Effects of chronic administration of huperzine a on memory in guinea pigs

Drug and Chemical Toxicology

Volumn 25, Issue 1, 2002, Pages 9-24

  Filliat, Pierre ^a   Foquin, Annie ^a   Lallement, Guy ^a  

^a CENTRE DE RECHERCHES   (France)

Author keywords

Chronic administration; Guinea pigs; Huperzine A; Morris water maze; Spatial memory

Indexed keywords

CHOLINESTERASE; HUPERZINE A; PHYSOSTIGMINE; TACRINE;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLINERGIC SYSTEM; CHOLINESTERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERABILITY; ENZYME ACTIVITY; FASCICULATION; FORCED SWIMMING TEST; GUINEA PIG; LEARNING; MAZE TEST; NONHUMAN; OSMOTIC MINIPUMP; SPATIAL MEMORY; WORKING MEMORY;

ACETYLCHOLINESTERASE; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CHOLINESTERASE INHIBITORS; GUINEA PIGS; MALE; MAZE LEARNING; MEMORY; SESQUITERPENES;

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0036171969     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.1081/DCT-100108469     Document Type: Article

References (46)

1. Synthesis of huperzine A and its analogues and their anticholinesterase activity
2. Mechanism of inhibition of cholinesterases by huperzine A
3. The cholinergic hypothesis of geriatric memory dysfunction
4. Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities
5. Cholinergic strategies in the treatment of Alzheimer's disease
6. Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type
7. Chronic oral physostigmine without lecithin improves memory in Alzheimer's disease
8. Hepatotoxicity of tetrahydroacridine
9. Antiamnesic and cholinomimetic side-effects of the cholinesterase inhibitors, physostigmine, tacrine and NIK-247 in rats
10. Pharmacokinetics of tablet huperzine A in six volunteers
11. Acute and chronic studies with the anticholinesterase huperzine A: Effect on central nervous system cholinergic parameters
12. Physostigmine, tacrine, and metrifonate: Effect of multiple doses on acetylcholine metabolism in the brain
13. The protection of animals against organophosphate poisoning by pretreatment with a carbamate
14. Huperzine A as a pretreatment candidate drug against nerve agent toxicity
15. Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat
16. Efficacy of huperzine in preventing soman-induced seizures, neuropathological changes and lethality
17. Studies with huperzine A, a new candidate in the research of prophylaxis against nerve agent
18. Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance
19. Effect of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats
20. Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: Comparison with E2020 and tacrine
21. Huperzine A ameliorates the spatial working memory impairments induced by AF64
22. Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities
23. Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit
24. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment
25. Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students
26. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease
27. Evaluation of the toxicity and treatment of GF poisoning in rhesus monkeys
28. Developments of a water-maze procedure for studying spatial learning in the rat
29. Continuous administration of low dose rates of physostigmine and hyoscine to guinea-pigs prevents the toxicity and reduces the incapacitation produced by soman poisoning
30. A new and rapid colorimetric determination of acetylcholinesterase activity
31. Protein measurement with the folin phenol reagent
32. Relationships between testing-induced alterations of hippocampal cholinergic activity and memory performance on two spatial tasks in mice
33. The effects of neonatal choline dietary supplementation on adult spatial and configural learning and memory in rats
34. Interactions between scopolamine and muscarinic cholinergic agonists or cholinesterase inhibitors on spatial alternation performance in rats
35. Reversal by tetrahydroaminoacridine of scopolamine-induced memory and performance deficits in rats
36. Behavioral screening for cognition enhancers: From indiscriminate to valid testing: Part II
37. A pharmacological analysis of processes underlying differential responding: A review and further experiments with scopolamine, amphetamine, lysergic acid diethylamide (LSD-25), chlordiazepoxide, physostigmine and chlorpromazine
38. Tetrahydroaminoacridine alleviates medial septal lesion-induced and age-related spatial reference but not working memory deficits
39. Tetrahydroaminoacridine improves passive avoidance retention defects induced by aging and medial septal lesion but not by fimbria-fornix lesion
40. Effects of tacrine (THA) on spatial reference memory and cholinergic enzymes in specific rat brain regions
41. Tetrahydroaminoacridine attenuates dizocilpine-induced behavioural changes
42. Side effects of physostigmine as a pretreatment in guinea pigs
43. Subchronic physostigmine pretreatment in guinea pigs: Effective against soman and without side effect
44. Effects of low doses of cholinesterase inhibitors on behavioral performance of robottested marmosets
45. Evidence for the involvement of presynaptic cholinergic functions in tolerance to diisopropylfluorophosphate
46. Active avoidance behaviour in guinea pigs: Effects of physostigmine and scopolamine