Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling

Science

Volumn 302, Issue 5652, 2003, Pages 1984-1988

  Lyuksyutova, Anna I ^a   Lu, Chin Chun ^a   Milanesio, Nancy ^a   King, Leslie A ^a   Guo, Nini ^b   Wang, Yanshu ^b   Nathans, Jeremy ^b   Tessier Lavigne, Marc ^c,d   Zou, Yimin ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c STANFORD UNIVERSITY   (United States)

^d GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELLS; LIVING SYSTEMS STUDIES; PROTEINS; RNA;

MAMMALS;

NEUROLOGY;

CELL RECEPTOR; CHEMOATTRACTANT; FRIZZLED3 PROTEIN; GENE PRODUCT; MESSENGER RNA; UNCLASSIFIED DRUG; WNT PROTEIN;

BIOLOGY; NEUROLOGY; PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ANTERIOR POSTERIOR AXIS; ARTICLE; CONTROLLED STUDY; EMBRYO; FLOOR PLATE; FRIZZLED GENE; GENE; GENE EXPRESSION; NERVE FIBER GROWTH; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; SPINAL CORD VENTRAL HORN; WNT GENE; WNT4 GENE;

ANIMALS; AXONS; BRAIN; CENTRAL NERVOUS SYSTEM; COS CELLS; CUES; CULTURE TECHNIQUES; DIFFUSION; FRIZZLED RECEPTORS; GENE EXPRESSION PROFILING; GROWTH CONES; IN SITU HYBRIDIZATION; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NEURONS; PROTEINS; PROTO-ONCOGENE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SPINAL CORD; TRANSFECTION; WNT PROTEINS;

ANIMALIA; MAMMALIA; RODENTIA;

EID: 0348017150     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1089610     Document Type: Article

References (17)

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17. We thank X. He for the Wnt5a and sFRP1 cDNA constructs, G. Martin for FGF4 and FGF8 cDNAs, W.-b. Gan for help in establishing the lontophoresis labeling method, and V. Bindokas for help with confocal microscopy and quantification with NIH ImageJ software. Supported by a Basil O'Connor Starting Scholar Award from the March of Dimes Foundation, a Schweppe Foundation Career Development Award, and a University of Chicago Brain Research Foundation Seed Grant (Y.Z.). Y.Z. is an Alfred P. Sloan Research Fellow.