Activation of bis-electrophiles to mutagenic conjugates by human O 6-alkylgvanine-DNA alkyltransferase

Chemical Research in Toxicology

Volumn 17, Issue 7, 2004, Pages 972-982

  Valadez, J Gerardo ^a   Liu, Liping ^b,c   Loktionova, Natalia A ^b   Pegg, Anthony E ^b   Guengerich, F Peter ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIBROMOETHANE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; ALKANE; BROMINE; BUTADIENE DIEPOXIDE; CARBENE; CHLORINE; DIBROMOMETHANE; HALIDE; IODINE; MUTAGENIC AGENT; TOXIN;

ARTICLE; CELL SURVIVAL; CROSS LINKING; DRUG ACTIVITY; DRUG CONJUGATION; ENZYME ACTIVATION; ESCHERICHIA COLI; GENE MUTATION; GENOTOXICITY; HISTIDINE OPERON REVERSION; IN VITRO STUDY; MUTAGENICITY; OPERON; REVERTANT; SALMONELLA TYPHIMURIUM;

BIOTRANSFORMATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; HUMANS; HYDROCARBONS, HALOGENATED; MUTAGENICITY TESTS; MUTAGENS; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; SALMONELLA TYPHIMURIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA COLI; SALMONELLA TYPHIMURIUM;

EID: 3242704994     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx049897u     Document Type: Article

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