Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes

Journal of Molecular Biology

Volumn 304, Issue 3, 2000, Pages 323-334

  Schoonjans, Kristina ^a   Gelman, Laurent ^a   Haby, Céline ^a   Briggs, Michael ^b   Auwerx, Johan ^a  

^a CNRS   (France)

^b LIGAND PHARMACEUTICALS INC   (United States)

Author keywords

Adipocyte differentiation and determination factor 1; Atherosclerosis; Cholesterol; Lipid metabolism; Sterol regulatory element binding protein

Indexed keywords

CHOLESTEROL; MESSENGER RNA; STEROL DERIVATIVE; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; FATTY ACID METABOLISM; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIPID METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN STRUCTURE; STEROL METABOLISM;

ANIMALIA;

EID: 0034406804     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4218     Document Type: Article

References (50)

1. Specificity in cholesterol regulation of gene expression by co-evolution of sterol regulatory DNA element and its binding protein
2. Lipoprotein lipase gene expression in THP-1 cells
3. Lipoprotein lipase: Recent contributions from molecular biology
4. Sterol regulation of fatty acid synthase promoter; coordinate feedback regulation of two major lipid pathways
5. Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors
6. Nuclear protein that binds sterol regulatory element of LDL receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence
7. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
8. Characterization of a high affinity octamer transcription factor binding site in the human lipoprotein lipase promoter
9. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
10. Characterization of the human lipoprotein lipase (LPL) promotor: Evidence of two cis-regulatory regions, LP-α and LP-β, of importance for the differentiation-linked induction of the LPL gene during adipogenesis
11. Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene
12. Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene
13. Sterol regulatory element binding protein 1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
14. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose
15. Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene
16. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
17. An oxysterol signalling pathway mediated by the nuclear receptor LXRα
18. Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro
19. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism
20. Dual DNA binding specificity of ADD-1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain
21. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
22. ADD1/SREBP1 activates PPARγ through the production of endogeneous ligand
23. Sterol regulation of acetyl coenzyme A carboxylase: A mechanism for coordinate control of cellular lipid
24. Construction of plasmids that express E. coli β-galactosidase in mammalian cells
25. Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty acid synthase promoter
26. Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins
27. Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase
28. Cloning of cDNA sequences of hormone-regulated genes from MCF-7 human breast cancer cell line
29. Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter
30. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
31. SREBP-1 binds to multiple sites and transactivates the human ApoA-II promoter in vitro: SREBP-1 mutants defective in DNA binding or transcriptional activation repress ApoA-II promoter activity
32. Transcriptional regulation of the human lipoprotein lipase gene in 3T3-L1 adipocytes
33. Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene
34. Developmental extinction of liver lipoprotein lipase mRNA expression might be regulated by an NF-1 like site
35. PPARα and PPARγ activators direct a tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
36. HMG-CoA reductase inhibitors reduce serum triglyceride levels through effects on apolipoprotein C-III and lipoprotein lipase levels
37. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
38. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
39. Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver
40. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
41. Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene
42. Identification of diazepam-binding inhibitor/acyl-coA-binding protein as a sterol regulatory element-binding protein-responsive gene
43. Transcriptional activation of the stearoyl-coA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differenciation factor 1
44. Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins
45. ADD1: A novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation
46. A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene
47. Nuclear protein that binds sterol regulatory element of LDL receptor promoter: II. Purification and characterization
48. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
49. Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein