Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration

Journal of Neuroscience

Volumn 26, Issue 47, 2006, Pages 12106-12117

  Katsuno, Masahisa ^a   Adachi, Hiroaki ^a   Minamiyama, Makoto ^a   Waza, Masahiro ^a   Tokui, Keisuke ^a   Banno, Haruhiko ^a   Suzuki, Keisuke ^a   Onoda, Yu ^a   Tanaka, Fumiaki ^a   Doyu, Manabu ^a   Sobue, Gen ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Androgen; Axonal transport; Dynactin; Neurofilament; Polyglutamine; Retrograde; Spinal and bulbar muscular atrophy

Indexed keywords

ANDROGEN RECEPTOR; DYNACTIN; POLYGLUTAMINE; PROTEIN DYNACTIN 1; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASTRATION; CELL CULTURE; CONTROLLED STUDY; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOTOR NEURON DISEASE; MOUSE; MUSCLE ATROPHY; NERVE DEGENERATION; NEUROFILAMENT; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RETROGRADE NERVE FIBER TRANSPORT; SKELETAL MUSCLE; SYMPTOMATOLOGY;

ANALYSIS OF VARIANCE; ANIMALS; AXONAL TRANSPORT; BLOTTING, WESTERN; BUNGAROTOXINS; CASTRATION; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; MOTOR NEURON DISEASE; MUSCLE, SKELETAL; NEUROBLASTOMA; NEUROFILAMENT PROTEINS; PEPTIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCIATIC NEUROPATHY; SPINAL CORD; STILBAMIDINES; SYNAPTOPHYSIN; TIME FACTORS;

EID: 33751339785     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3032-06.2006     Document Type: Article

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