Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine

Biochemical Pharmacology

Volumn 58, Issue 2, 1999, Pages 237-244

  Loktionova, Natalia A ^a   Xu Welliver, Meng ^a   Crone, Tina M ^a   Kanugula, Sreenivas ^a   Pegg, Anthony E ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Alkyltransferase; Cancer chemotherapy; Chloroethylating agents; DNA repair; O6 benzylguanine

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE; CARMUSTINE; MUTANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CANCER RESISTANCE; CELL PROTECTION; CHO CELL; CYTOTOXICITY; DNA REPAIR; ENZYME ACTIVITY; ENZYME INACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CARMUSTINE; CELL SURVIVAL; CHO CELLS; CRICETINAE; DRUG INTERACTIONS; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; GUANINE; HUMANS; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE;

EID: 0033566313     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00095-7     Document Type: Article

References (39)

1. 6-alkylguanine DNA alkyltransferase . Proc Am Assoc Cancer Res. 35:1994;699-700.
2. 6-alkylguanine-DNA alkyltransferase. Prog Nucleic Acid Res Mol Biol. 51:1995;167-223.
3. Dolan M.E. Inhibition of DNA repair as a means of increasing the antitumor activity of DNA reactive agents. Adv Drug Delivery Rev. 26:1997;105-118.
4. 6-Benzylguanine and its role in chemotherapy. Clin Cancer Res. 3:1997;837-847.
5. 6-benzylguanine for patients undergoing surgery for malignant glioma. J Clin Oncol. 16:1998;3570-3575.
6. 6-Benzylguanine in humans Metabolic, pharmacokinetic and pharmacodynamic findings . J Clin Oncol. 16:1998;1803-1810.
7. 6-benzylguanine in human plasma by reversed-phase high-performance liquid chromatography. J Chromatogr. 704:1997;289-298.
8. Sorsa M., Hemminki K., Vainio H. Occupational exposure to anticancer drugs. Potential and real hazards. Mutat Res. 154:1985;135-149.
9. Pedersen-Bjergaard J. Long-term complications of cancer chemotherapy. J Clin Oncol. 13:1995;1534-1536.
10. Smith M.A., McCaffrey R.P., Karp J.E. The secondary leukemias Challenges and research directions . J Natl Cancer Inst. 88:1996;407-418.
11. 6-benzylguanine. Cancer Res. 53:1993;4750-4753.
12. 6-benzylguanine. Cancer Res. 54:1994;6221-6227.
13. 6-benzylguanine. Cancer Res. 56:1996;5571-5575.
14. 6-benzylguanine. Cancer Res. 57:1997;2007-2012.
15. Encell L.P., Coates M.M., Loeb L.A. Engineering human DNA alkyltransferases for gene therapy using random sequence mutagenesis. Cancer Res. 58:1998;1013-1020.
16. 6-benzylguanine. Cancer Res. 59:1998;1936-1945.
17. 6-alkylguanine-DNA alkyltransferase. Cancer Res. 54:1994;5123-5130.
18. 6-alkylguanine-DNA alkyltransferase. J Biol Chem. 272:1997;8332-8339.
19. 6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine. Carcinogenesis. 16:1995;1687-1692.
20. 6-alkylguanine-DNA alkyltransferase . Gene Ther. 5:1998;842-847.
21. 6-alkylating agents in vitro . Gene Ther. 5:1998;835-841.
22. 6-benzylguanine and chloroethylnitrosourea treatment. J Invest Med. 44:1998;318A.
23. 6-benzylguanine plus 1,3-bis(chloroethyl)-1-nitrosourea. Proc Natl Acad Sci USA. 93:1996;14088-14093.
24. 6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res. 57:1997;5093-5099.
25. 6-benzylguanine and BCNU and allows intensive therapy of BCNU resistant human colon cancer xenografts. Human Gene Therapy. 10:1999;1021-1030.
26. 6-benzylguanine to killing by N,N′-bis(2-chloroethyl)-N-nitrosourea. Cancer Res. 56:1996;1578-1583.
27. 6-benzylguanine as determined by site-directed mutagenesis and molecular modelling comparisons. Biochim Biophys Acta. 1342:1997;90-102.
28. 6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc Natl Acad Sci USA. 87:1990;5368-5372.
29. 6-alkylguanine-DNA alkyltransferase. J Med Chem. 38:1995;359-365.
30. 6-benzylguanine. Biochemistry. 34:1995;7113-7119.
31. Erickson L.C., Laurent G., Sharkey N.A., Kohn K.W. DNA cross-linking and monoadduct repair in nitrosourea-treated human tumor cells. Nature. 288:1980;727-729.
32. 6-alkylguanine-DNA alkyltransferase. Biochemistry. 37:1998;12489-12495.
33. 6-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts. Carcinogenesis. 12:1991;1671-1677.
34. Ludlum D.B. DNA alkylation by the haloethylnitrosoureas Nature of modifications produced and their enzymatic repair or removal . Mutat Res. 233:1990;117-126.
35. 6-alkylguanine-DNA alkyltransferase from human leukemic cells. Prevention of chloroethylnitrosourea-induced cross-links by purified enzyme. Pharmacol Ther. 31:1985;121-140.
36. Erickson L.C., Bradley M.O., Ducore J.M., Ewig R.A., Kohn K.W. DNA cross-linking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas. Proc Natl Acad Sci USA. 77:1980;467-471.
37. Ayi T.C., Loh K.C., Ali R.B., Li B.F.L. Intracellular localization of human DNA repair enzyme methylguanine-DNA methyltransferase by antibodies and its importance. Cancer Res. 52:1992;6423-6430.
38. 6-alkylguanine-DNA alkyltransferase. Gene Ther. 3:1996;868-877.
39. 6-benzylguanine in oligodeoxyribonucleotides. J Biol Chem. 273:1998;10863-10867.