메뉴 건너뛰기




Volumn 8, Issue 3, 2002, Pages 126-132

Glycogen synthase kinase 3: An emerging therapeutic target

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; UNCLASSIFIED DRUG;

EID: 0036090823     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(01)02266-3     Document Type: Review
Times cited : (406)

References (61)
  • 4
    • 0027379099 scopus 로고
    • Mitogen-activated protein kinase activation is not sufficient for stimulation of glucose transport or glycogen synthase in 3T3-L1 adipocytes
    • (1993) J. Biol. Chem. , vol.268 , pp. 26422-26427
    • Robinson, L.J.1
  • 5
    • 0025522071 scopus 로고
    • The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle
    • (1990) Nature , vol.348 , pp. 302-308
    • Dent, P.1
  • 7
    • 0034053069 scopus 로고    scopus 로고
    • Wnt signaling in oncogenesis and embryogenesis - A look outside the nucleus
    • (2000) Science , vol.287 , pp. 1606-1609
    • Peifer, M.1    Polakis, P.2
  • 10
    • 0030803367 scopus 로고    scopus 로고
    • Heat stress induces tyrosine phosphorylation/activation of kinase FA/GSK-3 α (a human carcinoma dedifferentiation modulator) in A431 cells
    • (1997) J. Cell. Biochem. , vol.66 , pp. 16-26
    • Yang, S.1
  • 11
    • 0028302780 scopus 로고
    • Okadaic acid a serine/threonine phosphatase inhibitor, induces tyrosine dephosphorylation/inactivation of protein kinase FA/GSK-3 α in A431 cells
    • (1994) J. Biol. Chem , vol.269 , pp. 14341-14344
    • Yu, J.-S.1    Yang, S.-D.2
  • 12
    • 0033597936 scopus 로고    scopus 로고
    • Transient increases in intracellular calcium result in prolonged site-selective increases in Tau phosphorylation through a glycogen synthase kinase-3 β-dependent pathway
    • (1999) J. Biol. Chem. , vol.274 , pp. 21395-21401
    • Hartigan, J.A.1    Johnson, G.V.2
  • 13
    • 0034718421 scopus 로고    scopus 로고
    • Regulation and localization of tyrosine 216 phosphorylation of glycogen synthase kinase-3β in cellular and animal models of neuronal degeneration
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 11074-11079
    • Bhat, R.V.1
  • 15
    • 0032734021 scopus 로고    scopus 로고
    • The novel tyrosine kinase ZAK1 activates GSK3 to direct cell fate specification
    • (1999) Cell , vol.99 , pp. 399-408
    • Kim, L.1
  • 17
    • 0035875098 scopus 로고    scopus 로고
    • Crystal structure of glycogen synthase kinase 3β: Structural basis for phosphate-primed substrate specificity and autoinhibition
    • (2001) Cell , vol.105 , pp. 721-732
    • Dajani, R.1
  • 18
    • 0034969088 scopus 로고    scopus 로고
    • A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation
    • (2001) Mol. Cell , vol.7 , pp. 1321-1327
    • Frame, S.1
  • 21
    • 0033499747 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 is an insulin-regulated C/EBPα kinase
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 8433-8441
    • Ross, S.E.1
  • 23
    • 0032802629 scopus 로고    scopus 로고
    • Increased glycogen synthase kinase-3 activity in diabetes and obesity prone C57BL/6J mice
    • (1999) Diabetes , vol.48 , pp. 1662-1666
    • Eldar-Finkelman, H.1
  • 24
    • 0033958644 scopus 로고    scopus 로고
    • Potential role of GSK-3 in skeletal muscle insulin resistance type 2 diabetes
    • (2000) Diabetes , vol.49 , pp. 263-271
    • Nikoulina, S.E.1
  • 26
    • 0025813375 scopus 로고
    • Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
    • (1991) Nature , vol.352 , pp. 73-77
    • Sun, X.J.1
  • 27
    • 0029804116 scopus 로고    scopus 로고
    • Mechanism of activation of protein kinase B by insulin and IGF-1
    • (1996) EMBO J. , vol.15 , pp. 6541-6551
    • Alessi, D.R.1
  • 28
    • 0027182367 scopus 로고
    • The function of GRB2 in linking the insulin receptor to Ras signaling pathways
    • (1993) Science , vol.260 , pp. 1953-1955
    • Skolnik, E.Y.1
  • 29
    • 0028023002 scopus 로고
    • Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling
    • (1994) J. Biol. Chem. , vol.269 , pp. 6051-6057
    • Tanti, J.F.1
  • 30
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1 mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α and obesity induced insulin resistance
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1
  • 31
    • 0030669094 scopus 로고    scopus 로고
    • Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612
    • (1998) Biochemistry , vol.36 , pp. 12939-12947
    • Fea, K.D.1    Roth, R.2
  • 32
    • 0034708832 scopus 로고    scopus 로고
    • The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
    • (2000) J. Biol. Chem. , vol.275 , pp. 9047-9054
    • Aguirre, V.1
  • 33
    • 0033214461 scopus 로고    scopus 로고
    • Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function
    • (1999) J. Biol. Chem. , vol.274 , pp. 28816-28822
    • Paz, K.1
  • 35
    • 0026487365 scopus 로고
    • Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localization of the kinase
    • (1992) Neurosci. Lett. , vol.147 , pp. 58-62
    • Hanger, D.P.1
  • 36
    • 0026619584 scopus 로고
    • Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau
    • (1992) FEBS Lett. , vol.314 , pp. 315-321
    • Mandelkow, E.M.1
  • 37
    • 0035955512 scopus 로고    scopus 로고
    • Phosphorylation of tau by glycogen synthase kinase 3β in intact mammalian cells influences the stability of microtubules
    • (2001) Neurosci. Lett. , vol.312 , pp. 141-144
    • Sang, H.1
  • 38
    • 0032850599 scopus 로고    scopus 로고
    • Distribution of active glycogen synthase kinase 3β (GSK-3β) in brains staged for Alzheimer disease neurofibrillary changes
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 1010-1019
    • Pei, J.J.1
  • 39
    • 0029737421 scopus 로고    scopus 로고
    • Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 β and cyclin-dependent kinase 5, a component of TPK II
    • (1996) Acta Neuropathol. , vol.92 , pp. 232-241
    • Yamaguchi, H.1
  • 40
    • 0035863188 scopus 로고    scopus 로고
    • Decreased nuclear β-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3β conditional transgenic mice
    • (2001) EMBO J. , vol.20 , pp. 27-39
    • Lucas, J.J.1
  • 41
    • 0034731461 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3β phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice
    • (2000) J. Biol. Chem. , vol.275 , pp. 41340-41349
    • Spittaels, K.1
  • 42
    • 0028892186 scopus 로고
    • Amyloid β peptide induces cytoplasmic accumulation of amyloid protein precursor via tau protein kinase I/glycogen synthase kinase-3 β in rat hippocampal neurons
    • (1995) Neurosci. Lett. , vol.198 , pp. 83-86
    • Takashima, A.1
  • 44
  • 45
    • 0030788767 scopus 로고    scopus 로고
    • Presenilin 1 interaction in the brain with a novel member of the Armadillo family
    • (1997) NeuroReport , vol.8 , pp. 2085-2090
    • Zhou, J.1
  • 46
    • 0035980149 scopus 로고    scopus 로고
    • Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3
    • (2001) J. Biol. Chem. , vol.276 , pp. 32814-32821
    • Barber, A.J.1
  • 47
    • 0032493729 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway
    • (1998) J. Biol. Chem. , vol.273 , pp. 19929-19932
    • Pap, M.1    Cooper, G.2
  • 48
    • 0034971060 scopus 로고    scopus 로고
    • Activation of glycogen synthase kinase 3 β (GSK-3β) by platelet activating factor mediates migration and cell death in cerebellar granule neurons
    • (2001) Eur J. Neurosci. , vol.13 , pp. 1913-1922
    • Tong, N.1
  • 49
    • 0034677804 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 β facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium
    • (2000) J. Biol. Chem. , vol.275 , pp. 7583-7590
    • Bijur, G.N.1
  • 50
    • 0034602179 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 β activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal
    • (2000) J. Biol. Chem. , vol.275 , pp. 34266-34271
    • Crowder, R.J.1    Freeman, R.S.2
  • 51
    • 0035087123 scopus 로고    scopus 로고
    • Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death
    • (2001) J. Neurochem. , vol.77 , pp. 94-102
    • Cross, D.A.1
  • 52
    • 0034612636 scopus 로고    scopus 로고
    • Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation
    • (2000) Nature , vol.406 , pp. 86-90
    • Hoeflich, K.P.1
  • 54
    • 0021039875 scopus 로고
    • Insulin-like effect of lithium ion on isolated rat adipocytes stimulation of glycogenesis beyond glucose transport
    • (1983) Mol. Cell. Biochem. , vol.56 , pp. 177-182
    • Cheng, K.1
  • 55
    • 0030449964 scopus 로고    scopus 로고
    • Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signaling in intact cells
    • (1996) Curr. Biol. , vol.6 , pp. 1664-1668
    • Stambolic, V.1
  • 56
    • 0035943699 scopus 로고    scopus 로고
    • The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth
    • (2001) J. Biol. Chem. , vol.276 , pp. 31674-31683
    • Yuan, P.X.1
  • 57
    • 0033459559 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3β, β-catenin, and tau in postmortem bipolar brain
    • (1999) J. Neural Transm. , vol.106 , pp. 1217-1222
    • Lesort, M.1
  • 58
    • 0033776383 scopus 로고    scopus 로고
    • Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
    • (2000) Chem. Biol. , vol.7 , pp. 793-803
    • Coghlan, M.P.1
  • 59
    • 2142704952 scopus 로고    scopus 로고
    • In vitro GSK-3 inhibition enhances insulin-stimulated glucose transport in skeletal muscle of the Zucker diabetic rats
    • (1999) Diabetes , vol.S49 , pp. 63
    • Henriksen, R.1
  • 60
    • 0035963318 scopus 로고    scopus 로고
    • Anti-mitotic properties ofindirubin-3′-monoxime, a CDK/GSK-3 inhibitor: Induction of endoreplication following prophase arrest
    • (2001) Oncogene , vol.20 , pp. 3786-3797
    • Damiens, E.1
  • 61
    • 0034646792 scopus 로고    scopus 로고
    • The pathogenic L392V mutation of presenilin 1 decreases the affinity to glycogen synthase kinase-3 β
    • (2000) Neurosci. Lett. , vol.283 , pp. 217-220
    • Gantier, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.