A Natural Drug for the Treatment of Alzheimer's Disease

Author keywords

Acetylcholinesterase inhibitor; Alzheimer's Disease; Clinical trial; Huperzine A; Pharmacology; Plant Resource; Structural biology; Synthesis; ZT 1

Indexed keywords


EID: 34247588402     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/0471739340.ch4     Document Type: Chapter
Times cited : (10)

References (162)
  • 1
    • 84922342912 scopus 로고
    • The structures of huperzines A and B, two new alkaloids exhibiting marked anticholinesterase activity
    • Liu, J. S.; Zhu, Y. L.; Yu, C. M.; Zhou, Y. Z.; Han, Y. Y.; Wu, F. W.; Qi, B. F. The structures of huperzines A and B, two new alkaloids exhibiting marked anticholinesterase activity. Can. J. Chem., 1986, 64: 837-839.
    • (1986) Can. J. Chem. , vol.64 , pp. 837-839
    • Liu, J.S.1    Zhu, Y.L.2    Yu, C.M.3    Zhou, Y.Z.4    Han, Y.Y.5    Wu, F.W.6    Qi, B.F.7
  • 2
    • 0041791389 scopus 로고
    • Structural identification of Fordine
    • Chinese
    • Xu, Z. L.; Chu, B. M.; Luan, X. H.; Wu, W. Z.; Cai, D. G. Structural identification of Fordine. Med. J. Chinese PLA (in Chinese), 1985, 10(4): 263-264.
    • (1985) , vol.10 , Issue.4 , pp. 263-264
    • Xu, Z.L.1    Chu, B.M.2    Luan, X.H.3    Wu, W.Z.4    Cai, D.G.5
  • 3
    • 0022658345 scopus 로고
    • Anticholinesterase activity of huperzine A
    • Wang, Y. E.; Yue, D. X.; Tang, X. C. Anticholinesterase activity of huperzine A. Acta Pharmacol. Sin., 1986, 7(2): 110-113.
    • (1986) Acta Pharmacol. Sin. , vol.7 , Issue.2 , pp. 110-113
    • Wang, Y.E.1    Yue, D.X.2    Tang, X.C.3
  • 4
    • 0032771261 scopus 로고    scopus 로고
    • Huperzine A: a novel acetylcholinesterase inhibitor
    • Tang, X. C.; He, X. C.; Bai, D. L. Huperzine A: a novel acetylcholinesterase inhibitor. Drugs Future, 1999, 24(6): 647-663.
    • (1999) Drugs Future , vol.24 , Issue.6 , pp. 647-663
    • Tang, X.C.1    He, X.C.2    Bai, D.L.3
  • 5
    • 0001228360 scopus 로고    scopus 로고
    • Pharmacological profile of huperzine A, a novel acetylcholinesterase inhibitor from Chinese herb
    • Tang, X. C.; Han, Y. F. Pharmacological profile of huperzine A, a novel acetylcholinesterase inhibitor from Chinese herb. CNS Drug Rev., 1999, 5 (3): 281-300.
    • (1999) CNS Drug Rev. , vol.5 , Issue.3 , pp. 281-300
    • Tang, X.C.1    Han, Y.F.2
  • 6
    • 0345034775 scopus 로고    scopus 로고
    • Chemistry, pharmacology, and clinical efficacy of chinese nootropic agent huperzine A
    • Kozikowski, A. P.; Tuckmantel W. Chemistry, pharmacology, and clinical efficacy of chinese nootropic agent huperzine A. Acc. Chem. Res., 1999, 32: 641-650.
    • (1999) Acc. Chem. Res. , vol.32 , pp. 641-650
    • Kozikowski, A.P.1    Tuckmantel, W.2
  • 7
    • 0034098365 scopus 로고    scopus 로고
    • Huperzine A, potential therapeutic agent for treatment of Alzheimer's disease
    • Bai, D. L.; Tang, X. C.; He, X. C. Huperzine A, potential therapeutic agent for treatment of Alzheimer's disease. Curr. Med. Chem., 2000, 7: 355-374.
    • (2000) Curr. Med. Chem. , vol.7 , pp. 355-374
    • Bai, D.L.1    Tang, X.C.2    He, X.C.3
  • 8
    • 0141930683 scopus 로고    scopus 로고
    • Progress in synthesis and structural modification of huperzine A
    • Zeng, F. X.; Jiang, H. L.; Yang, Y. S.; Chen, K. X.; Ji, R. Y. Progress in synthesis and structural modification of huperzine A. Prog. Chem., 2000, 12 (1): 63-76.
    • (2000) Prog. Chem. , vol.12 , Issue.1 , pp. 63-76
    • Zeng, F.X.1    Jiang, H.L.2    Yang, Y.S.3    Chen, K.X.4    Ji, R.Y.5
  • 9
    • 0043204247 scopus 로고    scopus 로고
    • The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease
    • Zangara, A. The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease. Pharmarcol. Biochem. Behav., 2003, 75 (3): 675-686.
    • (2003) Pharmarcol. Biochem. Behav. , vol.75 , Issue.3 , pp. 675-686
    • Zangara, A.1
  • 10
    • 0141953955 scopus 로고    scopus 로고
    • Progress in clinic, pharmacological, chemical and structural biological studies of huperzine A: a drug of traditional Chinese medicine origin for the treatment of Alzheimer's disease
    • Jiang, H. L.; Bai, D. L.; Luo, X. M. Progress in clinic, pharmacological, chemical and structural biological studies of huperzine A: a drug of traditional Chinese medicine origin for the treatment of Alzheimer's disease. Curr. Med. Chem., 2003, 10: 2231-2252.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 2231-2252
    • Jiang, H.L.1    Bai, D.L.2    Luo, X.M.3
  • 11
    • 0037038813 scopus 로고    scopus 로고
    • Amyloidosis and Alzheimer's disease
    • Ghiso, J.; Frangione, B. Amyloidosis and Alzheimer's disease. Adv. Drug Deliver Rev., 2002, 54: 1539-1551.
    • (2002) Adv. Drug Deliver Rev. , vol.54 , pp. 1539-1551
    • Ghiso, J.1    Frangione, B.2
  • 13
    • 0028270519 scopus 로고
    • A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease.
    • Knapp, M. J.; Knopman, D. S.; Solomon, P. R.; Pendlebury,W.W.; Davis, C. S.; Gracon, S. I. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. JAMA, 1994, 271: 985-991.
    • (1994) JAMA , vol.271 , pp. 985-991
    • Knapp, M.J.1    Knopman, D.S.2    Solomon, P.R.3    Pendlebury, W.W.4    Davis, C.S.5    Gracon, S.I.6
  • 14
    • 0031883716 scopus 로고    scopus 로고
    • A 24-week, doubleblind, placebo-controlled trial of donepezil in patients with Alzheimer's disease
    • Rogers, S. L.; Farlow, M. R.; Doody, R. S.; Mohs, R.; Friedhoff, L.T. A 24-week, doubleblind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Neurology, 1998, 50 (1): 136-145.
    • (1998) Neurology , vol.50 , Issue.1 , pp. 136-145
    • Rogers, S.L.1    Farlow, M.R.2    Doody, R.S.3    Mohs, R.4    Friedhoff, L.T.5
  • 15
  • 17
    • 0142187807 scopus 로고    scopus 로고
    • Serratenetype triterpenoids from Huperzia serrata
    • Zhou, H.; Tan, C. H.; Jiang, S. H.; Zhu, D. Y. Serratenetype triterpenoids from Huperzia serrata. J. Nat. Prod., 2003, 66: 1328-1332.
    • (2003) J. Nat. Prod. , vol.66 , pp. 1328-1332
    • Zhou, H.1    Tan, C.H.2    Jiang, S.H.3    Zhu, D.Y.4
  • 18
    • 77957036390 scopus 로고
    • The Alkaloids
    • editor, New York: Academic Press
    • Manske, R. H. F. In Manske, R. H. F., editor. The Alkaloids, vol. 5. New York: Academic Press; 1955, 295-300.
    • (1955) , vol.5 , pp. 295-300
    • Manske, R.H.F.1    Manske, F.R.H.2
  • 19
    • 77956663802 scopus 로고
    • The Alkaloids
    • editor, New York: Academic Press
    • Manske, R. H. F. In Manske, R. H. F., editor. The Alkaloids, vol. 7. New York: Academic Press; 1960, 505-507.
    • (1960) , vol.7 , pp. 505-507
    • Manske, R.H.F.1    Manske, R.H.F.2
  • 20
    • 25144521742 scopus 로고
    • The Alkaloids
    • editor, New York: Academic Press
    • MacLean, D. B. In Manske, R. H. F., editor. The Alkaloids, vol. 10. New York: Academic Press; 1968, 305-382.
    • (1968) , vol.10 , pp. 305-382
    • MacLean, D.B.1    Manske, F.R.H.2
  • 21
    • 0000762599 scopus 로고
    • The Alkaloids
    • New York: Academic Press
    • MacLean, D. B. In Manske, R. H. F., editor. The Alkaloids, vol. 14. New York: Academic Press; 1973, 348-406.
    • (1973) , vol.14 , pp. 348-406
    • MacLean, D.B.1    Manske, F.R.H.2
  • 22
    • 84889624171 scopus 로고
    • The Alkaloids
    • New York: Academic Press
    • Blumenkopf, T. A.; Heathcock, C. H. In Pelletier, S.W., The Alkaloids, vol. 3. New York: Academic Press; 1983, 185-240.
    • (1983) , vol.3 , pp. 185-240
    • Blumenkopf, T.A.1    Heathcock, C.H.2    Pelletier, S.W.3
  • 23
    • 0026232163 scopus 로고
    • The Lycopodium alkaloids
    • Ayer, W. A. The Lycopodium alkaloids. Nat. Prod. Rep., 1991, 8: 455-463.
    • (1991) Nat. Prod. Rep. , vol.8 , pp. 455-463
    • Ayer, W.A.1
  • 24
    • 77957098031 scopus 로고
    • The Alkaloids: Chemistry and Pharmacology
    • editors, New York: Academic Press
    • Ayer, W. A.; Trifonov, L. S. In Cordell, G. A.; Brossi, A., editors. The Alkaloids: Chemistry and Pharmacology, vol. 45. New York: Academic Press; 1994, 233-266.
    • (1994) , vol.45 , pp. 233-266
    • Ayer, W.A.1    Trifonov, L.S.2    Cordell, G.A.3    Brossi, A.4
  • 25
    • 4644248620 scopus 로고    scopus 로고
    • The progress in the research of Lycopodium alkaloids
    • Chinese
    • Tan, C. H.; Zhu, D. Y. The progress in the research of Lycopodium alkaloids. Chin. J. Nat. Med. (in Chinese), 2003, 1: 1-7.
    • (2003) Chin. J. Nat. Med. , vol.1 , pp. 1-7
    • Tan, C.H.1    Zhu, D.Y.2
  • 26
    • 0020200919 scopus 로고
    • Studies on the alkaloids of Chinese medicine, Lycopodium serratum
    • Yu, C. M.; Shen, W. Z.; Han, J. W.; Chen, Y. C.; Zhu, Y. L. Studies on the alkaloids of Chinese medicine, Lycopodium serratum. Acta Pharm. Sin., 1982, 17 (10): 795-797.
    • (1982) Acta Pharm. Sin. , vol.17 , Issue.10 , pp. 795-797
    • Yu, C.M.1    Shen, W.Z.2    Han, J.W.3    Chen, Y.C.4    Zhu, Y.L.5
  • 27
    • 0026424834 scopus 로고
    • a potent acetylcholinesterase inhibitor of use in the treatment of Alzheimer's disease
    • Geib, S. J.; Tuckmantel, W.; Kozikowski, A. P. Huperzine A, a potent acetylcholinesterase inhibitor of use in the treatment of Alzheimer's disease. Acta Crystallogr. C, 1991, 47: 824-827.
    • (1991) Acta Crystallogr. C , vol.47 , pp. 824-827
    • Geib, S.J.1    Tuckmantel, W.2    Kozikowski, A.P.3    Huperzine, A.4
  • 28
  • 29
    • 0007959134 scopus 로고
    • Studies on the bioactive Lycopodium alkaloid-the structure and activity of isoselagine from Lycopodium serratum var.longipetiolatum.
    • Chen, C. H.; Lee, S. S. Studies on the bioactive Lycopodium alkaloid-the structure and activity of isoselagine from Lycopodium serratum var. longipetiolatum. J. Taiwan Pharm. Assoc., 1984, 36: 1-7.
    • (1984) J. Taiwan Pharm. Assoc. , vol.36 , pp. 1-7
    • Chen, C.H.1    Lee, S.S.2
  • 30
    • 0027381720 scopus 로고
    • Revised stereochemistry of so-called isoselagine and spectroscopic analysis of 6a-hydroxylycopodine from Lycopodium serratum var.longipetiolatum.
    • Sun, C. M.; Ho, L. K.; Sun, M. L. Revised stereochemistry of so-called isoselagine and spectroscopic analysis of 6a-hydroxylycopodine from Lycopodium serratum var. longipetiolatum. Planta Med., 1993, 59: 467-471.
    • (1993) Planta Med. , vol.59 , pp. 467-471
    • Sun, C.M.1    Ho, L.K.2    Sun, M.L.3
  • 31
    • 0037196125 scopus 로고    scopus 로고
    • Insecticidal activity of Huperzine A from the New Zealand clubmoss, Lycopodium varium
    • Ainge, G. D.; Lorimer, S. D.; Gerard, P. J.; Ruf, L. D. Insecticidal activity of Huperzine A from the New Zealand clubmoss, Lycopodium varium. J. Agr. Food Chem., 2002, 50 (3): 491-494.
    • (2002) J. Agr. Food Chem. , vol.50 , Issue.3 , pp. 491-494
    • Ainge, G.D.1    Lorimer, S.D.2    Gerard, P.J.3    Ruf, L.D.4
  • 32
    • 84889626460 scopus 로고    scopus 로고
    • Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    • Ph.D thesis
    • Ma, X. Q. Ph.D thesis. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 1997.
    • (1997)
    • Ma, X.Q.1
  • 33
    • 0031666920 scopus 로고    scopus 로고
    • Alkaloid patterns in huperzia and some related genera of Lycopodiaceae Sensu Lato occuring in China and their contribution to classification
    • Ma, X. Q.; Jiang, S. H.; Zhu, D. Y. Alkaloid patterns in huperzia and some related genera of Lycopodiaceae Sensu Lato occuring in China and their contribution to classification. Biochem. Syst. Ecol., 1998, 26: 723-727.
    • (1998) Biochem. Syst. Ecol. , vol.26 , pp. 723-727
    • Ma, X.Q.1    Jiang, S.H.2    Zhu, D.Y.3
  • 34
    • 84889626187 scopus 로고
    • Applied high performed thin-layer scanning method to detect the content of fordine of 14 Lycopodium plants
    • Chu, B. M.; Li, J. Applied high performed thin-layer scanning method to detect the content of fordine of 14 Lycopodium plants. Trad. Chin. Herbs, 1986, 17 (8): 109-110.
    • (1986) Trad. Chin. Herbs , vol.17 , Issue.8 , pp. 109-110
    • Chu, B.M.1    Li, J.2
  • 35
    • 33644811612 scopus 로고
    • A new and rapid colorimetric determination of acetylcholinesterase activity
    • Ellman, G. L.; Courtney, K. D.; Andre, V.; Featherstone, R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol., 1961, 7: 88-95.
    • (1961) Biochem. Pharmacol. , vol.7 , pp. 88-95
    • Ellman, G.L.1    Courtney, K.D.2    Andre, V.3    Featherstone, R.M.4
  • 36
    • 0030896029 scopus 로고    scopus 로고
    • Huperzine A, a novel promising acetylcholinesterase inhibitor
    • Cheng, D. H. Ren, H.; Tang, X. C. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport, 1996, 8: 97-101.
    • (1996) Neuroreport , vol.8 , pp. 97-101
    • Cheng, D.H.1    Ren, H.2    Tang, X.C.3
  • 37
    • 0033668050 scopus 로고    scopus 로고
    • A review of its use in Alzheimer's disease
    • Scott, L. J.; Gao, K. L. Galantamine, a review of its use in Alzheimer's disease. Drugs, 2000, 60 (5): 1095-1122.
    • (2000) Drugs , vol.60 , Issue.5 , pp. 1095-1122
    • Scott, L.J.1    Gao, K.L.2    Galantamine3
  • 38
    • 0036363671 scopus 로고    scopus 로고
    • Advances in the treatment of Alzheimer's disease: benefits of dual cholinesterase inhibition
    • Ballard, C. G. Advances in the treatment of Alzheimer's disease: benefits of dual cholinesterase inhibition. Eur. Neurol., 2002, 47: 64-70.
    • (2002) Eur. Neurol. , vol.47 , pp. 64-70
    • Ballard, C.G.1
  • 39
    • 0031458235 scopus 로고    scopus 로고
    • Butyrylcholinesterase in the life cycle of amyloid plaques
    • Guillozet, A.; Smiley, J. F.; Mash, D. C.; Mesulam, M. M. Butyrylcholinesterase in the life cycle of amyloid plaques. Ann. Neurol., 1997, 42: 909-918.
    • (1997) Ann. Neurol. , vol.42 , pp. 909-918
    • Guillozet, A.1    Smiley, J.F.2    Mash, D.C.3    Mesulam, M.M.4
  • 40
    • 0032101015 scopus 로고    scopus 로고
    • Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities
    • Cheng, D. H.; Tang, X. C. Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacol. Biochem. Behav., 1998, 60: 377-386.
    • (1998) Pharmacol. Biochem. Behav. , vol.60 , pp. 377-386
    • Cheng, D.H.1    Tang, X.C.2
  • 41
    • 0024460902 scopus 로고
    • Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat
    • Tang, X. C.; De Sarno, P.; Sugaya, K.; Giacobini, E. Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat. J. Neurosci. Res., 1989, 24: 276-285.
    • (1989) J. Neurosci. Res. , vol.24 , pp. 276-285
    • Tang, X.C.1    De Sarno, P.2    Sugaya, K.3    Giacobini, E.4
  • 42
    • 0028670610 scopus 로고
    • Comparison of the effects of natural and synthetic huperzine A on rat brain cholinergic function in vitro and in vivo
    • Tang, X. C.; Kindel, G. H.; Kozikowski, A. P.; Hanin, I. Comparison of the effects of natural and synthetic huperzine A on rat brain cholinergic function in vitro and in vivo. J. Enthnopharmacol., 1994, 44: 147-155.
    • (1994) J. Enthnopharmacol. , vol.44 , pp. 147-155
    • Tang, X.C.1    Kindel, G.H.2    Kozikowski, A.P.3    Hanin, I.4
  • 43
    • 0031883728 scopus 로고    scopus 로고
    • Anticholinesterase effects of huperzine A, E2020, and tacrine in rats
    • Wang, H.; Tang, X. C. Anticholinesterase effects of huperzine A, E2020, and tacrine in rats. Acta Pharmacol. Sin., 1998, 19: 27-30.
    • (1998) Acta Pharmacol. Sin. , vol.19 , pp. 27-30
    • Wang, H.1    Tang, X.C.2
  • 44
    • 0025820369 scopus 로고
    • Acute and chronic studies with the anticholinesterase huperzine A: effect on central nervous system cholinergic parameters
    • Laganiere, S.; Corey, J.; Tang, X. C.; Wulfert, E.; Hanin, I. Acute and chronic studies with the anticholinesterase huperzine A: effect on central nervous system cholinergic parameters. Neuropharmacology, 1991, 30: 763-768.
    • (1991) Neuropharmacology , vol.30 , pp. 763-768
    • Laganiere, S.1    Corey, J.2    Tang, X.C.3    Wulfert, E.4    Hanin, I.5
  • 45
    • 0003161506 scopus 로고    scopus 로고
    • Preclinical and clinical progress with huperzine A: a novel acetylcholinesterase inhibitor
    • Becker, R.; Giacobini, E., editors. Alzheimer Disease: From Molecular Biology to Therapy. Boston, MA: Birkhaüser
    • Han, Y. F.; Tang, X. C. Preclinical and clinical progress with huperzine A: a novel acetylcholinesterase inhibitor. In Becker, R.; Giacobini, E., editors. Alzheimer Disease: From Molecular Biology to Therapy. Boston, MA: Birkhaüser; 1996, 245-250.
    • (1996) , pp. 245-250
    • Han, Y.F.1    Tang, X.C.2
  • 46
    • 0031719785 scopus 로고    scopus 로고
    • Effects of synthetic-huperzine A on cholinesterase activities and mouse water maze performance
    • Liu, J.; Zhang, H. Y.; Tang, X. C.; Wang, B.; He, X. C.; Bai, D. L. Effects of synthetic-huperzine A on cholinesterase activities and mouse water maze performance. Acta Pharmacol. Sin., 1998, 19: 413-416.
    • (1998) Acta Pharmacol. Sin. , vol.19 , pp. 413-416
    • Liu, J.1    Zhang, H.Y.2    Tang, X.C.3    Wang, B.4    He, X.C.5    Bai, D.L.6
  • 47
    • 0023776131 scopus 로고
    • Improving effect of huperzine A on discrimination performance in aged rats and adult rats with experimental cognitive impairment
    • Lu, W. H.; Shou, J.; Tang, X. C. Improving effect of huperzine A on discrimination performance in aged rats and adult rats with experimental cognitive impairment. Acta Pharmacol. Sin., 1988, 9: 11-15.
    • (1988) Acta Pharmacol. Sin. , vol.9 , pp. 11-15
    • Lu, W.H.1    Shou, J.2    Tang, X.C.3
  • 48
    • 0023033045 scopus 로고
    • Effects of huperzineAon learning and retrieval process of discrimination performance in rats
    • Tang,X. C.; Han,Y. F.; Chen, X. P.; Zhu,X.D. Effects of huperzineAon learning and retrieval process of discrimination performance in rats. Acta Pharmacol. Sin., 1986, 7: 501-511.
    • (1986) Acta Pharmacol. Sin. , vol.7 , pp. 501-511
    • Tang, X.C.1    Han, Y.F.2    Chen, X.P.3    Zhu, X.D.4
  • 49
    • 0010334089 scopus 로고
    • Cognitive improvement by oral huperzine A: a novel acetylcholinesterase inhibitor
    • Giacobini, E.; Becker, R., editors. Alzheimer Therapy: Therapeutic Strategies. Boston,MA: Birkhaüser
    • Tang, X. C.; Xiong, Z. Q.; Qian, B. C.; Zhou, Z. F.; Zhang, C. C. Cognitive improvement by oral huperzine A: a novel acetylcholinesterase inhibitor. In Giacobini, E.; Becker, R., editors. Alzheimer Therapy: Therapeutic Strategies. Boston,MA: Birkhaüser; 1994, 113-119.
    • (1994) , pp. 113-119
    • Tang, X.C.1    Xiong, Z.Q.2    Qian, B.C.3    Zhou, Z.F.4    Zhang, C.C.5
  • 50
    • 0032557464 scopus 로고    scopus 로고
    • Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine
    • Wang, T.; Tang, X. C. Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine. Eur. J. Pharmacol., 1998, 349: 137-142.
    • (1998) Eur. J. Pharmacol. , vol.349 , pp. 137-142
    • Wang, T.1    Tang, X.C.2
  • 51
    • 0029058585 scopus 로고
    • Effects of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats
    • Xiong, Z. Q.; Tang, X. C. Effects of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats. Pharmacol. Biochem. Behav., 1995,51: 415-419.
    • (1995) Pharmacol. Biochem. Behav. , vol.51 , pp. 415-419
    • Xiong, Z.Q.1    Tang, X.C.2
  • 52
    • 0028880830 scopus 로고
    • Huperzine A ameliorates the spatial working memory impairments induced by AF64A
    • Xiong, Z. Q.; Han, Y. F.; Tang, X. C. Huperzine A ameliorates the spatial working memory impairments induced by AF64A. Neuroreport, 1995, 6: 2221-2224.
    • (1995) Neuroreport , vol.6 , pp. 2221-2224
    • Xiong, Z.Q.1    Han, Y.F.2    Tang, X.C.3
  • 53
    • 0142000031 scopus 로고    scopus 로고
    • Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit
    • Xiong, Z. Q.; Cheng, D. H.; Tang, X. C. Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit. Acta Pharmacol. Sin., 1998, 19: 128-132.
    • (1998) Acta Pharmacol. Sin. , vol.19 , pp. 128-132
    • Xiong, Z.Q.1    Cheng, D.H.2    Tang, X.C.3
  • 54
    • 0004052706 scopus 로고    scopus 로고
    • Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment
    • Ye, J. W.; Cai, J. X.; Wang, L. M.; Tang, X. C. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J. Pharmacol. Exp. Ther., 1999, 288: 814-819.
    • (1999) J. Pharmacol. Exp. Ther. , vol.288 , pp. 814-819
    • Ye, J.W.1    Cai, J.X.2    Wang, L.M.3    Tang, X.C.4
  • 55
    • 0033965420 scopus 로고    scopus 로고
    • Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance
    • Ye, J.W.; Shang, Y. Z.;Wang, Z. M.; Tang, X. C. Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance. Acta Pharmacol. Sin., 2000, 21 (1): 65-69.
    • (2000) Acta Pharmacol. Sin. , vol.21 , Issue.1 , pp. 65-69
    • Ye, J.W.1    Shang, Y.Z.2    Wang, Z.M.3    Tang, X.C.4
  • 56
    • 0034528063 scopus 로고    scopus 로고
    • Huperzine A reverses scopolamine-and muscimol-induced memory deficits in chick
    • Gao, Y.; Tang, X. C.; Guan, L. C.; Kuang, P. Z. Huperzine A reverses scopolamine-and muscimol-induced memory deficits in chick. Acta Pharmacol. Sin., 2000, 21: 1169-1173.
    • (2000) Acta Pharmacol. Sin. , vol.21 , pp. 1169-1173
    • Gao, Y.1    Tang, X.C.2    Guan, L.C.3    Kuang, P.Z.4
  • 57
    • 0032856585 scopus 로고    scopus 로고
    • Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students
    • Sun, Q. Q.; Xu, S. S.; Pan, J. L.; Guo, H. M.; Cao,W. Q. Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Acta Pharmacol. Sin., 1999, 20 (7): 601-603.
    • (1999) Acta Pharmacol. Sin. , vol.20 , Issue.7 , pp. 601-603
    • Sun, Q.Q.1    Xu, S.S.2    Pan, J.L.3    Guo, H.M.4    Cao, W.Q.5
  • 58
    • 0035930841 scopus 로고    scopus 로고
    • Effect of huperzine A on working memory in reserpineor yohimbine-treated monkeys
    • Ou, L. Y.; Tang, X. C.; Cai, J. X. Effect of huperzine A on working memory in reserpineor yohimbine-treated monkeys. Eur. J. Pharmacol., 2001, 433(2-3): 151-156.
    • (2001) Eur. J. Pharmacol. , vol.433 , Issue.2 , pp. 151-156
    • Ou, L.Y.1    Tang, X.C.2    Cai, J.X.3
  • 59
    • 0036171969 scopus 로고    scopus 로고
    • Effects of chronic administration of huperzine A on memory in guinea pigs
    • Filliat, P.; Foquin, A.; Lallement, G. Effects of chronic administration of huperzine A on memory in guinea pigs. Drug Chem. Toxicol., 2002, 25 (1): 9-24.
    • (2002) Drug Chem. Toxicol. , vol.25 , Issue.1 , pp. 9-24
    • Filliat, P.1    Foquin, A.2    Lallement, G.3
  • 60
    • 0032465788 scopus 로고    scopus 로고
    • J. Int. J. Geriatr. Psychopharmacol
    • Schmidt, B. H.; Van Der Staay, F. J. Int. J. Geriatr. Psychopharmacol., 1998, 1: 134.
    • (1998) , vol.1 , pp. 134
    • Schmidt, B.H.1    Van Der Staay, F.2
  • 62
    • 0030893633 scopus 로고    scopus 로고
    • Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate
    • Ved, H. S.; Koenig, M. L.; Dave, J. R.; Doctor, B. P. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. Neuroreport, 1997, 8 (4): 963-968.
    • (1997) Neuroreport , vol.8 , Issue.4 , pp. 963-968
    • Ved, H.S.1    Koenig, M.L.2    Dave, J.R.3    Doctor, B.P.4
  • 63
    • 0036141139 scopus 로고    scopus 로고
    • Huperzine A attenuates amyloid b-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation
    • Xiao, X. Q.; Zhang, H. Y.; Tang, X. C. Huperzine A attenuates amyloid b-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation. J. Neurosci. Res., 2002, 67 (1): 30-36.
    • (2002) J. Neurosci. Res , vol.67 , Issue.1 , pp. 30-36
    • Xiao, X.Q.1    Zhang, H.Y.2    Tang, X.C.3
  • 64
    • 0034284410 scopus 로고    scopus 로고
    • Huperzine A and tacrine attenuate b-amyloid peptide-induced oxidative injury
    • Xiao, X. Q.; Wang, R.; Tang, X. C. Huperzine A and tacrine attenuate b-amyloid peptide-induced oxidative injury. J. Neurosci. Res., 2000, 61 (5): 564-569.
    • (2000) J. Neurosci. Res , vol.61 , Issue.5 , pp. 564-569
    • Xiao, X.Q.1    Wang, R.2    Tang, X.C.3
  • 65
    • 0034625561 scopus 로고    scopus 로고
    • Protective effects of huperzine A on bamyloid (25-35) induced oxidative injury in rat pheochromocytoma cells
    • Xiao, X. Q.; Wang, R.; Han, Y. F.; Tang, X. C. Protective effects of huperzine A on bamyloid (25-35) induced oxidative injury in rat pheochromocytoma cells. Neurosci. Lett., 2000, 286 (3): 155-158.
    • (2000) Neurosci. Lett , vol.286 , Issue.3 , pp. 155-158
    • Xiao, X.Q.1    Wang, R.2    Han, Y.F.3    Tang, X.C.4
  • 66
    • 0035876056 scopus 로고    scopus 로고
    • Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by b-amyloid protein-(1-40) in rat
    • Wang, R.; Zhang, H. Y.; Tang, X. C. Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by b-amyloid protein-(1-40) in rat. Eur. J. Pharmacol., 2001, 421 (3): 149-156.
    • (2001) Eur. J. Pharmacol. , vol.421 , Issue.3 , pp. 149-156
    • Wang, R.1    Zhang, H.Y.2    Tang, X.C.3
  • 67
    • 0344562900 scopus 로고    scopus 로고
    • Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury
    • Xiao, X. Q.; Yang, J.W.; Tang, X. C. Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury. Neurosci. Lett., 1999, 275 (2): 73-76.
    • (1999) Neurosci. Lett. , vol.275 , Issue.2 , pp. 73-76
    • Xiao, X.Q.1    Yang, J.W.2    Tang, X.C.3
  • 68
    • 0035964415 scopus 로고    scopus 로고
    • Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells
    • Wang, R.; Xiao, X. Q.; Tang, X. C. Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells. Neuroreport, 2001, 12 (12): 2629-2634.
    • (2001) Neuroreport , vol.12 , Issue.12 , pp. 2629-2634
    • Wang, R.1    Xiao, X.Q.2    Tang, X.C.3
  • 69
    • 0037072513 scopus 로고    scopus 로고
    • Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia
    • Wang, L. S.; Zhou, J.; Shao, X. M.; Tang, X. C. Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia. Brain Res., 2002, 949(1-2): 162-170.
    • (2002) Brain Res. , vol.949 , Issue.1 , pp. 162-170
    • Wang, L.S.1    Zhou, J.2    Shao, X.M.3    Tang, X.C.4
  • 70
    • 0028345360 scopus 로고
    • Huperzine A as a pretreatment candidate drug against nerve agent toxicity
    • Grunwald, J.; Raveh, L.; Doctor, B. P.; Ashani, Y. Huperzine A as a pretreatment candidate drug against nerve agent toxicity. Life Sci., 1994, 54: 991-997.
    • (1994) Life Sci. , vol.54 , pp. 991-997
    • Grunwald, J.1    Raveh, L.2    Doctor, B.P.3    Ashani, Y.4
  • 72
    • 0034023864 scopus 로고    scopus 로고
    • Molecular mechanisms of calcium-dependent excitotoxicity
    • Sattler, R.; Tymianski, M. Molecular mechanisms of calcium-dependent excitotoxicity. J. Mol. Med., 2000, 78 (1): 3-13.
    • (2000) J. Mol. Med. , vol.78 , Issue.1 , pp. 3-13
    • Sattler, R.1    Tymianski, M.2
  • 73
    • 0028642274 scopus 로고
    • Calcium and excitotoxic neuronal injury
    • Choi, D. W. Calcium and excitotoxic neuronal injury. Ann. N Y Acad. Sci., 1994, 747: 162-171.
    • (1994) Ann. N Y Acad. Sci. , vol.747 , pp. 162-171
    • Choi, D.W.1
  • 74
    • 0032947742 scopus 로고    scopus 로고
    • Modulation of NMDA receptor by huperzine A in rat cerebral cortex
    • Wang, X. D.; Zhang, J. M.; Yang, H. H.; Hu, G. Y. Modulation of NMDA receptor by huperzine A in rat cerebral cortex. Acta Pharmacol. Sin., 1999, 20: 31-35.
    • (1999) Acta Pharmacol. Sin. , vol.20 , pp. 31-35
    • Wang, X.D.1    Zhang, J.M.2    Yang, H.H.3    Hu, G.Y.4
  • 75
    • 0036151857 scopus 로고    scopus 로고
    • Neuroprotection and neurodegenerative disease
    • Vajda, F. J. Neuroprotection and neurodegenerative disease. J. Clin. Neurosci., 2002, 9 (1): 4-8.
    • (2002) J. Clin. Neurosci. , vol.9 , Issue.1 , pp. 4-8
    • Vajda, F.J.1
  • 77
    • 0022654027 scopus 로고
    • Isolation of low-molecularweight proteins from amyloid plaque fibers in Alzheimer's disease
    • Selkoe, D. J.; Abraham, C. R.; Podlisny, M. B.; Duffy, L. K. Isolation of low-molecularweight proteins from amyloid plaque fibers in Alzheimer's disease. J. Neurochem., 1986, 46 (6): 1820-1834.
    • (1986) J. Neurochem. , vol.46 , Issue.6 , pp. 1820-1834
    • Selkoe, D.J.1    Abraham, C.R.2    Podlisny, M.B.3    Duffy, L.K.4
  • 78
    • 0003093544 scopus 로고    scopus 로고
    • Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats
    • Wang, L. M.; Han, Y. F.; Tang, X. C. Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Eur. J. Pharmacol., 2002, 398 (1): 65-72.
    • (2002) Eur. J. Pharmacol. , vol.398 , Issue.1 , pp. 65-72
    • Wang, L.M.1    Han, Y.F.2    Tang, X.C.3
  • 79
    • 0035919804 scopus 로고    scopus 로고
    • Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation
    • Zhou, J.; Fu, Y.; Tang, X. C. Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation. Neuroreport, 2001, 12: 2073-2077.
    • (2001) Neuroreport , vol.12 , pp. 2073-2077
    • Zhou, J.1    Fu, Y.2    Tang, X.C.3
  • 80
    • 0023117477 scopus 로고
    • Effects of huperzine A and B on skeletal muscle and electroencephalogram
    • Yan, X. F.; Lu, W. H.; Lou, W. J.; Tang, X. C. Effects of huperzine A and B on skeletal muscle and electroencephalogram. Acta Pharmacol. Sin., 1987, 8: 117-123.
    • (1987) Acta Pharmacol. Sin. , vol.8 , pp. 117-123
    • Yan, X.F.1    Lu, W.H.2    Lou, W.J.3    Tang, X.C.4
  • 81
    • 0041805147 scopus 로고
    • Mutagenicity and comutagenicity of three nootropics: huperzine A, aniracetam and piracetam
    • Tu, Z. H.;Wu, M. Y. Mutagenicity and comutagenicity of three nootropics: huperzine A, aniracetam and piracetam. New Drugs Clin. Remedies, 1990, 9: 65-68.
    • (1990) New Drugs Clin. Remedies , vol.9 , pp. 65-68
    • Tu, Z.H.1    Wu, M.Y.2
  • 82
    • 0032731341 scopus 로고    scopus 로고
    • Ginkgolide A, B, and huperzine A inhibit nitric oxide production from rat C6 and human BT325 glioma cells
    • Zhao, H.W.; Li, X. Y. Ginkgolide A, B, and huperzine A inhibit nitric oxide production from rat C6 and human BT325 glioma cells. Acta Pharmacol. Sin., 1999, 20 (10): 941-943.
    • (1999) Acta Pharmacol. Sin. , vol.20 , Issue.10 , pp. 941-943
    • Zhao, H.W.1    Li, X.Y.2
  • 83
    • 0037052701 scopus 로고    scopus 로고
    • Huperzine A, a nootropic agent, inhibits fast transient potassium current in rat dissociated hippocampal neurons
    • Li, Y.; Hu, G. Y. Huperzine A, a nootropic agent, inhibits fast transient potassium current in rat dissociated hippocampal neurons. Neurosci. Lett., 2002, 324 (1): 25-28.
    • (2002) Neurosci. Lett. , vol.324 , Issue.1 , pp. 25-28
    • Li, Y.1    Hu, G.Y.2
  • 84
    • 0037199662 scopus 로고    scopus 로고
    • Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons
    • Li, Y.; Hu, G. Y. Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons. Neurosci. Lett., 2002, 329 (2): 153-156.
    • (2002) Neurosci. Lett. , vol.329 , Issue.2 , pp. 153-156
    • Li, Y.1    Hu, G.Y.2
  • 85
    • 0035199071 scopus 로고    scopus 로고
    • Antinociceptive profile of the natural cholinesterase inhibitor huperzine A
    • Galeotti, N.; Ghelardini, C.; Mannelli, L. D.; Bartolini, A. Antinociceptive profile of the natural cholinesterase inhibitor huperzine A. Drug Develop. Res., 2001, 54 (1): 19-26.
    • (2001) Drug Develop. Res. , vol.54 , Issue.1 , pp. 19-26
    • Galeotti, N.1    Ghelardini, C.2    Mannelli, L.D.3    Bartolini, A.4
  • 86
    • 0001282177 scopus 로고
    • Therapeutic effects of huperzine A on the aged with memory impairment
    • Zhang, C. L. Therapeutic effects of huperzine A on the aged with memory impairment. New Drugs Clin. Remedies, 1986, 5: 260-262.
    • (1986) New Drugs Clin. Remedies , vol.5 , pp. 260-262
    • Zhang, C.L.1
  • 87
    • 0039394596 scopus 로고
    • Effects of huperzine A tablet on memory
    • Zhang, C. L.; Wang, G. Z. Effects of huperzine A tablet on memory. New Drugs Clin. Remedies, 1990, 9: 339-341.
    • (1990) New Drugs Clin. Remedies , vol.9 , pp. 339-341
    • Zhang, C.L.1    Wang, G.Z.2
  • 91
    • 0042807119 scopus 로고    scopus 로고
    • An open label trial of huperzine A in the treatment of Alzheimer's disease
    • Mazurek, A. An open label trial of huperzine A in the treatment of Alzheimer's disease. Altern. Ther., 1999, 5 (2): 97-98.
    • (1999) Altern. Ther. , vol.5 , Issue.2 , pp. 97-98
    • Mazurek, A.1
  • 92
    • 12444253508 scopus 로고    scopus 로고
    • Double-blind trial of huperzine-A on cognitive deterioration in 314 cases of benign senescent forgetfulness, vascular dementia, and Alzheimer's disease
    • Ma, Y. X.; Zhu, Y.; Gu, Y. D.; Yu, Z. Y.; Yu, S. M.; Ye, Y. Z. Double-blind trial of huperzine-A on cognitive deterioration in 314 cases of benign senescent forgetfulness, vascular dementia, and Alzheimer's disease. Ann. NY Acad. Sci., 1998, 854: 506-507.
    • (1998) Ann. NY Acad. Sci. , vol.854 , pp. 506-507
    • Ma, Y.X.1    Zhu, Y.2    Gu, Y.D.3    Yu, Z.Y.4    Yu, S.M.5    Ye, Y.Z.6
  • 93
    • 12444285418 scopus 로고    scopus 로고
    • Double-blind trail of huperzine-A (HUP) on cognitive impairment and dementia in 314 cases
    • Ma, Y. X.; Zhu, Y.; Gu, Y. D.; Yu, Z. Y.; Yu, S. M.; Ye, Y. Z. Double-blind trail of huperzine-A (HUP) on cognitive impairment and dementia in 314 cases. N-S Arch. Pharmacol., 1998, 358(SUPPL. 1): P35194.
    • (1998) N-S Arch. Pharmacol. , vol.358 , Issue.SUPPL. 1
    • Ma, Y.X.1    Zhu, Y.2    Gu, Y.D.3    Yu, Z.Y.4    Yu, S.M.5    Ye, Y.Z.6
  • 94
    • 0037173785 scopus 로고    scopus 로고
    • Clinical efficacy and safety of huperzine A in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial
    • Zhang, Z. X.; Wang, X. D.; Chen, Q. T.; Shu, L.; Wang, J. Z.; Shan, G. L. Clinical efficacy and safety of huperzine A in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial. Chinese Med. J. Peking, 2002, 82 (14): 941-944.
    • (2002) Chinese Med. J. Peking , vol.82 , Issue.14 , pp. 941-944
    • Zhang, Z.X.1    Wang, X.D.2    Chen, Q.T.3    Shu, L.4    Wang, J.Z.5    Shan, G.L.6
  • 95
    • 30144443041 scopus 로고    scopus 로고
    • A clinical study of the effect of huperzine A to improve the ability of verbal recall, retention and repetition in middle-aged and elderly patients with dysmnesia
    • Chang, S. Y.; Chen, S. M.; Cao, Q. L.; Liu, P;Wang, F. G.;Wang, Z. X. A clinical study of the effect of huperzine A to improve the ability of verbal recall, retention and repetition in middle-aged and elderly patients with dysmnesia. Herald Med. (in Chinese), 2002, 21 (5): 263-265.
    • (2002) Herald Med. (in Chinese) , vol.21 , Issue.5 , pp. 263-265
    • Chang, S.Y.1    Chen, S.M.2    Cao, Q.L.3    Liu, P.4    Wang, F.G.5    Wang, Z.X.6
  • 96
    • 0024518339 scopus 로고
    • A total synthesis of (±)Huperzine A
    • Qian, L. G.; Ji, R. Y. A total synthesis of (±)Huperzine A. Tetrahedron Lett., 1989, 30: 2089-2090.
    • (1989) Tetrahedron Lett. , vol.30 , pp. 2089-2090
    • Qian, L.G.1    Ji, R.Y.2
  • 97
    • 0024338668 scopus 로고
    • A practical synthesis of the Chinese ''nootropic'' agent huperzine A: a possible lead in the treatment of Alzheimer's disease
    • Xia, Y.; Kozikowski, A. P. A practical synthesis of the Chinese ''nootropic'' agent huperzine A: a possible lead in the treatment of Alzheimer's disease. J. Am. Chem. Soc., 1989, 111: 4116-4117.
    • (1989) J. Am. Chem. Soc. , vol.111 , pp. 4116-4117
    • Xia, Y.1    Kozikowski, A.P.2
  • 98
    • 37049074569 scopus 로고
    • A simplified route to a key intermediate in the synthesis of the Chinese noortropic agent huperzine A
    • Kozikwoski, A. P.; Reddy, E. R.; Miller, C. P. A simplified route to a key intermediate in the synthesis of the Chinese noortropic agent huperzine A. J. Chem. Soc. Perkin. Trans. 1, 1990, 195-197.
    • (1990) J. Chem. Soc. Perkin. Trans. , vol.1 , pp. 195-197
    • Kozikwoski, A.P.1    Reddy, E.R.2    Miller, C.P.3
  • 99
    • 0027729990 scopus 로고
    • A palladiumcatalyzed route to huperzine A and its analogues and their anticholinesrterase activity
    • Campiani, G.; Sun, L. Q.; Kozikowski, A. P.; Aagaard, P.; McKinney, M. A palladiumcatalyzed route to huperzine A and its analogues and their anticholinesrterase activity. J. Org. Chem., 1993, 58: 7660-7669.
    • (1993) J. Org. Chem. , vol.58 , pp. 7660-7669
    • Campiani, G.1    Sun, L.Q.2    Kozikowski, A.P.3    Aagaard, P.4    McKinney, M.5
  • 100
    • 0000735889 scopus 로고
    • An approach to open-chain and modified heterocyclic-analogs of the acetylcholinesterase inhibitor huperzine-A through a bicyclo[3.3.1]nonane intermediate
    • Kozikowski, A. P.; Campiani, G.; Tuckmantel, W. An approach to open-chain and modified heterocyclic-analogs of the acetylcholinesterase inhibitor huperzine-A through a bicyclo[3.3.1]nonane intermediate. Heterocycles, 1994, 39 (1): 101-116.
    • (1994) Heterocycles , vol.39 , Issue.1 , pp. 101-116
    • Kozikowski, A.P.1    Campiani, G.2    Tuckmantel, W.3
  • 101
    • 0030023667 scopus 로고    scopus 로고
    • Improved synthesis of methyl 7,7-ethylenedioxy-3-methyl-9-oxobicyclo[3.3.1]non-3-ene-1-carboxylate intermediate for the synthesis of huperzine A analogues
    • Camps, P.; Contreras, J.; Fontbardia, M.; Solans, X. Improved synthesis of methyl 7,7-ethylenedioxy-3-methyl-9-oxobicyclo[3.3.1]non-3-ene-1-carboxylate intermediate for the synthesis of huperzine A analogues. Synthetic Commun., 1996, 26 (1): 9-18.
    • (1996) Synthetic Commun. , vol.26 , Issue.1 , pp. 9-18
    • Camps, P.1    Contreras, J.2    Fontbardia, M.3    Solans, X.4
  • 102
    • 0034705526 scopus 로고    scopus 로고
    • New syntheses of rac-huperzine A and its rac-7-ethyl-derivative. Evaluation of several huperzine A analogues as acetylcholinesterase inhibitors
    • Camps, P.; Contreras, J.; El Achab, R.; Morral, J.; Munoz-Torrero, D.; Font-Bardia, M.; Solans, X.; Badia, A.; Vivas, N. M. New syntheses of rac-huperzine A and its rac-7-ethyl-derivative. Evaluation of several huperzine A analogues as acetylcholinesterase inhibitors. Tetrahedron, 2000, 56 (26): 4541-4553.
    • (2000) Tetrahedron , vol.56 , Issue.26 , pp. 4541-4553
    • Camps, P.1    Contreras, J.2    El Achab, R.3    Morral, J.4    Munoz-Torrero, D.5    Font-Bardia, M.6    Solans, X.7    Badia, A.8    Vivas, N.M.9
  • 103
    • 0025777337 scopus 로고
    • A route to optically pure (-)-huperzine-A-molecular modeling and in vitro pharmacology
    • Yamada, F.; Kozikowski, A. P.; Reddy, E. R.; Pang, Y. P.; Miller, J. H.; Mckinney, M. A route to optically pure (-)-huperzine-A-molecular modeling and in vitro pharmacology. J. Am. Chem. Soc., 1991, 113 (12): 4695-4696.
    • (1991) J. Am. Chem. Soc. , vol.113 , Issue.12 , pp. 4695-4696
    • Yamada, F.1    Kozikowski, A.P.2    Reddy, E.R.3    Pang, Y.P.4    Miller, J.H.5    Mckinney, M.6
  • 104
    • 0003133138 scopus 로고
    • Asymmetric total synthesis of optically active huperzine A
    • Chen, W. P.; Yang, F. Q. Asymmetric total synthesis of optically active huperzine A. Chinese J. Med. Chem., 1995, 5 (1): 10-17.
    • (1995) Chinese J. Med. Chem. , vol.5 , Issue.1 , pp. 10-17
    • Chen, W.P.1    Yang, F.Q.2
  • 105
    • 0030989410 scopus 로고    scopus 로고
    • A novel enantioselective synthesis of the key intermediate of (-)-huperzine A employing asymmetric palladium-catalyzed bicycloannulation
    • Kaneko, S.; Yoshino, T.; Katoh, T.; Terashima, S. A novel enantioselective synthesis of the key intermediate of (-)-huperzine A employing asymmetric palladium-catalyzed bicycloannulation. Tetrahedron-Asymmetry, 1997, 8 (6): 829-832.
    • (1997) Tetrahedron-Asymmetry , vol.8 , Issue.6 , pp. 829-832
    • Kaneko, S.1    Yoshino, T.2    Katoh, T.3    Terashima, S.4
  • 106
    • 0032576817 scopus 로고    scopus 로고
    • Studies on asymmetric synthesis of huperzine A-1. Palladium-catalyzed asymmetric bicycloannulation of 5,6,7,8-tetrahydro-2-methoxy-6-oxo-5-quinolinecarboxylic esters
    • He, X. C.; Wang, B.; Bai, D. L. Studies on asymmetric synthesis of huperzine A-1. Palladium-catalyzed asymmetric bicycloannulation of 5,6,7,8-tetrahydro-2-methoxy-6-oxo-5-quinolinecarboxylic esters. Tetrahedron Lett., 1998, 39(5-6): 411-414.
    • (1998) Tetrahedron Lett. , vol.39 , Issue.5 , pp. 411-414
    • He, X.C.1    Wang, B.2    Bai, D.L.3
  • 107
    • 0035931034 scopus 로고    scopus 로고
    • Studies on the asymmetric synthesis of huperzine A. Part 2: highly enantioselective palladium-catalyzed bicycloannulation of the beta-keto-ester using new chiral ferrocenylphosphine ligands
    • He, X. C.; Wang, B.; Yu, G. L.; Bai, D. L. Studies on the asymmetric synthesis of huperzine A. Part 2: highly enantioselective palladium-catalyzed bicycloannulation of the beta-keto-ester using new chiral ferrocenylphosphine ligands. Tetrahedron-Asymmetry, 2001, 12 (23): 3213-3216.
    • (2001) Tetrahedron-Asymmetry , vol.12 , Issue.23 , pp. 3213-3216
    • He, X.C.1    Wang, B.2    Yu, G.L.3    Bai, D.L.4
  • 108
    • 0037170640 scopus 로고    scopus 로고
    • Synthesis of huperzine intermediates via Mn(III)-mediated radical cyclization
    • Lee, I. Y. C.; Jung, M. H.; Lee, H. W.; Yang, J. Y. Synthesis of huperzine intermediates via Mn(III)-mediated radical cyclization. Tetrahedron Lett., 2002, 43 (13): 2407-2409.
    • (2002) Tetrahedron Lett. , vol.43 , Issue.13 , pp. 2407-2409
    • Lee, I.Y.C.1    Jung, M.H.2    Lee, H.W.3    Yang, J.Y.4
  • 109
    • 0025286378 scopus 로고
    • Synthetic chemistry, neurotransmission and second messengers
    • Kozikowski, A. P. Synthetic chemistry, neurotransmission and second messengers. J. Heterocyclic Chem., 1990, 27: 97-105.
    • (1990) J. Heterocyclic Chem. , vol.27 , pp. 97-105
    • Kozikowski, A.P.1
  • 110
    • 0025730681 scopus 로고
    • Synthesis of huperzine A and its analogues and their anticholinesterase activity
    • Kozikowski, A. P.; Xia, Y.; Reddy, E. R.; Tuckmantel, W.; Hanin, I.; Tang, X. C. Synthesis of huperzine A and its analogues and their anticholinesterase activity. J. Org. Chem., 1991, 56 (15): 4636-4645.
    • (1991) J. Org. Chem. , vol.56 , Issue.15 , pp. 4636-4645
    • Kozikowski, A.P.1    Xia, Y.2    Reddy, E.R.3    Tuckmantel, W.4    Hanin, I.5    Tang, X.C.6
  • 111
    • 0026327743 scopus 로고
    • Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity
    • Kozikowski, A. P.; Miller, C. P.; Yamada, F.; Pang, Y. P.; Miller, J. H.; McKinney, M.; Ball, R. G. Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity. J. Med. Chem., 1991, 34 (12): 3399-3402.
    • (1991) J. Med. Chem. , vol.34 , Issue.12 , pp. 3399-3402
    • Kozikowski, A.P.1    Miller, C.P.2    Yamada, F.3    Pang, Y.P.4    Miller, J.H.5    McKinney, M.6    Ball, R.G.7
  • 112
    • 0032555048 scopus 로고    scopus 로고
    • Synthesis and biological activity of an optically pure 10-spirocyclopropyl analog of huperzine A
    • Kozikowski, A. P.; Prakash, K. R. C.; Saxena, A.; Doctor, B. P. Synthesis and biological activity of an optically pure 10-spirocyclopropyl analog of huperzine A. Chem. Commum., 1998, 12: 1287-1288.
    • (1998) Chem. Commum. , vol.12 , pp. 1287-1288
    • Kozikowski, A.P.1    Prakash, K.R.C.2    Saxena, A.3    Doctor, B.P.4
  • 113
    • 0032474510 scopus 로고    scopus 로고
    • Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring
    • Campiani, G.; Kozikowski, A. P.; Wang, S.; Ming, L.; Nacci, V.; Saxena, A.; Doctor, B. P. Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring. Bioorg. Med. Chem. Lett., 1998, 8 (11): 1413-1418.
    • (1998) Bioorg. Med. Chem. Lett. , vol.8 , Issue.11 , pp. 1413-1418
    • Campiani, G.1    Kozikowski, A.P.2    Wang, S.3    Ming, L.4    Nacci, V.5    Saxena, A.6    Doctor, B.P.7
  • 114
    • 0001052820 scopus 로고    scopus 로고
    • An approach to modified heterocyclic analogues of huperzine A and isohuperzine A. Synthesis of the pyrimidone and pyrazole analogues, and their anticholinesterase activity
    • Kozikowski, A. P.; Campiani, G., Nacci, V., Sega, A., Saxena, A., Doctor, B. P. An approach to modified heterocyclic analogues of huperzine A and isohuperzine A. Synthesis of the pyrimidone and pyrazole analogues, and their anticholinesterase activity. J. Chem. Soc. Perkin Trans. 1, 1996, 11: 1287-1297.
    • (1996) J. Chem. Soc. Perkin Trans. 1 , vol.11 , pp. 1287-1297
    • Kozikowski, A.P.1    Campiani, G.2    Nacci, V.3    Sega, A.4    Saxena, A.5    Doctor, B.P.6
  • 116
    • 2342634601 scopus 로고    scopus 로고
    • Studies on analogues of huperzine A for treatment of senile dementia. VI. Asymmetric total synthesis of 14-norhuperzine A and its inhibitory activity of acetylcholinesterase
    • He, X. C.; Yu, G. L.; Bai, D. L. Studies on analogues of huperzine A for treatment of senile dementia. VI. Asymmetric total synthesis of 14-norhuperzine A and its inhibitory activity of acetylcholinesterase. Acta Pharm. Sin., 2003, 38 (5): 346-349.
    • (2003) Acta Pharm. Sin. , vol.38 , Issue.5 , pp. 346-349
    • He, X.C.1    Yu, G.L.2    Bai, D.L.3
  • 117
    • 0030594963 scopus 로고    scopus 로고
    • Synthesis and acetylcholinesterase inhibitory activity of fluorinated analogues of huperzine A
    • Kaneko, S.; Nakajima, N.; Shikano, M.; Katoh, T.; Terashima, S. Synthesis and acetylcholinesterase inhibitory activity of fluorinated analogues of huperzine A. Bioorg. Med. Chem. Lett., 1996, 6: 1927-1930.
    • (1996) Bioorg. Med. Chem. Lett. , vol.6 , pp. 1927-1930
    • Kaneko, S.1    Nakajima, N.2    Shikano, M.3    Katoh, T.4    Terashima, S.5
  • 118
    • 0032493401 scopus 로고    scopus 로고
    • Synthesis and acetylcholinesterase inhibitory activity of (±)-14-fluorohuperzine A
    • Zeng, F. X.; Jiang, H. L.; Tang, X. C.; Chen, K. X.; Ji, R. Y. Synthesis and acetylcholinesterase inhibitory activity of (±)-14-fluorohuperzine A. Bioorg. Med. Chem. Lett., 1998, 8 (13): 1661-1664.
    • (1998) Bioorg. Med. Chem. Lett. , vol.8 , Issue.13 , pp. 1661-1664
    • Zeng, F.X.1    Jiang, H.L.2    Tang, X.C.3    Chen, K.X.4    Ji, R.Y.5
  • 119
    • 0033822607 scopus 로고    scopus 로고
    • Synthesis of 5-substituted analogues of huperzine A
    • Zhou, G. C.; Zhu, D. Y. Synthesis of 5-substituted analogues of huperzine A. Bioorg. Med. Chem. Lett., 2000, 10 (18): 2055-2057.
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , Issue.18 , pp. 2055-2057
    • Zhou, G.C.1    Zhu, D.Y.2
  • 120
    • 0034716028 scopus 로고    scopus 로고
    • Synthesis of (±)-desamino huperzine A
    • Hogenauer, K.; Baumann, K.; Mulzer, J. Synthesis of (±)-desamino huperzine A. Tetrahedron Lett., 2000, 41 (48): 9229-9232.
    • (2000) Tetrahedron Lett. , vol.41 , Issue.48 , pp. 9229-9232
    • Hogenauer, K.1    Baumann, K.2    Mulzer, J.3
  • 121
    • 0035829165 scopus 로고    scopus 로고
    • Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives
    • Hogenauer, K.; Baumann, K.; Enz, A.; Mulzer, J. Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives. Bioorg. Med. Chem. Lett., 2001, 11 (19): 2627-2630.
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , Issue.19 , pp. 2627-2630
    • Hogenauer, K.1    Baumann, K.2    Enz, A.3    Mulzer, J.4
  • 122
    • 0028353291 scopus 로고
    • Effect of cholinesterase inhibition in vitro by huperzine A analogs
    • Tang, X. C.; Xu, H.; Feng, J.; Zhou, T. X.; Liu, J. S. Effect of cholinesterase inhibition in vitro by huperzine A analogs. Acta Pharmacol. Sin., 1994, 15 (2): 107-110.
    • (1994) Acta Pharmacol. Sin. , vol.15 , Issue.2 , pp. 107-110
    • Tang, X.C.1    Xu, H.2    Feng, J.3    Zhou, T.X.4    Liu, J.S.5
  • 123
    • 84889630548 scopus 로고    scopus 로고
    • Huperzine A derivatives, their preparation and their use
    • European Patent, 0 806 416 B1
    • Zhu, D. Y.; Tang, X. C., et al. Huperzine A derivatives, their preparation and their use. European Patent, 0 806 416 B1
    • Zhu, D.Y.1    Tang, X.C.2
  • 124
    • 0028835625 scopus 로고
    • Effects of isovanihuperzine A on cholinesterase and scopolamine-induced memory impairment
    • Iong, Z. Q.; Tang, X. C.; Lin, J. L.; Zhu, D. Y. Effects of isovanihuperzine A on cholinesterase and scopolamine-induced memory impairment. Acta Pharmacol. Sin., 1995, 16 (1): 21-25.
    • (1995) Acta Pharmacol. Sin. , vol.16 , Issue.1 , pp. 21-25
    • Iong, Z.Q.1    Tang, X.C.2    Lin, J.L.3    Zhu, D.Y.4
  • 125
    • 0001694113 scopus 로고
    • Hanin
    • Maryanoff, B. E.; Maryanoff, C. A., editors, Greenwich, CT: JAI Press
    • Kozikowski, A. P.; Thiels, E.; Tang, X. C.; Hanin. In Maryanoff, B. E.; Maryanoff, C. A., editors. Advance inMedicinal Chemistry., vol. 1. Greenwich, CT: JAI Press; 1992, 175-205.
    • (1992) Advance inMedicinal Chemistry. , vol.1 , pp. 175-205
    • Kozikowski, A.P.1    Thiels, E.2    Tang, X.C.3
  • 126
    • 3142538924 scopus 로고
    • Studies on analogues of huperzine A for the treatment od Alzheimer's disease
    • He, X. C.;Wang, Z. Y.; Li, Y. L.; Bai, D. L. Studies on analogues of huperzine A for the treatment od Alzheimer's disease. I synthesis of 5-substituted aminomethyl-2(1H)-pyridones and 5-substituted amino-5,6,7,8-tetrahydroquinolones. Chinese J. Med. Chem., 1994, 4: 257-262.
    • (1994) Chinese J. Med. Chem. , vol.4 , pp. 257-262
    • He, X.C.1    Wang, Z.Y.2    Li, Y.L.3    Bai, D.L.4
  • 127
    • 0029131257 scopus 로고
    • Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease
    • Fink, D. M.; Bores, G. M.; Effland, R. C.; Huger, F. P.; Kurys, B. E.; Rush, D. K.; Selk, D. E. Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease. J. Med. Chem., 1995, 38 (18): 3645-3651.
    • (1995) J. Med. Chem. , vol.38 , Issue.18 , pp. 3645-3651
    • Fink, D.M.1    Bores, G.M.2    Effland, R.C.3    Huger, F.P.4    Kurys, B.E.5    Rush, D.K.6    Selk, D.E.7
  • 128
    • 84889621520 scopus 로고    scopus 로고
    • Ph. D thesis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    • Wu, B. G. Ph. D thesis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 1996.
    • (1996)
    • Wu, B.G.1
  • 129
    • 0000357247 scopus 로고
    • Synthesis of analogues of huperzine A-3. The preparation of some single ring analogues of huperzine A
    • Wu, B. G.; Zhen, W. P.; Bo, Y. X.; He, X. C.; Bai, D. L. Synthesis of analogues of huperzine A-3. The preparation of some single ring analogues of huperzine A. Chinese Chem. Lett., 1995, 6 (3): 193-196.
    • (1995) Chinese Chem. Lett. , vol.6 , Issue.3 , pp. 193-196
    • Wu, B.G.1    Zhen, W.P.2    Bo, Y.X.3    He, X.C.4    Bai, D.L.5
  • 130
    • 84889618028 scopus 로고
    • Synthesis of huperzine A analogues
    • Wu, B. G.; Bai, D. L. Synthesis of huperzine A analogues. Chinese Pharm. J., 1995, 30(SUPPL.): 63-66.
    • (1995) Chinese Pharm. J. , vol.30 , Issue.SUPPL , pp. 63-66
    • Wu, B.G.1    Bai, D.L.2
  • 132
    • 0034803791 scopus 로고    scopus 로고
    • Easy access to 4-substituted (±)-huperzine A analogues
    • Camps, P.; Munoztorrero, D.; Simon, M. Easy access to 4-substituted (±)-huperzine A analogues. Synthetic Commun., 2001, 31 (22): 3507-3516.
    • (2001) Synthetic Commun. , vol.31 , Issue.22 , pp. 3507-3516
    • Camps, P.1    Munoztorrero, D.2    Simon, M.3
  • 133
    • 0032054003 scopus 로고    scopus 로고
    • Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease
    • Badia, A.; Banos, J. E.; Camps, P.; Contreras, J.; Gorbig, D. M.; Munoztorrero, D.; Simon, M.; Vivas, N. M. Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease. Bioorg. Med. Chem., 1998, 6 (4): 427-440.
    • (1998) Bioorg. Med. Chem. , vol.6 , Issue.4 , pp. 427-440
    • Badia, A.1    Banos, J.E.2    Camps, P.3    Contreras, J.4    Gorbig, D.M.5    Munoztorrero, D.6    Simon, M.7    Vivas, N.M.8
  • 134
    • 0033575679 scopus 로고    scopus 로고
    • Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors
    • Carlier, P. R.; Du, D. M.; Han, Y. F.; Liu, J.; Pang, Y. P. Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors. Bioorg. Med. Chem. Lett., 1999, 9 (16): 2335-2338.
    • (1999) Bioorg. Med. Chem. Lett. , vol.9 , Issue.16 , pp. 2335-2338
    • Carlier, P.R.1    Du, D.M.2    Han, Y.F.3    Liu, J.4    Pang, Y.P.5
  • 135
    • 0029817834 scopus 로고    scopus 로고
    • Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase
    • Pang, Y. P.; Quiram, P.; Jelacic, T.; Hong, F.; Brimijoin, S. Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. J. Biol. Chem., 1996, 271: 23646-23649.
    • (1996) J. Biol. Chem. , vol.271 , pp. 23646-23649
    • Pang, Y.P.1    Quiram, P.2    Jelacic, T.3    Hong, F.4    Brimijoin, S.5
  • 136
    • 0034657522 scopus 로고    scopus 로고
    • Dimerization of an inactive fragment of huperzine A produces a drug with twice the potency of the natural product
    • Carlier, P. R.; Du, D. M.; Han, Y. F.; Liu, J.; Perola, E.; Williams, I. D.; Pang, Y. P. Dimerization of an inactive fragment of huperzine A produces a drug with twice the potency of the natural product. Angew. Chem. Int. Ed. Engl., 2000, 39 (10): 1775-1777.
    • (2000) Angew. Chem. Int. Ed. Engl. , vol.39 , Issue.10 , pp. 1775-1777
    • Carlier, P.R.1    Du, D.M.2    Han, Y.F.3    Liu, J.4    Perola, E.5    Williams, I.D.6    Pang, Y.P.7
  • 137
    • 0036003645 scopus 로고    scopus 로고
    • Synthesis of alkylene-linked dieters of (-)-huperzine A
    • Jin, G. Y.; He, X. C.; Zhang, H. Y.; Bai, D. L. Synthesis of alkylene-linked dieters of (-)-huperzine A. Chinese Chem. Lett., 2002, 13 (1): 23-26.
    • (2002) Chinese Chem. Lett. , vol.13 , Issue.1 , pp. 23-26
    • Jin, G.Y.1    He, X.C.2    Zhang, H.Y.3    Bai, D.L.4
  • 138
    • 0344441744 scopus 로고    scopus 로고
    • Synthesis and docking studies of alkylene-linked dimers of (-)-huperzine A
    • Jin, G. Y.; Luo, X. M.; He, X. C.; Jiang, H. L.; Zhang, H. Y.; Bai, D. L. Synthesis and docking studies of alkylene-linked dimers of (-)-huperzine A. Arzneimittel-Forsch, 2003; 53(11): 753-757.
    • (2003) Arzneimittel-Forsch , vol.53 , Issue.11 , pp. 753-757
    • Jin, G.Y.1    Luo, X.M.2    He, X.C.3    Jiang, H.L.4    Zhang, H.Y.5    Bai, D.L.6
  • 139
    • 0041779607 scopus 로고    scopus 로고
    • Synthesis and pharmacological study of huperzine A-E2020 combined compound
    • Zeng, F. X.; Jiang, H. L.; Yang, Y. S.; Liu, D. X.; Zhang, H. Y.; Chen, K. X.; Ji, R. Y. Synthesis and pharmacological study of huperzine A-E2020 combined compound. Acta Chim. Sin., 2000, 58 (5): 580-587.
    • (2000) Acta Chim. Sin. , vol.58 , Issue.5 , pp. 580-587
    • Zeng, F.X.1    Jiang, H.L.2    Yang, Y.S.3    Liu, D.X.4    Zhang, H.Y.5    Chen, K.X.6    Ji, R.Y.7
  • 140
    • 0033007422 scopus 로고    scopus 로고
    • Inhibitory effects of huperzine B on cholinesterase activity in mice
    • Liu, J.; Zhang, H. Y.; Wang, L. M.; Tang, X. C. Inhibitory effects of huperzine B on cholinesterase activity in mice. Acta Pharmacol. Sin., 1999, 20 (2): 141-145.
    • (1999) Acta Pharmacol. Sin. , vol.20 , Issue.2 , pp. 141-145
    • Liu, J.1    Zhang, H.Y.2    Wang, L.M.3    Tang, X.C.4
  • 141
    • 0035817218 scopus 로고    scopus 로고
    • Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B
    • Rajendran, V.; Rong, S. B.; Saxena, A.; Doctor, B. P.; Kozikowski, A. P. Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B. Tetrahedron Lett., 2001, 42 (32): 5359-5361.
    • (2001) Tetrahedron Lett. , vol.42 , Issue.32 , pp. 5359-5361
    • Rajendran, V.1    Rong, S.B.2    Saxena, A.3    Doctor, B.P.4    Kozikowski, A.P.5
  • 142
    • 0037013437 scopus 로고    scopus 로고
    • Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B
    • Rajendran, V.; Saxena, A.; Doctor, B. P.; Kozikowski, A. P. Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B. Bioorg. Med. Chem. Lett., 2002, 12 (11): 1521-1523.
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , Issue.11 , pp. 1521-1523
    • Rajendran, V.1    Saxena, A.2    Doctor, B.P.3    Kozikowski, A.P.4
  • 143
    • 0032513139 scopus 로고    scopus 로고
    • Enantioselective synthesis of tacrine-huperzine A hybrids. Preparative chiral MPLC separation of their racemic mixtures and absolute configuration assignments by x-ray diffraction analysis
    • Camps, P.; Contreras, J.; Font-Bardia, M.; Morral, J.; Munoz-Torrero, D.; Solans, X. Enantioselective synthesis of tacrine-huperzine A hybrids. Preparative chiral MPLC separation of their racemic mixtures and absolute configuration assignments by x-ray diffraction analysis. Tetrahedron-Asymmetry, 1998, 9 (5): 835-849.
    • (1998) Tetrahedron-Asymmetry , vol.9 , Issue.5 , pp. 835-849
    • Camps, P.1    Contreras, J.2    Font-Bardia, M.3    Morral, J.4    Munoz-Torrero, D.5    Solans, X.6
  • 144
    • 13044253491 scopus 로고    scopus 로고
    • Synthesis in vitro pharmacology and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease
    • Camps, P.; El Achab, R.; Gorbig, D. M.; Morral, J.; Munoz-Torrero, D.; Badia, A.; Banos, J. E.; Vivas, N. M.; Barril, X.; Orozco, M.; Luque, F. J. Synthesis in vitro pharmacology and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease. J. Med. Chem., 1999, 42 (17): 3227-3242.
    • (1999) J. Med. Chem. , vol.42 , Issue.17 , pp. 3227-3242
    • Camps, P.1    El Achab, R.2    Gorbig, D.M.3    Morral, J.4    Munoz-Torrero, D.5    Badia, A.6    Banos, J.E.7    Vivas, N.M.8    Barril, X.9    Orozco, M.10    Luque, F.J.11
  • 145
    • 0031015343 scopus 로고    scopus 로고
    • Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A
    • Raves, M. L.; Harel, M.; Pang, Y. P.; Silman, I.; Kozikowski, A. P.; Sussman, J. L. Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A. Nat. Struct. Biol., 1997, 4 (1): 57-63.
    • (1997) Nat. Struct. Biol. , vol.4 , Issue.1 , pp. 57-63
    • Raves, M.L.1    Harel, M.2    Pang, Y.P.3    Silman, I.4    Kozikowski, A.P.5    Sussman, J.L.6
  • 146
    • 0026752611 scopus 로고
    • Mechanism of inhibition of cholinesterases by huperzine-A
    • Ashani, Y.; Peggins, J. O.; Doctor, B. P. Mechanism of inhibition of cholinesterases by huperzine-A. Biochem. Biophys. Res. Commun., 1992, 184 (2): 719-726.
    • (1992) Biochem. Biophys. Res. Commun. , vol.184 , Issue.2 , pp. 719-726
    • Ashani, Y.1    Peggins, J.O.2    Doctor, B.P.3
  • 148
    • 0025778840 scopus 로고
    • Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein
    • Sussman, J. L.; Harel, M.; Frolow, F.; Oefner, C.; Goldman, A.; Toker, L.; Silman, I. Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein. Science, 1991, 253: 872-879.
    • (1991) Science , vol.253 , pp. 872-879
    • Sussman, J.L.1    Harel, M.2    Frolow, F.3    Oefner, C.4    Goldman, A.5    Toker, L.6    Silman, I.7
  • 149
    • 0035312645 scopus 로고    scopus 로고
    • Steered molecular dynamics and mechanical functions of proteins
    • Isralewitz, B.; Gao, M.; Schulten, K. Steered molecular dynamics and mechanical functions of proteins. Curr. Opin. Struc. Biol., 2001, 11: 224-230.
    • (2001) Curr. Opin. Struc. Biol. , vol.11 , pp. 224-230
    • Isralewitz, B.1    Gao, M.2    Schulten, K.3
  • 150
    • 0041691306 scopus 로고    scopus 로고
    • How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations
    • Xu, Y. C.; Shen, J. H.; Luo, X.M.; Silman, I.; Sussman, J. L.; Chen, K. X.; Jiang, H. L. How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations. J. Am. Chem. Soc., 2003, 125 (37): 11340-11349.
    • (2003) J. Am. Chem. Soc. , vol.125 , Issue.37 , pp. 11340-11349
    • Xu, Y.C.1    Shen, J.H.2    Luo, X.M.3    Silman, I.4    Sussman, J.L.5    Chen, K.X.6    Jiang, H.L.7
  • 151
    • 0034098363 scopus 로고    scopus 로고
    • Molecular modelling and QSAR of reversible acetylcholinesterase inhibitors
    • Kaur, J.; Zhang, M. Q. Molecular modelling and QSAR of reversible acetylcholinesterase inhibitors. Curr. Med. Chem., 2000, 7 (3): 273-294.
    • (2000) Curr. Med. Chem. , vol.7 , Issue.3 , pp. 273-294
    • Kaur, J.1    Zhang, M.Q.2
  • 152
    • 0033966913 scopus 로고    scopus 로고
    • Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer's disease
    • Camps, P.; Cusack, B.; Mallender, W. D.; El Achab, R.; Morral, J.; Munoz-Torrero, D.; Rosenberry, T. L. Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer's disease. Mol. Pharmacol., 2000, 57 (2): 409-417.
    • (2000) Mol. Pharmacol. , vol.57 , Issue.2 , pp. 409-417
    • Camps, P.1    Cusack, B.2    Mallender, W.D.3    El Achab, R.4    Morral, J.5    Munoz-Torrero, D.6    Rosenberry, T.L.7
  • 153
    • 0034736034 scopus 로고    scopus 로고
    • New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease
    • Camps, P.; El Achab, R.; Morral, J.; Munoz-Torrero, D.; Badia, A.; Banos, J. E.; Vivas, N. M.; Barril, X.; Orozco, M.; Luque, F. J. New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease. J. Med. Chem., 2000, 43 (24): 4657-4666.
    • (2000) J. Med. Chem. , vol.43 , Issue.24 , pp. 4657-4666
    • Camps, P.1    El Achab, R.2    Morral, J.3    Munoz-Torrero, D.4    Badia, A.5    Banos, J.E.6    Vivas, N.M.7    Barril, X.8    Orozco, M.9    Luque, F.J.10
  • 154
    • 0035856633 scopus 로고    scopus 로고
    • On the regioselectivity of the Friedlander reaction leading to huprines: stereospecific acid-promoted isomerization of syn-huprines to their anti-regioisomers
    • Camps, P.; Gomez, E.; Munoz-Torrero, D.; Arno, M. On the regioselectivity of the Friedlander reaction leading to huprines: stereospecific acid-promoted isomerization of syn-huprines to their anti-regioisomers. Tetrahedron-Asymmetry, 2001, 12 (20): 2909-2914.
    • (2001) Tetrahedron-Asymmetry , vol.12 , Issue.20 , pp. 2909-2914
    • Camps, P.1    Gomez, E.2    Munoz-Torrero, D.3    Arno, M.4
  • 155
    • 0035817444 scopus 로고    scopus 로고
    • The pharmacology of novel acetylcholinesterase inhibitors (±)-huprines Y and X on the Torpedo electric organ
    • Ros, E.; Aleu, J.; De Aranda, I. G.; Munoz-Torrero, D.; Camps, P.; Badia, A.; Marsal, J.; Solsona, C. The pharmacology of novel acetylcholinesterase inhibitors (±)-huprines Y and X on the Torpedo electric organ. Eur. J. Pharmacol., 2001, 421 (2): 77-84.
    • (2001) Eur. J. Pharmacol. , vol.421 , Issue.2 , pp. 77-84
    • Ros, E.1    Aleu, J.2    De Aranda, I.G.3    Munoz-Torrero, D.4    Camps, P.5    Badia, A.6    Marsal, J.7    Solsona, C.8
  • 156
    • 0035924211 scopus 로고    scopus 로고
    • Synthesis in vitro pharmacology and molecular modeling of synhuprines as acetylcholinesterase inhibitors
    • Camps, P.; Gomez, E.; Munoz-Torrero, D.; Badia, A.; Vivas, N. M.; Barril, X.; Orozco, M.; Luque, F. J. Synthesis in vitro pharmacology and molecular modeling of synhuprines as acetylcholinesterase inhibitors. J. Med. Chem., 2001, 44 (26): 4733-4736.
    • (2001) J. Med. Chem. , vol.44 , Issue.26 , pp. 4733-4736
    • Camps, P.1    Gomez, E.2    Munoz-Torrero, D.3    Badia, A.4    Vivas, N.M.5    Barril, X.6    Orozco, M.7    Luque, F.J.8
  • 157
    • 0033044911 scopus 로고    scopus 로고
    • Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis
    • Carlier, P. R.; Han, Y. F.; Chow, E. S. H.; Li, C. P. L.;Wang, H.; Lieu, T. X.;Wong, H. S.; Pang, Y. P. Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis. Bioorg. Med. Chem., 1999, 7 (2): 351-357.
    • (1999) Bioorg. Med. Chem. , vol.7 , Issue.2 , pp. 351-357
    • Carlier, P.R.1    Han, Y.F.2    Chow, E.S.H.3    Li, C.P.L.4    Wang, H.5    Lieu, T.X.6    Wong, H.S.7    Pang, Y.P.8
  • 159
    • 0037022789 scopus 로고    scopus 로고
    • 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 angstrom resolution: kinetic and molecular dynamic correlates
    • Dvir, H.; Wong, D. M.; Harel, M.; Barril, X.; Orozco, M.; Luque, F. J.; Munoz-Torrero, D.; Camps, P.; Rosenberry, T. L.; Silman, I.; Sussman, J. L. 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 angstrom resolution: kinetic and molecular dynamic correlates. Biochemistry, 2002, 41 (9): 2970-2981.
    • (2002) Biochemistry , vol.41 , Issue.9 , pp. 2970-2981
    • Dvir, H.1    Wong, D.M.2    Harel, M.3    Barril, X.4    Orozco, M.5    Luque, F.J.6    Munoz-Torrero, D.7    Camps, P.8    Rosenberry, T.L.9    Silman, I.10    Sussman, J.L.11
  • 160
    • 0036793068 scopus 로고    scopus 로고
    • Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase. Acta Crystallogr
    • Felder, C. E.; Harel, M.; Silman, I.; Sussman, J. L. Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase. Acta Crystallogr. D Biol. Crystallogr., 2002, 58: 1765-1771.
    • (2002) D Biol. Crystallogr. , vol.58 , pp. 1765-1771
    • Felder, C.E.1    Harel, M.2    Silman, I.3    Sussman, J.L.4
  • 161
    • 0037438531 scopus 로고    scopus 로고
    • Acetylcholinesterase complexed with bivalent ligands related to huperzine A: experimental evidence for species-dependent protein-ligand complementarity
    • Wong, D. M.; Greenblatt, H. M.; Dvir, H.; Carlier, P. R.; Han, Y. F.; Pang, Y. P.; Silman, I.; Sussman, J. L. Acetylcholinesterase complexed with bivalent ligands related to huperzine A: experimental evidence for species-dependent protein-ligand complementarity. J. Am. Chem. Soc., 2003, 125 (2): 363-373.
    • (2003) J. Am. Chem. Soc. , vol.125 , Issue.2 , pp. 363-373
    • Wong, D.M.1    Greenblatt, H.M.2    Dvir, H.3    Carlier, P.R.4    Han, Y.F.5    Pang, Y.P.6    Silman, I.7    Sussman, J.L.8
  • 162
    • 0037015151 scopus 로고    scopus 로고
    • X-ray structures of Torpedo californica acetylcholinesterase complexed with ({thorn})-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement
    • Dvir, H.; Jiang, H. L.; Wong, D. M.; Harel, M.; Chetrit, M.; He, X. C.; Jin, G. Y.; Yu, G. L.; Tang, X. C.; Silman, I.; Bai, D. L.; Sussman, J. L. X-ray structures of Torpedo californica acetylcholinesterase complexed with ({thorn})-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement. Biochemistry, 2002, 41 (35): 10810-10818.
    • (2002) Biochemistry , vol.41 , Issue.35 , pp. 10810-10818
    • Dvir, H.1    Jiang, H.L.2    Wong, D.M.3    Harel, M.4    Chetrit, M.5    He, X.C.6    Jin, G.Y.7    Yu, G.L.8    Tang, X.C.9    Silman, I.10    Bai, D.L.11    Sussman, J.L.12


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