Cystine knot of the gonadotropin α subunit is critical for intracellular behavior but not for in vitro biological activity

Journal of Biological Chemistry

Volumn 272, Issue 29, 1997, Pages 18098-18103

  Sato, Asomi ^a   Perlas, Emerald ^b   Ben Menahem, David ^a   Kudo, Masataka ^b   Pixley, Mary R ^a   Furuhashi, Madoka ^b,c   Hsueh, Aaron J W ^b   Boime, Irving ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Handa City Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GONADOTROPIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DISULFIDE BOND; GONADOTROPIN RELEASE; HORMONE RECEPTOR INTERACTION; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING, COMPETITIVE; CHORIONIC GONADOTROPIN; CYSTINE; DISULFIDES; EXONS; GLYCOPROTEIN HORMONES, ALPHA SUBUNIT; GROWTH SUBSTANCES; HUMANS; KIDNEY; MODELS, STRUCTURAL; MUTAGENESIS, SITE-DIRECTED; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, LH; RECOMBINANT PROTEINS; SEQUENCE DELETION; SIGNAL TRANSDUCTION; TRANSFECTION; VARIATION (GENETICS);

ANIMALIA;

EID: 0030739370     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.29.18098     Document Type: Article

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