Dimerization of an inactive fragment of Huperzine A produces a drug with twice the potency of the natural product

Angewandte Chemie - International Edition

Volumn 39, Issue 10, 2000, Pages 1775-1777

  Carlier, Paul R ^a   Du, Da Ming ^a   Han, Yi Fan ^a   Liu, Jing ^a   Perola, Emanuele ^b   Williams, Ian D ^a   Pang, Yuan Ping ^b  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b MAYO CLINIC CANCER CENTER   (United States)

Author keywords

Dimerizations; Drug research; Enzyme inhibitors; Natural products; Noncovalent interactions

Indexed keywords

ACETYLCHOLINESTERASE; AMINOQUINOLINE DERIVATIVE; CHOLINESTERASE INHIBITOR; HUPERZINE A; NATURAL PRODUCT; NEW DRUG;

ALZHEIMER DISEASE; ARTICLE; DIMERIZATION; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 0034657522     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(20000515)39:10<1775::AID-ANIE1775>3.0.CO;2-Q     Document Type: Article

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24. The docking study was performed with the SYSDOC program by employing the AMBER 95 force field and the RESP charge model, as described in the Supporting Information.