Animal models of Alzheimer's disease

Molecular Medicine Today

Volumn 5, Issue 6, 1999, Pages 274-276

  Higgins, Linda Slanec ^a  

^a SCIOS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; AUTOSOMAL DOMINANT INHERITANCE; COGNITIVE DEFECT; GENE MUTATION; GENE OVEREXPRESSION; PATHOLOGICAL ANATOMY; SHORT SURVEY; TRANSGENIC ANIMAL;

EID: 0033153209     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-4310(99)01465-3     Document Type: Short Survey

References (5)

1. Lendon C.L., Ashall F., Goate A.M. Exploring the etiology of Alzheimer disease using molecular genetics. J. Am. Med. Assoc. 277:1997;825-831.
2. Higgins L.S., Cordell B. Genetically engineered animal models of Alzheimer's disease. Methods Enzymol. 10:1996;384-391.
3. Duff K. Recent work on Alzheimer's disease transgenics. Curr. Opin. Biotechnol. 9:1998;561-564.
4. Moran P.M., Higgins L.S., Cordell B., Moser P.C. Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human β-amyloid precursor protein. Proc. Natl. Acad. Sci. U. S. A. 92:1995;5341-5345.
5. Bales K.R.et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat. Genet. 3:1997;263-264.