Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine

Cancer Research

Volumn 58, Issue 9, 1998, Pages 1936-1945

  Xu Welliver, Meng ^a   Kanugula, Sreenivas ^a   Pegg, Anthony E ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE; METHYLNITRONITROSOGUANIDINE; ANTISENSE OLIGONUCLEOTIDE; BACTERIAL DNA; DRUG DERIVATIVE; ENZYME INHIBITOR; GUANINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; O(6) BENZYLGUANINE; O(6)-BENZYLGUANINE; PRIMER DNA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; DNA ADDUCT; DNA LIBRARY; DRUG RESISTANCE; DRUG SCREENING; ESCHERICHIA COLI; HUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; ANTIBIOTIC RESISTANCE; BACTERIAL COUNT; BACTERIAL GENE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE LIBRARY; GENETICS; METABOLISM; PLASMID; SITE DIRECTED MUTAGENESIS;

COLONY COUNT, MICROBIAL; DNA PRIMERS; DNA, BACTERIAL; DRUG RESISTANCE, MICROBIAL; ENZYME INHIBITORS; ESCHERICHIA COLI; GENES, BACTERIAL; GENOMIC LIBRARY; GUANINE; HUMANS; MUTAGENESIS, SITE-DIRECTED; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; OLIGONUCLEOTIDES, ANTISENSE; PLASMIDS; POINT MUTATION;

EID: 0032056361     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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