메뉴 건너뛰기




Volumn 23, Issue 3, 2007, Pages 351-357

Bayesian-based selection of metabolic objective functions

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; SUCCINIC ACID;

EID: 33847307148     PISSN: 13674803     EISSN: 13674811     Source Type: Journal    
DOI: 10.1093/bioinformatics/btl619     Document Type: Article
Times cited : (74)

References (67)
  • 1
    • 0018393802 scopus 로고
    • Identification of metabolic model: Citrate production from glucose by Candida lipolytica
    • Aiba,S. and Matsuoka,M. (1979) Identification of metabolic model: citrate production from glucose by Candida lipolytica. Biotechnol. Bioeng., 21, 1373-1386.
    • (1979) Biotechnol. Bioeng. , vol.21 , pp. 1373-1386
    • Aiba, S.1    Matsuoka, M.2
  • 2
    • 18844392599 scopus 로고    scopus 로고
    • Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli
    • Alper,H. et al. (2005) Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli. Metab. Eng., 7, 155-164.
    • (2005) Metab. Eng. , vol.7 , pp. 155-164
    • Alper, H.1
  • 3
    • 0034995375 scopus 로고    scopus 로고
    • Complex biology with no parameters
    • Bailey,J.E. (2001) Complex biology with no parameters. Nat. Biotechnol., 19, 503-504.
    • (2001) Nat. Biotechnol. , vol.19 , pp. 503-504
    • Bailey, J.E.1
  • 4
    • 0030570128 scopus 로고    scopus 로고
    • Metabolic flux analysis of hybridoma cells in different culture media using mass balances
    • Bonarius,H.P.J. et al. (1996) Metabolic flux analysis of hybridoma cells in different culture media using mass balances. Biotechnol. Bioeng., 50, 299-318.
    • (1996) Biotechnol. Bioeng. , vol.50 , pp. 299-318
    • Bonarius, H.P.J.1
  • 5
    • 0030804853 scopus 로고    scopus 로고
    • Flux analysis of underdetermined metabolic networks: The quest for the missing constraints
    • Bonarius,H.P.J. et al. (1997) Flux analysis of underdetermined metabolic networks: The quest for the missing constraints. Trends Biotechnol., 15, 308-314.
    • (1997) Trends Biotechnol. , vol.15 , pp. 308-314
    • Bonarius, H.P.J.1
  • 6
    • 0038293216 scopus 로고    scopus 로고
    • Optimization-based framework for inferring and testing hypothesized metabolic objective functions
    • Burgard,A.P. and Maranas,C.D. (2003) Optimization-based framework for inferring and testing hypothesized metabolic objective functions. Biotechnol. Bioeng., 82, 670-677.
    • (2003) Biotechnol. Bioeng. , vol.82 , pp. 670-677
    • Burgard, A.P.1    Maranas, C.D.2
  • 8
    • 0035125986 scopus 로고    scopus 로고
    • In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data
    • Edwards,J.S. et al. (2001) In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nat. Biotechnol., 19, 125-130.
    • (2001) Nat. Biotechnol. , vol.19 , pp. 125-130
    • Edwards, J.S.1
  • 9
    • 0033580813 scopus 로고    scopus 로고
    • Systems properties of the Haemophilus influenzae Rd metabolic genotype
    • Edwards,J.S. and Palsson,B.O. (1999) Systems properties of the Haemophilus influenzae Rd metabolic genotype. J. Biol. Chem., 274, 17410-17416.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17410-17416
    • Edwards, J.S.1    Palsson, B.O.2
  • 10
    • 0034625143 scopus 로고    scopus 로고
    • The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities
    • Edwards,J.S. and Palsson,B.O. (2000) The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities. Proc. Natl Acad. Sci. USA, 97, 5528-5533.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 5528-5533
    • Edwards, J.S.1    Palsson, B.O.2
  • 12
    • 0022493181 scopus 로고
    • Fat synthesis in adipose tissue. An examination of stoichiometric constraints
    • Fell,D.A. and Small,J.R. (1986) Fat synthesis in adipose tissue. An examination of stoichiometric constraints. Biochem. J., 238, 781-786.
    • (1986) Biochem. J. , vol.238 , pp. 781-786
    • Fell, D.A.1    Small, J.R.2
  • 13
    • 20044375201 scopus 로고    scopus 로고
    • Large-scale in vivo flux analysis shows rigidity and suboptimal performance of Bacillus subtilis metabolism
    • Fischer,E. and Sauer,U. (2005) Large-scale in vivo flux analysis shows rigidity and suboptimal performance of Bacillus subtilis metabolism. Nat. Genet., 37, 636-640.
    • (2005) Nat. Genet. , vol.37 , pp. 636-640
    • Fischer, E.1    Sauer, U.2
  • 14
    • 0033587379 scopus 로고    scopus 로고
    • Metabolic flux analysis of hybridoma continuous culture steady state multiplicity
    • Follstad,B.D. et al. (1999) Metabolic flux analysis of hybridoma continuous culture steady state multiplicity. Biotechnol. Bioeng., 63, 675-683.
    • (1999) Biotechnol. Bioeng. , vol.63 , pp. 675-683
    • Follstad, B.D.1
  • 15
    • 0037313750 scopus 로고    scopus 로고
    • Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network
    • Forster,J. et al. (2003) Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network. Genome Res., 13, 244-253.
    • (2003) Genome Res. , vol.13 , pp. 244-253
    • Forster, J.1
  • 16
    • 0027909872 scopus 로고
    • Analysis of metabolic fluxes in batch and continuous cultures of Bacillus subtilis
    • Goel,A. et al. (1993) Analysis of metabolic fluxes in batch and continuous cultures of Bacillus subtilis. Biotechnol. Bioeng., 42, 686-696.
    • (1993) Biotechnol. Bioeng. , vol.42 , pp. 686-696
    • Goel, A.1
  • 17
    • 0033587789 scopus 로고    scopus 로고
    • Metabolic fluxes, pools, and enzyme measurements suggest a tighter coupling of energetics and biosynthetic reactions associated with reduced pyruvate kinase flux
    • Goel,A. et al. (1999) Metabolic fluxes, pools, and enzyme measurements suggest a tighter coupling of energetics and biosynthetic reactions associated with reduced pyruvate kinase flux. Biotechnol. Bioeng., 64, 129-134.
    • (1999) Biotechnol. Bioeng. , vol.64 , pp. 129-134
    • Goel, A.1
  • 18
    • 0030463296 scopus 로고    scopus 로고
    • Flux analysis and control of the central metabolic pathways in Escherichia coli
    • Holms,H. (1996) Flux analysis and control of the central metabolic pathways in Escherichia coli. FEMS Microbiol. Rev., 19, 85-116.
    • (1996) FEMS Microbiol. Rev. , vol.19 , pp. 85-116
    • Holms, H.1
  • 19
    • 0037079023 scopus 로고    scopus 로고
    • Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth
    • Ibarra,R.U. et al. (2002) Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth. Nature, 420, 186-189.
    • (2002) Nature , vol.420 , pp. 186-189
    • Ibarra, R.U.1
  • 20
    • 0024842144 scopus 로고
    • Metabolic dynamics in the human red cell. Part I - A comprehensive kinetic model
    • Joshi,A. and Palsson,B.O. (1989a) Metabolic dynamics in the human red cell. Part I - A comprehensive kinetic model. J. Theor. Biol., 141, 515-528.
    • (1989) J. Theor. Biol. , vol.141 , pp. 515-528
    • Joshi, A.1    Palsson, B.O.2
  • 21
    • 0024799182 scopus 로고
    • Metabolic dynamics in the human red cell. Part II - Interactions with the environment
    • Joshi,A. and Palsson,B.O. (1989b) Metabolic dynamics in the human red cell. Part II - Interactions with the environment. J. Theor. Biol., 141, 529-545.
    • (1989) J. Theor. Biol. , vol.141 , pp. 529-545
    • Joshi, A.1    Palsson, B.O.2
  • 22
    • 0025095641 scopus 로고
    • Metabolic dynamics in the human red cell. Part III - Metabolic reaction rates
    • Joshi,A. and Palsson,B.O. (1990a) Metabolic dynamics in the human red cell. Part III - Metabolic reaction rates. J. Theor. Biol., 142, 41-68.
    • (1990) J. Theor. Biol. , vol.142 , pp. 41-68
    • Joshi, A.1    Palsson, B.O.2
  • 23
    • 0025166450 scopus 로고
    • Metabolic dynamics in the human red cell. Part IV - Data prediction and some model computations
    • Joshi,A. and Palsson,B.O. (1990b) Metabolic dynamics in the human red cell. Part IV - Data prediction and some model computations. J. Theor. Biol., 142, 69-85.
    • (1990) J. Theor. Biol. , vol.142 , pp. 69-85
    • Joshi, A.1    Palsson, B.O.2
  • 25
    • 0036500993 scopus 로고    scopus 로고
    • Systems biology: A brief overview
    • Kitano,H. (2002) Systems biology: A brief overview. Science, 295, 1662-1664.
    • (2002) Science , vol.295 , pp. 1662-1664
    • Kitano, H.1
  • 26
    • 0042825675 scopus 로고    scopus 로고
    • Systematic quantification of complex metabolic flux networks using stable isotopes and mass spectrometry
    • Klapa,M.I. et al. (2003) Systematic quantification of complex metabolic flux networks using stable isotopes and mass spectrometry. Eur. J. Biochem., 270, 3525-3542.
    • (2003) Eur. J. Biochem. , vol.270 , pp. 3525-3542
    • Klapa, M.I.1
  • 27
    • 0033585824 scopus 로고    scopus 로고
    • Metabolite and isotopomer balancing in the analysis of metabolic cycles: I. Theory
    • Klapa,M.I. et al. (1999) Metabolite and isotopomer balancing in the analysis of metabolic cycles: I. Theory. Biotechnol. Bioeng., 62, 375-391.
    • (1999) Biotechnol. Bioeng. , vol.62 , pp. 375-391
    • Klapa, M.I.1
  • 28
    • 17444425371 scopus 로고    scopus 로고
    • Evaluation of HIV-1 kinetic models using quantitative discrimination analysis
    • Knorr,A.L. and Srivastava,R. (2005) Evaluation of HIV-1 kinetic models using quantitative discrimination analysis. Bioinformatics, 21, 1668-1677.
    • (2005) Bioinformatics , vol.21 , pp. 1668-1677
    • Knorr, A.L.1    Srivastava, R.2
  • 29
    • 20444420179 scopus 로고    scopus 로고
    • Strain improvement by metabolic engineering: Lysine production as a case study for systems biology
    • Koffas,M. and Stephanopoulos,G. (2005) Strain improvement by metabolic engineering: Lysine production as a case study for systems biology. Curr. Opin. Biotechnol., 16, 361-366.
    • (2005) Curr. Opin. Biotechnol. , vol.16 , pp. 361-366
    • Koffas, M.1    Stephanopoulos, G.2
  • 30
    • 0022755363 scopus 로고
    • Investigation of bacterial growth on mixed substrates: Experimental evaluation of cybernetic models
    • Kompala,D.S. et al. (1986) Investigation of bacterial growth on mixed substrates: Experimental evaluation of cybernetic models. Biotechnol. Bioeng., 28, 1044-1055.
    • (1986) Biotechnol. Bioeng. , vol.28 , pp. 1044-1055
    • Kompala, D.S.1
  • 31
    • 0034496510 scopus 로고    scopus 로고
    • Metabolic flux analysis of postburn hepatic hypermetabolism
    • Lee,K. et al. (2000) Metabolic flux analysis of postburn hepatic hypermetabolism. Metab. Eng., 2, 312-327.
    • (2000) Metab. Eng. , vol.2 , pp. 312-327
    • Lee, K.1
  • 32
    • 0032787428 scopus 로고    scopus 로고
    • Metabolic flux analysis: A powerful tool for monitoring tissue function
    • Lee,K. et al. (1999) Metabolic flux analysis: A powerful tool for monitoring tissue function. Tissue. Eng., 5, 347-368.
    • (1999) Tissue. Eng. , vol.5 , pp. 347-368
    • Lee, K.1
  • 33
    • 0034661295 scopus 로고    scopus 로고
    • Recursive MILP model for finding all the alternate optima in LP models for metabolic networks
    • Lee,S. et al. (2000) Recursive MILP model for finding all the alternate optima in LP models for metabolic networks. Comput. Chem. Eng., 24, 711-716.
    • (2000) Comput. Chem. Eng. , vol.24 , pp. 711-716
    • Lee, S.1
  • 34
    • 0030571222 scopus 로고    scopus 로고
    • Pathway analysis, engineering, and physiological considerations for redirecting central metabolism
    • Liao,J.C. et al. (1996) Pathway analysis, engineering, and physiological considerations for redirecting central metabolism. Biotechnol. Bioeng., 52, 129-140.
    • (1996) Biotechnol. Bioeng. , vol.52 , pp. 129-140
    • Liao, J.C.1
  • 35
    • 0025405421 scopus 로고
    • Simple constrained-optimization view of acetate overflow in E.coli
    • Majewski,R.A. and Domach,M.M. (1990) Simple constrained-optimization view of acetate overflow in E.coli. Biotechnol Bioeng., 35, 732-738.
    • (1990) Biotechnol Bioeng. , vol.35 , pp. 732-738
    • Majewski, R.A.1    Domach, M.M.2
  • 36
    • 0026880847 scopus 로고
    • Synthesis of biochemical production routes
    • Mavrovouniotis,M. et al. (1992) Synthesis of biochemical production routes. Comp. Chem. Eng., 16, 605-619.
    • (1992) Comp. Chem. Eng. , vol.16 , pp. 605-619
    • Mavrovouniotis, M.1
  • 37
    • 0023356336 scopus 로고
    • Reducing complexity in metabolic networks: Making metabolic meshes manageable
    • Palsson,B.O. et al. (1987) Reducing complexity in metabolic networks: making metabolic meshes manageable. Fed. Proc., 46, 2485-2489.
    • (1987) Fed. Proc. , vol.46 , pp. 2485-2489
    • Palsson, B.O.1
  • 38
    • 0024835379 scopus 로고
    • Computer model of human erythrocyte metabolism
    • 133-150
    • Palsson,B.O. et al. (1989) Computer model of human erythrocyte metabolism. Prog. Clin. Biol. Res., 319, 133-150, 151-154.
    • (1989) Prog. Clin. Biol. Res. , vol.319 , pp. 151-154
    • Palsson, B.O.1
  • 39
    • 0033585823 scopus 로고    scopus 로고
    • Metabolite and isotopomer balancing in the analysis of metabolic cycles: II. Applications
    • Park,S.M. et al. (1999) Metabolite and isotopomer balancing in the analysis of metabolic cycles: II. Applications. Biotechnol. Bioeng., 62, 392-401.
    • (1999) Biotechnol. Bioeng. , vol.62 , pp. 392-401
    • Park, S.M.1
  • 40
    • 0035017810 scopus 로고    scopus 로고
    • Flux-balance analysis of mitochondrial energy metabolism: Consequences of systemic stoichiometric constraints
    • Ramakrishna,R. et al. (2001) Flux-balance analysis of mitochondrial energy metabolism: Consequences of systemic stoichiometric constraints. Am J. Physiol. Regul. Integr. Comp. Physiol., 280, R695-R704.
    • (2001) Am J. Physiol. Regul. Integr. Comp. Physiol. , vol.280
    • Ramakrishna, R.1
  • 41
    • 33847654799 scopus 로고    scopus 로고
    • Flux balance analysis of mycolic acid pathway: Targets for anti-tubercular drugs
    • Raman,K. et al. (2005) Flux balance analysis of mycolic acid pathway: targets for anti-tubercular drugs. PLoS Comput. Biol., 1, e46.
    • (2005) PLoS Comput. Biol. , vol.1
    • Raman, K.1
  • 42
    • 4644220226 scopus 로고    scopus 로고
    • Genome-scale in silico models of E.coli have multiple equivalent phenotypic states: Assessment of correlated reaction subsets that comprise network states
    • Reed,J.L. and Palsson,B.O. (2004) Genome-scale in silico models of E.coli have multiple equivalent phenotypic states: Assessment of correlated reaction subsets that comprise network states. Genome Res., 14, 1797-1805.
    • (2004) Genome Res. , vol.14 , pp. 1797-1805
    • Reed, J.L.1    Palsson, B.O.2
  • 43
    • 0344328817 scopus 로고    scopus 로고
    • An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR)
    • Reed,J.L. et al. (2003) An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR). Genome Biol., 4, R54.
    • (2003) Genome Biol. , vol.4
    • Reed, J.L.1
  • 44
    • 0032551605 scopus 로고    scopus 로고
    • Metabolic capacity of Bacillus subtilis for the production of purine nucleosides, riboflavin, and folic acid
    • Sauer,U. et al. (1998) Metabolic capacity of Bacillus subtilis for the production of purine nucleosides, riboflavin, and folic acid. Biotechnol. Bioeng., 59, 227-238.
    • (1998) Biotechnol. Bioeng. , vol.59 , pp. 227-238
    • Sauer, U.1
  • 45
    • 0031004921 scopus 로고    scopus 로고
    • Metabolic fluxes in riboflavin-producing Bacillus subtilis
    • Sauer,U. et al. (1997) Metabolic fluxes in riboflavin-producing Bacillus subtilis. Nat. Biotechnol., 15, 448-452.
    • (1997) Nat. Biotechnol. , vol.15 , pp. 448-452
    • Sauer, U.1
  • 46
    • 0029781898 scopus 로고    scopus 로고
    • Physiology and metabolic fluxes of wild-type and riboflavin-producing Bacillus subtilis
    • Sauer,U. et al. (1996) Physiology and metabolic fluxes of wild-type and riboflavin-producing Bacillus subtilis. Appl. Environ. Microbiol., 62, 3687-3696.
    • (1996) Appl. Environ. Microbiol. , vol.62 , pp. 3687-3696
    • Sauer, U.1
  • 47
    • 0014649230 scopus 로고
    • Biochemical systems analysis. I. Some mathematical properties of the rate law for the component enzymatic reactions
    • Savageau,M.A. (1969a) Biochemical systems analysis. I. Some mathematical properties of the rate law for the component enzymatic reactions. J. Theor. Biol., 25, 365-369.
    • (1969) J. Theor. Biol. , vol.25 , pp. 365-369
    • Savageau, M.A.1
  • 48
    • 0014658880 scopus 로고
    • Biochemical systems analysis. II. The steady-state solutions for an n-pool system using a power-law approximation
    • Savageau,M.A. (1969b) Biochemical systems analysis. II. The steady-state solutions for an n-pool system using a power-law approximation. J. Theor. Biol., 25, 370-379.
    • (1969) J. Theor. Biol. , vol.25 , pp. 370-379
    • Savageau, M.A.1
  • 49
    • 0026516223 scopus 로고
    • Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism
    • Savinell,J.M. and Palsson,B.O. (1992) Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism. J. Theor. Biol., 154, 421-454.
    • (1992) J. Theor. Biol. , vol.154 , pp. 421-454
    • Savinell, J.M.1    Palsson, B.O.2
  • 51
    • 0036330798 scopus 로고    scopus 로고
    • Genome-scale metabolic model of Helicobacter pylori 26695
    • Schilling,C.H. et al. (2002) Genome-scale metabolic model of Helicobacter pylori 26695. J. Bacteriol., 184, 4582-4593.
    • (2002) J. Bacteriol. , vol.184 , pp. 4582-4593
    • Schilling, C.H.1
  • 52
    • 0034447725 scopus 로고    scopus 로고
    • Combining pathway analysis with flux balance analysis for the comprehensive study of metabolic systems
    • Schilling,C.H. et al. (2000) Combining pathway analysis with flux balance analysis for the comprehensive study of metabolic systems. Biotechnol. Bioeng., 71, 286-306.
    • (2000) Biotechnol. Bioeng. , vol.71 , pp. 286-306
    • Schilling, C.H.1
  • 53
    • 0034615788 scopus 로고    scopus 로고
    • Assessment of the metabolic capabilities of Haemophilus influenzae Rd through a genome-scale pathway analysis
    • Schilling,C.H. and Palsson,B.O. (2000) Assessment of the metabolic capabilities of Haemophilus influenzae Rd through a genome-scale pathway analysis. J. Theor. Biol., 203, 249-283.
    • (2000) J. Theor. Biol. , vol.203 , pp. 249-283
    • Schilling, C.H.1    Palsson, B.O.2
  • 54
    • 0033136109 scopus 로고    scopus 로고
    • Metabolic pathway analysis: Basic concepts and scientific applications in the post-genomic era
    • Schilling,C.H. et al. (1999) Metabolic pathway analysis: Basic concepts and scientific applications in the post-genomic era. Biotechnol. Prog., 15, 296-303.
    • (1999) Biotechnol. Prog. , vol.15 , pp. 296-303
    • Schilling, C.H.1
  • 55
    • 0033080396 scopus 로고    scopus 로고
    • Detection of elementary flux modes in biochemical networks: A promising tool for pathway analysis and metabolic engineering
    • Schuster,S. et al. (1999) Detection of elementary flux modes in biochemical networks: A promising tool for pathway analysis and metabolic engineering. Trends Biotechnol., 17, 53-60.
    • (1999) Trends Biotechnol. , vol.17 , pp. 53-60
    • Schuster, S.1
  • 56
    • 0032600888 scopus 로고    scopus 로고
    • Metabolic fluxes and metabolic engineering
    • Stephanopoulos,G. (1999) Metabolic fluxes and metabolic engineering. Metab. Eng., 1, 1-11.
    • (1999) Metab. Eng. , vol.1 , pp. 1-11
    • Stephanopoulos, G.1
  • 57
    • 0025866296 scopus 로고
    • Network rigidity and metabolic engineering in metabolite overproduction
    • Stephanopoulos,G. and Vallino,J.J. (1991) Network rigidity and metabolic engineering in metabolite overproduction. Science, 252, 1675-1681.
    • (1991) Science , vol.252 , pp. 1675-1681
    • Stephanopoulos, G.1    Vallino, J.J.2
  • 59
    • 0026864325 scopus 로고
    • Parameter estimation from multiresponse data
    • Stewart,W.E. et al. (1992) Parameter estimation from multiresponse data. AIChE J., 38, 641-650.
    • (1992) AIChE J. , vol.38 , pp. 641-650
    • Stewart, W.E.1
  • 60
    • 0030288156 scopus 로고    scopus 로고
    • Model discrimination and criticism with single-response data
    • Stewart,W.E. et al. (1996) Model discrimination and criticism with single-response data. AIChE J., 42, 3055-3062.
    • (1996) AIChE J. , vol.42 , pp. 3055-3062
    • Stewart, W.E.1
  • 61
    • 0032095686 scopus 로고    scopus 로고
    • Discrimination and goodness of fit of multiresponse mechanistic models
    • Stewart,W.E. et al. (1998) Discrimination and goodness of fit of multiresponse mechanistic models. AIChE J., 44, 1404-1412.
    • (1998) AIChE J. , vol.44 , pp. 1404-1412
    • Stewart, W.E.1
  • 62
    • 0001065908 scopus 로고
    • Bayesian estimation of common parameters from multiresponse data with missing observations
    • Stewart,W.E. and Sorenson,J.P. (1981) Bayesian estimation of common parameters from multiresponse data with missing observations. Technometrics, 23, 131-141.
    • (1981) Technometrics , vol.23 , pp. 131-141
    • Stewart, W.E.1    Sorenson, J.P.2
  • 63
    • 33749133230 scopus 로고    scopus 로고
    • Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction
    • Reprinted from Biotechnology and Bioengineering, 41, 633-646 (1993)
    • Vallino,J.J. and Stephanopoulos,G. (2000) Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction. Reprinted from Biotechnology and Bioengineering, 41, 633-646 (1993). Biotechnol. Bioeng., 67, 872-885.
    • (2000) Biotechnol. Bioeng. , vol.67 , pp. 872-885
    • Vallino, J.J.1    Stephanopoulos, G.2
  • 64
    • 0027723421 scopus 로고
    • Metabolic capabilities of Escherichia-coli 2. Optimal-growth patterns
    • Varma,A. and Palsson,B.O. (1993) Metabolic capabilities of Escherichia-coli 2. Optimal-growth patterns. J. Theor. Biol., 165, 503-522.
    • (1993) J. Theor. Biol. , vol.165 , pp. 503-522
    • Varma, A.1    Palsson, B.O.2
  • 65
    • 0028108519 scopus 로고
    • Metabolic flux balancing_basic concepts, scientific and practical use
    • Varma,A. and Palsson,B.O. (1994) Metabolic flux balancing_basic concepts, scientific and practical use. Biotechnology, 12, 994-998.
    • (1994) Biotechnology , vol.12 , pp. 994-998
    • Varma, A.1    Palsson, B.O.2
  • 66
    • 4544288672 scopus 로고    scopus 로고
    • Reconstruction and functional characterization of the human mitochondrial metabolic network based on proteomic and biochemical data
    • Vo,T.D. et al. (2004) Reconstruction and functional characterization of the human mitochondrial metabolic network based on proteomic and biochemical data. J. Biol. Chem., 279, 39532-39540.
    • (2004) J Biol. Chem. , vol.279 , pp. 39532-39540
    • Vo, T.D.1
  • 67
    • 33847251246 scopus 로고    scopus 로고
    • Building a Virtual Microbe, Gene by Gene
    • New York
    • Zimmer,C. (2005) Building a Virtual Microbe, Gene by Gene. The New York Times. New York.
    • (2005) The New York Times
    • Zimmer, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.