Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase

Journal of Biological Chemistry

Volumn 277, Issue 40, 2002, Pages 37920-37928

  Liu, Liping ^a   Pegg, Anthony E ^a   Williams, Kevin M ^b   Peter Guengerich, F ^a,b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSTS; ENZYMES; ESCHERICHIA COLI; MASS SPECTROMETRY; TOXICITY;

INCUBATION;

DNA;

1,2 DIBROMOETHANE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; ARGININE; BROMINE DERIVATIVE; CYSTEINE; DNA; GLUTATHIONE; GLUTATHIONE DERIVATIVE; GLUTATHIONE TRANSFERASE; GLYCINE; MUTANT PROTEIN; OLIGODEOXYRIBONUCLEOTIDE; PEPTIDE DERIVATIVE; RECOMBINANT ENZYME;

ARTICLE; COMPLEX FORMATION; CONJUGATE; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; CYTOTOXICITY TEST; DNA ADDUCT; DNA REPAIR; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ESCHERICHIA COLI; GENOTOXICITY; HYDROLYSIS; IN VITRO STUDY; MASS SPECTROMETRY; MOLECULAR INTERACTION; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FUNCTION;

AMINO ACID SUBSTITUTION; BASE SEQUENCE; CELL LINE; CLONING, MOLECULAR; DNA PRIMERS; DNA REPAIR; ESCHERICHIA COLI; ETHYLENE DIBROMIDE; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PLASMIDS; RECOMBINANT PROTEINS;

ESCHERICHIA COLI;

EID: 0037020154     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205548200     Document Type: Article

References (47)

1. Lindahl, T., Sedgwick, B., Sekiguchi, M., and Nakabeppu, Y. (1988) Annu. Rev. Biochem. 57, 133-157
2. Samson, L. (1992) Mol. Microbiol. 6, 825-831
3. Pegg, A. E., Dolan, M. E., and Moschel, R. C. (1995) Progr. Nucleic Acids Res. Mol. Biol. 51, 167-223
4. Sekiguchi, M., and Sakumi, K. (1997) Jpn. J. Human Genet. 42, 389-399
5. Pieper, R. O. (1997) Pharmacol. Ther. 74, 285-297
6. Pegg, A. E. (2000) Mutat. Res. 462, 83-100
7. Abril, N., Luque-Romero, F. L., Prito-Alamo, M. J., Margison, G. P., and Pueyo, C. (1995) Mol. Carcinogenesis 12, 110-117
8. Abril, N., Luque-Romero, L., Prieto-Alamo, M.-J., Rafferty, J. A., Margison, G. P., and Pueyo, C. (1997) Carcinogenesis 18, 1883-1888
9. Abril, N., Luque-Romero, L., Christians, F. C., Encell, L. P., Loeb, L., and Pueyo, C. (1999) Carcinogenesis 20, 2089-2094
10. Liu, H., Xu-Welliver, M., and Pegg, A. E. (2000) Mutat. Res. 452, 1-10
11. Abril, N., Luque-Romero, F. L., Yamada, M., Nohmi, T., and Pueyo, C. (2001) Mutat, Res. 497, 111-121
12. Abril, N., and Margison, G. P. (1999) Chem. Res. Toxicol. 12, 544-551
13. Rannug, U. (1980) Mutat. Res. 76, 269-295
14. Letz, G. A., Pond, S. M., Osterloh, J. D., Wade, R. L., and Becker, C. E. (1984) J. Am. Med. Assoc. 252, 2428-2431
15. Foster, P. L., Wilkinson, W. G., Miller, J. K., Sullivan, A. D., and Barnes, W. M. (1988) Mutat. Res. 194, 171-181
16. van Bladeren, P. J., Breimer, D. D., van Huijgevoort, J. A., T. C. M., Vermeulen, N. P. E., and van der Gen, A. (1981) Biochem. Pharmacol. 30, 2499-2502
17. Guengerich, F. P., Kim, D.-H., and Iwasaki, M. (1991) Chem. Res. Toxicol. 4, 168-179
18. Guengerich, F. P., Mason, P. S., Stott, W. T., Fox, T. R., and Watanabe, P. G. (1981) Cancer Res. 41, 4391-4398
19. Guengerich, F. P. (1992) Chem. Res. Toxicol. 5, 2-5
20. Guengerich, F. P., and Persmark, M. (1994) Chem. Res. Toxicol. 7, 205-208
21. van Bladeren, P. J., Breimer, D. D., Rotteveel-Smijs, G. M. T., de Jong, R. A. W., Buijs, W., van der Gen, A., and Mohn, G. R. (1980) Biochem. Pharmacol. 29, 2975-2982
22. Ozaki, K., Kato, T., Asamoto, M., Wild, C. P., Montesano, R., Nagao, S., Iwase, T., Matsumoto, K., and Tsuda, H. (1993) Jpn. J. Cancer Res. 84, 1245-1251
23. Ozaki, K., Sukata, T., Yamamoto, S., Uwagawa, S., Seki, T., Kawasaki, H., and Yoshitake, A. (1998) Cancer Res. 58, 3806-3811
24. Ozawa, N., and Guengerich, F. P. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 5266-5270
25. Ozawa, N., and Guengerich, F. P. (1983) Toxicologist 3, 114
26. Wheeler, J. B., Stourman, N. V., Armstrong, R. N., and Guengerich, F. P. (2001) Chem. Res. Toxicol. 14, 1107-1117
27. Wheeler, J. B., Stourman, N. V., Thier, R., Dommermuth, A., Vuilleumier, S., Rose, J. A., Armstrong, R. N., and Guengerich, F. P. (2001) Chem. Res. Toxicol. 14, 1118-1127
28. Peterson, L. A., Harris, T., M., and Guengerich, F. P. (1988) J. Am. Chem. Soc. 110, 3284-3291
29. Kim, M.-S., and Guengerich, F. P. (1998) Chem. Res. Toxicol. 11, 311-316
30. Wang, L., Spratt, T. E., Liu, X.-L., Hecht, S. S., Pegg, A., E., and Peterson, L. A., (1997) Chem. Res. Toxicol. 10, 562-567
31. Goodtzova, K., Kanugula, S., Edara, S., Pauly, G. T., Moschel, R. C., and Pegg, A. E. (1997) J. Biol. Chem. 272, 8332-8339
32. Gonzaga, P. E., Potter, P. M., Niu, T., Yu, D., Ludlum, D. B., Rafferty, J. A., Margison, G. P., and Brent, T. P. (1992) Cancer Res. 52, 6052-6058
33. Gonzaga, P. E., Harris, L., Margison, G. P., and Brent, T. P. (1990) Nucleic Acids Res. 18, 3961-3966
34. Samson, L., Han, S., Marquis, J. C., and Rasmussen, L. J. (1997) Carcinogenesis 18, 919-924
35. Edara, S., Kanugula, S., and Pegg, A. E. (1999) Carcinogenesis 20, 103-108
36. Kim, M.-S., and Guengerich, F. P. (1997) Chem. Res. Toxicol. 10, 1133-1143
37. Humphreys, W. G., Kim, D.-H., Cmarik, J. L., Shimada, T., and Guengerich, F. P. (1990) Biochemistry 29, 10342-10350
38. Dolan, M. E., Moschel, R. C., and Pegg, A. E. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 5368-5372
39. Dolan, M. E., Pegg, A. E., Dumenco, L. L., Moschel, R. C., and Gerson, S. L. (1991) Carcinogenesis 12, 2305-2310
40. Xu-Welliver, M., Kanugula, S., and Pegg, A. E. (1998) Cancer Res. 58, 1936-1945
41. Liu, L., Xu-Welliver, M., Kanugula, S., and Pegg, A. E. (2002) Cancer Res. 62, 3037-3043
42. Daniels, D. S., Mol, C. D., Arval, A. S., Kanugula, S., Pegg, A. E., and Tainer, J. A. (2000) EMBO J. 19, 1719 -1730
43. Xu-Welliver, M., and Pegg, A. E. (2002) Carcinogenesis 23, 823-830
44. Olson, W. A., Habermann, R. T., Weisburger, E. K., Ward, J. M., and Weisburger, J. H. (1973) J. Natl. Cancer Inst. I 51, 1993-1995
45. Pegg, A. E., Boosalis, M., Samson, L., Moschel, R. C., Byers, T. L., Swenn, K., and Dolan, M. E. (1993) Biochemistry 32, 11998-12006
46. Wibley, J. E. A., Pegg, A. E., and Moody, P. C. E. (2000) Nucleic Acids Res. 28, 393-401
47. Sekiguchi Sekiguehi, M., Nakabeppu, Y., Sakumi, K., and Tuzuki, T. (1996) J. Cancer Res. Clin. Oncol. 122, 199-206