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Volumn 23, Issue 4-5, 2002, Pages 569-580

Acute mitochondrial and chronic toxicological effects of 1-methyl-4-phenylpyridinium in human neuroblastoma cells

Author keywords

DAT; Mitochondria; Monoamine; MPP+; Neurotoxicity; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; DOPAMINE TRANSPORTER; ROTENONE; TETRAPHENYLPHOSPHONIUM; CARRIER PROTEIN; CATION; COLORING AGENT; MEMBRANE PROTEIN; NERVE PROTEIN; ORGANOPHOSPHORUS COMPOUND; SLC6A3 PROTEIN, HUMAN;

EID: 0036777178     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-813X(02)00060-8     Document Type: Conference Paper
Times cited : (22)

References (47)
  • 1
    • 0035074475 scopus 로고    scopus 로고
    • Subthalamic infusion of an NMDA antagonist prevents basal ganglia metabolic changes and nigral degeneration in a rodent model of Parkinson's disease
    • Blandini F, Nappi G, Greenamyre JT. Subthalamic infusion of an NMDA antagonist prevents basal ganglia metabolic changes and nigral degeneration in a rodent model of Parkinson's disease. Ann Neurol 2001;49:525-9.
    • (2001) Ann Neurol , vol.49 , pp. 525-529
    • Blandini, F.1    Nappi, G.2    Greenamyre, J.T.3
  • 2
    • 0001496694 scopus 로고
    • A primate model of Parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Burns RS, Chiueh CC, Markey SP, Ebert MH, Jacobowitz DM, Kopin IJ. A primate model of Parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA 1983;80:4546-50.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 4546-4550
    • Burns, R.S.1    Chiueh, C.C.2    Markey, S.P.3    Ebert, M.H.4    Jacobowitz, D.M.5    Kopin, I.J.6
  • 4
    • 0021276089 scopus 로고
    • Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase
    • Chiba K, Trevor A, Castagnoli Jr, N. Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Biochem Biophys Res Commun 1984;120:574-8.
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 574-578
    • Chiba, K.1    Trevor, A.2    Castagnoli N., Jr.3
  • 7
    • 0026598930 scopus 로고
    • Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: Evidence for free radical involvement
    • Cleeter MW, Cooper JM, Schapira AH. Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvement. J Neurochem 1992;58:786-9.
    • (1992) J Neurochem , vol.58 , pp. 786-789
    • Cleeter, M.W.1    Cooper, J.M.2    Schapira, A.H.3
  • 8
    • 0026464732 scopus 로고
    • Uptake and accumulation of 1-methyl-4-phenylpyridinium by rat liver mitochondria measured using an ion-selective electrode
    • Davey GP, Tipton KF, Murphy MP. Uptake and accumulation of 1-methyl-4-phenylpyridinium by rat liver mitochondria measured using an ion-selective electrode. Biochem J 1992;288:439-43.
    • (1992) Biochem J , vol.288 , pp. 439-443
    • Davey, G.P.1    Tipton, K.F.2    Murphy, M.P.3
  • 9
    • 0030877835 scopus 로고    scopus 로고
    • Dopamine transporter is required for in vivo MPTP neurotoxicity: Evidence from mice lacking the transporter
    • Gainetdinov RR, Fumagalli F, Jones SR, Caron MG. Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter. J Neurochem 1997;69:1322-5.
    • (1997) J Neurochem , vol.69 , pp. 1322-1325
    • Gainetdinov, R.R.1    Fumagalli, F.2    Jones, S.R.3    Caron, M.G.4
  • 10
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
    • (1992) J Cell Biol , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 12
    • 0021280826 scopus 로고
    • Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice
    • Heikkila RE, Hess A, Duvoisin RC. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice. Science 1984a;224:1451-3.
    • (1984) Science , vol.224 , pp. 1451-1453
    • Heikkila, R.E.1    Hess, A.2    Duvoisin, R.C.3
  • 13
    • 0021224694 scopus 로고
    • Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors
    • Heikkila RE, Manzino L, Cabbat FS, Duvoisin RC. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature 1984b;311:467-9.
    • (1984) Nature , vol.311 , pp. 467-469
    • Heikkila, R.E.1    Manzino, L.2    Cabbat, F.S.3    Duvoisin, R.C.4
  • 14
    • 0029665268 scopus 로고    scopus 로고
    • 3H]dihydrorotenone binding to NADH: Ubiquinone reductase (complex I) of the electron transport chain: An autoradiographic study
    • 3H]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study. J Neurosci 1996;16:3807-16.
    • (1996) J Neurosci , vol.16 , pp. 3807-3816
    • Higgins D.S., Jr.1    Greenamyre, J.T.2
  • 15
    • 0019332217 scopus 로고
    • Determination of the mitochondrial protonmotive force in isolated hepatocytes
    • Hoek JB, Nicholls DG, Williamson JR. Determination of the mitochondrial protonmotive force in isolated hepatocytes. J Biol Chem 1980;255:1458-64.
    • (1980) J Biol Chem , vol.255 , pp. 1458-1464
    • Hoek, J.B.1    Nicholls, D.G.2    Williamson, J.R.3
  • 18
    • 0000340348 scopus 로고
    • Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity
    • Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci USA 1985;82:2173-7.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 2173-2177
    • Javitch, J.A.1    D'Amato, R.J.2    Strittmatter, S.M.3    Snyder, S.H.4
  • 19
    • 0026671035 scopus 로고
    • +: Uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA
    • +: uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA. Ann Neurol 1992;32:109-11.
    • (1992) Ann Neurol , vol.32 , pp. 109-111
    • Kitayama, S.1    Shimada, S.2    Uhl, G.R.3
  • 21
    • 0020680904 scopus 로고
    • Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston JW, Ballard P, Tetrud JW, Irwin I. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983;219:979-80.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 22
    • 0033557640 scopus 로고    scopus 로고
    • Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons
    • Lotharius J, Dugan LL, O'Malley KL. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J Neurosci 1999;19:1284-93.
    • (1999) J Neurosci , vol.19 , pp. 1284-1293
    • Lotharius, J.1    Dugan, L.L.2    O'Malley, K.L.3
  • 23
    • 0021137683 scopus 로고
    • Intraneuronal generation of a pyridinium metabolite may cause drug-induced Parkinsonism
    • Markey SP, Johannessen JN, Chiueh CC, Burns RS, Herkenham MA. Intraneuronal generation of a pyridinium metabolite may cause drug-induced Parkinsonism. Nature 1984;311:464-7.
    • (1984) Nature , vol.311 , pp. 464-467
    • Markey, S.P.1    Johannessen, J.N.2    Chiueh, C.C.3    Burns, R.S.4    Herkenham, M.A.5
  • 24
    • 0022388516 scopus 로고
    • Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP
    • Melamed E, Rosenthal J, Cohen O, Globus M, Uzzan A. Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP. Eur J Pharmacol 1985;116:179-81.
    • (1985) Eur J Pharmacol , vol.116 , pp. 179-181
    • Melamed, E.1    Rosenthal, J.2    Cohen, O.3    Globus, M.4    Uzzan, A.5
  • 28
    • 0033934847 scopus 로고    scopus 로고
    • The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: The role of mitochondrial complex I and reactive oxygen species revisited
    • Nakamura K, Bindokas VP, Marks JD, Wright DA, Frim DM, Miller RJ, Kang UJ. The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited. Mol Pharmacol 2000;58:271-8.
    • (2000) Mol Pharmacol , vol.58 , pp. 271-278
    • Nakamura, K.1    Bindokas, V.P.2    Marks, J.D.3    Wright, D.A.4    Frim, D.M.5    Miller, R.J.6    Kang, U.J.7
  • 30
    • 0021810979 scopus 로고
    • Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
    • Nicklas WJ, Vyas I, Heikkila RE. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci 1985;36:2503-8.
    • (1985) Life Sci , vol.36 , pp. 2503-2508
    • Nicklas, W.J.1    Vyas, I.2    Heikkila, R.E.3
  • 32
    • 0027454020 scopus 로고
    • Dopamine transporter expression confers cytotoxicity to low doses of the Parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium
    • Pifl C, Giros B, Caron MG. Dopamine transporter expression confers cytotoxicity to low doses of the Parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium. J Neurosci 1993;13:4246-53.
    • (1993) J Neurosci , vol.13 , pp. 4246-4253
    • Pifl, C.1    Giros, B.2    Caron, M.G.3
  • 33
    • 0026602988 scopus 로고
    • Effects of excitotoxin exposure on metabolic rate of primary hippocampal cultures: Application of silicon microphysiometry to neurobiology
    • Raley-Susman KM, Miller KR, Owicki JC, Sapolsky RM. Effects of excitotoxin exposure on metabolic rate of primary hippocampal cultures: application of silicon microphysiometry to neurobiology. J Neurosci 1992;12:773-80.
    • (1992) J Neurosci , vol.12 , pp. 773-780
    • Raley-Susman, K.M.1    Miller, K.R.2    Owicki, J.C.3    Sapolsky, R.M.4
  • 34
    • 0022516015 scopus 로고
    • Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic Parkinsonism
    • Ramsay RR, Salach JI, Dadgar J, Singer TP. Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic Parkinsonism. Biochem Biophys Res Commun 1986;135:269-75.
    • (1986) Biochem Biophys Res Commun , vol.135 , pp. 269-275
    • Ramsay, R.R.1    Salach, J.I.2    Dadgar, J.3    Singer, T.P.4
  • 35
    • 0026754078 scopus 로고
    • Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: Relationship to the dopamine uptake system and inhibition of mitochondrial respiration
    • Saporito MS, Heikkila RE, Youngster SK, Nicklas WJ, Geller HM. Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration. J Pharmacol Exp Ther 1992;260:1400-9.
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 1400-1409
    • Saporito, M.S.1    Heikkila, R.E.2    Youngster, S.K.3    Nicklas, W.J.4    Geller, H.M.5
  • 37
    • 0026532177 scopus 로고
    • Dopamine transporter mRNA: Dense expression in ventral midbrain neurons
    • Shimada S, Kitayama S, Walther D, Uhl G. Dopamine transporter mRNA: dense expression in ventral midbrain neurons. Ann Neurol 1992;13:359-62.
    • (1992) Ann Neurol , vol.13 , pp. 359-362
    • Shimada, S.1    Kitayama, S.2    Walther, D.3    Uhl, G.4
  • 38
    • 0028129692 scopus 로고
    • The reaction sites of rotenone and ubiquinone with mitochondrial NADH dehydrogenase
    • Singer TP, Ramsay RR. The reaction sites of rotenone and ubiquinone with mitochondrial NADH dehydrogenase. Biochim Biophys Acta 1994;118:192-202.
    • (1994) Biochim Biophys Acta , vol.118 , pp. 192-202
    • Singer, T.P.1    Ramsay, R.R.2
  • 39
    • 0028559817 scopus 로고
    • +-induced hydroxyl radical formation and nigrostriatal MPTP toxicity by inhibiting nitric oxide synthase
    • +-induced hydroxyl radical formation and nigrostriatal MPTP toxicity by inhibiting nitric oxide synthase. Neuroreport 1994;5:2598-600.
    • (1994) Neuroreport , vol.5 , pp. 2598-2600
    • Smith, T.S.1    Swerdlow, R.H.2    Parker W.D., Jr.3    Bennett J.P., Jr.4
  • 41
    • 0030865963 scopus 로고    scopus 로고
    • Cytotoxic effects of MPTP on SH-SY5Y human neuroblastoma cells
    • Song X, Perkins S, Jortner BS, Ehrich M. Cytotoxic effects of MPTP on SH-SY5Y human neuroblastoma cells. Neurotoxicology 1997;18:341-53.
    • (1997) Neurotoxicology , vol.18 , pp. 341-353
    • Song, X.1    Perkins, S.2    Jortner, B.S.3    Ehrich, M.4
  • 42
    • 0026719208 scopus 로고
    • 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism
    • Storey E, Hyman BT, Jenkins B, Brouillet E, Miller JM, Rosen BR, Beal MF. 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism. J Neurochem 1992;58:1975-8.
    • (1992) J Neurochem , vol.58 , pp. 1975-1978
    • Storey, E.1    Hyman, B.T.2    Jenkins, B.3    Brouillet, E.4    Miller, J.M.5    Rosen, B.R.6    Beal, M.F.7
  • 44
    • 0031979752 scopus 로고    scopus 로고
    • Hypothesis: The role of dopaminergic transporters in selective vulnerability of cells in Parkinson's disease
    • Uhl GR. Hypothesis: the role of dopaminergic transporters in selective vulnerability of cells in Parkinson's disease. Ann Neurol 1998;43:555-60.
    • (1998) Ann Neurol , vol.43 , pp. 555-560
    • Uhl, G.R.1
  • 45
    • 0035894881 scopus 로고    scopus 로고
    • Caspase-9 activation results in downstream caspase-8 activation and Bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease
    • Viswanath V, Wu Y, Boonplueang R, Chen S, Stevenson FF, Yantiri F, Yang L, Beal MF, Anderson JK. Caspase-9 activation results in downstream caspase-8 activation and Bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease. J Neurosci 2001;21:9519-28.
    • (2001) J Neurosci , vol.21 , pp. 9519-9528
    • Viswanath, V.1    Wu, Y.2    Boonplueang, R.3    Chen, S.4    Stevenson, F.F.5    Yantiri, F.6    Yang, L.7    Beal, M.F.8    Anderson, J.K.9
  • 46
    • 0022503139 scopus 로고
    • Studies on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Inhibition of NAD-linked substrate oxidation by its metabolite, 1-methyl-4-phenylpyridinium
    • Vyas I, Heikkila RE, Nicklas WJ. Studies on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: inhibition of NAD-linked substrate oxidation by its metabolite, 1-methyl-4-phenylpyridinium. J Neurochem 1986;46:1501-7.
    • (1986) J Neurochem , vol.46 , pp. 1501-1507
    • Vyas, I.1    Heikkila, R.E.2    Nicklas, W.J.3
  • 47
    • 0026752794 scopus 로고
    • MK-801 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in primates
    • Zuddas A, Oberto G, Vaglini F, Fascetti F, Fornai F, Corsini GU. MK-801 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in primates. J Neurochem 1992;59:733-9.
    • (1992) J Neurochem , vol.59 , pp. 733-739
    • Zuddas, A.1    Oberto, G.2    Vaglini, F.3    Fascetti, F.4    Fornai, F.5    Corsini, G.U.6


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