Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication

Molecular Cell

Volumn 9, Issue 3, 2002, Pages 481-491

  Méndez, Juan ^a   Zou Yang, X Helena ^a,b   Kim, So Young ^a   Hidaka, Masumi ^a   Tansey, William P ^a   Stillman, Bruce ^a,c  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b Iris Pharmaceuticals   (United States)

^c NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN DEPENDENT KINASE 2; PROTEASOME; PROTEIN; PROTEIN HORC1P; PROTEIN SUBUNIT; S PHASE KINASE ASSOCIATED PROTEIN 2; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE S PHASE; CELL DIVISION; CELL PROLIFERATION; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; EUKARYOTIC CELL; HUMAN; HUMAN CELL; MITOSIS; PLOIDY; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EUKARYOTA;

EID: 0036208817     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00467-7     Document Type: Article

References (62)

1. Cell cycle modulation of protein-DNA interactions at a human replication origin
2. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase
3. E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila
4. The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing
5. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
6. The control of mammalian DNA replication: A brief history of space and timing
7. Chromatin-bound Cdc6 persists in S and G2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process
8. Identification and characterization of the human ORC6 homolog
9. The spatial position and replication timing of chromosomal domains are both established in early G1 phase
10. Initiation of DNA replication in eukaryotic cells
11. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
12. Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication
13. Triggering ubiquitination of a CDK inhibitor at origins of DNA replication
14. Conserved initiator proteins in eukaryotes
15. Making sense of eukaryotic DNA replication origins
16. Skp2 is oncogenic and overexpressed in human cancers
17. The ubiquitin system
18. Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2
19. Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein
20. Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: Human homologue (ORC5L) maps to 7q22
21. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
22. Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product
23. Regulation of chromosome replication
24. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase
25. The human origin recognition complex protein 1 dissociates from chromatin during S phase in HeLa cells
26. Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants
27. Structure and function of Cdc6/Cdc18: Implications for origin recognition and checkpoint control
28. XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
29. Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation
30. Geminin, an inhibitor of DNA replication, is degraded during mitosis
31. Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: Assembly of prereplication complexes in late mitosis
32. Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro
33. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
34. Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals
35. Aaa+: A class of chaperone-like atpases associated with the assembly, operation, and disassembly of protein complexes
36. Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms
37. The Cdt1 protein is required to license DNA for replication in fission yeast
38. The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase
39. Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor
40. Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle
41. Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis
42. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization
43. Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1
44. Identification of HsORC4, a member of the human origin of replication recognition complex
45. ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases
46. Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins
47. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase
48. Destruction of Myc by ubiquitin-mediated proteolysis: Cancer-associated and transforming mutations stabilize Myc
49. Regulation of transcriptional activation domain function by ubiquitin
50. Cell cycle control of DNA replication
51. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line
52. Chromosome association of minichromosome maintenance proteins in Drosophila mitotic cycles
53. p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells
54. Association of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structures
55. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain
56. The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p
57. Assembly of the human origin recognition complex
58. A human protein related to yeast Cdc6p
59. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
60. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells
61. Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication
62. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase