Mutational analysis of Norrin-Frizzled4 recognition

Journal of Biological Chemistry

Volumn 282, Issue 6, 2007, Pages 4057-4068

  Smallwood, Philip M ^a   Williams, John ^a   Xu, Qiang ^a   Leahy, Daniel J ^a   Nathans, Jeremy ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINES; LIGAND-BINDING DOMAIN; NORRIN-CRD BINDING; VASCULAR DEVELOPMENT;

AMINO ACIDS; BINDING ENERGY; GROWTH KINETICS; LIGANDS; MOLECULAR INTERACTIONS; MUTAGENESIS;

PROTEINS;

AMINO ACID; CYSTEINE; DISULFIDE; FRIZZLED 4 PROTEIN; FRIZZLED PROTEIN; HEPARIN; HOMODIMER; LIGAND; MONOMER; NORRIN PROTEIN; PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; EYE PROTEIN; FZD4 PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR; NDP PROTEIN, HUMAN; NERVE PROTEIN; WNT8A PROTEIN, XENOPUS; XENOPUS PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BETA SHEET; CONTROLLED STUDY; DISULFIDE BOND; LIGAND BINDING; MAMMAL; MOLECULAR RECOGNITION; MUTATIONAL ANALYSIS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; XENOPUS; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

MAMMALIA; MUS;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CYSTEINE; DNA MUTATIONAL ANALYSIS; EYE PROTEINS; FRIZZLED RECEPTORS; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; WNT PROTEINS; XENOPUS PROTEINS;

EID: 33947533683     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609618200     Document Type: Article

References (60)

1. Gubb, D., and Garcia-Bellido, A. (1982) J. Embryol. Exp. Morphol. 68, 37-57
2. Bhanot, P., Fish, M., Jemison, J. A., Nusse, R., Nathans, J., and Cadigan, K. M. (1999) Development 126, 4175-4186
3. Chen, C. M., and Struhl, G. (1999) Development 126, 5441-5452
4. Wang, Y., Thekdi, N., Smallwood, P. M., Macke, J. P., and Nathans, J. (2002) J. Neurosci. 22, 8563-8573
5. Lyuksyutova, A. I., Lu, C. C., Milanesio, N., King, L. A., Guo, N., Wang, Y., Nathans, J., Tessier-Lavigne, M., and Zou, Y. (2003) Science 302, 1984-1988
6. Guo, N., Hawkins, C., and Nathans, J. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 9277-9281
7. Xu, Q., Wang, Y., Dabdoub, A., Smallwood, P. M., Williams, J., Woods, C., Kelley, M. W., Jiang, L., Tasman, W., Zhang, K., and Nathans, J. (2004) Cell 116, 883-895
8. Logan, C. Y., and Nusse R. (2004) Annu. Rev. Cell Dev. Biol. 20, 781-810
9. Bhanot, P., Brink, M., Samos, C. H., Hsieh, J. C., Wang, Y., Macke, J. P., Andrew, D., Nathans, J., and Nusse, R. (1996) Nature 382, 225-230
10. Hsieh, J. C., Rattner, A., Smallwood, P. M., and Nathans, J. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3546-3551
11. Dann, C. E., Hsieh, J. C., Rattner, A., Sharma, D., Nathans, J., and Leahy, D. J. (2001) Nature 412, 86-90
12. Rattner, A., Hsieh, J. C., Smallwood, P. M., Gilbert, D. J., Copeland, N. G., Jenkins, N. A., and Nathans, J. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 2859-2863
13. Chang, J. T., Esumi, N., Moore, K., Li, Y., Zhang, S., Chew, C., Goodman, B., Rattner, A., Moody, S., Stetten, G., Campochiaro, P. A., and Zack, D. J. (1999) Hum. Mol. Genet. 8, 575-583
14. Berger, W., Meindl, A., van de Pol, T. J., Cremers, F. P., Ropers, H. H., Doerner, C., Monaco, A., Bergen, A. A., Lebo, R., Warburg, M., Zergollern, L., Lorenz, B., Gal, A., Bleeker-Wagemakers, E. M., and Meitinger, T. (1992) Nat. Genet. 1, 199-203
15. Chen, Z. Y., Hendriks, R. W., Jobling, M. A., Powell, J. F., Breakefield, X. O., Sims, K. B., and Craig, I. W. (1992) Nat. Genet. 1, 204-208
16. Meindl, A., Berger, W., Meitinger, T., van de Pol, D., Achatz, H., Dorner, C., Haasemann, M., Hellebrand, H., Gal, A., Cremers, F., and Ropers, H. H. (1992) Nat. Genet. 2, 139-143
17. Meitinger, T., Meindl, A., Bork, P., Rost, B., Sander, C., Haasemann, M., and Murken, J. (1993) Nat. Genet. 5, 376-380
18. Berger, W., and Ropers, H. H. (2001) in Metabolic and Molecular Bases of Inherited Disease (Scriver, C. R., Beaudet, A. L., Sly, W. S., and Valle, D., eds) pp. 5977-5985, McGraw Hill Inc., New York
19. Robitaille, J., MacDonald, M. L., Kaykas, A., Sheldahl, L. C., Zeisler, J., Dube, M. P., Zhang, L. H., Singaraja, R. R., Guernsey, D. L., Zheng, B., Siebert, L. F., Hoskin-Mott, A., Trese, M. T., Pimstone, S. N., Shastry, B. S., Moon, R. T., Hayden, M. R., Goldberg, Y. P., and Samuels, M. E. (2002) Nat. Genet. 32, 326-330
20. Toomes, C., Bottomley, H. M., Scott, S., Mackey, D. A., Craig, J. E., Appukuttan, B., Stout, J. T., Flaxel, C. J., Zhang, K., Black, G. C., Fryer, A., Downey, L. M., and Inglehearn, C. F. (2004) Invest. Ophthalmol. Vis. Sci. 45, 2083-2090
21. Toomes, C., Bottomley, H. M., Jackson, R. M., Towns, K. V., Scott, S., Mackey, D. A., Craig, J. E., Jiang, L., Yang, Z., Trembath, R., Woodruff, G., Gregory-Evans, C. Y., Gregory-Evans, K., Parker, M. J., Black, G. C., Downey, L. M., Zhang, K., and Inglehearn, C. F. (2004) Am. J. Hum. Genet. 74, 721-730
22. Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., Zacharin, M., Oexle, K., Marcelino, J., Suwairi, W., Heeger, S., Sabatakos, G., Apte, S., Adkins, W. N., Allgrove, J., Arslan-Kirchner, M., Batch, J. A., Beighton, P., Black, G. C., Boles, R. G., Boon, L. M., Borrone, C., Brunner, H. G., Carle, G. F., Dallapiccola, B., De Paepe, A., Floege, B., Halfhide, M. L., Hall, B., Hennekam, R. C., Hirose, T., Jans, A., Juppner, H., Kim, C. A., Keppler-Noreuil, K., Kohlschuetter, A., LaCombe, D., Lambert, M., Lemyre, E., Letteboer, T., Peltonen, L., Ramesar, R. S., Romanengo, M., Somer, H., Steichen-Gersdorf, E., Steinmann, B., Sullivan, B., Superti-Furga, A., Swoboda, W., van den Boogaard, M. J., Van Hul, W., Vikkula, M., Votruba, M., Zabel, B., Garcia, T., Baron, R., Olsen, B. R., and Warman, M. L. (2001) Cell 107, 513-523
23. Kato, M., Patel, M. S., Levasseur, R., Lobov, I., Chang, B. H., Glass, D. A., II, Hartmann, C., Li, L., Hwang, T. H., Brayton, C. F., Lang, R. A., Karsenty, G., and Chan, L. (2002) J. Cell Biol. 157, 303-314
24. Richter, M., Gottanka, J., May, C. A., Welge-Lussen, U., Berger, W., and Lutjen-Drecoll, E. (1998) Invest. Ophthalmol. Vis. Sci. 39, 2450-2457
25. Rehm, H. L., Zhang, D. S., Brown, M. C., Burgess, B., Halpin, C., Berger, W., Morton, C. C., Corey, D. P., and Chen, Z. Y. (2002) J. Neurosci. 22, 4286-4292
26. Luhmann, U. F., Lin, J., Acar, N., Lammel, S., Feil, S., Grimm, C., Seeliger, M. W., Hammes, H. P., and Berger, W. (2005) Invest. Ophthalmol. Vis. Sci. 46, 3372-3382
27. Daopin, S., Piez, K. A., Ogawa, Y., and Davies, D. R. (1992) Science 257, 369-373
28. Mittl, P. R., Priestle, J. P., Cox, D. A., McMaster, G., Cerletti, N., and Grutter, M. G. (1996) Protein Sci. 5, 1261-1271
29. Griffith, D. L., Keck, P. C., Sampath, T. K., Rueger, D. C., and Carlson, W. D. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 878-883
30. Allendorph, G. P., Vale, W. W., and Choe, S. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 7643-7648
31. Potterton, E., McNicholas, S., Krissinel, E., Cowtan, K., and Noble, M. (2002) Acta Crystallogr. D 58, 1955-1957
32. Wu, C. H., and Nusse, R. (2002) J. Biol. Chem. 277, 41762-41769
33. Hsieh, J. C., Kodjabachian, L., Rebbert, M. L., Rattner, A., Smallwood, P. M., Samos, C. H., Nusse, R., Dawid, I. B., and Nathans, J. (1999) Nature 398, 431-436
34. Povelones, M., and Nusse, R. (2005) EMBO J. 24, 3493-3503
35. Lapthorn, A. J., Harris, D. C., Littlejohn, A., Lustbader, J. W., Canfield, R. E., Machin, K. J., Morgan, F. J., and Isaacs, N. W. (1994) Nature 369, 455-461
36. Wu, H., Lustbader, J. W., Liu, Y., Canfield, R. E., and Hendrickson, W. A. (1994) Structure 2, 545-558
37. Perez-Vilar, J., and Hill, R. L. (1998) J. Biol. Chem. 273, 6982-6988
38. Perez-Vilar, J., and Hill, R. L. (1997) J. Biol. Chem. 272, 33410-33415
39. Kirsch, T., Sebald, W., and Dreyer, M. K. (2000) Nat. Struct. Biol. 7, 492-496
40. Hart, P. J., Deep, S., Taylor, A. B., Shu, Z., Hinck, C. S., and Hinck, A. P. (2002) Nat. Struct. Biol. 9, 203-208
41. Thompson, T. B., Woodruff, T. K., and Jardetzky, T. S. (2003) EMBO J. 22, 1555-1566
42. Groppe, J., Greenwald, J., Wiater, E., Rodriguez-Leon, J., Economides, A. N., Kwiatkowski, W., Affolter, M., Vale, W. W., Belmonte, J. C., and Choe, S. (2002) Nature 420, 636-642
43. Furuhashi, M., Ando, H., Bielinska, M., Pixley, M. R., Shikone, T., Hsueh, A. J., and Boime, I. (1994) J. Biol. Chem. 269, 25543-25548
44. Sato, A., Perlas, E., Ben-Menahem, D., Kudo, M., Pixley, M. R., Furuhashi, M., Hsueh, A. J., and Boime, I. (1997) J. Biol. Chem. 272, 18098-18103
45. Reichsman, F., Smith, L., and Cumberledge, S. (1996) J. Cell Biol. 135, 819-827
46. Paine-Saunders, S., Viviano, B. L., Economides, A. N., and Saunders, S. (2002) J. Biol. Chem. 277, 2089-2096
47. Mohammadi, M., Olsen, S. K., and Goetz, R. (2005) Curr. Opin. Struct. Biol. 15, 506-516
48. Rider, C. C. (2006) Biochem. Soc. Trans. 34, 458-460
49. Binari, R. C., Staveley, B. E., Johnson, W. A., Godavarti, R., Sasisekharan, R., and Manoukian, A. S. (1997) Development 124, 2623-2632
50. Lin, X., and Perrimon, N. (1999) Nature 400, 281-284
51. Tsuda, M., Kamimura, K., Nakato, H., Archer, M., Staatz, W., Fox, B., Humphrey, M., Olson, S., Futch, T., Kaluza, V., Siegfried, E., Stam, L., and Selleck, S. B. (1999) Nature 400, 276-280
52. Belenkaya, T. Y., Han, C., Yan, D., Opoka, R. J., Khodoun, M., Liu, H., and Lin, X. (2004) Cell 119, 231-244
53. Han, C., Yan, D., Belenkaya, T. Y., and Lin, X. (2005) Development 132, 667-679
54. Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., and Ornitz, D. M. (1991) Cell 64, 841-848
55. Pellegrini, L., Burke, D. F., von Delft, F., Mulloy, B., and Blundell, T. L. (2000) Nature 407, 1029-1034
56. Schlessinger, J., Plotnikov, A. N., Ibrahimi, O. A., Eliseenkova, A. V., Yeh, B. K., Yayon, A., Linhardt, R. J., and Mohammadi, M. (2000) Mol. Cell 6, 743-750
57. Stauber, D. J., DiGabriele, A. D., and Hendrickson, W. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 49-54
58. McLellan, J. S., Yao, S., Zheng, X., Geisbrecht, B. V., Ghirlando, R., Beachy, P. A., and Leahy, D. J. (2006) Proc. Natl. Acad. Sci. U. S. A., 103, 17208-17213
59. Bendtsen, J. D., Nielsen, H., von Heijne, G., and Brunak, S. (2004) J. Mol. Biol. 340, 783-795
60. Schlunegger, M. P., and Grutter, M. G. (1992) Nature 358, 430-434