Effect of alterations of key active site residues in O6- alkylguanine-DNA alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane

Chemical Research in Toxicology

Volumn 20, Issue 1, 2007, Pages 155-163

  Liu, Liping ^a,c   Watanabe, Kengo ^b   Fang, Qingming ^a   Williams, Kevin M ^b,d   Guengerich, F Peter ^b   Pegg, Anthony E ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d WESTERN KENTUCKY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIBROMOETHANE; 1,5 DIBROMOPENTANE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; ALKYLATING AGENT; ARGININE; CYSTEINE; DIBROMOMETHANE; GLYCINE; PROLINE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL PROTECTION; CONTROLLED STUDY; DNA ADDUCT; GENOTOXICITY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; POINT MUTATION;

BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; ETHYLENE DIBROMIDE; HALF-LIFE; MUTAGENS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; POINT MUTATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 33846857161     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx600257g     Document Type: Article

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