Association of hypo-responsive toll-like receptor 4 variants with risk of myocardial infarction

European Heart Journal

Volumn 25, Issue 16, 2004, Pages 1447-1453

  Edfeldt, Kristina ^a   Bennet, Anna M ^a   Eriksson, Per ^a   Frostegård, Johan ^b   Wiman, Björn ^a   Hamsten, Anders ^a,b   Hansson, Göran K ^a   Faire, Ulf De ^a,b   Yan, Zhong Qun ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Genetics; Immune system; Myocardial infarction; Single nucleotide polymorphism; Toll like receptor 4

Indexed keywords

ASPARTIC ACID; GLYCINE; ISOLEUCINE; THREONINE; TOLL LIKE RECEPTOR 4;

ADULT; AGED; ARTICLE; ATHEROGENESIS; CARDIOVASCULAR RISK; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HEART INFARCTION; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; RECEPTOR GENE; RECEPTOR SENSITIVITY; RISK ASSESSMENT; RISK FACTOR; SMOKING; SURVIVAL; WILD TYPE;

AGED; CASE-CONTROL STUDIES; FEMALE; GENOTYPE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MYOCARDIAL INFARCTION; POLYMORPHISM, GENETIC; RECEPTORS, CELL SURFACE; RISK FACTORS; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 4043067215     PISSN: 0195668X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ehj.2004.05.004     Document Type: Article

References (33)

1. Ross R. Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 340:1999;115-126
2. Hansson G.K., Libby P., Schonbeck U., et al. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ. Res. 91:2002;281-291
3. Wick G., Perschinka H., Millonig G. Atherosclerosis as an autoimmune disease: an update. Trends Immunol. 22:2001;665-669
4. Xu Q. Role of heat shock proteins in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 22:2002;1547-1559
5. Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1:2001;135-145
6. Medzhitov R., Preston-Hurlburt P., Janeway C.A. Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 388:1997;394-397
7. Ohashi K., Burkart V., Flohe S., et al. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol. 164:2000;558-561
8. Vabulas R.M., Ahmad-Nejad P., da Costa C., et al. Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J. Biol. Chem. 276:2001;31332-31339
9. Edfeldt K., Swedenborg J., Hansson G.K., et al. Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation. Circulation. 105:2002;1158-1161
10. Xu X.H., Shah P.K., Faure E., et al. Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL. Circulation. 104:2001;3103-3108
11. Frantz S., Kobzik L., Kim Y.D., et al. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J. Clin. Invest. 104:1999;271-280
12. Raby B.A., Klimecki W.T., Laprise C., et al. Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Am. J. Respir. Crit. Care Med. 166:2002;1449-1456
13. Arbour N.C., Lorenz E., Schutte B.C., et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 25:2000;187-191
14. Erridge C., Stewart J., Poxton I.R. Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling. J. Exp. Med. 197:2003;1787-1791
15. von Aulock S., Schroder N.W., Gueinzius K., et al. Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood. J. Infect. Dis. 188:2003;938-943
16. Kiechl S., Lorenz E., Reindl M., et al. Toll-like receptor 4 polymorphisms and atherogenesis. N. Engl. J. Med. 347:2002;185-192
17. Ameziane N., Beillat T., Verpillat P., et al. Association of the toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events. Arterioscler. Thromb. Vasc. Biol. 23:2003;e61-e64
18. Yang I.A., Holloway J.W., Ye S. TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis. Atherosclerosis. 170:2003;187-190
19. Reuterwall C., Hallqvist J., Ahlbom A., et al. Higher relative, but lower absolute risks of myocardial infarction in women than in men: analysis of some major risk factors in the SHEEP study. The SHEEP Study Group. J. Intern. Med. 246:1999;161-174
20. Vermylen C., de Vreker R.A., Verstraete M. A rapid enzymatic method for assay of fibrinogen fibrin polymerization time (FTP test). Clin. Chim. Acta. 8:1963;418-424
21. Read R.C., Pullin J., Gregory S., et al. A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease. J. Infect. Dis. 184:2001;640-642
22. Rothman K. Interaction between causes. Modern epidemiology. 1st ed.:1986;311-326 Little Brown & Co, Boston
23. Lundberg M., Fredlund P., Hallqvist J., et al. A SAS program calculating three measures of interaction with confidence intervals. Epidemiology. 7:1996;655-656
24. Boekholdt S.M., Agema W.R., Peters R.J., et al. Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events. Circulation. 107:2003;2416-2421
25. Vink A., Schoneveld A.H., van der Meer J.J., et al. In vivo evidence for a role of toll-like receptor 4 in the development of intimal lesions. Circulation. 106:2002;1985-1990
26. Danenberg H.D., Welt F.G., Walker M. 3rd, et al. Systemic inflammation induced by lipopolysaccharide increases neointimal formation after balloon and stent injury in rabbits. Circulation. 105:2002;2917-2922
27. Ambrose J.A., Tannenbaum M.A., Alexopoulos D., et al. Angiographic progression of coronary artery disease and the development of myocardial infarction. J. Am. Coll. Cardiol. 12:1988;56-62
28. Falk E., Shah P.K., Fuster V. Coronary plaque disruption. Circulation. 92:1995;657-671
29. Stary H.C., Chandler A.B., Dinsmore R.E., et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 92:1995;1355-1374
30. Fuster V., Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology. Circulation. 90:1994;2126-2146
31. Libby P. Molecular bases of the acute coronary syndromes. Circulation. 91:1995;2844-2850
32. Sasu S., LaVerda D., Qureshi N., et al. Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation. Circ. Res. 89:2001;244-250
33. Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994;344:1383-9