Lack of association between genetic polymorphism of CYP11B2 and hypertension in Japanese: The Suita study

Hypertension Research

Volumn 24, Issue 2, 2001, Pages 105-109

  Tsujita, Y ^a   Iwai, N ^a   Katsuya, T ^a   Higaki, J ^a   Ogihara, T ^a   Tamaki, S ^a   Kinoshita, M ^a   Mannami, T ^a   Ogata, J ^a   Baba, S ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Aldosterone; Blood pressure; Cytochrome P 450 CYP11B2; Genetics; Hypertension

Indexed keywords

ALDOSTERONE SYNTHASE; ANTIHYPERTENSIVE AGENT;

ADULT; AGED; ANTIHYPERTENSIVE THERAPY; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; FEMALE; GENDER; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPERTENSION; JAPAN; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PULSE PRESSURE; SYSTOLIC BLOOD PRESSURE;

AGED; ALDOSTERONE SYNTHASE; BLOOD PRESSURE; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; HYPERTENSION; JAPAN; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PREJUDICE; RISK FACTORS;

EID: 0035030830     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.24.105     Document Type: Article

References (22)

1. Role of steroid 11-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans
2. The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex
3. A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension
4. Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2
5. The nature of the defect in a salt-wasting disorder in Jews of Iran
6. Congenitally defective aldosterone biosynthesis in humans: Inactivation of the P-450C18 gene (CYP11B2) due to nucleotide deletion in CMO I-deficient patients
7. Haplotype analysis of CYP11B2
8. Genetic variation in P450c11AS in Chilean patients with low-renin hypertension
9. Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function
10. Genetic polymorphism of CYP11B2 gene and hypertension in Japanese
11. Associations between aldosterone synthase gene polymorphism and the adrenocortical function in males
12. Genetic determination of plasma aldosterone levels in essential hypertension
13. Structural analysis and evaluation of the aldosterone synthase gene in hypertension
14. Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2
15. Lys(173)Arg and -344T/C variants of CYP11B2 in Japanese patients with low-renin hypertension
16. Genotype-phenotype relationships for the renin-aldosterone system in a normal population
17. Comprehensive analysis of the renin-angiotensin gene polymorphisms with relation to hypertension in the Japanese
18. Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure
19. Aldosterone synthase gene (CYP11B2) C -344T polymorphism in Caucasians from the Berlin Salt-Sensitivity Trial (BeSST)
20. Prevalence of asymptomatic carotid atherosclerotic lesions detected by high-resolution ultrasonography and its relation to cardiovascular risk factors in the general population of a Japanese city: The Suita study
21. Human prostacyclin synthase gene and hypertension: The Suita study
22. Association of polymorphism in the promoter region of the apolipoprotein E. gene with diastolic blood pressure in normotensive Japanese