A strategy for designing inhibitors of β-amyloid toxicity

Journal of Biological Chemistry

Volumn 271, Issue 47, 1996, Pages 29525-29528

  Ghanta, Jyothi ^a   Shen, Chih Lung ^b   Kiessling, Laura L ^a   Murphy, Regina M ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b Wisconsin Electric Machines and Power Electronics Consortium   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID INHIBITOR; BETA AMYLOID PEPTIDE; BETA CYCLODEXTRIN; HEXADECYL N METHYLPIPERIDINIUM BROMIDE; UNCLASSIFIED DRUG;

AMYLOID NEUROPATHY; ARTICLE; HUMAN; HUMAN CELL; INHIBITION KINETICS; PEPTIDE ANALYSIS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; SENILE PLAQUE;

AMYLOID BETA-PROTEIN; ANIMALS; DRUG DESIGN; MICROSCOPY, ELECTRON; PC12 CELLS; RATS; SPECTRUM ANALYSIS;

EID: 0029910347     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.47.29525     Document Type: Article

References (27)

1. Glenner, G. G., and Wong, C. W. (1984) Biochem. Biophys. Res. Commun. 120, 885-890
2. Wong, C. W., Quaranta, V., and Glenner, G. G. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 8729-8732
3. Joachim, C. L., and Selkoe, D. J. (1992) Alzheimer Dis. Assoc. Disord. 6, 7-34
4. Pike, D. J., Burdick, D., Walencewicz, A. J., Glabe, C. G., and Cotman, C. W. (1993) J. Neurosci. 13, 1676-1687
5. Simmons, L. K., May, P. C., Tomaselli, K. J., Rydel, R. E., Fuson, K. S., Brigham, E. F., Wright, S., Lieberburg, I., Becker, G. W., Brems, D. N., and Li, W. (1994) Mol. Pharmacol. 45, 373-379
6. Ueda, K., Fukui, Y., and Kageyama, H. (1994) Brain Res. 639, 240-244
7. Terzi, E., Holzemann, G., and Seelig, J. (1995) J. Mol. Biol. 633-642
8. Jarrett, J. T., Berger, E. P., and Lansbury, P. T., Jr. (1993) Biochemistry 32, 4693-4697
9. Hilbich, C., Kisters-Woike, B., Reed, J., Masters, C. L., and Beyreuther, K. (1992) J. Mol. Biol. 228, 460-473
10. Fraser, P. E., Nguyen, J. T., Surewicz, W. K., and Kirschner, D. A. (1991) Biophys. J. 60, 1190-1201
11. Fraser, P. E., McLachlan, D. R., Surewicz, W. K., Mizzen, C. A., Snow, A. D., Nguyen, J. T., and Kirschner, D. A. (1994) J. Mol. Biol. 244, 64-73
12. Shen, C.-L., and Murphy, R. M. (1995) Biophys. J. 69, 640-651
13. Lomakin, A., Chung, D. S., Benedek, G. B., Kirschner, D. A., and Teplow, D. B. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 1125-1129
14. Pollack, S. J., Sadler, I.I. J., Hawtin, S. R., Tailor, V. J., and Shearman, M. S. (1995) Neurosci. Lett. 197, 211-214
15. Kisilevsky, R., Lemieux, L. J., Fraser, P. E., Kong, X., Hultin, P. G., and Szarek, W. A. (1995) Nat. Med. 1, 143-148
16. Wood, S. J., MacKenzie, L., Maleeff, B., Hurle, M. R., and Wetzel, R. (1996) J. Biol. Chem. 271, 4086-4092
17. Camilleri, P., Haskins, N. J., and Howlett, D. R. (1994) FEBS Lett. 341, 256-258
18. Tjernberg, L. O., Naslund, J., Lindqvist, F., Johansson, J., Karlstrom, A. R., Thyberg, J., Terenius, L., and Nordstedt, C. (1996) J. Biol. Chem. 271, 8545-8548
19. Hughes, S. R., Goyal, S., Sun, J. E., Gonzalez-DeWhitt, P., Fortes, M., Riedel, N. G., and Sahasrabudhe, S. R. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 2065-2070
20. Shen, C.-L., Scott, G. L., Merchant, F., and Murphy, R. M. (1993) Biophys. J. 65, 2383-2395
21. LeVine, H. (1993) Protein Sci. 2, 404-410
22. Shen, C.-L., Fitzgerald, M. C., and Murphy, R. M. (1994) Biophys. J. 65, 2383-2395
23. Shearman, M. S., Ragan, C. I., and Iverson, L. L. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 1470-1474
24. Halverson, K., Fraser, P. E., Kirschner, D. A., and Lansbury, P. T., Jr. (1990) Biochemistry 29, 2639-2644
25. Wood, S. J., Wetzel, R., Martin, J. D., and Hurle, M. R. (1995) Biochemistry 34, 724-730
26. Lee, J. P., Stimson, E. R., Ghilardi, J. R., Mantyh, P. W., Lu, Y.-A., Felix, A. M., Llanos, W., Behbin, A., Cummings, M., Van Criekinge, M., Timms, W., and Maggio, J. E. (1995) Biochemistry 34, 5191-5200
27. Esler, W. P., Simson, E. R., Ghilardi, J. R., Vinters, H. V., Lee, J. P., Mantyh, P. W., and Maggio, J. E. (1996) Biochemistry 35, 749-57