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Volumn 30, Issue 4, 2007, Pages 159-166

Neuronal death: where does the end begin?

Author keywords

[No Author keywords available]

Indexed keywords

POLYGLUTAMINE;

EID: 33947724269     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tins.2007.02.004     Document Type: Review
Times cited : (127)

References (80)
  • 1
    • 0014764097 scopus 로고
    • On the degeneration of rat neuromuscular junctions after nerve section
    • Miledi R., and Slater C.R. On the degeneration of rat neuromuscular junctions after nerve section. J. Physiol. 207 (1970) 507-528
    • (1970) J. Physiol. , vol.207 , pp. 507-528
    • Miledi, R.1    Slater, C.R.2
  • 2
    • 24344506747 scopus 로고    scopus 로고
    • The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves
    • Beirowski B., et al. The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves. BMC Neurosci. 6 (2005) 6
    • (2005) BMC Neurosci. , vol.6 , pp. 6
    • Beirowski, B.1
  • 3
    • 0028269017 scopus 로고
    • Ventral root avulsion: an experimental model of death of adult motor neurons
    • Koliatsos V.E., et al. Ventral root avulsion: an experimental model of death of adult motor neurons. J. Comp. Neurol. 342 (1994) 35-44
    • (1994) J. Comp. Neurol. , vol.342 , pp. 35-44
    • Koliatsos, V.E.1
  • 4
    • 1242328756 scopus 로고    scopus 로고
    • Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice
    • Beirowski B., et al. Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice. J. Neurosci. Methods 134 (2004) 23-35
    • (2004) J. Neurosci. Methods , vol.134 , pp. 23-35
    • Beirowski, B.1
  • 5
    • 23744445580 scopus 로고    scopus 로고
    • A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis
    • Schaefer A.M., et al. A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis. J. Comp. Neurol. 490 (2005) 209-219
    • (2005) J. Comp. Neurol. , vol.490 , pp. 209-219
    • Schaefer, A.M.1
  • 6
    • 33344462702 scopus 로고    scopus 로고
    • Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF
    • Pun S., et al. Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF. Nat. Neurosci. 9 (2006) 408-419
    • (2006) Nat. Neurosci. , vol.9 , pp. 408-419
    • Pun, S.1
  • 7
    • 0037106522 scopus 로고    scopus 로고
    • s mutant and Ube4b/Nmnat transgenic mice
    • s mutant and Ube4b/Nmnat transgenic mice. J. Physiol. 543 (2002) 739-755
    • (2002) J. Physiol. , vol.543 , pp. 739-755
    • Gillingwater, T.H.1
  • 8
    • 33750359354 scopus 로고    scopus 로고
    • The slow Wallerian degeneration gene in vivo protects motor axons but not their cell bodies after avulsion and neonatal axotomy
    • Adalbert R., et al. The slow Wallerian degeneration gene in vivo protects motor axons but not their cell bodies after avulsion and neonatal axotomy. Eur. J. Neurosci. 24 (2006) 2163-2168
    • (2006) Eur. J. Neurosci. , vol.24 , pp. 2163-2168
    • Adalbert, R.1
  • 9
    • 77955614345 scopus 로고    scopus 로고
    • Susceptibility to neurodegeneration in glaucoma is modified by Bax gene dosage
    • Libby R.T., et al. Susceptibility to neurodegeneration in glaucoma is modified by Bax gene dosage. PLoS Genet 1 (2005) 17-26
    • (2005) PLoS Genet , vol.1 , pp. 17-26
    • Libby, R.T.1
  • 10
    • 27644591304 scopus 로고    scopus 로고
    • Axon degeneration mechanisms: commonality amid diversity
    • Coleman M. Axon degeneration mechanisms: commonality amid diversity. Nat. Rev. Neurosci. 6 (2005) 889-898
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 889-898
    • Coleman, M.1
  • 11
    • 33745058436 scopus 로고    scopus 로고
    • Delayed synaptic degeneration in the CNS of Wlds mice after cortical lesion
    • Gillingwater T.H., et al. Delayed synaptic degeneration in the CNS of Wlds mice after cortical lesion. Brain 129 (2006) 1546-1556
    • (2006) Brain , vol.129 , pp. 1546-1556
    • Gillingwater, T.H.1
  • 12
    • 33745740498 scopus 로고    scopus 로고
    • In vivo imaging of the diseased nervous system
    • Misgeld T., and Kerschensteiner M. In vivo imaging of the diseased nervous system. Nat. Rev. Neurosci. 7 (2006) 449-463
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 449-463
    • Misgeld, T.1    Kerschensteiner, M.2
  • 13
    • 30944450665 scopus 로고    scopus 로고
    • Deep tissue two-photon microscopy
    • Helmchen F., and Denk W. Deep tissue two-photon microscopy. Nat. Methods 2 (2005) 932-940
    • (2005) Nat. Methods , vol.2 , pp. 932-940
    • Helmchen, F.1    Denk, W.2
  • 14
    • 33751100104 scopus 로고    scopus 로고
    • Survival motor neuron function in motor axons is independent of functions required for small nuclear ribonucleoprotein biogenesis
    • Carrel T.L., et al. Survival motor neuron function in motor axons is independent of functions required for small nuclear ribonucleoprotein biogenesis. J. Neurosci. 26 (2006) 11014-11022
    • (2006) J. Neurosci. , vol.26 , pp. 11014-11022
    • Carrel, T.L.1
  • 15
    • 21344472483 scopus 로고    scopus 로고
    • A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice
    • Kieran D., et al. A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice. J. Cell Biol. 169 (2005) 561-567
    • (2005) J. Cell Biol. , vol.169 , pp. 561-567
    • Kieran, D.1
  • 16
    • 20044385920 scopus 로고    scopus 로고
    • Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease
    • Stokin G.B., et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 307 (2005) 1282-1288
    • (2005) Science , vol.307 , pp. 1282-1288
    • Stokin, G.B.1
  • 17
    • 33749056809 scopus 로고    scopus 로고
    • ALS: a disease of motor neurons and their nonneuronal neighbors
    • Boillee S., et al. ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron 52 (2006) 39-59
    • (2006) Neuron , vol.52 , pp. 39-59
    • Boillee, S.1
  • 18
    • 0036842251 scopus 로고    scopus 로고
    • A missense mutation in Tbce causes progressive motor neuronopathy in mice
    • Martin N., et al. A missense mutation in Tbce causes progressive motor neuronopathy in mice. Nat. Genet. 32 (2002) 443-447
    • (2002) Nat. Genet. , vol.32 , pp. 443-447
    • Martin, N.1
  • 19
    • 0037734370 scopus 로고    scopus 로고
    • Mutations in dynein link motor neuron degeneration to defects in retrograde transport
    • Hafezparast M., et al. Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science 300 (2003) 808-812
    • (2003) Science , vol.300 , pp. 808-812
    • Hafezparast, M.1
  • 20
    • 27644469489 scopus 로고    scopus 로고
    • Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse
    • Schmitt-John T., et al. Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse. Nat. Genet. 37 (2005) 1213-1215
    • (2005) Nat. Genet. , vol.37 , pp. 1213-1215
    • Schmitt-John, T.1
  • 21
    • 0345742771 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man
    • Fischer L.R., et al. Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp. Neurol. 185 (2004) 232-240
    • (2004) Exp. Neurol. , vol.185 , pp. 232-240
    • Fischer, L.R.1
  • 22
    • 33748261830 scopus 로고    scopus 로고
    • Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS
    • Gould T.W., et al. Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. J. Neurosci. 26 (2006) 8774-8786
    • (2006) J. Neurosci. , vol.26 , pp. 8774-8786
    • Gould, T.W.1
  • 23
    • 0035886428 scopus 로고    scopus 로고
    • Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histochemical reactivity
    • Bendotti C., et al. Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histochemical reactivity. J. Neurol. Sci. 191 (2001) 25-33
    • (2001) J. Neurol. Sci. , vol.191 , pp. 25-33
    • Bendotti, C.1
  • 24
    • 33845361630 scopus 로고    scopus 로고
    • Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death
    • Martin L.J., et al. Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death. J. Comp. Neurol. 500 (2006) 20-46
    • (2006) J. Comp. Neurol. , vol.500 , pp. 20-46
    • Martin, L.J.1
  • 25
    • 32244441514 scopus 로고    scopus 로고
    • Activation of the p38MAPK cascade is associated with upregulation of TNFα receptors in the spinal motor neurons of mouse models of familial ALS
    • Veglianese P., et al. Activation of the p38MAPK cascade is associated with upregulation of TNFα receptors in the spinal motor neurons of mouse models of familial ALS. Mol. Cell. Neurosci. 31 (2006) 218-231
    • (2006) Mol. Cell. Neurosci. , vol.31 , pp. 218-231
    • Veglianese, P.1
  • 26
    • 33645822300 scopus 로고    scopus 로고
    • Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL
    • Raoul C., et al. Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 6007-6012
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 6007-6012
    • Raoul, C.1
  • 27
    • 0344950387 scopus 로고    scopus 로고
    • Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease
    • Ferri A., et al. Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease. Curr. Biol. 13 (2003) 669-673
    • (2003) Curr. Biol. , vol.13 , pp. 669-673
    • Ferri, A.1
  • 28
    • 0030756459 scopus 로고    scopus 로고
    • Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Kostic V., et al. Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis. Science 277 (1997) 559-562
    • (1997) Science , vol.277 , pp. 559-562
    • Kostic, V.1
  • 29
    • 20244390181 scopus 로고    scopus 로고
    • S gene modestly prolongs survival in the SOD1(G93A) fALS mouse
    • S gene modestly prolongs survival in the SOD1(G93A) fALS mouse. Neurobiol. Dis. 19 (2005) 293-300
    • (2005) Neurobiol. Dis. , vol.19 , pp. 293-300
    • Fischer, L.R.1
  • 30
    • 0042887389 scopus 로고    scopus 로고
    • Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding
    • McWhorter M.L., et al. Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding. J. Cell Biol. 162 (2003) 919-931
    • (2003) J. Cell Biol. , vol.162 , pp. 919-931
    • McWhorter, M.L.1
  • 31
    • 33644990213 scopus 로고    scopus 로고
    • Spinal muscular atrophy: the RNP connection
    • Eggert C., et al. Spinal muscular atrophy: the RNP connection. Trends Mol. Med. 12 (2006) 113-121
    • (2006) Trends Mol. Med. , vol.12 , pp. 113-121
    • Eggert, C.1
  • 32
    • 0042202619 scopus 로고    scopus 로고
    • Active transport of the survival motor neuron protein and the role of exon-7 in cytoplasmic localization
    • Zhang H.L., et al. Active transport of the survival motor neuron protein and the role of exon-7 in cytoplasmic localization. J. Neurosci. 23 (2003) 6627-6637
    • (2003) J. Neurosci. , vol.23 , pp. 6627-6637
    • Zhang, H.L.1
  • 33
    • 0345599021 scopus 로고    scopus 로고
    • Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of β-actin mRNA in growth cones of motoneurons
    • Rossoll W., et al. Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of β-actin mRNA in growth cones of motoneurons. J. Cell Biol. 163 (2003) 801-812
    • (2003) J. Cell Biol. , vol.163 , pp. 801-812
    • Rossoll, W.1
  • 34
    • 71749091926 scopus 로고    scopus 로고
    • Neurofilament accumulation at the motor endplate and lack of axonal sprouting in a spinal muscular atrophy mouse model
    • Cifuentes-Diaz C., et al. Neurofilament accumulation at the motor endplate and lack of axonal sprouting in a spinal muscular atrophy mouse model. Hum. Mol. Genet. 11 (2002) 1439-1447
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 1439-1447
    • Cifuentes-Diaz, C.1
  • 35
    • 31544437449 scopus 로고    scopus 로고
    • Distinct and overlapping alterations in motor and sensory neurons in a mouse model of spinal muscular atrophy
    • Jablonka S., et al. Distinct and overlapping alterations in motor and sensory neurons in a mouse model of spinal muscular atrophy. Hum. Mol. Genet. 15 (2006) 511-518
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 511-518
    • Jablonka, S.1
  • 36
    • 25844461744 scopus 로고    scopus 로고
    • Reduced U snRNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy
    • Winkler C., et al. Reduced U snRNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy. Genes Dev. 19 (2005) 2320-2330
    • (2005) Genes Dev. , vol.19 , pp. 2320-2330
    • Winkler, C.1
  • 37
    • 0141430092 scopus 로고    scopus 로고
    • Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model
    • Martin K.R., et al. Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model. Invest. Ophthalmol. Vis. Sci. 44 (2003) 4357-4365
    • (2003) Invest. Ophthalmol. Vis. Sci. , vol.44 , pp. 4357-4365
    • Martin, K.R.1
  • 38
    • 0019523221 scopus 로고
    • Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage
    • Quigley H.A., et al. Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage. Arch. Ophthalmol. 99 (1981) 635-649
    • (1981) Arch. Ophthalmol. , vol.99 , pp. 635-649
    • Quigley, H.A.1
  • 39
    • 33646199680 scopus 로고    scopus 로고
    • Optic nerve degeneration in the DBA/2NNia mouse: is the lamina cribrosa important in the development of glaucomatous optic neuropathy?
    • May C.A., and Mittag T. Optic nerve degeneration in the DBA/2NNia mouse: is the lamina cribrosa important in the development of glaucomatous optic neuropathy?. Acta Neuropathol. (Berl.) 111 (2006) 158-167
    • (2006) Acta Neuropathol. (Berl.) , vol.111 , pp. 158-167
    • May, C.A.1    Mittag, T.2
  • 40
    • 33750381831 scopus 로고    scopus 로고
    • Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric
    • Schlamp C.L., et al. Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC Neurosci. 7 (2006) 66
    • (2006) BMC Neurosci. , vol.7 , pp. 66
    • Schlamp, C.L.1
  • 41
    • 0034060114 scopus 로고    scopus 로고
    • Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma
    • Pease M.E., et al. Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 41 (2000) 764-774
    • (2000) Invest. Ophthalmol. Vis. Sci. , vol.41 , pp. 764-774
    • Pease, M.E.1
  • 42
    • 33745019901 scopus 로고    scopus 로고
    • Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucoma
    • Martin K.R., et al. Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucoma. Exp. Eye Res. 83 (2006) 255-262
    • (2006) Exp. Eye Res. , vol.83 , pp. 255-262
    • Martin, K.R.1
  • 43
    • 27544480984 scopus 로고    scopus 로고
    • Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice
    • Jakobs T.C., et al. Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J. Cell Biol. 171 (2005) 313-325
    • (2005) J. Cell Biol. , vol.171 , pp. 313-325
    • Jakobs, T.C.1
  • 44
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe D.J. Alzheimer's disease is a synaptic failure. Science 298 (2002) 789-791
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 45
    • 0345276572 scopus 로고    scopus 로고
    • Synaptic slaughter in Alzheimer's disease
    • Coleman P.D., and Yao P.J. Synaptic slaughter in Alzheimer's disease. Neurobiol. Aging 24 (2003) 1023-1027
    • (2003) Neurobiol. Aging , vol.24 , pp. 1023-1027
    • Coleman, P.D.1    Yao, P.J.2
  • 46
    • 0037111838 scopus 로고    scopus 로고
    • Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Aβ amyloidosis
    • Sheng J.G., et al. Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Aβ amyloidosis. J. Neurosci. 22 (2002) 9794-9799
    • (2002) J. Neurosci. , vol.22 , pp. 9794-9799
    • Sheng, J.G.1
  • 47
    • 34047181415 scopus 로고    scopus 로고
    • Adalbert, R. et al. (2007) Aβ, tau and ApoE4 in Alzheimer's disease: the axonal connection. Trends in Mol. Med. doi:10.1016/j.molmed.2007.02.004
  • 48
    • 7044220336 scopus 로고    scopus 로고
    • Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
    • Tsai J., et al. Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat. Neurosci. 7 (2004) 1181-1183
    • (2004) Nat. Neurosci. , vol.7 , pp. 1181-1183
    • Tsai, J.1
  • 49
    • 23444448170 scopus 로고    scopus 로고
    • Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
    • Spires T.L., et al. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J. Neurosci. 25 (2005) 7278-7287
    • (2005) J. Neurosci. , vol.25 , pp. 7278-7287
    • Spires, T.L.1
  • 50
    • 33645520634 scopus 로고    scopus 로고
    • Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease
    • Jacobsen J.S., et al. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 5161-5166
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 5161-5166
    • Jacobsen, J.S.1
  • 51
    • 13044287361 scopus 로고    scopus 로고
    • Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
    • Hsia A.Y., et al. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 3228-3233
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 3228-3233
    • Hsia, A.Y.1
  • 52
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the α-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos M.H., et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276 (1997) 2045-2047
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1
  • 53
    • 30644471051 scopus 로고    scopus 로고
    • Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
    • Martin L.J., et al. Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J. Neurosci. 26 (2006) 41-50
    • (2006) J. Neurosci. , vol.26 , pp. 41-50
    • Martin, L.J.1
  • 54
    • 27544507306 scopus 로고    scopus 로고
    • Alpha-synuclein cooperates with CSPα in preventing neurodegeneration
    • Chandra S., et al. Alpha-synuclein cooperates with CSPα in preventing neurodegeneration. Cell 123 (2005) 383-396
    • (2005) Cell , vol.123 , pp. 383-396
    • Chandra, S.1
  • 55
    • 32544442518 scopus 로고    scopus 로고
    • Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
    • Braak H., et al. Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci. Lett. 396 (2006) 67-72
    • (2006) Neurosci. Lett. , vol.396 , pp. 67-72
    • Braak, H.1
  • 56
    • 31544465246 scopus 로고    scopus 로고
    • Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models
    • Day M., et al. Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models. Nat. Neurosci. 9 (2006) 251-259
    • (2006) Nat. Neurosci. , vol.9 , pp. 251-259
    • Day, M.1
  • 57
    • 1542380508 scopus 로고    scopus 로고
    • s-mediated protection of dopaminergic fibers in an animal model of parkinson disease
    • s-mediated protection of dopaminergic fibers in an animal model of parkinson disease. Curr. Biol. 14 (2004) 326-330
    • (2004) Curr. Biol. , vol.14 , pp. 326-330
    • Sajadi, A.1
  • 58
    • 33748432246 scopus 로고    scopus 로고
    • S mice are protected against the Parkinsonian mimetic MPTP
    • S mice are protected against the Parkinsonian mimetic MPTP. Exp. Neurol. 202 (2006) 93-99
    • (2006) Exp. Neurol. , vol.202 , pp. 93-99
    • Hasbani, D.M.1    O'Malley, K.L.2
  • 59
    • 0035956874 scopus 로고    scopus 로고
    • Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    • Vila M., et al. Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 2837-2842
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 2837-2842
    • Vila, M.1
  • 60
    • 28644433087 scopus 로고    scopus 로고
    • Normal huntingtin function: an alternative approach to Huntington's disease
    • Cattaneo E., et al. Normal huntingtin function: an alternative approach to Huntington's disease. Nat. Rev. Neurosci. 6 (2005) 919-930
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 919-930
    • Cattaneo, E.1
  • 61
    • 27544477225 scopus 로고    scopus 로고
    • Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease
    • Benn C.L., et al. Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease. Hum. Mol. Genet. 14 (2005) 3065-3078
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 3065-3078
    • Benn, C.L.1
  • 62
    • 20044377268 scopus 로고    scopus 로고
    • Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements
    • DiProspero N.A., et al. Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements. J. Neurocytol. 33 (2004) 517-533
    • (2004) J. Neurocytol. , vol.33 , pp. 517-533
    • DiProspero, N.A.1
  • 63
    • 0037444445 scopus 로고    scopus 로고
    • Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease
    • Yu Z.X., et al. Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease. J. Neurosci. 23 (2003) 2193-2202
    • (2003) J. Neurosci. , vol.23 , pp. 2193-2202
    • Yu, Z.X.1
  • 64
    • 0034234519 scopus 로고    scopus 로고
    • Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation
    • Murphy K.P., et al. Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation. J. Neurosci. 20 (2000) 5115-5123
    • (2000) J. Neurosci. , vol.20 , pp. 5115-5123
    • Murphy, K.P.1
  • 65
    • 0035503511 scopus 로고    scopus 로고
    • Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice
    • Li H., et al. Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice. J. Neurosci. 21 (2001) 8473-8481
    • (2001) J. Neurosci. , vol.21 , pp. 8473-8481
    • Li, H.1
  • 66
    • 4344636957 scopus 로고    scopus 로고
    • Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice
    • Schilling G., et al. Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice. Hum. Mol. Genet. 13 (2004) 1599-1610
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 1599-1610
    • Schilling, G.1
  • 67
    • 24944482408 scopus 로고    scopus 로고
    • Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation
    • Iwata A., et al. Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 13135-13140
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 13135-13140
    • Iwata, A.1
  • 68
    • 33750363298 scopus 로고    scopus 로고
    • The roles of intracellular protein-degradation pathways in neurodegeneration
    • Rubinsztein D.C. The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 443 (2006) 780-786
    • (2006) Nature , vol.443 , pp. 780-786
    • Rubinsztein, D.C.1
  • 69
    • 7244236320 scopus 로고    scopus 로고
    • Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
    • Arrasate M., et al. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 431 (2004) 805-810
    • (2004) Nature , vol.431 , pp. 805-810
    • Arrasate, M.1
  • 70
    • 33646831610 scopus 로고    scopus 로고
    • CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity
    • Arango M., et al. CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity. J. Neurosci. 26 (2006) 4649-4659
    • (2006) J. Neurosci. , vol.26 , pp. 4649-4659
    • Arango, M.1
  • 71
    • 16844375290 scopus 로고    scopus 로고
    • Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
    • Parker J.A., et al. Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat. Genet. 37 (2005) 349-350
    • (2005) Nat. Genet. , vol.37 , pp. 349-350
    • Parker, J.A.1
  • 72
    • 29244462838 scopus 로고    scopus 로고
    • In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets
    • Zhai W., et al. In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets. Cell 123 (2005) 1241-1253
    • (2005) Cell , vol.123 , pp. 1241-1253
    • Zhai, W.1
  • 73
    • 33751339785 scopus 로고    scopus 로고
    • Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration
    • Katsuno M., et al. Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration. J. Neurosci. 26 (2006) 12106-12117
    • (2006) J. Neurosci. , vol.26 , pp. 12106-12117
    • Katsuno, M.1
  • 74
    • 0141750470 scopus 로고    scopus 로고
    • Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila
    • Gunawardena S., et al. Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. Neuron 40 (2003) 25-40
    • (2003) Neuron , vol.40 , pp. 25-40
    • Gunawardena, S.1
  • 75
    • 13244297167 scopus 로고    scopus 로고
    • Polyglutamine expansion diseases: failing to deliver
    • Morfini G., et al. Polyglutamine expansion diseases: failing to deliver. Trends Mol. Med. 11 (2005) 64-70
    • (2005) Trends Mol. Med. , vol.11 , pp. 64-70
    • Morfini, G.1
  • 76
    • 27144470284 scopus 로고    scopus 로고
    • Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration
    • Cunningham C., et al. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J. Neurosci. 25 (2005) 9275-9284
    • (2005) J. Neurosci. , vol.25 , pp. 9275-9284
    • Cunningham, C.1
  • 77
    • 33744926927 scopus 로고    scopus 로고
    • The Drosophila cell corpse engulfment receptor draper mediates glial clearance of severed axons
    • Macdonald J.M., et al. The Drosophila cell corpse engulfment receptor draper mediates glial clearance of severed axons. Neuron 50 (2006) 869-881
    • (2006) Neuron , vol.50 , pp. 869-881
    • Macdonald, J.M.1
  • 78
    • 33744922406 scopus 로고    scopus 로고
    • s protection distinguishes axon degeneration following injury from naturally occurring developmental pruning
    • s protection distinguishes axon degeneration following injury from naturally occurring developmental pruning. Neuron 50 (2006) 883-895
    • (2006) Neuron , vol.50 , pp. 883-895
    • Hoopfer, E.D.1
  • 79
    • 0037373633 scopus 로고    scopus 로고
    • Dying for a cause: invertebrate genetics takes on human neurodegeneration
    • Driscoll M., and Gerstbrein B. Dying for a cause: invertebrate genetics takes on human neurodegeneration. Nat. Rev. Genet. 4 (2003) 181-194
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 181-194
    • Driscoll, M.1    Gerstbrein, B.2
  • 80
    • 0025777705 scopus 로고
    • A new mouse mutant with progressive motor neuronopathy
    • Schmalbruch H., et al. A new mouse mutant with progressive motor neuronopathy. J. Neuropathol. Exp. Neurol. 50 (1991) 192-204
    • (1991) J. Neuropathol. Exp. Neurol. , vol.50 , pp. 192-204
    • Schmalbruch, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.