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Volumn 6, Issue 8, 2007, Pages 888-894

Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance

Author keywords

ACC; AMPK; Macrophage; Protein phosphatase 2C; Skeletal muscle; TNF

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2C; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 34247489726     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.6.8.4135     Document Type: Review
Times cited : (124)

References (98)
  • 3
    • 0003731907 scopus 로고    scopus 로고
    • The world health report 2002. Reducing Risks
    • Organization WH, World Health Organization
    • Organization WH. The world health report 2002. Reducing Risks. Geneva: Promoting Healthy Life World Health Organization, 2002.
    • (2002) Geneva: Promoting Healthy Life
  • 4
    • 33745848775 scopus 로고    scopus 로고
    • Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
    • Herman MA, Kahn BB. Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest 2006; 116:1767-1775.
    • (2006) J Clin Invest , vol.116 , pp. 1767-1775
    • Herman, M.A.1    Kahn, B.B.2
  • 5
    • 0030669392 scopus 로고    scopus 로고
    • A molecular basis for insulin resistance: Elevated serine/threonine phosphorylation of irs-1 and irs-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
    • Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y. A molecular basis for insulin resistance: Elevated serine/threonine phosphorylation of irs-1 and irs-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J Biol Chem 1997; 272:29911-8.
    • (1997) J Biol Chem , vol.272 , pp. 29911-29918
    • Paz, K.1    Hemi, R.2    LeRoith, D.3    Karasik, A.4    Elhanany, E.5    Kanety, H.6    Zick, Y.7
  • 8
    • 0037073679 scopus 로고    scopus 로고
    • Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa b kinase complex
    • Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ, Ye J. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa b kinase complex. J Biol Chem 2002; 277:48115-21.
    • (2002) J Biol Chem , vol.277 , pp. 48115-48121
    • Gao, Z.1    Hwang, D.2    Bataille, F.3    Lefevre, M.4    York, D.5    Quon, M.J.6    Ye, J.7
  • 9
    • 0034708832 scopus 로고    scopus 로고
    • The c-jun nh(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of ser(307)
    • Aguirre V, Uchida T, Yenush L, Davis R, White MF. The c-jun nh(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of ser(307). J Biol Chem 2000; 275:9047-54.
    • (2000) J Biol Chem , vol.275 , pp. 9047-9054
    • Aguirre, V.1    Uchida, T.2    Yenush, L.3    Davis, R.4    White, M.F.5
  • 11
    • 2942628012 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 (socs-1) and socs-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
    • Ueki K, Kondo T, Kahn CR. Suppressor of cytokine signaling 1 (socs-1) and socs-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 2004; 24:5434-5446.
    • (2004) Mol Cell Biol , vol.24 , pp. 5434-5446
    • Ueki, K.1    Kondo, T.2    Kahn, C.R.3
  • 12
    • 33644782904 scopus 로고    scopus 로고
    • Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance
    • Shi H, Cave B, Inouye K, Bjorbaek C, Flier JS. Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance. Diabetes 2006; 55:699-707.
    • (2006) Diabetes , vol.55 , pp. 699-707
    • Shi, H.1    Cave, B.2    Inouye, K.3    Bjorbaek, C.4    Flier, J.S.5
  • 13
    • 0033662759 scopus 로고    scopus 로고
    • Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in pkc-theta localization
    • Bell KS, Schmitz-Peiffer C, Lim-Fraser M, Biden TJ, Cooney GJ, Kraegen EW. Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in pkc-theta localization. Am J Physiol 2000; 279:E1196-1201.
    • (2000) Am J Physiol , vol.279
    • Bell, K.S.1    Schmitz-Peiffer, C.2    Lim-Fraser, M.3    Biden, T.J.4    Cooney, G.J.5    Kraegen, E.W.6
  • 14
    • 0033861608 scopus 로고    scopus 로고
    • Involvement of protein kinase c in human skeletal muscle insulin resistance in obesity
    • Itani SI, Zhou Q, Pories WJ, MacDonald KG, Dohm GL. Involvement of protein kinase c in human skeletal muscle insulin resistance in obesity. Diabetes 2000; 49:1353-1358.
    • (2000) Diabetes , vol.49 , pp. 1353-1358
    • Itani, S.I.1    Zhou, Q.2    Pories, W.J.3    MacDonald, K.G.4    Dohm, G.L.5
  • 16
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of ikkbeta
    • Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of ikkbeta. Science 2001; 293:1673-1677.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.W.5    Karin, M.6    Shoelson, S.E.7
  • 21
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil G, Shargill N, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 1993; 259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.1    Shargill, N.2    Spiegelman, B.M.3
  • 22
    • 0028362194 scopus 로고
    • Tumor necrosis factor {alpha} inhibits signaling from the insulin receptor
    • Hotamisligil G, Murray D, Choy L, Spiegelman B. Tumor necrosis factor {alpha} inhibits signaling from the insulin receptor. Proc Natl Acad Sci 1994; 91:4854-4858.
    • (1994) Proc Natl Acad Sci , vol.91 , pp. 4854-4858
    • Hotamisligil, G.1    Murray, D.2    Choy, L.3    Spiegelman, B.4
  • 23
  • 24
    • 0028031569 scopus 로고
    • Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes: Central role of tumor necrosis factor-alpha
    • Hotamisligil G, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes: Central role of tumor necrosis factor-alpha. J Clin Invest 1994; 94:1543-1549.
    • (1994) J Clin Invest , vol.94 , pp. 1543-1549
    • Hotamisligil, G.1    Budavari, A.2    Murray, D.3    Spiegelman, B.M.4
  • 25
    • 0028931724 scopus 로고
    • Increased adipose expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995; 95:2409-2415.
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 26
    • 0030061922 scopus 로고    scopus 로고
    • Irs-1 mediated inhibition of insulin receptor tyrosine kinase activity in tnf-alpha- and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis BA, White MF, Spiegelman BM. Irs-1 mediated inhibition of insulin receptor tyrosine kinase activity in tnf-alpha- and obesity-induced insulin resistance. Science 1996; 271:665-668.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, B.A.4    White, M.F.5    Spiegelman, B.M.6
  • 27
    • 33845864967 scopus 로고    scopus 로고
    • Adipocytes as regulators of energy balance and glucose homeostasis
    • Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006; 444:847-53.
    • (2006) Nature , vol.444 , pp. 847-853
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 28
    • 0035055823 scopus 로고    scopus 로고
    • Relationship between serum tumor necrosis factor-alpha and insulin resistance in obese men with type 2 diabetes mellitus
    • Mishima Y, Kuyama A, Tada A, Takahashi K, Ishioka T, Kibata M. Relationship between serum tumor necrosis factor-alpha and insulin resistance in obese men with type 2 diabetes mellitus. Diabetes Res Clin Pract 2001; 52:119-23.
    • (2001) Diabetes Res Clin Pract , vol.52 , pp. 119-123
    • Mishima, Y.1    Kuyama, A.2    Tada, A.3    Takahashi, K.4    Ishioka, T.5    Kibata, M.6
  • 30
    • 0032922944 scopus 로고    scopus 로고
    • Circulating tumor necrosis factor-alpha concentrations in a native canadian population with high rates of type 2 diabetes mellitus
    • Zinman B, Hanley AJG, Harris SB, Kwan J, Fantus IG. Circulating tumor necrosis factor-alpha concentrations in a native canadian population with high rates of type 2 diabetes mellitus. J Clin Endocrinol Metab 1999; 84:272-278.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 272-278
    • Zinman, B.1    Hanley, A.J.G.2    Harris, S.B.3    Kwan, J.4    Fantus, I.G.5
  • 31
    • 0030028606 scopus 로고    scopus 로고
    • The expression of tnfalpha by human muscle: Relationship to insulin resistance
    • Saghizadeh M, Ong JM, Garvey WT, Henry RR, Kern PA. The expression of tnfalpha by human muscle: Relationship to insulin resistance. J Clin Invest 1996; 97:1111-1116.
    • (1996) J Clin Invest , vol.97 , pp. 1111-1116
    • Saghizadeh, M.1    Ong, J.M.2    Garvey, W.T.3    Henry, R.R.4    Kern, P.A.5
  • 32
    • 0035023128 scopus 로고    scopus 로고
    • Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
    • Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol 2001; 280:E745-E751.
    • (2001) Am J Physiol , vol.280
    • Kern, P.A.1    Ranganathan, S.2    Li, C.3    Wood, L.4    Ranganathan, G.5
  • 33
    • 25844456730 scopus 로고    scopus 로고
    • Tumor necrosis factor-{alpha} induces skeletal muscle insulin resistance in healthy human subjects via inhibition of akt substrate 160 phosphorylation
    • Plomgaard P, Bouzakri K, Krogh-Madsen R, Mittendorfer B, Zierath JR, Pedersen BK. Tumor necrosis factor-{alpha} induces skeletal muscle insulin resistance in healthy human subjects via inhibition of akt substrate 160 phosphorylation. Diabetes 2005; 54:2939-45.
    • (2005) Diabetes , vol.54 , pp. 2939-2945
    • Plomgaard, P.1    Bouzakri, K.2    Krogh-Madsen, R.3    Mittendorfer, B.4    Zierath, J.R.5    Pedersen, B.K.6
  • 34
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking tnf-alpha function
    • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking tnf-alpha function. Nature 1997; 389:610-4.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 35
    • 0029906375 scopus 로고    scopus 로고
    • Effects of an engineered human anti-tnf-alpha antibody (cdp571) on insulin sensitivity and glycemic control in patients with niddm
    • Ofei F, Hurel S, Newkirk J, Sopwith M, Taylor R. Effects of an engineered human anti-tnf-alpha antibody (cdp571) on insulin sensitivity and glycemic control in patients with niddm. Diabetes 1996; 45:881-885.
    • (1996) Diabetes , vol.45 , pp. 881-885
    • Ofei, F.1    Hurel, S.2    Newkirk, J.3    Sopwith, M.4    Taylor, R.5
  • 38
  • 39
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase c, and ikappab-alpha
    • Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase c, and ikappab-alpha. Diabetes 2002; 51:2005-2011.
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 40
    • 0141844653 scopus 로고    scopus 로고
    • Reciprocal modulation of toll-like receptor-4 signaling pathways involving myd88 and phosphatidylinositol 3-kinase/akt by saturated and polyunsaturated fatty acids
    • Lee JY, Ye J, Gao Z, Youn HS, Lee WH, Zhao L, Sizemore N, Hwang DH. Reciprocal modulation of toll-like receptor-4 signaling pathways involving myd88 and phosphatidylinositol 3-kinase/akt by saturated and polyunsaturated fatty acids. J Biol Chem 2003; 278:37041-51.
    • (2003) J Biol Chem , vol.278 , pp. 37041-37051
    • Lee, J.Y.1    Ye, J.2    Gao, Z.3    Youn, H.S.4    Lee, W.H.5    Zhao, L.6    Sizemore, N.7    Hwang, D.H.8
  • 44
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of ikk-beta and nf-kappab
    • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of ikk-beta and nf-kappab. Nat Med 2005; 11:183-90.
    • (2005) Nat Med , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 46
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006; 444:860-7.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 47
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 2000; 106:171-176.
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 48
    • 1442326017 scopus 로고    scopus 로고
    • Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: Evidence from cultured myotubes
    • Gaster M, Rustan AC, Aas V, Beck-Nielsen H. Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: Evidence from cultured myotubes. Diabetes 2004; 53:542-548.
    • (2004) Diabetes , vol.53 , pp. 542-548
    • Gaster, M.1    Rustan, A.C.2    Aas, V.3    Beck-Nielsen, H.4
  • 49
    • 0027946529 scopus 로고
    • Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus
    • Kelley DE, Simoneau JA. Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus. Journal of Clinical Investigation 1994; 94:2349-2356.
    • (1994) Journal of Clinical Investigation , vol.94 , pp. 2349-2356
    • Kelley, D.E.1    Simoneau, J.A.2
  • 51
    • 0036298225 scopus 로고    scopus 로고
    • Leptin increases fa oxidation in lean but not obese human skeletal muscle: Evidence of peripheral leptin resistance
    • Steinberg GR, Parolin ML, Heigenhauser GJ, Dyck DJ. Leptin increases fa oxidation in lean but not obese human skeletal muscle: Evidence of peripheral leptin resistance. Am J Physiol Endocrinol Metab 2002; 283:E187-92.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Steinberg, G.R.1    Parolin, M.L.2    Heigenhauser, G.J.3    Dyck, D.J.4
  • 54
    • 17844400342 scopus 로고    scopus 로고
    • Wojtaszewski JFP, Birk JB, Frøsig C, Holten M, Pilegaard H, Dela F. 5′amp activated protein kinase expression in human skeletal muscle: Effects of strength training and type 2 diabetes. J Physiol 2005; 564.2:563-573.
    • Wojtaszewski JFP, Birk JB, Frøsig C, Holten M, Pilegaard H, Dela F. 5′amp activated protein kinase expression in human skeletal muscle: Effects of strength training and type 2 diabetes. J Physiol 2005; 564.2:563-573.
  • 56
    • 0029561919 scopus 로고
    • 5′-amp inhibits dephosphorylation, as well as promoting phosphorylation, of the amp-activated protein kinase: Studies using bacterially expressed human protein phosphatase-2c alpha and native bovine protein phosphatase-2ac
    • Davies SP, Helps NR, Cohen PT, Hardie DG. 5′-amp inhibits dephosphorylation, as well as promoting phosphorylation, of the amp-activated protein kinase: Studies using bacterially expressed human protein phosphatase-2c alpha and native bovine protein phosphatase-2ac. FEBS Lett 1995; 377:421-425.
    • (1995) FEBS Lett , vol.377 , pp. 421-425
    • Davies, S.P.1    Helps, N.R.2    Cohen, P.T.3    Hardie, D.G.4
  • 57
    • 33846955046 scopus 로고    scopus 로고
    • Scott JW, Ross FA, Liu JK, Hardie DG. Regulation of amp-activated protein kinase by a pseudosubstrate sequence on the gamma subunit. Embo J 2007.
    • Scott JW, Ross FA, Liu JK, Hardie DG. Regulation of amp-activated protein kinase by a pseudosubstrate sequence on the gamma subunit. Embo J 2007.
  • 61
    • 0037370773 scopus 로고    scopus 로고
    • Ampk expression and phosphorylation are increased in rodent muscle after chronic leptin treatment
    • Steinberg GR, Rush JWE, Dyck DJ. Ampk expression and phosphorylation are increased in rodent muscle after chronic leptin treatment. Am J Physiol Endocrinol Metab 2003; 284: E648-654.
    • (2003) Am J Physiol Endocrinol Metab , vol.284
    • Steinberg, G.R.1    Rush, J.W.E.2    Dyck, D.J.3
  • 63
    • 0037059013 scopus 로고    scopus 로고
    • Enhanced muscle fat oxidation and glucose transport by acrp30 globular domain: Acetyl-coa carboxylase inhibition and amp-activated protein kinase activation
    • Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang CC, Itani SI, Lodish HF, Ruderman NB. Enhanced muscle fat oxidation and glucose transport by acrp30 globular domain: Acetyl-coa carboxylase inhibition and amp-activated protein kinase activation. Proc Natl Acad Sci USA 2002; 99:16309-16313.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16309-16313
    • Tomas, E.1    Tsao, T.S.2    Saha, A.K.3    Murrey, H.E.4    Zhang, C.C.5    Itani, S.I.6    Lodish, H.F.7    Ruderman, N.B.8
  • 67
    • 4043085036 scopus 로고    scopus 로고
    • Adenovirus-mediated chronic "Hyper-resistinemia" Leads to in vivo insulin resistance in normal rats
    • Satoh H, Nguyen MTA, Miles PDG, Imamura T, Usui I, Olefsky JM. Adenovirus-mediated chronic "Hyper-resistinemia" Leads to in vivo insulin resistance in normal rats. J Clin Invest 2004; 114:224-231.
    • (2004) J Clin Invest , vol.114 , pp. 224-231
    • Satoh, H.1    Nguyen, M.T.A.2    Miles, P.D.G.3    Imamura, T.4    Usui, I.5    Olefsky, J.M.6
  • 68
    • 33749370466 scopus 로고    scopus 로고
    • Increased malonyl-coa levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects
    • Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM. Increased malonyl-coa levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes 2006; 55:2277-85.
    • (2006) Diabetes , vol.55 , pp. 2277-2285
    • Bandyopadhyay, G.K.1    Yu, J.G.2    Ofrecio, J.3    Olefsky, J.M.4
  • 69
    • 12144271041 scopus 로고    scopus 로고
    • Leptinomimetic effects of the amp kinase activator aicar in leptin-resistant rats: Prevention of diabetes and ectopic lipid deposition
    • Yu X, McCorkle S, Wang M, Lee Y, Li J, Saha AK, Unger RH, Ruderman NB. Leptinomimetic effects of the amp kinase activator aicar in leptin-resistant rats: Prevention of diabetes and ectopic lipid deposition. Diabetaologia 2004; 47:2012-2021.
    • (2004) Diabetaologia , vol.47 , pp. 2012-2021
    • Yu, X.1    McCorkle, S.2    Wang, M.3    Lee, Y.4    Li, J.5    Saha, A.K.6    Unger, R.H.7    Ruderman, N.B.8
  • 70
    • 0036723810 scopus 로고    scopus 로고
    • Isoform specific regulation of 5' amp-activated protein kinase in skeletal muscle from obese zucker (fa/fa) rats in response to contraction
    • Barnes BR, Ryder JW, Steiler TL, Fryer LG, Carling D, Zierath JR. Isoform specific regulation of 5' amp-activated protein kinase in skeletal muscle from obese zucker (fa/fa) rats in response to contraction. Diabetes 2002; 51:2703-2708.
    • (2002) Diabetes , vol.51 , pp. 2703-2708
    • Barnes, B.R.1    Ryder, J.W.2    Steiler, T.L.3    Fryer, L.G.4    Carling, D.5    Zierath, J.R.6
  • 72
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the lkb1 tumor suppressor, stradalpha/beta and mo25alpha/beta are upstream kinases in the amp-activated protein kinase cascade
    • Hawley S, Boudeau J, Reid J, Mustard K, Udd L, Makela T, Alessi D, Hardie DG. Complexes between the lkb1 tumor suppressor, stradalpha/beta and mo25alpha/beta are upstream kinases in the amp-activated protein kinase cascade. Journal of Biology 2003; 2:28.
    • (2003) Journal of Biology , vol.2 , pp. 28
    • Hawley, S.1    Boudeau, J.2    Reid, J.3    Mustard, K.4    Udd, L.5    Makela, T.6    Alessi, D.7    Hardie, D.G.8
  • 73
    • 12144287284 scopus 로고    scopus 로고
    • Lizcano JM, Olga Göransson, Rachel Toth, Maria Deak, Nick A Morrice, Jérôme Boudeau, Simon A Hawley, Lina Udd, Tomi P Mäkelä, Hardie DG, Alessi DR. Lkb1 is a master kinase that activates 13 kinases of the ampk subfamily, including mark/par-1. EMBO J 2004; 23:833-843.
    • Lizcano JM, Olga Göransson, Rachel Toth, Maria Deak, Nick A Morrice, Jérôme Boudeau, Simon A Hawley, Lina Udd, Tomi P Mäkelä, Hardie DG, Alessi DR. Lkb1 is a master kinase that activates 13 kinases of the ampk subfamily, including mark/par-1. EMBO J 2004; 23:833-843.
  • 74
    • 1542618348 scopus 로고    scopus 로고
    • Inaugural article: The tumor suppressor lkb1 kinase directly activates amp-activated kinase and regulates apoptosis in response to energy stress
    • Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. Inaugural article: The tumor suppressor lkb1 kinase directly activates amp-activated kinase and regulates apoptosis in response to energy stress. PNAS 2004; 101:3329-3335.
    • (2004) PNAS , vol.101 , pp. 3329-3335
    • Shaw, R.J.1    Kosmatka, M.2    Bardeesy, N.3    Hurley, R.L.4    Witters, L.A.5    DePinho, R.A.6    Cantley, L.C.7
  • 76
    • 0037059330 scopus 로고    scopus 로고
    • Phosphorylation of ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
    • Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 2002; 277:1531-1537.
    • (2002) J Biol Chem , vol.277 , pp. 1531-1537
    • Aguirre, V.1    Werner, E.D.2    Giraud, J.3    Lee, Y.H.4    Shoelson, S.E.5    White, M.F.6
  • 77
    • 0035861644 scopus 로고    scopus 로고
    • Ampk phosphorylates irs-1 on ser789 in mouse c2c12 myotubes in response to 5-aminoimidazole-4- carboxamide riboside
    • Jakobsen SN, Hardie DG, Morrice N, Tornqvist HE. Ampk phosphorylates irs-1 on ser789 in mouse c2c12 myotubes in response to 5-aminoimidazole-4- carboxamide riboside. J Biol Chem 2001; 276:46912-46916.
    • (2001) J Biol Chem , vol.276 , pp. 46912-46916
    • Jakobsen, S.N.1    Hardie, D.G.2    Morrice, N.3    Tornqvist, H.E.4
  • 78
    • 33847062845 scopus 로고    scopus 로고
    • The rab gtpase-activating protein as160 integrates akt, protein kinase c, and amp-activated protein kinase signals regulating glut4 traffic
    • Thong FS, Bilan PJ, Klip A. The rab gtpase-activating protein as160 integrates akt, protein kinase c, and amp-activated protein kinase signals regulating glut4 traffic. Diabetes 2007; 56:414-23.
    • (2007) Diabetes , vol.56 , pp. 414-423
    • Thong, F.S.1    Bilan, P.J.2    Klip, A.3
  • 79
    • 34247471438 scopus 로고    scopus 로고
    • Prior exercise increases phosphorylation of akt substrate of 160 kda (as160) in rat skeletal muscle
    • Arias EB, Kim J, Funai K, Cartee GD. Prior exercise increases phosphorylation of akt substrate of 160 kda (as160) in rat skeletal muscle. Am J Physiol Endocrinol Metab 2006.
    • (2006) Am J Physiol Endocrinol Metab
    • Arias, E.B.1    Kim, J.2    Funai, K.3    Cartee, G.D.4
  • 80
    • 34247470973 scopus 로고    scopus 로고
    • As160 phosphorylation is associated with activation of {alpha}2{beta}2{gamma}1 but not {alpha}2{beta}2{gamma}3 ampk trimeric complex in skeletal muscle during exercise in humans
    • Treebak JT, Birk JB, Rose AJ, Kiens B, Richter EA, Wojtaszewski JF. As160 phosphorylation is associated with activation of {alpha}2{beta}2{gamma}1 but not {alpha}2{beta}2{gamma}3 ampk trimeric complex in skeletal muscle during exercise in humans. Am J Physiol Endocrinol Metab 2006.
    • (2006) Am J Physiol Endocrinol Metab
    • Treebak, J.T.1    Birk, J.B.2    Rose, A.J.3    Kiens, B.4    Richter, E.A.5    Wojtaszewski, J.F.6
  • 83
    • 14344257169 scopus 로고    scopus 로고
    • Ampk inhibits fatty acid-induced increases in nf-kappab transactivation in cultured human umbilical vein endothelial cells
    • Cacicedo JM, Yagihashi N, Keaney Jr JF, Ruderman NB, Ido Y. Ampk inhibits fatty acid-induced increases in nf-kappab transactivation in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun 2004; 324:1204-9.
    • (2004) Biochem Biophys Res Commun , vol.324 , pp. 1204-1209
    • Cacicedo, J.M.1    Yagihashi, N.2    Keaney Jr, J.F.3    Ruderman, N.B.4    Ido, Y.5
  • 84
    • 0030661983 scopus 로고    scopus 로고
    • Tnf-alpha-induced insulin resistance in vivo and its prevention by troglitazone
    • Miles PDG, Romeo OM, Higo K, Cohen A, Rafaat K, Olefsky J. Tnf-alpha-induced insulin resistance in vivo and its prevention by troglitazone. Diabetes 1997; 46:1678-1683.
    • (1997) Diabetes , vol.46 , pp. 1678-1683
    • Miles, P.D.G.1    Romeo, O.M.2    Higo, K.3    Cohen, A.4    Rafaat, K.5    Olefsky, J.6
  • 85
    • 0036828912 scopus 로고    scopus 로고
    • Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-{alpha}: Implications for insulin resistance
    • Ruan H, Miles PDG, Ladd CM, Ross K, Golub TR, Olefsky JM, Lodish HF. Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-{alpha}: Implications for insulin resistance. Diabetes 2002; 51:3176-3188.
    • (2002) Diabetes , vol.51 , pp. 3176-3188
    • Ruan, H.1    Miles, P.D.G.2    Ladd, C.M.3    Ross, K.4    Golub, T.R.5    Olefsky, J.M.6    Lodish, H.F.7
  • 90
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 2004; 350:664-71.
    • (2004) N Engl J Med , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.I.5
  • 91
    • 0037058977 scopus 로고    scopus 로고
    • Amp kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    • Zong H, Ren JM, Young LH, Pypaert M, Mu J, Birnbaum MJ, Shulman GI. Amp kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci 2002; 99:15983-15987.
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 15983-15987
    • Zong, H.1    Ren, J.M.2    Young, L.H.3    Pypaert, M.4    Mu, J.5    Birnbaum, M.J.6    Shulman, G.I.7
  • 93
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate amp- activated protein kinase through distinct signaling pathways
    • Fryer LG, Parbu-Patel A, Carling D. The anti-diabetic drugs rosiglitazone and metformin stimulate amp- activated protein kinase through distinct signaling pathways. J Biol Chem 2002; 277:25226-32.
    • (2002) J Biol Chem , vol.277 , pp. 25226-25232
    • Fryer, L.G.1    Parbu-Patel, A.2    Carling, D.3
  • 95
    • 0031888958 scopus 로고    scopus 로고
    • Ppar-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang C, Ting AT, Seed B. Ppar-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 1998; 391:82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 96
    • 0035029255 scopus 로고    scopus 로고
    • Pioglitazone ameliorates tumor necrosis factor-alpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator-activated receptor-gamma
    • Iwata M, Haruta T, Usui I, Takata Y, Takano A, Uno T, Kawahara J, Ueno E, Sasaoka T, Ishibashi O, Kobayashi M. Pioglitazone ameliorates tumor necrosis factor-alpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator-activated receptor-gamma. Diabetes 2001; 50:1083-92.
    • (2001) Diabetes , vol.50 , pp. 1083-1092
    • Iwata, M.1    Haruta, T.2    Usui, I.3    Takata, Y.4    Takano, A.5    Uno, T.6    Kawahara, J.7    Ueno, E.8    Sasaoka, T.9    Ishibashi, O.10    Kobayashi, M.11


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