Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor

Journal of Lipid Research

Volumn 45, Issue 10, 2004, Pages 1929-1942

  Quinet, Elaine M ^a   Savio, Dawn A ^a   Halpern, Anita R ^a   Chen, Liang ^a   Miller, Christopher P ^a   Nambi, Ponnal ^a  

^a PFIZER INC   (United States)

Author keywords

Atherosclerosis; ATP binding cassette transporter A1; Cholesterol efflux; Lipoproteins; Macrophages; Nuclear receptors; Sterol response element binding protein 1c

Indexed keywords

22 HYDROXYCHOLESTEROL; 25 HYDROXYCHOLESTEROL; 3 [3 (2 CHLORO 3 TRIFLUOROMETHYLBENZYL 2,2 DIPHENYLETHYLAMINO)PROPOXY]PHENYLACETIC ACID; 3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; ABC TRANSPORTER; ABC TRANSPORTER A1; CHOLESTEROL; HORMONE RECEPTOR STIMULATING AGENT; LIGAND; LIVER X RECEPTOR; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; N,N DIMETHYL 3BETA HYDROXYCHOLENAMIDE; OXYSTEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TO 901317; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; CCAAT ENHANCER BINDING PROTEIN; CELL RECEPTOR; CHOLESTEROL DERIVATIVE; CHOLIC ACID DERIVATIVE; DNA BINDING PROTEIN; N,N DIMETHYL 3 HYDROXY 5 CHOLENAMIDE; N,N-DIMETHYL-3-HYDROXY-5-CHOLENAMIDE; OXYSTEROL RECEPTOR; SREBF1 PROTEIN, HUMAN; SREBF1 PROTEIN, MOUSE; STEROID RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY WALL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DRUG TARGETING; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPID STORAGE; LIPOGENESIS; LIVER; MACROPHAGE; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; SMALL INTESTINE; TRANSCRIPTION INITIATION; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; ARTERIOSCLEROSIS; BLOOD; C57BL MOUSE; DRUG EFFECT; GENETICS; LIVER CELL; METABOLISM; TRANSACTIVATION; TUMOR CELL LINE;

ANIMALS; ARTERIOSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE, TUMOR; CHOLESTEROL; CHOLIC ACIDS; DNA-BINDING PROTEINS; HEPATOCYTES; HUMANS; HYDROXYCHOLESTEROLS; LIGANDS; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRIGLYCERIDES;

EID: 13544267956     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M400257-JLR200     Document Type: Article

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