Increase of mast cells in the liver and lung may be associated with but not a cause of fibrosis: Demonstration using mast cell-deficient Ws/Ws rats

Laboratory Investigation

Volumn 78, Issue 11, 1998, Pages 1431-1438

  Okazaki, Toshihiko ^a   Hirota, Seiichi ^a   Xu, Zu De ^b   Maeyama, Kazutaka ^c   Nakama, Akihiro ^a   Kawano, Sunao ^a   Hori, Masatsugu ^a   Kitamura, Yukihiko ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b FUDAN UNIVERSITY   (China)

^c EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE; STEM CELL FACTOR;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; BASE PAIRING; FIBROBLAST; GENE DELETION; GENE INDUCTION; LIVER FIBROSIS; LUNG FIBROSIS; MAST CELL; MEDIATOR RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SECRETORY GRANULE;

ANIMALS; CELL COUNT; HYDROXYPROLINE; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; LUNG; MALE; MAST CELLS; PULMONARY FIBROSIS; RATS; RATS, MUTANT STRAINS;

EID: 0031762190     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Arizono N, Kasugai T, Yamada M, Okada M, Morimoto M, Tei H, Newlands GFJ, Miller HRP, and Kitamura Y (1993). Infection of Nippostrongylus brasiliensis induces development of mucosal-type but not connective tissue-type mast cells in genetically mast cell-deficient Ws/Ws rats. Blood 81:2572-2578.
2. Armbrust T, Batusic D, Ringe B, and Ramadori G (1997). Mast cells distribution in human liver disease and experimental rat liver fibrosis: Indications for mast cell participation in development of liver fibrosis. J Hepatol 26:1042-1054.
3. Arthur MJ (1990). Matrix degradation in the liver. Semin Liver Dis 10:47-55.
4. Bhunchet E and Wake K (1992). Role of mesenchymal cell populations in porcine serum-induced rat liver fibrosis. Hepatology 16:1452-1473.
5. Cairns JA and Walls AF (1997). Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts. J Clin Invest 99:1313-1321.
6. Cameron GR and Oakley CL (1932). Ligation of the common bile duct. J Pathol Bacteriol 35:769-798.
7. Chabot B, Stephenson DA, Chapman VM, Besmer P, and Bernstein A (1988). The proto-oncogene c-kit encoding a transmenbrane tyrosine kinase receptor maps to the mouse W locus. Nature 335:88-89.
8. Chanez P, Lacoste JY, Guillot B, Giron J, Barneon G, Enander I, Godard P, Michel FB, and Bousquet J (1993). Mast cells' contribution to the fibrosing alveolitis of the scleroderma lung. Am Rev Respir Dis 147:1497-1502.
9. Collins JF, Johanson WG Jr, McCullough B, Jones MA, and Waugh HJ Jr (1978). Effects of compensatory lung growth in irradiation-induced regional pulmonary fibrosis in the baboon. Am Rev Respir Dis 117:1079-1089.
10. Craig SS, DeBlois G, and Schwartz LB (1986). Mast cells in human keloid, small intestine, and lung by an immunoperoxidase technique using a murine monoclonal antibody against tryptase. Am J Pathol 124:427-435.
11. Ebi Y, Kanakura Y, Jippo Kanemoto T, Tsujimura T, Furitsu T, Ikeda H, Adachi S, Kasugai T, Nomura S, and Kanayama Y (1992). Low c-kit expression of cultured mast cells of mi/mi genotype may be involved in their defective responses to fibroblasts that express the ligand for c-kit. Blood 80:1454-1462.
12. Ebi Y, Kasugai T, Seino Y, Onoue H, Kanemoto T, and Kitamura Y (1990). Mechanism of mast cell deficiency in mutant mice of mi/mi genotype: An analysis by co-culture of mast cells and fibroblasts. Blood 75:1247-1251.
13. Fang KC, Raymond WW, Lazarus SC, and Caughey GH (1996). Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase. J Clin Invest 97:1589-1596.
14. Flanagan JG and Leder P (1990). The kit ligand: A cell surface molecule altered in steel mutant fibroblast. Cell 63:185-194.
15. Galli SJ (1993). New concepts about mast cell. N Engl J Med 328:257-265.
16. Galli SJ, Gordon JR, and Wershil BK (1991). Cytokine production by mast cells and basophils. Curr Opinion Immunol 3:865-873.
17. v and Sl/Sld mice - Their value for the analysis of the roles of mast cells in biologic responses in vivo. Am J Pathol 127:191-198.
18. Galli SJ and Wershil BK (1996). The two faces of the mast cell (comment). Nature 381:21-22.
19. Geissler EN, Ryan MA, and Housman DE (1988). The dominant white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55:185-192.
20. Goto T, Befus AD, Low R, and Bienenstock J (1984). Mast cell heterogenity and hyperplasia in bleomycin-induced pulmonary fibrosis of rats. Am Rev Respir Dis 130:797-802.
21. Gressner AM (1996). Mediators of hepatic fibrogenesis. Hepatogastroenterology 43:92-103.
22. Gruber BL, Marchese MJ, Suzuki K, Schwartz LB, Okada Y, Nagase H, and Ramamurthy NS (1989). Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation. J Clin Invest 84:1657-1662.
23. Hartmann T, Ruoss SJ, Raymond WW, Seuwen K, and Caughey GH (1992). Human tryptase as a potent, cell specific mitogen: Role of signaling pathways in synergistic responses. Am J Physiol 262:L528-L534.
24. Hodgkinson CA, Moore KJ, Nakayama A, Steingrimsson E, Copeland NG, Jenkins-NA, and Arnheiter H (1993). Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 74:395-404.
25. Huang E, Nocka K, Beier DR, Chu TY, Buck J, Lahm HW, Wellner D, Leder P, and Besmer P (1990). The hematopoietic growth factor KL is encoded by the S1 locus and is the ligand for the c-kit receptor, the gene product of the W locus. Cell 63:225-233.
26. Isozaki K, Tsujimura T, Nomura S, Morii E, Koshimizu U, Nishimune Y, and Kitamura Y (1994). Cell type-specific deficiency of c-kit gene expression in mutant mice of mi/mi genotype. Am J Pathol 145:827-836.
27. Jonker AM, Dijkhuis FW, Hardonk MJ, Moerkerk P, Ten KJ, and Grand J (1994). Immunohistochemical study of hepatic fibrosis induced in rats by multiple galactosamine injections. Hepatology 19:775-781.
28. v mice and their increase by bone marrow transplantation. Blood 52:447-452.
29. Kivirikko KI, Laitinen O, and Prockop DJ (1967). Modifications of a specific assay for hydroxyproline in urine. Anal Biochem 19:249-255.
30. Lees M, Taylor DJ, and Woolley DE (1994). Mast cell proteinases activate precursor forms of collagenase and stromelysis, but not of gelatinases A and B. Eur J Biochem 223:171-177.
31. Miao S, Bao-en W, Annoni G, Esposti SD, Biempica L, and Zern MA (1990). Two rat models of hepatic fibrosis. Lab Invest 63:467-475.
32. v mice and mechanism of the suppresive effects of tranilast, an antiallergic drug inhibiting mediator release from mast cells, on fibrosis. Int Arch Allergy Appl Immunol 95:195-201.
33. Murata K, Okudaira M, and Asashio K (1973). Mast cells in human liver tissue. Acta Derm Venereol 73:157-166.
34. Niwa Y, Kasugai T, Ohno K, Morimoto M, Yamazaki M, Dohmae K, Nishimune Y, Kondo K, and Kitamura Y (1991). Anemia and mast cell depletion in mutant rats that are homozygous at "white spotting (Ws)" locus. Blood 78:1936-1941.
35. Nocka K, Majumder S, Chabot B, Ray P, Cervone M, Bernstein A, and Besmer P (1989). Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice-evidence for an impaired c-kit kinase in mutant mice. Genes Dev 3:816-826.
36. O'Brien-Ladner AR, Wesselius LJ, and Stechschulte DJ (1993). Bleomycin injury of lung in a mast-cell-deficient model. Agents Actions 39:20-24.
37. Onoue H, Maeyama K, Nomura S, Kasugai T, Tei H, Kim HM, Watanabe T, and Kitamura Y (1993). Absense of immature mast cells in the skin of Ws/Ws rats with a small deletion at tyrosine kinase domain of the c-kit gene. Am J Pathol 142:1001-1007.
38. Paronetto F and Popper H (1965). Aggravation of hepatic lesions in mice by in vivo localization of immune complexes (acute hepatitis). Am J Pathol 47:549-563.
39. Pesci A, Bertorelli G, and Gabrielli M (1993). Mast cells in fibrotic lung disorders. Chest 103:989-996.
40. Pesci A, Majori M, Piccoli ML, Casalini A, Curti A, Franchini D, and Gabrielli M (1996). Mast cells in bronchiolitis obliterans organizing pneumonia: Mast cell hyperplasia and evidence for extracellular release of tryptase. Chest 110:383-391.
41. Pierce RA, Glaug MR, Greco RS, Mackenzie JW, Boyd CD, and Deak SB (1987). Increased procollagen mRNA levels in carbon tetrachloride-induced liver fibrosis in rats. J Biol Chem 262:1652-1658.
42. Ramos SG, Montenegro AP, Goissis G, and Rossi MA (1994). Captoril reduces collagen and mast cell and eosinophil accumulation in pig serum-induced rat liver fibrosis. Pathol Int 44:655-661.
43. Reith AD, Rottapel R, Giddens E, Brady C, Forrester L, and Bernstein A (1990). W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor. Genes Dev 4:390-400.
44. Rioux KP, Sharkey KA, Wallace JL, and Swain MG (1996). Hepatic mucosal mast cell hyperplasia in rats with secondary biliary cirrhosis. Hepatology 23:888-895.
45. Rubin E, Hutterer F, and Popper H (1968). Experimental hepatic fibrosis without hepatocellular regeneration. Am J Pathol 52:111-120.
46. Ruoss SJ, Hartmann T, and Caughey GH (1991). Mast cell tryptase is a mitogen for cultured fibroblasts. J Clin Invest 88:493-499.
47. Russell JD, Russell SB, and Trupin KM (1977). The effect of histamine on the growth of cultured fibroblasts isolated from normal and keloid tissue. J Cell Physiol 93:389-394.
48. Saarinen J, Kalkkinen N, Welgus HG, and Kovanen PT (1994). Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase. J Biol Chem 269:18134-18140.
49. Schaffer FL and Rubinchik E (1995). Activated mast cells are fibrogenic for 3T3 fibroblasts. J Invest Dermatol 104:999-1003.
50. Schwartz LB (1994). Mast cells: Function and contents. Curr Opin Immunol 6:91-97.
51. Stechschulte DJ, Sharma R, Dileepan KN, Simpson KM, Aggarwal N, Clancy J Jr, and Jilka RL (1987). Effect of the mi allele on mast cells, basophils, natural killer cells, and osteoclasts in C57BI/6J mice. J Cell Physiol 132:565-570.
52. Suzuki K, Lees M, Newlands GFJ, Nagase H, and Woolley DE (1995). Activation of precursors for matrix metalloproteinases 1 (interstitial collagenase) and 3 (stromelysin) by rat mast cell proteinases I and II. Biochem J 305:301-306.
53. Tamayo RP (1983). Is cirrhosis of the liver experimentally produced by CCI4 an adequate model of human cirrhosis? Hepatology 3:112-120.
54. Tei H, Kasugai T, Tsujimura T, Adachi S, Furitsu T, Tohya K, Kimura M, Zsubo KM, Newlands GF, Miller HRP, Kanakura Y, and Kitamura Y (1994). Characterization of cultured mast cells derived from Ws/Ws mast cell-deficient rats with a small deletion at tyrosine kinase domain of c-kit. Blood 83:916-925.
55. Tsujimura T, Hirota S, Nomura S, Niwa Y, Yamazaki M, Tono T, Morii E, Kim HE, Kondo K, Nishimune Y, and Kitamura Y (1991). Characterization of Ws mutant allele of rats; a 12-base deletion in tyrosine kinase domain of c-kit gene. Blood 78:1942-1946.
56. Tsujimura T, Morii E, Nozaki M, Hashimoto K, Moriyama Y, Takebayashi K, Kondo T, Kanakura Y, and Kitamura Y (1996). Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice. Blood 15:1225-1233.
57. Woessner JF Jr (1991). Matrix metalloproteinases and their inhibitors in connective tissue.
58. Woodbury RG, Everitt MT, and Neurath H (1981). Mast cell proteases. Methods Enzymol 80:588-609.
59. Wu J and Danielsson A (1994). Inhibition of hepatic fibrogenesis: A review of pharmacologic candidates. Scand J Gastroenterol 29:385-391.
60. Yamatodani A, Fukuda H, Wada H, Iwaeda T, and Watanabe T (1985). High-performance liquid chromatographic determination of plasma and brain histamine without previous purification of biological samples: Cation-exchange chromatography coupled with post-column derivatization fluorometry. J Chromatogr 344:115-123.
61. Yamatodani A, Maeyama K, Watanabe T, Wada H, and Kitamura Y (1982). Tissue distribution of histamine in a mutant mouse deficient in mast cells: Clear evidence for the presence of no-mast cell histamine. Biochem Pharmacol 31:305-309.
62. Zsebo KM, Williams DA, Geissler EN, Broudy VC, Martin FH, Atkins HL, Hsu RY, Birkett NC, Okino KH, and Murdock DC (1990). Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 63:213-224.