C17,20-Lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 9, 2004, Pages 2251-2273

  Matsunaga, Nobuyuki ^a   Kaku, Tomohiro ^a   Itoh, Fumio ^a   Tanaka, Toshimasa ^a   Hara, Takahito ^a   Miki, Hiroshi ^a   Iwasaki, Masahiko ^a   Aono, Tetsuya ^a   Yamaoka, Masuo ^a   Kusaka, Masami ^a   Tasaka, Akihiro ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Androgen; Benzo b thiophene; C17,20 Lyase; Testosterone

Indexed keywords

1 (2 NAPHTHYLMETHYL) 1H IMIDAZOLE; 1 [(1,1' BIPHENYL) 4 YLMETHYL] 1H IMIDAZOLE; 1 [3 (2 NAPHTHYL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 1 [3 (2 NAPHTHYL)PROPAN 1 YL] 1H IMIDAZOLE FURMATE; 1 [3 (2 PHENYLETHENYL)BENZYL] 1H IMIDAZOLE; 1 [3 (2 PHENYLETHENYL)PHENYL] 1H IMIDAZOLE; 1 [3 (2H CHROMEN 3 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 1 [3 (3 QUINOLINYL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 1 [3 (4 FLUOROBENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 1 [3 (5 CHLORO 3 METHYLBENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 1 [3 (5 CHLOROBENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 1 [3 (5 FLUORO 3 METHYLBENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 1 [3 (5 FLUOROBENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 1 [3 (5 METHOXY 3 METHYLBENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 1 [3 (6 FLUOROBENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 1 [3 (7 FLUOROBENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 1 [3 (BENZO[B]FURAN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 1 [3 (BENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 4 [3 (3 TERT BUTYL 5 FLUOROBENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 4 [3 (4 FLUOROBENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 4 [3 (5 FLUORO 3 METHYLBENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 4 [3 (5,7 DIFLUORO 3 METHYLBENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 4 [3 (6 FLUOROBENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 4 [3 (7 FLUOROBENZO[B]THIOPHEN 2 YL) 2 PROPEN 1 YL] 1H IMIDAZOLE; 4 [4 (5 FLUORO 3 METHYLBENZO[B]THIOPHEN 2 YL) 3 BUTEN 2 YL] 1H IMIDAZOLE; 4 [4 (5 FLUOROBENZO[B]THIOPHEN 2 YL) 3 BUTEN 2 YL] 1H IMIDAZOLE; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; STEROID 17,20 LYASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; STEROID 17ALPHA MONOOXYGENASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MALE; MOLECULAR MODEL; NONHUMAN; RAT; ANIMAL; DRUG ANTAGONISM; ENZYMOLOGY; HUMAN; INFRARED SPECTROPHOTOMETRY; MICROSOME; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANIMALS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES; RATS; SPECTROPHOTOMETRY, INFRARED; STEROID 17-ALPHA-HYDROXYLASE;

EID: 11144354613     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.02.007     Document Type: Article

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