Metabolic fluxes, pools, and enzyme measurements suggest a tighter coupling of energetics and biosynthetic reactions associated with reduced pyruvate kinase flux

Biotechnology and Bioengineering

Volumn 64, Issue 2, 1999, Pages 129-134

  Goel, Akshay ^a   Lee, Jinwoon ^b   Domach, Michael M ^b   Ataai, Mohammad M ^a  

^a PA 15213   (United States)

^b CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

Acid formation; Bacillus subtilis; Metabolic engineering; Pyruvate kinase mutant

Indexed keywords

BIOSYNTHESIS; CELL CULTURE; ENZYME INHIBITION; GLUCOSE; MATHEMATICAL MODELS; METABOLISM;

COMETABOLISM; PYRUVATE KINASE;

BACTERIA;

6 PHOSPHOFRUCTOKINASE; CITRIC ACID; GLUCOSE; PHOSPHOENOLPYRUVATE; PYRUVATE KINASE;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL METABOLISM; BIOSYNTHESIS; CELL ENERGY; CITRIC ACID CYCLE; ENZYME ASSAY; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; GROWTH RATE; METABOLIC BALANCE; NONHUMAN; STATISTICAL MODEL;

BACILLUS SUBTILIS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; MAGNESIUM; MODELS, BIOLOGICAL; MUTAGENESIS; PYRUVATE KINASE;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); POSIBACTERIA;

EID: 0033587789     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19990720)64:2<129::AID-BIT1>3.0.CO;2-I     Document Type: Article

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