Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine

Biochemical Journal

Volumn 347, Issue 2, 2000, Pages 519-526

  Xu Welliver, Meng ^a   Pegg, Anthony E ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Alkylating agents; Chemotherapy; DNA repair; O6 methylguanine

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE; ALKYLATING AGENT;

AMINO ACID SEQUENCE; ARTICLE; CANCER THERAPY; CONTROLLED STUDY; DNA REPAIR; DRUG RESISTANCE; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL; SENSITIZATION; TUMOR CELL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS; BINDING SITES; CONSERVED SEQUENCE; DNA REPAIR; DRUG RESISTANCE; ESCHERICHIA COLI; GENE LIBRARY; GUANINE; HUMANS; METHYLNITRONITROSOGUANIDINE; MOLECULAR SEQUENCE DATA; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; POINT MUTATION; SEQUENCE ALIGNMENT;

EID: 0034655768     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3470519     Document Type: Article

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