Chemoprotective gene transfer II: Multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human CP-alkylguanine-DNA alkyltransferase

Gene Therapy

Volumn 5, Issue 6, 1998, Pages 842-847

  Chinnasamy, N ^a   Rafferty, J A ^b   Hickson, I ^c   Lashford, L S ^d   Longhurst, S J ^d   Thatcher, N ^a   Margison, G P ^b   Dexter, T M ^c   Fairbairn, L J ^d  

^a CRC Sections of Genome Damage and Repair   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c Academic Unit of Paediatric Oncology   (United Kingdom)

^d CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

Alkyltransferase; CFU S; Micronucleus; O6 benzylguanine; Temozolomide

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; ANTINEOPLASTIC AGENT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; TEMOZOLOMIDE;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; COLONY FORMING UNIT S; CONTROLLED STUDY; DNA REPAIR; GENE TRANSFER; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; IMMUNOCYTOCHEMISTRY; MALE; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; TRANSGENE;

ANIMALIA; MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 0031826217     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300699     Document Type: Article

References (19)

1. 6-benzylguanine plus BCNU. Blood 1996; 88: 1649-1655.
2. 6-methyIguanine-DNA-methyltransferase. Oncol Res 1993; 5: 83-86.
3. 6-benzyIguanine on the sensitivity of human tumor xenografts to l,3-bis(2chloroethyD-1-nitrosourea and on DNA interstrand cross-link formation. Cancer Res 1992; 52: 1171-1175.
4. 6-benzylguanine and 1,3-bis(2-chloroethyl)-l-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone. Biochem Plmrmacol 1993; 45: 483-491.
5. Dolan ME, Pegg AE. OA-benzylguanine and its role in chemotherapy. Clin Cancer Res 1977; 3: 837-847.
6. 6-benzylguanineJtemozolomide combination: an evaluation in human melanoma xenograft model. Cancer Cheinollier Plwrmncol 1997; 40: 266-272.
7. 6-benzylguanine potentiates the in vivo toxicity and claslogenicity of temozolomide and BCNU in mouse bone marrow. Blood 1997; 89: 1566-1573.
8. 6-alkylating agents m vitro. Gene Therapy 1998; 5: 835-841.
9. 6-benzylguanine increases the sensitivity of human primary bone marrow cells to the cytotoxic effects of temozolomide. Exp Hcmalol 1995; 23: 112-116.
10. Moritz T et ni. Retrovirus-mediated expression of a cDNA repair protein in bone marrow protects haemopoietic cells from nitrosourea-induced toxicity IH vitro and in vivo. Cancer Res 1995; 55: 2608-2614.
11. Allay JA, Da vis BM, Gerson SL. Human alkyltransferase-transduced murine myeloid progenitors are enriched in vivo by BCNU treatment of transplanted mice. Exp Hematol 1997; 25: 1069-1076.
12. Newlands ES et al. Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856). Br JCancer 1992; 65: 287-291.
13. Smith MA, McCaffrey RP, Karp JE. The secondary leukemias: challenges nnd research directions. J Natl Cancer Inst 1996; 88: 407-418.
14. Tinwell H, Ashby J. Comparative activity of human carcinogens and NTP rodent carcinogens in the mouse bone marrow micronucleus assay: an integrative approach to genetic toxicity data assessment. Environ Health Perspect 1994; 102: 958-962.
15. Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. BioTcchniqiies 1989; 7: 980-990.
16. Fairbairn LJ, Spooncer E. Retroviral gene transfer into haemopoietic cells. In: Testa NG, Molineux G (eds). Haemopoiesis, A Practical Approach. IRL Press: Oxford, 1993, pp 175-188.
17. Han YM, Yoo OJ, Lee KK. Sex determination in single mouse blastomeres by polymerase chain reaction. J Assist Reprod Genet 1993; 10: 151-156.
18. 6-alkylguanine DNA alkyltransferase expression in human brain tumours - possible significance in nitrosourea therapy. Carcinogenesis 1996; 17: 637-641.
19. Tinwell H, Ashby J. Comparison of acridine orange and Giemsa stains in several mouse bone marrow micronucleus assays including a triple dose study. Mutagenesis 19S9; 4: 476-481.