Computational approaches to structure-based ligand design

Pharmacology and Therapeutics

Volumn 84, Issue 2, 1999, Pages 179-191

  Joseph Mccarthy, Diane ^a  

^a PFIZER INC   (United States)

Author keywords

Binding affinity prediction; Computer aided drug design; Database searching; De novo design; Docking; Virtual combinatorial library screening

Indexed keywords

FUNCTIONAL GROUP; LIGAND; PHENOL; THROMBIN INHIBITOR;

BINDING AFFINITY; BINDING SITE; COMPUTER AIDED DESIGN; DATA BASE; DRUG DESIGN; DRUG DEVELOPMENT; DRUG STRUCTURE; FUTUROLOGY; INFORMATION RETRIEVAL; LIGAND BINDING; MOLECULAR DYNAMICS; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW;

COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER-AIDED DESIGN; DATABASES, FACTUAL; DRUG DESIGN; LIGANDS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032828061     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(99)00031-5     Document Type: Review

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