Structure based de novo design of novel glycogen synthase kinase 3 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 11, 2007, Pages 3728-3736

  Dessalew, Nigus ^a   Bharatam, Prasad V ^b  

^a ADDIS ABABA UNIVERSITY   (Ethiopia)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

De novo design; GSK 3; Ludi; Molecular docking; Structure based design

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; BISARYLMALEIMIDE 1; BISARYLMALEIMIDE 2; CT 2006; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; HYMENIALDISINE; HYMENIALDISINE 1; HYMENIALDISINE 2; INDIRUBIN 1; INDIRUBIN 2; INDOLYLYLMALEIMIDE 1; INDOLYLYLMALEIMIDE 2; PAULLONE 1; PAULLONE 2; PYRAZOLOPYRIDAZINE 1; PYRAZOLOPYRIDAZINE 2; PYRAZOLOPYRIMIDINE 1; PYRAZOLOPYRIMIDINE 2; UNCLASSIFIED DRUG;

ARTICLE; CALIBRATION; COMPARATIVE STUDY; DRUG BINDING; DRUG BINDING SITE; DRUG DESIGN; DRUG STRUCTURE; ENZYME INHIBITION; SCORING SYSTEM; STRUCTURE ACTIVITY RELATION;

BINDING SITES; DRUG DESIGN; GLYCOGEN SYNTHASE KINASE 3; LIGANDS; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

RUMEX;

EID: 34247544379     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.03.048     Document Type: Article

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