Estrogen blocks neurotoxic effects of β-amyloid (1-42) and induces neurite extension on B103 cells

Neuroscience Letters

Volumn 235, Issue 3, 1997, Pages 101-104

  Mook Jung, Inhee ^a   Joo, Insoo ^a   Sohn, Seonghyang ^b   Jae Kwon, Hyuk ^b   Huh, Kyoon ^a   Whan Jung, Min ^b  

^a Ajou University School of Medicine   (South Korea)

^b Ajou University   (South Korea)

Author keywords

Alzheimer; Cell death; Estrogen; Necrosis; Neurite extension; Amyloid

Indexed keywords

AMYLOID BETA PROTEIN; FERROUS CHLORIDE;

ALZHEIMER DISEASE; CELL DEATH; CHROMOSOME 21; DISEASE PREDISPOSITION; ELECTRON MICROSCOPY; ESTROGEN THERAPY; FAMILIAL DISEASE; LIPID PEROXIDATION; NEURITE; NEUROTOXICITY; PRIORITY JOURNAL; REVIEW;

EID: 0031576349     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00632-0     Document Type: Article

References (17)

1. Behl C., Davis J.B., Klier F.G., Schubert D. Amyloid β peptide induces necrosis rather than apoptosis. Brain Res. 645:1994;253-264.
2. Behl C., Widmann M., Trapp T., Holsboer F. 17-β estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem. Biophys. Res. Commun. 216:1995;473-482.
3. Beyreuther K., Pollwein P., Multhaup G., Monning U., Konig G., Dyrks T., Schubert W., Masters C.L. Regulation and expression of the Alzheimer's beta/A4 amyloid protein precursor in health, disease, and Down's syndrome. Ann. N. Y. Acad. Sci. 695:1993;91-102.
4. Goate A., Chartier-Harlin M.-C., Mullan M., Brown J., Crawford F., Fidani L., Giuffra L., Haynes A., Irving N., James L., Mant R., Newton P., Rooke K., Roques P., Talbot C., Pericak-Vance M., Roses A., Williamson R., Rossor M., Owen M., Hardy J. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 349:1991;704-706.
5. Green P.S., Gridley K.E., Simpkins J.W. Estradiol protects against β-amyloid (25-35)-induced toxicity in SK-N-SH human neuroblastoma cells. Neurosci. Lett. 218:1996;165-168.
6. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F., Cole G. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science. 274:1996;99-102.
7. Jaffe A.B., Toran-Allerand C.D., Greengard P., Gandy S.E. Estrogen regulates metabolism of Alzheimer amyloid β precursor protein. J. Biol. Chem. 269:1994;13065-13068.
8. Johnston J., O'Neill C., Lannfelt L., Winblad B., Cowburn R.F. The significance of the Swedish APP670/671 mutation for the development of Alzheimer's disease amyloidosis. Neurochem. Int. 25:1994;73-80.
9. Loo D.T., Agata C., Pike C.J., Whittemore E.R., Wulencewicz A.J., Cotman C.W. Apoptosis is induced by β-amyloid in cultured nervous system neurons. Proc. Natl. Acad. Sci. USA. 90:1993;7951-7955.
10. Paganini-Hill A., Henderson V.W. Estrogen replacement therapy and risk of Alzheimer disease. Arch. Int. Med. 156:1996;2213-2217.
11. Selkoe D.J. Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease. Trends Neurosci. 16:1993;403-409.
12. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T.D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., Younkin S. Secreted amyloid betaprotein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2:1996;864-870.
13. Schubert D., Heinemann S., Carlisle W., Tarikas H., Kimes B., Patrick J., Steinbach J.H., Culp W., Brandt B.L. Clonal cell lines from the rat central nervous system. Nature. 249:1974;224-227.
14. Schulze-Osthoff K., Walczak H., Droge W., Krammer P.H. Cell nucleus and DNA fragmentation are not required for apoptosis. J. Cell, Biol. 127:1994;15-20.
15. Smalheiser N.R., Swanson D.R. Linking estrogen to Alzheimer's disease: an informatics approach. Neurology. 47:1996;809-810.
16. Tang M.X., Jacobs D., Stern Y., Marder K., Schofield P., Gurland B., Andrews H., Mayeux R. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet. 348:1996;429-432.
17. Yankner B.A., Duffy L.K., Kirschner D.A. Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science. 25:1990;279-282.