The role of human O6-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 452, Issue 1, 2000, Pages 1-10

  Liu, Hong ^a   Xu Welliver, Meng ^a   Pegg, Anthony E ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

1,2 Dibromoethane induced genotoxicity; Escherichia coli; Human O6 alkylguanine DNA alkyltransferase

Indexed keywords

1,2 DIBROMOETHANE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ARTICLE; CONTROLLED STUDY; DNA REPAIR; ESCHERICHIA COLI; GENOTOXICITY; LETHALITY; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

DNA, RECOMBINANT; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; ETHYLENE DIBROMIDE; HUMANS; MUTAGENICITY TESTS; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PLASMIDS; TRANSFORMATION, GENETIC;

ESCHERICHIA COLI;

EID: 0034691834     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(00)00062-2     Document Type: Article

References (51)

1. Rannug U. Genotoxic effects of 1,2-dibromoethane and 1,2-dichloroethane. Mutat. Res. 76:1980;269-295.
2. Letz G.A., Pond S.M., Osterloh J.D., Wade R.L., Becker C.E. Two fatalities after acute occupational exposure to ethylene dibromide. J. Am. Med. Assoc. 252:1984;2428-2431.
3. 7-guanyl)ethyl]glutathione in DNA. J. Am. Chem. Soc. 110:1988;3284-3291.
4. 7-guanyl)ethyl]glutathione, the major DNA adduct formed from 1,2-dibromoethane. Biochemistry. 25:1986;2192-2198.
5. 6-guanyl)ethyl]glutathione. Chem. Res. Toxicol. 11:1998;311-316.
6. 6-alkylguanine-DNA alkyltransferase. Progr. Nucleic Acid Res. Mol. Biol. 51:1995;167-223.
7. 6-alkylguanine-DNA alkyltransferase. Nucleic Acid Res. 28:2000;393-401.
8. 6-methylguanine-DNA methyltransferase. Zeller W.J., D'Incalci M., Newell D.R. Novel Approaches in Anticancer Drug Design Molecular Modelling - New Treatment Strategies. 1995;16-24 Karger, Basel.
9. 6-methylguanine-DNA methyltransferase. J. Mol. Biol. 292:1999;707-716.
10. Daniels D.S., Mol C.D., Arval A.S., Kanugula S., Pegg A.E., Tainer J.A. Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical binding. DNA damage reversal revealed by mutants and structures of active and alkylated human AGT. EMBO J. 2000;. in press.
11. 6-alkylguanine DNA alkyltransferase protein. Biochem. Biophys. Res. Comm. 187:1992;425-431.
12. 6-methylguanine-DNA methyltransferase stability, activity and substrate specificity. Carcinogenesis. 15:1994;1895-1902.
13. 6-methylguanine-DNA methyltransferase activity revealed by saturation mutagenesis with negative and positive screening. Mol. Gen. Genet. 243:1994;379-389.
14. 6-benzylguanine. Biochemistry. 34:1995;7113-7119.
15. 6-benzylguanine. Cancer Res. 53:1993;4750-4753.
16. 6-alkylguanine-DNA alkyltransferase. Mutat. Res. 363:1996;15-25.
17. 6-alkylguanine-DNA alkyltransferase. Biochemistry. 37:1998;12489-12495.
18. 6-methylguanine is protonated by the protein to effect methyl transfer. Biochemistry. 31:1992;3688-3694.
19. 6-alkylguanine-DNA alkyltransferase. Biochemistry. 38:1999;6801-6806.
20. 6-alkylguanine-DNA alkyltransferase. Chem. Res. Toxicol. 10:1997;562-567.
21. 6-alkylguanine-DNA alkyltransferase. J. Biol. Chem. 272:1997;8332-8339.
22. Foster P.L., Wilkinson W.G., Miller J.K., Sullivan A.D., Barnes W.M. An analysis of the mutagenicity of 1,2-dibromoethane to Escherichia coli: Influence of DNA repair activities and metabolic pathways. Mutat. Res. 194:1988;171-181.
23. Abril N., Luque-Romero F.L., Prito-Alamo M.J., Margison G.P., Pueyo C. Ogt Alkyltransferase enhances dibromoalkane mutagenicity in excision repair-deficient Escherichia coli K-12. Mol. Carcinog. 12:1995;110-117.
24. Abril N., Luque-Romero L., Prieto-Alamo M.-J., Rafferty J.A., Margison G.P., Pueyo C. Bacterial and mammalian DNA alkyltransferases sensitize Escheria coli to the lethal and mutagenic effects of dibromoalkanes. Carcinogenesis. 18:1997;1883-1888.
25. 6-alkylguanine-DNA alkyltransferases are hypersenstivie to dibromoalkanes. Chem. Res. Toxicol. 12:1999;544-551.
26. 6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc. Natl. Acad. Sci. U. S. A. 87:1990;5368-5372.
27. 6-benzylguanine. Cancer Res. 59:1998;1936-1945.
28. 6-benzylguanine. Cancer Res. 59:1999;1514-1519.
29. 6-benzylguanine, (Eds.), PhD thesis, Pennsylvania State University, 1998, pp. 1-189.
30. 6-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts. Carcinogenesis. 12:1991;1671-1677.
31. 6-methylguanine DNA repair methyltransferase. J. Bacteriol. 173:1991;2068-2076.
32. 6-alkylguanine-DNA alkyltransferase in E. coli increases cell killing and mutations by N-methyl-N′-nitro-N-nitrosoguanidine. Carcinogenesis. 20:1999;103-108.
33. 6-benzylguanine. Cancer Res. 54:1994;6221-6227.
34. Encell L.P., Coates M.M., Loeb L.A. Engineering human DNA alkyltransferases for gene therapy using random sequence mutagenesis. Cancer Res. 58:1998;1013-1020.
35. 6-methylguanine-DNA methyltransferase and chloroethylnitrosourea-treated DNA. Cancer Res. 52:1992;6052-6058.
36. 6-alkylguanine function. Nucleic Acids Res. 18:1990;3961-3966.
37. 4MeT from nucleotide excision repair. Carcinogenesis. 18:1997;919-924.
38. 6-benzylguanine. Biochem. Pharmacol. 58:1999;1279-1285.
39. 6-benzylguanine to killing by N, N′-bis(2-chloroethyl)-N-nitrosourea. Cancer Res. 56:1996;1578-1583.
40. 6-8-oxo-benzylguanine. Biochem. Pharmacol. 58:1999;237-244.
41. 6-alkylguanine-DNA alkyltransferase. Gene Ther. 5:1998;842-847.
42. 6-benzylguanine and BCNU and allows intensive therapy of BCNU resistant human colon cancer xenografts. Hum. Gene Ther. 10:1999;1021-1030.
43. 6-alkylguanine-DNA alkyltransferase: protection against alkylating agents and sensitization to dibromoalkanes. Carcinogenesis. 20:1999;2089-2094.
44. 6-Benzylguanine and its role in chemotherapy. Clin. Cancer Res. 3:1997;837-847.
45. 6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a southwest oncology group study. J. Clin. Oncol. 16:1998;3310-3315.
46. Friedman H.S., McLendon R.E., Dolan M.E., Pegg A.E., Moschel R.C., Colvin O.M., Cokgor I., Friedman A.H., Schold S.C., Bigner D.D., Modrich P.L. The biology of sensitivity and resistance to the molecule (temozolomide). Proc. Am. Assoc. Cancer Res. 40:1999;754-755.
47. 6-benzylguanine for patients undergoing surgery for malignant glioma. J. Clin. Oncol. 16:1998;3570-3575.
48. 6-Benzylguanine in humans: metabolic, pharmacokinetic and pharmacodynamic findings. J. Clin. Oncol. 16:1998;1803-1810.
49. 6-Benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair. Cancer Res. 59:1999;2402-2410.
50. 6-benzylguanine sensitization to chloroethylnitrosourea treatment. J. Pharmacol. Exp. Ther. 290:1999;1467-1474.
51. Kleibl K., Margison G.P. Increasing DNA repair capacity in bone marrow by gene transfer as a prospective tool in cancer therapy. Neoplasma. 45:1998;181-186.