Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT)

Molecular Psychiatry

Volumn 2, Issue 5, 1997, Pages 398-402

  Rees, M ^a   Norton, N ^a   Jones, I ^a   McCandless, F ^a   Scourfield, J ^a   Holmans, P ^a   Moorhead, S ^b   Feldman, E ^b   Sadler, S ^a   Cole, T ^a   Redman, K ^a   Farmer, A ^a   McGuffin, P ^a   Owen, M J ^a   Craddock, N ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

5HTT; Affective disorder; Bipolar disorder; Genetics; Serotonin; SERT

Indexed keywords

CARRIER PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BIPOLAR DISORDER; FEMALE; GENETIC LINKAGE; GENETICS; GENOTYPE; HUMAN; MALE; MIDDLE AGED;

ADULT; AGED; BIPOLAR DISORDER; CARRIER PROTEINS; FEMALE; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0031229750     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000256     Document Type: Article

References (10)

1. Craddock N, McGuffin P. Approaches to the genetics of affective disorder. Ann Med 1993; 25: 317-322.
2. Craddock N, Khodel V, Van Eerdewegh P, Reich T. Mathematical limits of multilocus models: the genetic transmission of bipolar disorder. Am J Hum Genet 1995; 57: 690-702.
3. Maes M, Meltzer HY. The serotonin hypothesis of major depression. In: Bloom FE, Kupfer DJ (eds). Psychopharmacology: the Fourth Generation. Raven Press: New York, 1995, pp 933-944.
4. Goodwin FK, Jamison KR. Manic-depressive Illness. Oxford University Press: New York, 1990.
5. Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, Ganapathy V, Blakely RD. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 1993; 90: 2542-2546.
6. Lesch K-P, Balling U, Strauss K, Wolozin BL, Murphy DL, Riederer P. Organization of the human serotonin transporter gene. J Neural Trans (GenSect) 1994; 95: 157-162.
7. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996; 66: 1-4.
8. Collier DA, Stöber G, Li T et al. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorder. Mol Psychiatry 1996; 1: 453-460.
9. Kelsoe JR, Remick RA, Sadovnick AD et al. Genetic linkage study of bipolar disorder and the serotonin transporter. Am J Med Genet (Neuropsy Genet) 1996; 67: 215-217.
10. Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwin GM, Smith CAD. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 1996; 347: 731-733.