Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection

Gut

Volumn 52, Issue 8, 2003, Pages 1206-1210

  Wright, M ^a   Goldin, R ^a   Hellier, S ^b   Knapp, S ^a   Frodsham, A ^b   Hennig, B ^b   Hill, A ^b   Apple, R ^c   Cheng, S ^c   Thomas, H ^a   Thursz, M ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ROCHE MOLECULAR SYSTEMS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; PROTHROMBIN;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BLOOD CLOTTING; CAUCASIAN; DISEASE ASSOCIATION; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HETEROZYGOTE; HISTOPATHOLOGY; HUMAN; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; REPRODUCIBILITY;

ADULT; DISEASE PROGRESSION; FACTOR V; FEMALE; GENOTYPE; HEPATITIS C, CHRONIC; HUMANS; LIVER CIRRHOSIS; MALE; MULTIVARIATE ANALYSIS; POLYMORPHISM, GENETIC; SENSITIVITY AND SPECIFICITY;

EID: 0038637369     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.52.8.1206     Document Type: Article

References (21)

1. Poynard T, Bedosso P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet 1997;349:825-32.
2. Wright M, Goldin RD, Fabre A, et al. Measurement and determinants of the natural history of liver fibrosis in hepatitis C virus infection: a cross sectional and longitudinal study. Gut 2003;52:574-9.
3. Knight JC, Udalova I, Hill AV, et al. A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. Nat Genet 1999;22:145-50.
4. Thursz MR, Thomas HC, Greenwood BM, et al. Heterozygote advantage for HLA class-II type in hepatitis B virus infection. Nat Genet 1997;17:11-2.
5. Thursz MR, Kwiatkowski D, Allsopp CE, et al. Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia. N Engl J Med 1995;332:1065-9.
6. Thursz M, Yallop R, Goldin R, et al. Influence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European Network for Cooperative Research. Lancet 1999;354:2119-24.
7. Cramp M, Carucci P, Underhill JA, et al. Association between HLA class II genotype and spontaneous clearance of hepatitis C viraemia. J Hepatol 1998;29:207-13.
8. Powell EE, Edwards-Smith CJ, Hay JL, et al. Host genetic factors influence disease progression in chronic hepatitis C. Hepatology 2000;31:828-33.
9. Thorburn D, Curry G, Spooner R, et al. The role of iron and haemochromatosis gene mutations in the progression of liver disease in chronic hepatitis C. Gut 2002;50:248-52.
10. Smith BC, Gorve J, Guzail MA, et al. Heterozygosity for hereditary hemochromatosis is associated with more fibrosis in chronic hepatitis C (see comments). Hepatology 1998;27:1695-9.
11. Kenny-Walsh E. Clinical outcomes after hepatitis C infection from contaminated anti- D immune globulin. Irish Hepatology Research Group. N Engl J Med 1999;340:1228-33.
12. Neubauer K, Knittel T, Armbrust T, et al. Accumulation and cellular localization of fibrinogen/fibrin during short-term and long-term rat liver injury. Gastroenterology 1995;108:1124-35.
13. Marra F, DeFranco R, Grappone C, et al. Expression of the thrombin receptor in human liver: up-regulation during acute and chronic injury. Hepatology 1998;27:462-71.
14. Marra F, Grandaliano G, Valente AJ, et al. Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: potential role in liver injury. Hepatology 1995;22:780-7.
15. Franco RF, Trip MD, ten Cate H, et al. The 20210 G→A mutation in the 3′- untranslated region of the prothrombin gene and the risk for arterial thrombotic disease. Br J Haematol 1999;104:50-4.
16. Bertina RM, Koeleman BP, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:64-7.
17. Hencore Report. European Community, Directorate Generale V. 1997.
18. Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995;22:696-9.
19. Cheng S, Grow MA, Pallaud C, et al. A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res 1999;9:936-49.
20. Cui J, Eitzman DT, Westrick RJ, et al. Spontaneous thrombosis in mice carrying the factor V Leiden mutation. Blood 2000;96:4222-6.
21. Xu Z, Westrick RJ, Shen YC, et al. Pulmonary fibrosis is increased in mice carrying the factor V Leiden mutation following bleomycin injury. Thromb Haemost 2001;85:441-4.