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Volumn 5, Issue 4, 1999, Pages 347-368

Metabolic flux analysis: A powerful tool for monitoring tissue function

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY; CALCULATION; CELL METABOLISM; CELL VIABILITY; ENERGY METABOLISM; ENGINEERING; MONITORING; NONHUMAN; PRIORITY JOURNAL; REVIEW; STOICHIOMETRY;

EID: 0032787428     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.1999.5.347     Document Type: Review
Times cited : (38)

References (147)
  • 1
    • 0022985811 scopus 로고
    • The central metabolic pathways of Escherichia coli: Relationship between flux and control at a branch point, efficiency of conversion to biomass, and excretion of acetate
    • Holms, W.H. The central metabolic pathways of Escherichia coli: Relationship between flux and control at a branch point, efficiency of conversion to biomass, and excretion of acetate. Curr. Top. Cell Regul. 28, 69, 1986.
    • (1986) Curr. Top. Cell Regul. , vol.28 , pp. 69
    • Holms, W.H.1
  • 3
    • 0027572102 scopus 로고
    • Metabolic flux distribution in corynebacterium glutamicum during growth and lysine overproduction
    • Vallino, J.J., and Stephanopoulos, G. Metabolic flux distribution in corynebacterium glutamicum during growth and lysine overproduction. Biotechnol. Bioeng. 41, 633, 1993.
    • (1993) Biotechnol. Bioeng. , vol.41 , pp. 633
    • Vallino, J.J.1    Stephanopoulos, G.2
  • 4
    • 0028086742 scopus 로고
    • Carbon flux distribution at the glucose-6-phosphate branch point in corynebacterium glutamicum during lysine overproduction
    • Vallino, J.J., and Stephanopoulos, G. Carbon flux distribution at the glucose-6-phosphate branch point in corynebacterium glutamicum during lysine overproduction. Biotechnol. Prog. 10, 327, 1994.
    • (1994) Biotechnol. Prog. , vol.10 , pp. 327
    • Vallino, J.J.1    Stephanopoulos, G.2
  • 5
    • 0025866296 scopus 로고
    • Network rigidity and metabolic engineering in metabolite overproduction
    • Stephanopoulos, G., and Vallino, J.J. Network rigidity and metabolic engineering in metabolite overproduction. Science 252, 1675, 1991.
    • (1991) Science , vol.252 , pp. 1675
    • Stephanopoulos, G.1    Vallino, J.J.2
  • 6
    • 0029278153 scopus 로고
    • Metabolic flux distribution in Penicilium chrysogenum during fed-batch cultivations
    • Joergensen, H., Nielsen, J., Villadsen, J., and Moellgaard, H. Metabolic flux distribution in Penicilium chrysogenum during fed-batch cultivations. Biotechnol. Bioeng. 46, 117, 1995.
    • (1995) Biotechnol. Bioeng. , vol.46 , pp. 117
    • Joergensen, H.1    Nielsen, J.2    Villadsen, J.3    Moellgaard, H.4
  • 7
  • 9
    • 0025895183 scopus 로고
    • Toward a science of metabolic engineering
    • Bailey, J.E. Toward a science of metabolic engineering. Science 252, 1668, 1991.
    • (1991) Science , vol.252 , pp. 1668
    • Bailey, J.E.1
  • 11
    • 0030914227 scopus 로고    scopus 로고
    • Metabolic engineering and human disease
    • Yarmush, M.L., and Berthiaume, F. Metabolic engineering and human disease. Nat. Biotechnol. 15, 525, 1997.
    • (1997) Nat. Biotechnol. , vol.15 , pp. 525
    • Yarmush, M.L.1    Berthiaume, F.2
  • 12
    • 0026900126 scopus 로고
    • Tissue engineering in the USA
    • Nerem, R.M. Tissue engineering in the USA. Med Biol Eng Comput 30, CE8, 1992.
    • (1992) Med Biol Eng Comput , vol.30
    • Nerem, R.M.1
  • 14
    • 0028765063 scopus 로고
    • Cerebral neurons, skeletal myoblasts, and cardiac muscle cells cultured on macroporous beads
    • Sahhar, A., Reuvney, S., David, Y., Budu, C., and Shainberg, A. Cerebral neurons, skeletal myoblasts, and cardiac muscle cells cultured on macroporous beads. Biotechnol. Bioeng. 43, 826, 1994.
    • (1994) Biotechnol. Bioeng. , vol.43 , pp. 826
    • Sahhar, A.1    Reuvney, S.2    David, Y.3    Budu, C.4    Shainberg, A.5
  • 15
    • 0028765042 scopus 로고
    • Stereotypic culture systems for liver and bone marrow: Evidence for the development of functional fissue in vitro and following implantation in vivo
    • Naughton, B.A., San Roman, J., Sibanda, B., Weintraub, J.P., and Kamali, V. Stereotypic culture systems for liver and bone marrow: Evidence for the development of functional fissue in vitro and following implantation in vivo. Biotechnol. Bioeng. 43, 810, 1994.
    • (1994) Biotechnol. Bioeng. , vol.43 , pp. 810
    • Naughton, B.A.1    San Roman, J.2    Sibanda, B.3    Weintraub, J.P.4    Kamali, V.5
  • 16
    • 0029263365 scopus 로고
    • Tissue engineering of a bioartificial pancreas: Modeling the cell environment and device function
    • Tziampazis, E., and Sambanis, A. Tissue engineering of a bioartificial pancreas: Modeling the cell environment and device function. Biotechnol. Prog. 11, 115, 1995.
    • (1995) Biotechnol. Prog. , vol.11 , pp. 115
    • Tziampazis, E.1    Sambanis, A.2
  • 17
    • 0028392725 scopus 로고
    • Tissue engineering of a bioartificial kidney
    • Cieslinski, D.A., and Humes, H.D. Tissue engineering of a bioartificial kidney. Biotechnol. Bioeng. 43, 678, 1994.
    • (1994) Biotechnol. Bioeng. , vol.43 , pp. 678
    • Cieslinski, D.A.1    Humes, H.D.2
  • 18
    • 0028392724 scopus 로고
    • Engineering organ perfusion protocols: NMR analysis of hepatocyte isolation from perfused rat liver
    • Foy, B.D., Toner, M., Tompkins, R.G., and Yarmush, M.L. Engineering organ perfusion protocols: NMR analysis of hepatocyte isolation from perfused rat liver. Biotechnol. Bioeng. 43, 661, 1994.
    • (1994) Biotechnol. Bioeng. , vol.43 , pp. 661
    • Foy, B.D.1    Toner, M.2    Tompkins, R.G.3    Yarmush, M.L.4
  • 19
    • 0027657693 scopus 로고
    • Metabolic engineering-Methodologies and future prospects
    • Stephanopoulos, G., and Sinskey, A.J. Metabolic engineering-Methodologies and future prospects. Trends. Biotechnol. 11, 392, 1993.
    • (1993) Trends. Biotechnol. , vol.11 , pp. 392
    • Stephanopoulos, G.1    Sinskey, A.J.2
  • 20
    • 0031945008 scopus 로고    scopus 로고
    • Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells
    • Fussenegger, M., Schlatter, S., Datwyler, D., Mazur, X., and Bailey, J.E. Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells [In Process Citation]. Nat. Biotechnol. 16, 468, 1998.
    • (1998) Nat. Biotechnol. , vol.16 , pp. 468
    • Fussenegger, M.1    Schlatter, S.2    Datwyler, D.3    Mazur, X.4    Bailey, J.E.5
  • 21
    • 0030003558 scopus 로고    scopus 로고
    • Isolation and culture of porcine hepatocytes for artificial liver support
    • Naik, S., Trenkler, D., Santangini, H., Pan, J., and Jauregui, H.O. Isolation and culture of porcine hepatocytes for artificial liver support. Cell Transplant. 5, 107, 1996.
    • (1996) Cell Transplant. , vol.5 , pp. 107
    • Naik, S.1    Trenkler, D.2    Santangini, H.3    Pan, J.4    Jauregui, H.O.5
  • 22
    • 0028938807 scopus 로고
    • Topical nutrients promote engraftment and inhibit wound contraction of cultured skin substitutes in athymic mice
    • Boyce, S.T., Supp, A.P., Harriger, M.D., Greenhalgh, D.G., and Warden, G.D. Topical nutrients promote engraftment and inhibit wound contraction of cultured skin substitutes in athymic mice. J. Invest. Dermatol. 104, 345, 1995.
    • (1995) J. Invest. Dermatol. , vol.104 , pp. 345
    • Boyce, S.T.1    Supp, A.P.2    Harriger, M.D.3    Greenhalgh, D.G.4    Warden, G.D.5
  • 23
    • 0030733932 scopus 로고    scopus 로고
    • A metabolically active human derman replacement for the treatment of diabetic foot ulcers
    • Naughton, G., Mansbridge, J., and Gentzkow, G. A metabolically active human derman replacement for the treatment of diabetic foot ulcers. Artif. Organs. 21, 1203, 1997.
    • (1997) Artif. Organs. , vol.21 , pp. 1203
    • Naughton, G.1    Mansbridge, J.2    Gentzkow, G.3
  • 24
    • 0031978661 scopus 로고    scopus 로고
    • Neural stem and progenitor cells: A strategy for gene therapy and brain repair
    • Pincus, D.W., Goodman, R.R., Fraser, R.A., Nedergaard, M., and Goldman, S.A. Neural stem and progenitor cells: a strategy for gene therapy and brain repair. Neurosurgery 42, 858, 1998.
    • (1998) Neurosurgery , vol.42 , pp. 858
    • Pincus, D.W.1    Goodman, R.R.2    Fraser, R.A.3    Nedergaard, M.4    Goldman, S.A.5
  • 25
    • 9444286985 scopus 로고    scopus 로고
    • High cell density and high monoclonal antibody production through medium design and rational control in a bioreactor
    • Xie, L., and Wang, D.I.C. High cell density and high monoclonal antibody production through medium design and rational control in a bioreactor. Biotechnol. Bioeng. 51, 725, 1996.
    • (1996) Biotechnol. Bioeng. , vol.51 , pp. 725
    • Xie, L.1    Wang, D.I.C.2
  • 26
    • 0031940398 scopus 로고    scopus 로고
    • Tissue engineering: Generation of differentiated artificial tissues for biomedical applications
    • Minuth, W.W., Sittinger, M., and Kloth, S. Tissue engineering: generation of differentiated artificial tissues for biomedical applications. Cell Tissue Res. 291, 1, 1998.
    • (1998) Cell Tissue Res. , vol.291 , pp. 1
    • Minuth, W.W.1    Sittinger, M.2    Kloth, S.3
  • 27
    • 0004155427 scopus 로고
    • New York: W.H. Freeman
    • Stryer, L. Biochemistry. New York: W.H. Freeman, 1995.
    • (1995) Biochemistry
    • Stryer, L.1
  • 29
    • 0028902940 scopus 로고
    • Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis
    • Des Rosiers, C., Di Donato, L., Comte, B., et al. Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis. J. Biol. Chem. 270, 10027, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 10027
    • Des Rosiers, C.1    Di Donato, L.2    Comte, B.3
  • 30
    • 0027513359 scopus 로고
    • Responses of metabolic systems to large changes in enzyme activities and effectors. 1. The linear treatment of unbranched chains
    • Small, J.R., and Kacser, H. Responses of metabolic systems to large changes in enzyme activities and effectors. 1. The linear treatment of unbranched chains. Eur. J. Biochem. 213, 613, 1993.
    • (1993) Eur. J. Biochem. , vol.213 , pp. 613
    • Small, J.R.1    Kacser, H.2
  • 32
    • 0026802334 scopus 로고
    • Metabolic control analysis: A survey of its theoretical and experimental development
    • Fell, D.A. Metabolic control analysis: A survey of its theoretical and experimental development. Biochem. J. 286, 313, 1992.
    • (1992) Biochem. J. , vol.286 , pp. 313
    • Fell, D.A.1
  • 33
    • 0028108519 scopus 로고
    • Metabolic flux balancing: Basic concepts, scientific, and practical use
    • Varma, A., and Palsson, B.O. Metabolic flux balancing: Basic concepts, scientific, and practical use. Biotechnology 12, 994, 1994.
    • (1994) Biotechnology , vol.12 , pp. 994
    • Varma, A.1    Palsson, B.O.2
  • 35
    • 0019702744 scopus 로고
    • Rectification of process measurement data in the presence of gross errors
    • Romagnoli, J.A., and Stephanopoulos, G. Rectification of process measurement data in the presence of gross errors. Chem. Eng. Sci. 36, 1849, 1984.
    • (1984) Chem. Eng. Sci. , vol.36 , pp. 1849
    • Romagnoli, J.A.1    Stephanopoulos, G.2
  • 36
    • 0020812944 scopus 로고
    • Application of macroscopic balances to the identification of gross measurement errors
    • Wang, N.S., and Stephanopoulos, G. Application of macroscopic balances to the identification of gross measurement errors. Biotechnol. Bioeng. 25, 2177, 1983.
    • (1983) Biotechnol. Bioeng. , vol.25 , pp. 2177
    • Wang, N.S.1    Stephanopoulos, G.2
  • 37
    • 0026603416 scopus 로고
    • Network analysis of intermediary metabolism using linear optimization. II. Interpretation of hybridoma cell metabolism
    • Savinell, J.M., and Palsson, B.O. Network analysis of intermediary metabolism using linear optimization. II. Interpretation of hybridoma cell metabolism. J. Theor. Biol. 154, 455, 1992.
    • (1992) J. Theor. Biol. , vol.154 , pp. 455
    • Savinell, J.M.1    Palsson, B.O.2
  • 38
    • 0026516223 scopus 로고
    • Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism
    • Savinell, J.M., and Palsson, B.O. Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism. J. Theor. Biol. 154, 421, 1992.
    • (1992) J. Theor. Biol. , vol.154 , pp. 421
    • Savinell, J.M.1    Palsson, B.O.2
  • 40
    • 0030804853 scopus 로고    scopus 로고
    • Flux analysis of underdetermined metabolic networks: The quest for the missing constraints
    • Bonarius, H.P.J., Schmid, G., and Tramper, J. Flux analysis of underdetermined metabolic networks: the quest for the missing constraints. Trends. Biotechnol. 15, 308, 1997.
    • (1997) Trends. Biotechnol. , vol.15 , pp. 308
    • Bonarius, H.P.J.1    Schmid, G.2    Tramper, J.3
  • 41
    • 0000491361 scopus 로고
    • Conversion of fatty acids to carbohydrate. Applications of isotopes to this problem and the role of the Krebs cycle as a synthetic pathway
    • Weinman, E.O., Strisower, E.H., and Chaikoff, I.L. Conversion of fatty acids to carbohydrate. Applications of isotopes to this problem and the role of the Krebs cycle as a synthetic pathway. Physiol. Rev. 37, 252, 1957.
    • (1957) Physiol. Rev. , vol.37 , pp. 252
    • Weinman, E.O.1    Strisower, E.H.2    Chaikoff, I.L.3
  • 42
    • 0015501832 scopus 로고
    • Gluconeogenesis in the kidney cortex. Quantitative estimation of carbon flow
    • Rognstad, R., and Katz, J. Gluconeogenesis in the kidney cortex. Quantitative estimation of carbon flow. J. Biol. Chem. 247, 6047, 1972.
    • (1972) J. Biol. Chem. , vol.247 , pp. 6047
    • Rognstad, R.1    Katz, J.2
  • 43
    • 0022017414 scopus 로고
    • 14C]citrate specific activity ratios
    • 14C]citrate specific activity ratios. Am. J. Physiol. 248, E252, 1985.
    • (1985) Am. J. Physiol. , vol.248
    • Kelleher, J.K.1
  • 44
    • 0022273142 scopus 로고
    • 2 ratios method for detecting pyruvate carboxylation
    • 2 ratios method for detecting pyruvate carboxylation. Anal. Biochem. 151, 55, 1985.
    • (1985) Anal. Biochem. , vol.151 , pp. 55
    • Kelleher, J.K.1    Bryan, B.M.D.2
  • 45
    • 0028342975 scopus 로고
    • SYNTAX: A rule-based stochastic simulation of the time-varying concentrations of positional isotopomers of metabolic intermediates
    • Cohen, D.M., and Bergman, R.N. SYNTAX: A rule-based stochastic simulation of the time-varying concentrations of positional isotopomers of metabolic intermediates. Comput. Biomed. Res. 27, 130, 1994.
    • (1994) Comput. Biomed. Res. , vol.27 , pp. 130
    • Cohen, D.M.1    Bergman, R.N.2
  • 46
    • 0028350061 scopus 로고
    • Prediction of positional isotopomers of the citric acid cycle: The syntactic approach
    • Cohen, D.M., and Bergman, R.N. Prediction of positional isotopomers of the citric acid cycle: the syntactic approach. Am. J. Physiol. 266, E341, 1994.
    • (1994) Am. J. Physiol. , vol.266
    • Cohen, D.M.1    Bergman, R.N.2
  • 47
    • 0028958118 scopus 로고
    • Estimation of TCA cycle flux, aminotransferase flux, and anaplerosis in heart: Validation with syntactic model
    • Cohen, D.M., and Bergman, R.N. Estimation of TCA cycle flux, aminotransferase flux, and anaplerosis in heart: Validation with syntactic model. Am. J. Physiol. 268, E397, 1995.
    • (1995) Am. J. Physiol. , vol.268
    • Cohen, D.M.1    Bergman, R.N.2
  • 50
    • 0028859430 scopus 로고
    • Kinetic analysis of dynamic.13C NMR spectra: Metabolic flux, regulation, and compartmentation in hearts
    • Yu, X., White, L.T., Doumen, C., et al. Kinetic analysis of dynamic.13C NMR spectra: Metabolic flux, regulation, and compartmentation in hearts. Biophys. J. 69, 2090, 1995.
    • (1995) Biophys. J. , vol.69 , pp. 2090
    • Yu, X.1    White, L.T.2    Doumen, C.3
  • 51
    • 0029894787 scopus 로고    scopus 로고
    • Subcellular metabolite transport and carbon isotope kinetics in the intramyocardial glutamate pool
    • Yu, X., White, L.T., Alpert, N.M., and Lewandowski, E.D. Subcellular metabolite transport and carbon isotope kinetics in the intramyocardial glutamate pool. Biochemistry 35, 6963, 1996.
    • (1996) Biochemistry , vol.35 , pp. 6963
    • Yu, X.1    White, L.T.2    Alpert, N.M.3    Lewandowski, E.D.4
  • 52
    • 0030743154 scopus 로고    scopus 로고
    • Modeling enrichment kinetics from dynamic 13C-NMR spectra: Theoretical analysis and practical considerations
    • Yu, X., Alpert, N.M., and Lewandowski, E.D. Modeling enrichment kinetics from dynamic 13C-NMR spectra: theoretical analysis and practical considerations. Am. J. Physiol. 272, C2037, 1997.
    • (1997) Am. J. Physiol. , vol.272
    • Yu, X.1    Alpert, N.M.2    Lewandowski, E.D.3
  • 53
    • 0343196707 scopus 로고    scopus 로고
    • Metabolic and physiological studies of Corynebacterium glutamicum mutants
    • Park, S.M., Sinksey, A.J., and Stephanopoulos, G. Metabolic and physiological studies of Corynebacterium glutamicum mutants. Biotechnol. Bioeng. 55, 864, 1997.
    • (1997) Biotechnol. Bioeng. , vol.55 , pp. 864
    • Park, S.M.1    Sinksey, A.J.2    Stephanopoulos, G.3
  • 55
    • 0031149582 scopus 로고    scopus 로고
    • Numerical isotopomer analysis: Estimation of metabolic activity
    • Zupke, C., Tompkins, R., Yarmush, D., and Yarmush, M. Numerical isotopomer analysis: estimation of metabolic activity. Anal. Biochem. 247, 287, 1997.
    • (1997) Anal. Biochem. , vol.247 , pp. 287
    • Zupke, C.1    Tompkins, R.2    Yarmush, D.3    Yarmush, M.4
  • 56
    • 0028036096 scopus 로고
    • Modeling of isotope distributions and intracellular fluxes in metabolic networks using atom mapping matrices
    • Zupke, C. and Stephanopoulos, G. Modeling of isotope distributions and intracellular fluxes in metabolic networks using atom mapping matrices. Biotechnol. Prog. 10, 489, 1994.
    • (1994) Biotechnol. Prog. , vol.10 , pp. 489
    • Zupke, C.1    Stephanopoulos, G.2
  • 58
    • 0028901694 scopus 로고
    • 13C mass isotopomer distribution analysis of intermediates
    • 13C mass isotopomer distribution analysis of intermediates. J. Biol. Chem. 270, 10037, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 10037
    • Fernandez, C.A.1    Des Rosiers, C.2
  • 59
    • 0343471424 scopus 로고    scopus 로고
    • Modeling isotopomer distributions in biochemical networks using isotopomer mapping matrices
    • Schmidt, K., Carlsen, M., Nielsen, J., and Villadsen, J. Modeling isotopomer distributions in biochemical networks using isotopomer mapping matrices. Biotechnol. Bioeng. 55, 831, 1997.
    • (1997) Biotechnol. Bioeng. , vol.55 , pp. 831
    • Schmidt, K.1    Carlsen, M.2    Nielsen, J.3    Villadsen, J.4
  • 60
    • 13044303200 scopus 로고    scopus 로고
    • System modeling and optimization: Proceedings of the seventeenth IFIP TC7 conference on system modeling and optimization
    • London: Chapman and Hall
    • Dolezal, J., and Fidler, J. System modeling and optimization: proceedings of the seventeenth IFIP TC7 conference on system modeling and optimization. In: IFIP Conference on System Modeling and Optimization. London: Chapman and Hall, 128-135, 1996.
    • (1996) IFIP Conference on System Modeling and Optimization , pp. 128-135
    • Dolezal, J.1    Fidler, J.2
  • 62
    • 0031554635 scopus 로고    scopus 로고
    • Bidirectional reaction steps in metabolic networks I
    • Wiechert, W. and de Graaf, A.A. Bidirectional reaction steps in metabolic networks I. Biotechnol. Bioeng. 55, 101, 1997.
    • (1997) Biotechnol. Bioeng. , vol.55 , pp. 101
    • Wiechert, W.1    De Graaf, A.A.2
  • 63
    • 0023709196 scopus 로고
    • Metabolic control theory - A structural approach
    • Reder, C. Metabolic control theory - A structural approach. J. Theor. Biol. 135, 175, 1988.
    • (1988) J. Theor. Biol. , vol.135 , pp. 175
    • Reder, C.1
  • 66
    • 0031014206 scopus 로고    scopus 로고
    • Altered fluxes responsible for reduced hepatic glucose production and gluconeogenesis by exogenous glucose in rats
    • Hellerstein, M.K., Neese, R.A., Schwarz, J.M., Turner, S., Faix, D., and Wu, K. Altered fluxes responsible for reduced hepatic glucose production and gluconeogenesis by exogenous glucose in rats. Am. J. Physiol. 272, E163, 1997.
    • (1997) Am. J. Physiol. , vol.272
    • Hellerstein, M.K.1    Neese, R.A.2    Schwarz, J.M.3    Turner, S.4    Faix, D.5    Wu, K.6
  • 70
    • 0024451950 scopus 로고
    • Glucose recycling and production in glycogenosis type I and III: Stable isotope technique study
    • Kalderon, B., Korman, S.H., Gutman, A., and Lapidot, A. Glucose recycling and production in glycogenosis type I and III: stable isotope technique study. Am. J. Physiol. 257, E346, 1989.
    • (1989) Am. J. Physiol. , vol.257
    • Kalderon, B.1    Korman, S.H.2    Gutman, A.3    Lapidot, A.4
  • 71
    • 0021986886 scopus 로고
    • A novel approach to the analysis of mass spectrally assayed stable isotope-labeling experiments
    • Strong, J.M., Upton, D.K., Anderson, L.W., Monks, A., Chisena, C.A., and Cysyk, R.L. A novel approach to the analysis of mass spectrally assayed stable isotope-labeling experiments. J. Biol. Chem. 260, 4276, 1985.
    • (1985) J. Biol. Chem. , vol.260 , pp. 4276
    • Strong, J.M.1    Upton, D.K.2    Anderson, L.W.3    Monks, A.4    Chisena, C.A.5    Cysyk, R.L.6
  • 72
    • 0025988275 scopus 로고
    • Use of mass isotopomer distributions in secreted lipids to sample lipogenic acetyl-CoA pool in vivo in humans
    • Hellerstein, M.K., Kletke, C., Kaempfer, S., Wu, K., and Shackleton, C.H. Use of mass isotopomer distributions in secreted lipids to sample lipogenic acetyl-CoA pool in vivo in humans. Am. J. Physiol. 261, E479, 1991.
    • (1991) Am. J. Physiol. , vol.261
    • Hellerstein, M.K.1    Kletke, C.2    Kaempfer, S.3    Wu, K.4    Shackleton, C.H.5
  • 73
    • 0026425183 scopus 로고
    • Relationship between precursor enrichment and ratio of excess M2/excess Ml isotopomer frequencies in a secreted polymer
    • Hellerstein, M.K. Relationship between precursor enrichment and ratio of excess M2/excess Ml isotopomer frequencies in a secreted polymer. J. Biol. Chem. 266, 10920, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 10920
    • Hellerstein, M.K.1
  • 74
    • 0025796935 scopus 로고
    • Measurement of de novo hepatic lipogenesis in humans using stable isotopes
    • Hellerstein, M.K., Christiansen, M., Kaempfer, S., et al. Measurement of de novo hepatic lipogenesis in humans using stable isotopes. J. Clin. Invest. 87, 1841, 1991.
    • (1991) J. Clin. Invest. , vol.87 , pp. 1841
    • Hellerstein, M.K.1    Christiansen, M.2    Kaempfer, S.3
  • 75
    • 0026448766 scopus 로고
    • Mass isotopomer distribution analysis: A technique for measuring biosynthesis and turnover of polymers
    • Hellerstein, M.K., and Neese, R.A. Mass isotopomer distribution analysis: A technique for measuring biosynthesis and turnover of polymers. Am. J. Physiol. 263, E988, 1992.
    • (1992) Am. J. Physiol. , vol.263
    • Hellerstein, M.K.1    Neese, R.A.2
  • 78
    • 0000053109 scopus 로고
    • The calculation of turnover rate and turnover time from experiments involving the use of labeling agents
    • Zilversmit, D.B., Entenman, C., and Fishier, M. The calculation of turnover rate and turnover time from experiments involving the use of labeling agents. J. Gen. Physiol. 26, 325, 1943.
    • (1943) J. Gen. Physiol. , vol.26 , pp. 325
    • Zilversmit, D.B.1    Entenman, C.2    Fishier, M.3
  • 79
    • 0025776369 scopus 로고
    • Noninvasive tracing of Krebs cycle metabolism in liver
    • Magnusson, I., Schumann, W.C., Bartsch, G.E., et al. Noninvasive tracing of Krebs cycle metabolism in liver. J. Biol. Chem. 266, 6975, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 6975
    • Magnusson, I.1    Schumann, W.C.2    Bartsch, G.E.3
  • 80
    • 0027487855 scopus 로고
    • Estimating gluconeogenic rates in NIDDM
    • Landau, B.R. Estimating gluconeogenic rates in NIDDM. Adv. Exp. Med. Biol. 334, 209, 1993.
    • (1993) Adv. Exp. Med. Biol. , vol.334 , pp. 209
    • Landau, B.R.1
  • 81
    • 0028980981 scopus 로고
    • Gluconeogenesis and intrahepatic triose phosphate flux in response to fasting or substrate loads. Application of the mass isotopomer distribution analysis technique with testing of assumptions and potential problems
    • Neese, R.A., Schwarz, J.M., Faix, D., et al. Gluconeogenesis and intrahepatic triose phosphate flux in response to fasting or substrate loads. Application of the mass isotopomer distribution analysis technique with testing of assumptions and potential problems. J. Biol. Chem. 270, 14452, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 14452
    • Neese, R.A.1    Schwarz, J.M.2    Faix, D.3
  • 82
    • 0029090128 scopus 로고
    • Limitations of the mass isotopomer distribution analysis of glucose to study gluconeogenesis. Substrate cycling between glycerol and triose phosphates in liver
    • Previs, S.F., Fernandez, C.A., Yang, D., Soloviev, M.V., David, F., and Brunengraber, H. Limitations of the mass isotopomer distribution analysis of glucose to study gluconeogenesis. Substrate cycling between glycerol and triose phosphates in liver. J. Biol. Chem. 270, 19806, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19806
    • Previs, S.F.1    Fernandez, C.A.2    Yang, D.3    Soloviev, M.V.4    David, F.5    Brunengraber, H.6
  • 84
    • 0028229961 scopus 로고
    • Isotopomer spectral analysis of cholesterol synthesis: Applications in human hepatoma cells
    • Kelleher, J.K., Kharroubi, A.T., Aldaghlas, T.A., et al. Isotopomer spectral analysis of cholesterol synthesis: applications in human hepatoma cells. Am. J. Physiol. 266, E384, 1994.
    • (1994) Am. J. Physiol. , vol.266
    • Kelleher, J.K.1    Kharroubi, A.T.2    Aldaghlas, T.A.3
  • 86
    • 0030873477 scopus 로고    scopus 로고
    • Acetyl-L-carnitine flux to lipids in cells estimated using isotopomer spectral analysis
    • Lligona-Trulla, L., Arduini, A., Aldaghlas, T.A., Calvani, M., and Kelleher, J.K. Acetyl-L-carnitine flux to lipids in cells estimated using isotopomer spectral analysis. J. Lipid Res. 38, 1454, 1997.
    • (1997) J. Lipid Res. , vol.38 , pp. 1454
    • Lligona-Trulla, L.1    Arduini, A.2    Aldaghlas, T.A.3    Calvani, M.4    Kelleher, J.K.5
  • 87
    • 0020609018 scopus 로고
    • Quantitative analysis of flux along the gluconeogenic, glycolytic and pentose phosphate pathways under reducing conditions in hepatocytes isolated from fed rats
    • Crawford, J.M., and Blum, J.J. Quantitative analysis of flux along the gluconeogenic, glycolytic and pentose phosphate pathways under reducing conditions in hepatocytes isolated from fed rats. Biochem. J. 212, 585, 1983.
    • (1983) Biochem. J. , vol.212 , pp. 585
    • Crawford, J.M.1    Blum, J.J.2
  • 89
    • 0028790261 scopus 로고
    • Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas
    • Zupke, C., Sinskey, A.J., and Stephanopoulos, G. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl. Microbiol. Biotechnol. 44, 27, 1995.
    • (1995) Appl. Microbiol. Biotechnol. , vol.44 , pp. 27
    • Zupke, C.1    Sinskey, A.J.2    Stephanopoulos, G.3
  • 90
    • 0030050268 scopus 로고    scopus 로고
    • Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing
    • Marx, A., de Graaf, A.A., Wiechert, W., Eggeling, L., and Sahm, H. Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing. Biotechnol. Bioeng. 49, 111, 1996.
    • (1996) Biotechnol. Bioeng. , vol.49 , pp. 111
    • Marx, A.1    De Graaf, A.A.2    Wiechert, W.3    Eggeling, L.4    Sahm, H.5
  • 93
    • 0030754067 scopus 로고    scopus 로고
    • Measurement of very low stable isotope enrichments by gas chromatography/mass spectrometry: Application to measurement of muscle protein synthesis
    • Patterson, B.W., Zhang, X.J., Chen, Y., Klein, S., and Wolfe, R.R. Measurement of very low stable isotope enrichments by gas chromatography/mass spectrometry: Application to measurement of muscle protein synthesis. Metabolism 46, 943, 1997.
    • (1997) Metabolism , vol.46 , pp. 943
    • Patterson, B.W.1    Zhang, X.J.2    Chen, Y.3    Klein, S.4    Wolfe, R.R.5
  • 94
    • 0027293771 scopus 로고
    • Retrobiosynthetic analysis of carbon fixation in the phototrophic eubacterium Chloroflexus aurantiacus
    • Eisenreich, W., Strauss, G., Werz, U., Fuchs, G., and Bacher, A. Retrobiosynthetic analysis of carbon fixation in the phototrophic eubacterium Chloroflexus aurantiacus. Eur. J. Biochem. 215, 619, 1993.
    • (1993) Eur. J. Biochem. , vol.215 , pp. 619
    • Eisenreich, W.1    Strauss, G.2    Werz, U.3    Fuchs, G.4    Bacher, A.5
  • 95
    • 0029146299 scopus 로고
    • 13C-labeling of proteinogenic amino acids. An efficient analytical tool to investigate intermediary metabolism
    • 13C-labeling of proteinogenic amino acids. An efficient analytical tool to investigate intermediary metabolism. Eur. J. Biochem. 232, 433, 1995.
    • (1995) Eur. J. Biochem. , vol.232 , pp. 433
    • Szyperski, T.1
  • 97
    • 0026611716 scopus 로고
    • 2 fixation pathways in the sulfur-reducing Archaebacterium Thermoproteus neutrophilus and in the phototrophic Eubacterium Chloroflexus aurantiacus
    • 2 fixation pathways in the sulfur-reducing Archaebacterium Thermoproteus neutrophilus and in the phototrophic Eubacterium Chloroflexus aurantiacus. Eur. J. Biochem. 205, 853, 1992.
    • (1992) Eur. J. Biochem. , vol.205 , pp. 853
    • Strauss, G.1    Eisenreich, W.2    Bacher, A.3    Fuchs, G.4
  • 98
    • 0031911824 scopus 로고    scopus 로고
    • Gluconeogenesis measured with [U-13C]glucose and mass isotopomer analysis of apoB-100 amino acids in pigs
    • Wykes, L.J., Jahoor, F., and Reeds, P.J. Gluconeogenesis measured with [U-13C]glucose and mass isotopomer analysis of apoB-100 amino acids in pigs. Am. J. Physiol. 274, E365, 1998.
    • (1998) Am. J. Physiol. , vol.274
    • Wykes, L.J.1    Jahoor, F.2    Reeds, P.J.3
  • 99
    • 0032521590 scopus 로고    scopus 로고
    • Effect of reversible reactions on isotope label redistribution - Analysis of the pentose phosphate pathway
    • Follstad, B.D., and Stephanopoulos, G. Effect of reversible reactions on isotope label redistribution - Analysis of the pentose phosphate pathway. Eur. J. Biochem. 252, 360, 1998.
    • (1998) Eur. J. Biochem. , vol.252 , pp. 360
    • Follstad, B.D.1    Stephanopoulos, G.2
  • 100
    • 0026566666 scopus 로고
    • Optimal selection of metabolic fluxes for in vivo measurement. II. Application to Escherichia coli and hybridoma cell metabolism
    • Savinell, J.M., and Palsson, B.O. Optimal selection of metabolic fluxes for in vivo measurement. II. Application to Escherichia coli and hybridoma cell metabolism. J. Theor. Biol. 155, 215, 1992.
    • (1992) J. Theor. Biol. , vol.155 , pp. 215
    • Savinell, J.M.1    Palsson, B.O.2
  • 101
    • 0026594358 scopus 로고
    • Optimal selection of metabolic fluxes for in vivo measurement. I. Development of mathematical methods
    • Savinell, J.M., and Palsson, B.O. Optimal selection of metabolic fluxes for in vivo measurement. I. Development of mathematical methods. J. Theor. Biol. 155, 201, 1992.
    • (1992) J. Theor. Biol. , vol.155 , pp. 201
    • Savinell, J.M.1    Palsson, B.O.2
  • 103
    • 0025078865 scopus 로고
    • Analysis of tricarboxylic acid cycle of the heart using 13C isotope isomers
    • Malloy, C.R., Sherry, A.D., and Jeffrey, F.M. Analysis of tricarboxylic acid cycle of the heart using 13C isotope isomers. Am. J. Physiol. 259, H987, 1990.
    • (1990) Am. J. Physiol. , vol.259
    • Malloy, C.R.1    Sherry, A.D.2    Jeffrey, F.M.3
  • 107
    • 0026058960 scopus 로고
    • Application of mass isotopomer analysis for determination of pathways of glycogen synthesis
    • Katz, J., and Lee, W.N. Application of mass isotopomer analysis for determination of pathways of glycogen synthesis. Am. J. Physiol. 261, E332, 1991.
    • (1991) Am. J. Physiol. , vol.261
    • Katz, J.1    Lee, W.N.2
  • 108
    • 0025965163 scopus 로고
    • 13C]glucose
    • published erratum appears in Proc. Natl. Acad. Sci. USA 88, 5477, 1991
    • 13C]glucose [published erratum appears in Proc. Natl. Acad. Sci. USA 88, 5477, 1991]. Proc. Natl. Acad. Sci. USA 88, 2103, 1991.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 2103
    • Katz, J.1    Wals, P.A.2    Lee, W.N.3
  • 109
    • 0026091862 scopus 로고
    • Studies on the compartmentation of DOG metabolism in the brain
    • Bachelard, H.S., Brooks, K.J., and Garofalo, O. Studies on the compartmentation of DOG metabolism in the brain. Neurochem. Res. 16, 1025, 1991.
    • (1991) Neurochem. Res. , vol.16 , pp. 1025
    • Bachelard, H.S.1    Brooks, K.J.2    Garofalo, O.3
  • 110
    • 0026527696 scopus 로고
    • Neuronal-glial metabolism under depolarizing conditions. A 13C-n.m.r. study
    • Badar-Goffer, R.S., Ben-Yoseph, O., Bachelard, H.S., and Morris, P.O. Neuronal-glial metabolism under depolarizing conditions. A 13C-n.m.r. study. Biochem. J. 282, 225, 1992.
    • (1992) Biochem. J. , vol.282 , pp. 225
    • Badar-Goffer, R.S.1    Ben-Yoseph, O.2    Bachelard, H.S.3    Morris, P.O.4
  • 111
    • 0025181507 scopus 로고
    • 13CN.M.R. spectroscopy. A technique for investigating metabolic compartmentation in the brain
    • 13CN.M.R. spectroscopy. A technique for investigating metabolic compartmentation in the brain. Biochem. J. 266, 133, 1990.
    • (1990) Biochem. J. , vol.266 , pp. 133
    • Badar-Goffer, R.S.1    Bachelard, H.S.2    Morris, P.G.3
  • 112
    • 0031182622 scopus 로고    scopus 로고
    • Metabolism of acetate in rat brain neurons, astrocytes and cocultures: Metabolic interactions between neurons and glia cells, monitored by NMR spectroscopy
    • Brand, A., Richter-Landsberg, C., and Leibriftz, D. Metabolism of acetate in rat brain neurons, astrocytes and cocultures: Metabolic interactions between neurons and glia cells, monitored by NMR spectroscopy. Cell. Mol. Biol. 43, 645, 1997.
    • (1997) Cell. Mol. Biol. , vol.43 , pp. 645
    • Brand, A.1    Richter-Landsberg, C.2    Leibriftz, D.3
  • 113
    • 0029850061 scopus 로고    scopus 로고
    • Mass isotopomer study of glutamine oxidation and synthesis in primary culture of astrocytes
    • Lee, W.N., Edmond, J., Bassilian, S., and Morrow, J.W. Mass isotopomer study of glutamine oxidation and synthesis in primary culture of astrocytes. Dev. Neurosci. 18, 469, 1996.
    • (1996) Dev. Neurosci. , vol.18 , pp. 469
    • Lee, W.N.1    Edmond, J.2    Bassilian, S.3    Morrow, J.W.4
  • 114
    • 0027174772 scopus 로고
    • Glucose metabolism in mammalian cells as determined by mass isotopomer analysis
    • Lin, Y.Y., Cheng, W.B., and Wright, C.E. Glucose metabolism in mammalian cells as determined by mass isotopomer analysis. Anal. Biochem. 209, 267, 1993.
    • (1993) Anal. Biochem. , vol.209 , pp. 267
    • Lin, Y.Y.1    Cheng, W.B.2    Wright, C.E.3
  • 115
    • 0030057186 scopus 로고    scopus 로고
    • Glucose and glutamine metabolism in C6 glioma cells studied by carbon 13 NMR
    • Portais, J.C., Voisin, P., Merle, M., and Canioni, P. Glucose and glutamine metabolism in C6 glioma cells studied by carbon 13 NMR. Biochimie 78, 155, 1996.
    • (1996) Biochimie , vol.78 , pp. 155
    • Portais, J.C.1    Voisin, P.2    Merle, M.3    Canioni, P.4
  • 116
    • 0029799731 scopus 로고    scopus 로고
    • MRS study of glutamate metabolism in cultured neurons/glia
    • Sonnewald, U., White, L.R., Odegard, E., et al. MRS study of glutamate metabolism in cultured neurons/glia. Neurochem. Res. 21, 987, 1996.
    • (1996) Neurochem. Res. , vol.21 , pp. 987
    • Sonnewald, U.1    White, L.R.2    Odegard, E.3
  • 117
    • 0024506188 scopus 로고
    • Quantitative analysis of intermediary metabolism in rat hepatocytes incubated in the presence and absence of ethanol with a substrate mixture including ketoleucine
    • Baranyai, J.M., and Blum, J.J. Quantitative analysis of intermediary metabolism in rat hepatocytes incubated in the presence and absence of ethanol with a substrate mixture including ketoleucine. Biochem. J. 258, 121, 1989.
    • (1989) Biochem. J. , vol.258 , pp. 121
    • Baranyai, J.M.1    Blum, J.J.2
  • 118
    • 0021933212 scopus 로고
    • Quantitative analysis of intermediary metabolism in hepatocytes incubated in the presence and absence of glucagon with a substrate mixture containing glucose, ribose, fructose, alanine and acetate
    • Rabkin, M., and Blum, J.J. Quantitative analysis of intermediary metabolism in hepatocytes incubated in the presence and absence of glucagon with a substrate mixture containing glucose, ribose, fructose, alanine and acetate. Biochem. J. 225, 761, 1985.
    • (1985) Biochem. J. , vol.225 , pp. 761
    • Rabkin, M.1    Blum, J.J.2
  • 119
    • 0028961757 scopus 로고
    • Isotopomer study of lipogenesis in human hepatoma cells in culture: Contribution of carbon and hydrogen atoms from glucose
    • Lee, W.N., Byerley, L.O., Bassilian, S., et al. Isotopomer study of lipogenesis in human hepatoma cells in culture: Contribution of carbon and hydrogen atoms from glucose. Anal. Biochem. 226, 100, 1995.
    • (1995) Anal. Biochem. , vol.226 , pp. 100
    • Lee, W.N.1    Byerley, L.O.2    Bassilian, S.3
  • 120
    • 0031804597 scopus 로고    scopus 로고
    • Mass isotopomer study of the nonoxidative pathways of the pentose cycle with [1,2-13C2]glucose
    • Lee, W.N., Boros, L.G., Puigjaner, J., Bassilian, S., Lim, S., and Cascante, M. Mass isotopomer study of the nonoxidative pathways of the pentose cycle with [1,2-13C2]glucose. Am. J. Physiol. 274, E843, 1998.
    • (1998) Am. J. Physiol. , vol.274
    • Lee, W.N.1    Boros, L.G.2    Puigjaner, J.3    Bassilian, S.4    Lim, S.5    Cascante, M.6
  • 121
    • 0029591465 scopus 로고
    • Glutamine metabolism in AS-30D hepatoma cells. Evidence for its conversion into lipids via reductive carboxylation
    • Holleran, A.L., Briscoe, D.A., Fiskum, G., and Kelleher, J.K. Glutamine metabolism in AS-30D hepatoma cells. Evidence for its conversion into lipids via reductive carboxylation. Mol. Cell. Biochem. 152, 95, 1995.
    • (1995) Mol. Cell. Biochem. , vol.152 , pp. 95
    • Holleran, A.L.1    Briscoe, D.A.2    Fiskum, G.3    Kelleher, J.K.4
  • 122
    • 0029239589 scopus 로고
    • Intracellular flux analysis in hybridomas using mass balances and in vitro 13C NMR
    • Zupke, C., and Stephanopoulos, G. Intracellular flux analysis in hybridomas using mass balances and in vitro 13C NMR. Biotechnol. Bioeng. 45, 292, 1995.
    • (1995) Biotechnol. Bioeng. , vol.45 , pp. 292
    • Zupke, C.1    Stephanopoulos, G.2
  • 123
    • 0029161732 scopus 로고
    • Cardiac responses to induced lactate oxidation: NMR analysis of metabolic equilibria
    • Lewandowski, E.D., Damico, L.A., White, L.T., and Yu, X. Cardiac responses to induced lactate oxidation: NMR analysis of metabolic equilibria. Am. J. Physiol. 269, H160, 1995.
    • (1995) Am. J. Physiol. , vol.269
    • Lewandowski, E.D.1    Damico, L.A.2    White, L.T.3    Yu, X.4
  • 124
    • 0029664367 scopus 로고    scopus 로고
    • Multiplet structure of 13C NMR signal from glutamate and direct detection of tricarboxylic acid (TCA) cycle intermediates
    • Lewandowski, E.D., Doumen, C., White, L.T., LaNoue, K.F., Damico, L.A., and Yu, X. Multiplet structure of 13C NMR signal from glutamate and direct detection of tricarboxylic acid (TCA) cycle intermediates. Magn. Reson. Med. 35, 149, 1996.
    • (1996) Magn. Reson. Med. , vol.35 , pp. 149
    • Lewandowski, E.D.1    Doumen, C.2    White, L.T.3    LaNoue, K.F.4    Damico, L.A.5    Yu, X.6
  • 125
    • 0343052764 scopus 로고    scopus 로고
    • Altered metabolite exchange between subcellular compartments in intact postischemic rabbit hearts
    • Lewandowski, E.D., Yu, X., LaNoue, K.F., White, L.T., Doumen, C., and O'Donnell, J.M. Altered metabolite exchange between subcellular compartments in intact postischemic rabbit hearts. Circ. Res. 81, 165, 1997.
    • (1997) Circ. Res. , vol.81 , pp. 165
    • Lewandowski, E.D.1    Yu, X.2    LaNoue, K.F.3    White, L.T.4    Doumen, C.5    O'Donnell, J.M.6
  • 128
    • 0028172061 scopus 로고
    • 13C isotopomer n.m.r. method for monitoring incomplete beta-oxidation of fatty acids in intact tissue
    • 13C isotopomer n.m.r. method for monitoring incomplete beta-oxidation of fatty acids in intact tissue. Biochem. J. 303, 847, 1994.
    • (1994) Biochem. J. , vol.303 , pp. 847
    • Gavva, S.R.1    Wiethoff, A.J.2    Zhao, P.3    Malloy, C.R.4    Sherry, A.D.5
  • 129
    • 0028793745 scopus 로고
    • Substrate selection in the isolated working rat heart: Effects of reperfusion, afterload, and concentration
    • Jeffrey, F.M., Diczku, V., Sherry, A.D., and Malloy, C.R. Substrate selection in the isolated working rat heart: effects of reperfusion, afterload, and concentration. Basic. Res. Cardiol. 90, 388, 1995.
    • (1995) Basic. Res. Cardiol. , vol.90 , pp. 388
    • Jeffrey, F.M.1    Diczku, V.2    Sherry, A.D.3    Malloy, C.R.4
  • 130
    • 0028953680 scopus 로고
    • Direct evidence that perhexiline modifies myocardial substrate utilization from fatty acids to lactate
    • Jeffrey, F.M., Alvarez, L., Diczku, V., Sherry, A.D., and Malloy, C.R. Direct evidence that perhexiline modifies myocardial substrate utilization from fatty acids to lactate. J. Cardiovasc. Pharmacol. 25, 469, 1995.
    • (1995) J. Cardiovasc. Pharmacol. , vol.25 , pp. 469
    • Jeffrey, F.M.1    Alvarez, L.2    Diczku, V.3    Sherry, A.D.4    Malloy, C.R.5
  • 132
    • 0027180438 scopus 로고
    • Effects of amino acids on substrate selection, anaplerosis, and left ventricular function in the ischemic reperfused rat heart
    • Jessen, M.E., Kovarik, T.E., Jeffrey, P.M., et al. Effects of amino acids on substrate selection, anaplerosis, and left ventricular function in the ischemic reperfused rat heart. J. Clin. Invest. 92, 831, 1993.
    • (1993) J. Clin. Invest. , vol.92 , pp. 831
    • Jessen, M.E.1    Kovarik, T.E.2    Jeffrey, P.M.3
  • 133
    • 0029869058 scopus 로고    scopus 로고
    • Effects of different oxidative insults on intermediary metabolism in isolated perfused rat hearts
    • Jones, J.G., Le, T.H., Storey, C.J., Sherry, A.D., Malloy, C.R., and Burton, K.P. Effects of different oxidative insults on intermediary metabolism in isolated perfused rat hearts. Free Radie. Biol. Med. 20, 515, 1996.
    • (1996) Free Radie. Biol. Med. , vol.20 , pp. 515
    • Jones, J.G.1    Le, T.H.2    Storey, C.J.3    Sherry, A.D.4    Malloy, C.R.5    Burton, K.P.6
  • 137
    • 0029899132 scopus 로고    scopus 로고
    • Substrate selection early after reperfusion of ischemic regions in the working rabbit heart
    • Solomon, M.A., Jeffrey, F.M., Storey, C.J., Sherry, A.D., and Malloy, G.R. Substrate selection early after reperfusion of ischemic regions in the working rabbit heart. Magn. Reson. Med. 35, 820, 1996.
    • (1996) Magn. Reson. Med. , vol.35 , pp. 820
    • Solomon, M.A.1    Jeffrey, F.M.2    Storey, C.J.3    Sherry, A.D.4    Malloy, G.R.5
  • 139
    • 0031031340 scopus 로고    scopus 로고
    • Use of labeling pattern of liver glutamate to calculate rates of citric acid cycle and gluconeogenesis
    • Large, V., Brunengraber, H., Odeon, M., and Beylot, M. Use of labeling pattern of liver glutamate to calculate rates of citric acid cycle and gluconeogenesis. Am. J. Physiol. 272, E51, 1997.
    • (1997) Am. J. Physiol. , vol.272
    • Large, V.1    Brunengraber, H.2    Odeon, M.3    Beylot, M.4
  • 140
  • 141
    • 0030789372 scopus 로고    scopus 로고
    • In vivo studies of intrahepatic metabolic pathways
    • Beylot, M., Peroni, O., Diraison, F., and Large, V. In vivo studies of intrahepatic metabolic pathways. Diabetes Metab. 23, 251, 1997.
    • (1997) Diabetes Metab. , vol.23 , pp. 251
    • Beylot, M.1    Peroni, O.2    Diraison, F.3    Large, V.4
  • 143
  • 144
    • 0031437519 scopus 로고    scopus 로고
    • Hepatic glucose-6-phosphatase flux and glucose phosphorylation, cycling, irreversible disposal, and net balance in vivo in rats. Measurement using the secreted glucuronate technique
    • Hellerstein, M.K., Neese, R.A., Letscher, A., Linfoot, P., and Turner, S. Hepatic glucose-6-phosphatase flux and glucose phosphorylation, cycling, irreversible disposal, and net balance in vivo in rats. Measurement using the secreted glucuronate technique. Metabolism 46, 1390, 1997.
    • (1997) Metabolism , vol.46 , pp. 1390
    • Hellerstein, M.K.1    Neese, R.A.2    Letscher, A.3    Linfoot, P.4    Turner, S.5
  • 145
    • 0027438281 scopus 로고
    • Isotopomer studies of gluconeogenesis and the Krebs cycle with 13C-labeled lactate
    • Katz, J., Wals, P., and Lee, W.N. Isotopomer studies of gluconeogenesis and the Krebs cycle with 13C-labeled lactate. J. Biol. Chem. 268, 25509, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 25509
    • Katz, J.1    Wals, P.2    Lee, W.N.3
  • 147
    • 0032523234 scopus 로고    scopus 로고
    • 13C NMR measurements of hepatocellular tricarboxylic acid cycle flux
    • 13C NMR measurements of hepatocellular tricarboxylic acid cycle flux. J. Biol. Chem. 273, 12187, 1998.
    • (1998) J. Biol. Chem. , vol.273 , pp. 12187
    • Jucker, B.M.1    Lee, J.Y.2    Shulman, R.G.3


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