Genetics of stress response and stress-related disorders

Dialogues in Clinical Neuroscience

Volumn 8, Issue 4, 2006, Pages 433-444

  Ising, Marcus ^a   Holsboer, Florian ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Bipolar disorder; Cardiovascular disorder; Genetics; Hypothalam c pituitary adrenocortical axis; Renin angiotensin aldosterone system; Stress; Sympathetic system; Unipolar depression

Indexed keywords

ACUTE STRESS DISORDER; ARTICLE; CARDIOVASCULAR DISEASE; GENETIC SELECTION; GENETIC VARIABILITY; GENETICS; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; MAJOR DEPRESSION; NEUROTRANSMISSION; STRESS;

BIPOLAR DISORDER; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INFLAMMATION; NEUROTRANSMITTER AGENTS; RENIN-ANGIOTENSIN SYSTEM; STRESS, PSYCHOLOGICAL;

EID: 33846201106     PISSN: 12948322     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (137)

1. Pacak K, Palkovits M. Stressor specificity of central neuroendocrine responses: implications for stress-related disorders. Endocr Rev. 2001;22:502-148.
2. McEwen BS. Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology. 2000;22:108-124.
3. Selye H. A syndrome produced by diverse nocuous agents. Nature. 1936;138:32.
4. Selye H. Stress and the general adaptation syndrome. BMJ. 1950;4667:1383-1392.
5. Chrousos GP, Gold PW. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA. 1992;267:1244-1252.
6. Mason JW. A re-evaluation of the concept of "non-specificity" in stress theory. J Psychiatr Res. 1971;8:323-333.
7. Schumacher J, Jamra RA, Freudenberg J, et al. Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder. Mol Psychiatry. 2004;9:203-207.
8. de Kloet ER, Joels M, Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci. 2005;6:463-475.
9. Holsboer F, von Bardeleben U, Wiedemann K, Müller OA, Stalla GK. Serial assessment of corticotropin-releasing hormone response after dexamethasone in depression. Implications for pathophysiology of DST non-suppression. Biol Psychiatry. 1987;22:228-234.
10. Heuser IJ, Yassouridis A, Holsboer F. The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders. J Psych Res. 1994;28:341-356.
11. Zobel AW, Nickel T, Sonntag A, Uhr M, Holsboer F, Ising M. Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression: a prospective study. J Psych Res. 2001;35:83-94.
12. Holsboer F, Barden N. Antidepressants and hypothalamic-pituitary- adrenocortical regulation. Endocr Rev. 1996;17:187-205.
13. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology. 2000;23:477-501.
14. Pariante CM, Thomas SA, Lovestone S, Makoff A, Kerwin RW. Do antidepressants regulate how cortisol affects the brain? Psychoneuroendocrinology. 2004;29:423-447.
15. Raison CL, Miller AH. When not enough is too much: the role of insufficient gluco-corticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry. 2003;160:1554-1565.
16. Zobel AW, Yassouridis A, Frieboes RM, Holsboer F. Prediction of medium-term outcome by cortisol response to the combined dexamethasone-CRH test in patients with remitted depression. Am J Psychiatry. 1999;156:949-951.
17. Ising M, Künzel HE, Binder EB, Nickel T, Modell S, Holsboer F. The combined dexamethasone/CRH test as a potential surrogate marker in depression. Prog Neuropsychopharmacol Biol Psychiatry. 2005 29:1085-1093.
18. Ising M, Horstmann S, Kloiber S, et al. Combined Dex/CRH test predicts treatment response in Major Depression - a potential biomarker? Biol Psychiatry. 2006. Nov 21 [Epub ahead of print].
19. Kirschbaum C, Pirke KM, Hellhammer DH. The Trier Social Stress Test - a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology. 1993;28:76-81.
20. Federenko IS, Nagamine M, Hellhammer DH, Wadhwa PD, Wust S. The heritability of hypothalamus pituitary adrenal axis responses to psychosocial stress is context dependent. J Clin Endocrinol Metab. 2004;89:6244-6250.
21. Kirschbaum C, Wust S, Faig HG, Hellhammer DH. Heritability of cortisol responses to human corticotropin-releasing hormone, ergometry, and psychological stress in humans. J Clin Endocrinol Metab. 1992;75:1526-1530.
22. Holsboer F, Lauer CJ, Schreiber W, Krieg JC. Altered hypothalamic- pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders. Neuroendocrinology. 1995;62:340-347.
23. Schüle C, Zill P, Baghai TC, et al. Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients. Psychoneuroendocrinology. 2006;31:1019-1025.
24. Modell S, Lauer CJ, Schreiber W, Huber J, Krieg JC, Holsboer F. Hormonal response pattern in the combined DEX-CRH test is stable over time in subjects at high familial risk for affective disorders. Neuropsychopharmacology. 1998;18:253-262.
25. Wüst S, van Rossum EFC, Federenko I, Koper JW, Kumsta R, Hellhammer DH. Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical response to psychosocial stress. J Clin Endocrinol Metab. 2004;89:565-573.
26. Uhart M, McCaul ME, Oswald LM, Choi L, Wand GS. GABRA6 gene polymorphism and an attenuated stress response. Mol Psychiatry. 2004;9:998-1006.
27. Chong RY, Oswald L, Yang X, Uhart M, Lin PI, Wand GS. The micro-opioid receptor polymorphism A118G predicts cortisol responses to naloxone and stress. Neuropsychopharmacology. 2006;31:204-211.
28. Huizenga NA, de Lange P, Koper JW, et al. Human adrenocorticotropin- secreting pituitary adenomas show frequent loss of heterozygosity at the glucocorticoid receptor gene locus. J Clin Endocrinol Metab. 1998;83:917-921.
29. van Rossum EF, Koper JW, van den Beld AW, et al. Identification of the BclI poly-morphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index. Clin Endocrinol (Oxf). 2003;59:585-592.
30. Baghai TC, Schule C, Zwanzger P, et al. Hypothalamic-pituitary- adrenocortical axis dysregulation in patients with major depression is influenced by the insertion/deletion polymorphism in the angiotensin I-converting enzyme gene. Neurosci Lett. 2002;328:299-303.
31. Baghai T, Binder EB, Schule C, et al. Polymorphisms in the angiotensin converting enzyme gene are associated with unipolar depression, ACE activity, and hypercortisolism. Mol Psychiatry. 2006; Apr 22 [Epub ahead of print].
32. Cohen J. The Global Burden of Disease Study: a useful projection of future global health? J Publ Health Med. 2000;22:518-524.
33. Center for Disease Control and Prevention. Hypertension. http://www.cdc.gov/nchs/fastats/hypertenshtml. Accessed 2002.
34. Ward R. Familial aggregation and genetic epidemiology of blood pressure. In: Laragh JH, Benner BM, eds. Hypertension. 2nd ed. New York, NY: Raven Press; 1995:67-88.
35. Jorde LB, Carey JC, Bamshad MJ, White RL. Medical Genetics. 3rd ed. St. Louis, Minn: Mosby; 2003.
36. Timmermann B, Mo R, Luft FC, et al. Beta-2 adrenoceptor genetic variation is associ-ated with genetic predisposition to essential hypertension: the Bergen Blood Pressure Study. Kidney Int. 1998;53:1455-1460.
37. Tomaszewski M, Brain NJ, Charchar FJ, et al. Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis. Hypertension. 2002;40:286-91.
38. Ranade K, Shue WH, Hung YJ, et al. The glycine allele of a glycine/arginine poly-morphism in the beta2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin. Am J Hypertens. 2001;14:1196-1200.
39. Herrmann SM, Nicaud V, Tiret L, et al. Polymorphisms of the beta2 - adrenoceptor (ADRB2) gene and essential hypertension: the ECTIM and PEGASE studies. J Hypertens. 2002;20:229-235.
40. Tonolo G, Melis MG, Secchi G, Atzeni MM, Angius MF, Carboni A, et al. Association of Trp64Arg beta 3-adrenergic-receptor gene polymorphism with essential hypertension in the Sardinian population. J Hypertens. 1999;17:33-38.
41. Ringel J, Kreutz R, Distler A, Sharma AM. The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with hypertension in men with type 2 diabetes mellitus. Am J Hypertens. 2000;13:1027-1031.
42. Staessen JA, Wang JG, Brand E, et al. Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population. J Hypertens. 2001;19:1349-1358.
43. Agachan B, Isbir T, Yilmaz H, Akoglu E. Angiotensin converting enzyme I/D, angio-tensinogen T174M-M235T and angiotensin II type 1 receptor A1166C gene polymorphisms in Turkish hypertensive patients. Exp Mol Med. 2003;35:545-549.
44. Giner V, Poch E, Bragulat E, Oriola J, Gonzalez D, Coca A, et al. Renin-angiotensin system genetic polymorphisms and salt sensitivity in essential hypertension. Hypertension. 2000;35:512-517.
45. Kario K, Hoshide S, Umeda Y, et al. Angiotensinogen and angiotensin-converting enzyme genotypes, and day and night blood pressures in elderly Japanese hypertensives. Hypertens Res. 1999;22:95-103.
46. Dzida G, Sobstyl J, Puzniak A, Golon P, Mosiewicz J, Hanzlik J. Polymorphisms of angiotensin-converting enzyme and angiotensin II receptor type 1 genes in essential hypertension in a Polish population. Med Sci Monit. 2001;7:1236-1241.
47. Tiret L, Blanc H, Ruidavets JB, et al. Gene polymorphisms of the renin-angiotensin system in relation to hypertension and parental history of myocardial infarction and stroke: the PEGASE study. Projet d'Etude des Genes de l'Hypertension Arterielle Severe a moderee Essentielle. J Hypertens. 1998;16:37-44.
48. Zaman MM, Yoshiike N, Date C, et al. Angiotensin converting enzyme genetic polymorphism is not associated with hypertension in a cross-sectional sample of a Japanese population: the Shibata Study. J Hypertens. 2001;19:47-53.
49. Castellano M, Glorioso N, Cusi D, Sarzani R, Fabris B, Opocher G, et al. Genetic polymorphism of the renin-angiotensin-aldosterone system and arterial hypertension in the Italian population: the GENIPER Project. J Hypertens. 2003;21:1853-1860.
50. Sato N, Katsuya T, Rakugi H, et al. Association of variants in critical core promoter element of angiotensinogen gene with increased risk of essential hypertension in Japanese. Hypertension. 1997;30:321-325.
51. Larson N, Hutchinson R, Boerwinkle E. Lack of association of 3 functional gene variants with hypertension in African Americans. Hypertension. 2000;35:1297-1300.
52. Casiglia E, Tikhonoff V, Mazza A, et al. C-344T polymorphism of the aldosterone synthase gene and blood pressure in the elderly: a population-based study. J Hypertens. 2005;23:1991-1996.
53. Komiya I, Yamada T, Takara M, et al. Lys(173)Arg and -344T/C variants of CYP11B2 in Japanese patients with low-renin hypertension. Hypertension. 2000;35:699-703.
54. Pamies-Andreu E, Ramirez-Lorca R, Stiefel Garcia-Junco P, et al. Renin-angiotensin-aldosterone system and G-protein beta-3 subunit gene polymorphisms in salt-sensitive essential hypertension. J Hum Hypertens. 2003;17:187-191.
55. Tiago AD, Badenhorst D, Nkeh B, et al. Impact of renin-angiotensin- aldosterone system gene variants on the severity of hypertension in patients with newly diagnosed hypertension. Am J Hypertens. 2003;16:1006-1010.
56. Tsukada K, Ishimitsu T, Teranishi M, et al. Positive association of CYP11B2 gene polymorphism with genetic predisposition to essential hypertension. J Hum Hypertens. 2002;16:789-793.
57. Tsujita Y, Iwai N, Katsuya T, et al. Lack of association between genetic polymorphism of CYP11B2 and hypertension in Japanese: the Suita Study. Hypertens Res. 2001;24:105-109.
58. Cusi D, Barlassina C, Azzani T, et al. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet. 1997;349:1353-1357.
59. Kato N, Sugiyama T, Morita H, et al. Genetic analysis of the atrial natriuretic peptide gene in essential hypertension. Clin Sci (Lond). 2000;98:251-258.
60. Cheung BM, Leung R, Shiu S, Tan KC, Lau CP, Kumana CR. HpaII polymorphism in the atrial natriuretic peptide gene and hypertension. Am J Hypertens. 1999;12:524-527.
61. Rahmutula D, Nakayama T, Soma M, et al. Association study between the variants of the human ANP gene and essential hypertension. Hypertens Res. 2001;24:291-294.
62. Chiang FT, Hsu KL, Tseng CD, Lo HM, Chern TH, Tseng YZ. Association of the renin gene polymorphism with essential hypertension in a Chinese population. Clin Genet. 1997;51:370-374.
63. Frossard PM, Lestringant GG, Elshahat YI, John A, Obineche EN. An Mbol two-allele polymorphism may implicate the human renin gene in primary hypertension. Hypertens Res. 1998;21:221-225.
64. Frossard PM, Lestringant GG, Malloy MJ, Kane JP. Human renin gene BglI dimorphism associated with hypertension in two independent populations. Clin Genet. 1999 56:428-33.
65. Agarwal AK, Giacchetti G, Lavery G, et al. CA-Repeat polymorphism in intron 1 of HSD11B2: effects on gene expression and salt sensitivity. Hypertension. 2000;36:187-194.
66. White PC, Agarwal AK, Li A, et al. Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11beta-hydroxysteroid dehydrogenase to hypertension in black people. Clin Endocrinol (Oxf). 2001;55:249-252.
67. Asai T, Ohkubo T, Katsuya T, et al. Endothelin-1 gene variant associates with blood pressure in obese Japanese subjects: the Ohasama Study. Hypertension. 2001;38:1321-1324.
68. Tiret L, Poirier O, Hallet V, et al. The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people. Hypertension. 1999;33:1169-1174.
69. Yamamoto M, Jin JJ, Wu Z, et al. Interaction between serotonin 2A receptor and endothelin-1 variants in association with hypertension in Japanese. Hypertens Res. 2006;29:227-232.
70. Lacolley P, Gautier S, Poirier O, Pannier B, Cambien F, Benetos A. Nitric oxide synthase gene polymorphisms, blood pressure and aortic stiffness in normotensive and hypertensive subjects. J Hypertens. 1998;16:31-35.
71. Kato N, Sugiyama T, Morita H, et al. Lack of evidence for association between the endothelial nitric oxide synthase gene and hypertension. Hypertension. 1999;33:933-936.
72. Tsujita Y, Baba S, Yamauchi R, et al. Association analyses between genetic polymorphisms of endothelial nitric oxide synthase gene and hypertension in Japanese: the Suita Study. J Hypertens. 2001;19:1941-1948.
73. Thomas GN, Tomlinson B, Critchley JA. Modulation of blood pressure and obesity with the dopamine D2 receptor gene Taql polymorphism. Hypertension. 2000;36:177-182.
74. Rosmond R, Rankinen T, Chagnon M, et al. Polymorphism in exon 6 of the dopamine D(2) receptor gene (DRD2) is associated with elevated blood pressure and personality disorders in men. J Hum Hypertens. 2001;15:553-558.
75. Dong Y, Zhu H, Sagnella GA, Carter ND, Cook DG, Cappuccio FP. Association between the C825T polymorphism of the G protein beta3-subunit gene and hypertension in blacks. Hypertension. 1999;34:1193-1196.
76. Buchmayer H, Sunder-Plassmann G, Hirschl MM, et al. G-protein beta3 subunit gene (GNB3) polymorphism 825C - >T in patients with hypertensive crisis. Crit Care Med. 2000;28:3203-3206.
77. Iwai N, Katsuya T, Mannami T, et al. Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension. Circulation. 2002;105:41-47.
78. Benjafield AV, Iwai N, Ishikawa K, Wang WY, Morris BJ. Overweight, but not hypertension, is associated with SAH polymorphisms in Caucasians with essential hypertension. Hypertens Res. 2003;26:591-595.
79. Hohda S, Kimura A, Sasaoka T, et al. Association study of CD14 polymorphism with myocardial infarction in a Japanese population. Jpn Heart J. 2003;44:613-622.
80. Hubacek JA, Rothe G, Pit'ha J, et al. C(-260) - >T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction. Circulation. 1999;99:3218-3220.
81. Shimada K, Watanabe Y, Mokuno H, Iwama Y, Daida H, Yamaguchi H. Common polymorphism in the promoter of the CD14 monocyte receptor gene is associated with acute myocardial infarction in Japanese men. Am J Cardiol. 2000;86:682-684, A8.
82. Nauck M, Winkelmann BR, Hoffmann MM, Bohm BO, Wieland H, Marz W. C(-260)T polymorphism in the promoter of the CD14 gene is not associated with coronary artery disease and myocardial infarction in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Am J Cardiol. 2002;90:1249-1252.
83. Koch W, Kastrati A, Mehilli J, von BN, Schomig A. CD14 gene -159C/T polymorphism is not associated with coronary artery disease and myocardial infarction. Am Heart J. 2002;143:971-976.
84. Ameziane N, Beillat T, Verpillat P, et al. Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events. Arterioscler Thromb Vasc Biol. 2003;23:E61-E64.
85. Edfeldt K, Bennet AM, Eriksson P, et al. Association of hyporesponsive toll-like receptor 4 variants with risk of myocardial infarction. Eur Heart J. 2004;25:1447-1453.
86. Pasterkamp G, Van Keulen JK, De Kleijn DP. Role of Toll-like receptor 4 in the ini-tiation and progression of atherosclerotic disease. Eur J Clin Invest. 2004;34:328-334.
87. Yang IA Holloway JW, Ye S. TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis. Atherosclerosis. 2003;170:187-190.
88. Helgadottir A Manolescu A, Thorleifsson G, Gretarsdottir S, Jonsdottir H, Thor-steinsdottir U, et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet. 2004 36:233-239.
89. Helgadottir A, Gretarsdottir S, St Clair D, et al. Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population. Am J Hum Genet. 2005;76:505-509.
90. Dwyer JH, Allayee H, Dwyer KM, et al. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med 2004;350:29-37.
91. Helgadottir A, Manolescu A, Helgason A, et al. A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet. 2006;38:68-74.
92. Ozaki K, Ohnishi Y, Iida A, et al. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet. 2002;32:650-654.
93. Iwanaga Y, Ono K, Takagi S, et al. Association analysis between polymorphisms of the lymphotoxin-alpha gene and myocardial infarction in a Japanese population. Atherosclerosis. 2004;172:197-198.
94. Laxton R, Pearce E, Kyriakou T, Ye S. Association of the lymphotoxin-alpha gene Thr26Asn polymorphism with severity of coronary atherosclerosis. Genes Immun. 2005;6:539-541.
95. Clarke R, Xu P, Bennett D, Lewington S, et al. Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study. PLoS Genet. 2006;2:E107.
96. Yamada A, Ichihara S, Murase Y, et al. Lack of association of polymorphisms of the lymphotoxin alpha gene with myocardial infarction in Japanese. J Mol Med. 2004;82:477-483.
97. Ozaki K, Inoue K, Sato H, et al. Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro. Nature. 2004;429:72-75.
98. Danesh J, Collins R, Peto R. Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies. Circulation. 2000;102:1082-1085.
99. Watkins H, Farrall M. Genetic susceptibility to coronary artery disease: from promise to progress. Nat Rev Genet. 2006;7:163-173.
100. Jacobi F, Wittchen HU, Holting C, et al. Prevalence, co-morbidity and correlates of mental disorders in the general population: results from the German Health Interview and Examination Survey (GHS). Psychol Med. 2004;34:597-611.
101. Kessler RC, McGonagle KA Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994;51:8-19.
102. Craddock N, Forty L. Genetics of affective (mood) disorders. Eur J Hum Genet. 2006;14:660-668.
103. Furlong RA, Ho L, Rubinsztein JS, Walsh C, Paykel ES, Rubinsztein DC. Analysis of the monoamine oxidase A (MAOA) gene in bipolar affective disorder by association studies, meta-analyses, and sequencing of the promoter. Am J Med Genet. 1999;88:398-406.
104. Preisig M, Bellivier F, Fenton BT, et al. Association between bipolar disorder and monoamine oxidase A gene polymorphisms: results of a multi-center study. Am J Psychiatry. 2000;157:948-955.
105. Craddock N, Dave S, Greening J. Association studies of bipolar disorder. Bipolar Disord. 2001;3:284-298.
106. Jones I, Craddock N. Candidate gene studies of bipolar disorder. Ann Med. 2001 33:248-256.
107. Shifman S, Bronstein M, Sternfeld M, et al. COMT: a common susceptibility gene in bipolar disorder and schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2004;128:61-64.
108. Ogilvie AD, Battersby S, Bubb VJ, et al. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet. 1996;347:731-733.
109. Collier DA, Stober G, Li T, et al. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry. 1996;1:453-460.
110. Rees M, Norton N, Jones I, et al. Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT). Mol Psychiatry. 1997;2:398-402.
111. Kunugi H, Hattori M, Kato T, et al. Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder. Mol Psychiatry. 1997;2:457-462.
112. Anguelova M, Benkelfat C, Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Mol Psychiatry. 2003;8:574-591.
113. Lasky-Su JA, Faraone SV, Glatt SJ, Tsuang MT. Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders. Am J Med Genet B Neuropsychiatr Genet. 2005;133:110-115.
114. Mendlewicz J, Massat I, Souery D, et al. Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multi-center study. Eur J Hum Genet. 2004;12:377-382.
115. Chen YS, Akula N, Detera-Wadleigh SD, Schulze TG, Thomas J, Potash JB, et al. Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33. Mol Psychiatry. 2004;9:87-92.
116. Hattori E, Liu C, Badner JA, et al. Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Am J Hum Genet. 2003;72:1131-1140.
117. Williams NM, Green EK, Macgregor S, et al. Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Arch Gen Psychiatry. 2006;63:366-373.
118. Craddock N, O'Donovan MC, Owen MJ. Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophr Bull. 2006;32:9-16.
119. Neves-Pereira M, Mundo E, Muglia P, King N, Macciardi F, Kennedy JL. The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am J Hum Genet. 2002;71:651-655.
120. Sklar P, Gabriel SB, McInnis MG, et al. Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutro-phic factor. Mol Psychiatry. 2002;7:579-593.
121. Hong CJ, Huo SJ, Yen FC, Tung CL, Pan GM, Tsai SJ. Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology. 2003;48:186-189.
122. Nakata K, Ujike H, Sakai A, et al. Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder. Neurosci Lett. 2003;337:17-20.
123. Oswald P, Del-Favero J, Massat I, Souery D, Claes S, Van BC, et al. Non-replication of the brain-derived neurotrophic factor (BDNF) association in bipolar affective disorder: a Belgian patient-control study. Am J Med Genet B Neuropsychiatr Genet. 2004;129:34-35.
124. Green EK, Raybould R, Macgregor S, et al. Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK. Br J Psychiatry. 2006;188:21-25.
125. Barden N, Harvey M, Gagne B, et al. Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet. 2006;141:374-382.
126. Shink E, Morissette J, Sherrington R, Barden N. A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12. Mol Psychiatry. 2005;10:545-552.
127. Zhang X, Gainetdinov RR, Beaulieu JM, et al. Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron. 2005;45:11-16.
128. Zill P, Baghai TC, Zwanzger P, et al. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol Psychiatry. 2004;9:1030-1036.
129. Zill P, Buttner A, Eisenmenger W, Moller HJ, Bondy B, Ackenheil M. Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol Psychiatry. 2004;56:581-586.
130. Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386-389.
131. Kendler KS, Kuhn JW, Vittum J, Prescott CA, Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry. 2005;62:529-535.
132. Gillespie NA, Whitfield JB, Williams B, Heath AC, Martin NG. The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychol Med. 2005;35:101-111.
133. van Rossum EFC, Binder EB, et al. Polymorphisms of the glucocorticoid receptor gene and major depression. Biol Psychiatry. 2006;59:681-688.
134. Barden N, Harvey M, Shink E, et al. Identification and characterisation of a gene predisposing to both bipolar and unipolar affective disorders. Am J Med Genetics. 2004;130B:122.
135. Lucae S, Salyakina D, Barden N, Harvey M, Gagne B, Labbe M, et al. P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. Hum Mol Genet. 2006;15:2438-2445.
136. Deuchars SA, Atkinson L, Brooke RE, Musa H, Milligan CJ, Batten TF, et al. Neu-ronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems. J Neurosci. 2001;21:7143-7152.
137. Wirkner K, Kofalvi A, Fischer W, et al. Supersensitivity of P2X receptors in cerebro-cortical cell cultures after in vitro ischemia. J Neurochem. 2005;95:1421-1437.