O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate

Chemical Research in Toxicology

Volumn 17, Issue 6, 2004, Pages 742-752

  Liu, Liping ^a,c   Williams, Kevin M ^b,d   Guengerich, F Peter ^b   Pegg, Anthony E ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d WESTERN KENTUCKY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIBROMOETHANE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; ACETIC ACID BROMOMETHYL ESTER; BROMINATED HYDROCARBON; BROMINE DERIVATIVE; CYSTEINE; DIBROMOMETHANE; DNA; OLIGODEOXYRIBONUCLEOTIDE; UNCLASSIFIED DRUG; DNA DIRECTED RNA POLYMERASE; METHYL BROMIDE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; RNA POLYMERASE BETA SUBUNIT;

ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DNA CROSS LINKING; DNA REPAIR; ENZYME ACTIVITY; ESCHERICHIA COLI; GENOTOXICITY; IN VITRO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MUTAGENICITY; NONHUMAN; DNA DAMAGE; DRUG EFFECT; ENZYMOLOGY; MASS SPECTROMETRY; METABOLISM; MUTAGEN TESTING; PHYSIOLOGY; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS;

ESCHERICHIA COLI;

DNA DAMAGE; DNA-DIRECTED RNA POLYMERASES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; HYDROCARBONS, BROMINATED; MASS SPECTROMETRY; MUTAGENICITY TESTS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PLASMIDS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 3042804053     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx049958o     Document Type: Article

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