-
1
-
-
0035074475
-
Subthalamic infusion of an NMDA antagonist prevents basal ganglia metabolic changes and nigral degeneration in a rodent model of Parkinson's disease
-
Blandini F, Nappi G, Greenamyre JT. Subthalamic infusion of an NMDA antagonist prevents basal ganglia metabolic changes and nigral degeneration in a rodent model of Parkinson's disease. Ann Neurol 2001;49:525-9.
-
(2001)
Ann Neurol
, vol.49
, pp. 525-529
-
-
Blandini, F.1
Nappi, G.2
Greenamyre, J.T.3
-
2
-
-
0001496694
-
A primate model of Parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
Burns RS, Chiueh CC, Markey SP, Ebert MH, Jacobowitz DM, Kopin IJ. A primate model of Parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA 1983;80:4546-50.
-
(1983)
Proc Natl Acad Sci USA
, vol.80
, pp. 4546-4550
-
-
Burns, R.S.1
Chiueh, C.C.2
Markey, S.P.3
Ebert, M.H.4
Jacobowitz, D.M.5
Kopin, I.J.6
-
4
-
-
0021276089
-
Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase
-
Chiba K, Trevor A, Castagnoli Jr, N. Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Biochem Biophys Res Commun 1984;120:574-8.
-
(1984)
Biochem Biophys Res Commun
, vol.120
, pp. 574-578
-
-
Chiba, K.1
Trevor, A.2
Castagnoli N., Jr.3
-
5
-
-
0035116226
-
+, oxidant and specific neurotoxicants shares the common molecular mechanism
-
+, oxidant and specific neurotoxicants shares the common molecular mechanism. J Neurochem 2001;76:1010-21.
-
(2001)
J Neurochem
, vol.76
, pp. 1010-1021
-
-
Chun, H.S.1
Gibson, G.E.2
DeGiorgio, L.A.3
Zhang, H.4
Kidd, V.J.5
Son, J.H.6
-
6
-
-
0028936065
-
The dopamine transporter: Immunochemical characterization and localization in brain
-
Ciliax BJ, Heilman C, Demchyshyn LL, Pristupa ZB, Ince E, Hersch SM, Niznik HB, Levey AI. The dopamine transporter: immunochemical characterization and localization in brain. J Neurosci 1995;15:1714-23.
-
(1995)
J Neurosci
, vol.15
, pp. 1714-1723
-
-
Ciliax, B.J.1
Heilman, C.2
Demchyshyn, L.L.3
Pristupa, Z.B.4
Ince, E.5
Hersch, S.M.6
Niznik, H.B.7
Levey, A.I.8
-
7
-
-
0026598930
-
Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: Evidence for free radical involvement
-
Cleeter MW, Cooper JM, Schapira AH. Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvement. J Neurochem 1992;58:786-9.
-
(1992)
J Neurochem
, vol.58
, pp. 786-789
-
-
Cleeter, M.W.1
Cooper, J.M.2
Schapira, A.H.3
-
8
-
-
0026464732
-
Uptake and accumulation of 1-methyl-4-phenylpyridinium by rat liver mitochondria measured using an ion-selective electrode
-
Davey GP, Tipton KF, Murphy MP. Uptake and accumulation of 1-methyl-4-phenylpyridinium by rat liver mitochondria measured using an ion-selective electrode. Biochem J 1992;288:439-43.
-
(1992)
Biochem J
, vol.288
, pp. 439-443
-
-
Davey, G.P.1
Tipton, K.F.2
Murphy, M.P.3
-
9
-
-
0030877835
-
Dopamine transporter is required for in vivo MPTP neurotoxicity: Evidence from mice lacking the transporter
-
Gainetdinov RR, Fumagalli F, Jones SR, Caron MG. Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter. J Neurochem 1997;69:1322-5.
-
(1997)
J Neurochem
, vol.69
, pp. 1322-1325
-
-
Gainetdinov, R.R.1
Fumagalli, F.2
Jones, S.R.3
Caron, M.G.4
-
10
-
-
0026648674
-
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
-
Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
-
(1992)
J Cell Biol
, vol.119
, pp. 493-501
-
-
Gavrieli, Y.1
Sherman, Y.2
Ben-Sasson, S.A.3
-
11
-
-
0029844003
-
Inhibition of neuronal nitric oxide synthase prevents MPTP-induced Parkinsonism in baboons
-
Hantraye P, Brouillet E, Ferrante R, Palfi S, Dolan R, Matthews RT, Beal MF. Inhibition of neuronal nitric oxide synthase prevents MPTP-induced Parkinsonism in baboons. Nat Med 1996;2:1017-21.
-
(1996)
Nat Med
, vol.2
, pp. 1017-1021
-
-
Hantraye, P.1
Brouillet, E.2
Ferrante, R.3
Palfi, S.4
Dolan, R.5
Matthews, R.T.6
Beal, M.F.7
-
12
-
-
0021280826
-
Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice
-
Heikkila RE, Hess A, Duvoisin RC. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice. Science 1984a;224:1451-3.
-
(1984)
Science
, vol.224
, pp. 1451-1453
-
-
Heikkila, R.E.1
Hess, A.2
Duvoisin, R.C.3
-
13
-
-
0021224694
-
Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors
-
Heikkila RE, Manzino L, Cabbat FS, Duvoisin RC. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature 1984b;311:467-9.
-
(1984)
Nature
, vol.311
, pp. 467-469
-
-
Heikkila, R.E.1
Manzino, L.2
Cabbat, F.S.3
Duvoisin, R.C.4
-
14
-
-
0029665268
-
3H]dihydrorotenone binding to NADH: Ubiquinone reductase (complex I) of the electron transport chain: An autoradiographic study
-
3H]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study. J Neurosci 1996;16:3807-16.
-
(1996)
J Neurosci
, vol.16
, pp. 3807-3816
-
-
Higgins D.S., Jr.1
Greenamyre, J.T.2
-
15
-
-
0019332217
-
Determination of the mitochondrial protonmotive force in isolated hepatocytes
-
Hoek JB, Nicholls DG, Williamson JR. Determination of the mitochondrial protonmotive force in isolated hepatocytes. J Biol Chem 1980;255:1458-64.
-
(1980)
J Biol Chem
, vol.255
, pp. 1458-1464
-
-
Hoek, J.B.1
Nicholls, D.G.2
Williamson, J.R.3
-
16
-
-
0343844458
-
Nitric oxide synthase and neuronal vulnerability in Parkinson's disease
-
Hunot S, Boissiere F, Faucheux B, Brugg B, Mouatt-Prigent A, Agid Y, Hirsch EC. Nitric oxide synthase and neuronal vulnerability in Parkinson's disease. Neuroscience 1996;72:355-63.
-
(1996)
Neuroscience
, vol.72
, pp. 355-363
-
-
Hunot, S.1
Boissiere, F.2
Faucheux, B.3
Brugg, B.4
Mouatt-Prigent, A.5
Agid, Y.6
Hirsch, E.C.7
-
18
-
-
0000340348
-
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity
-
Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci USA 1985;82:2173-7.
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 2173-2177
-
-
Javitch, J.A.1
D'Amato, R.J.2
Strittmatter, S.M.3
Snyder, S.H.4
-
19
-
-
0026671035
-
+: Uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA
-
+: uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA. Ann Neurol 1992;32:109-11.
-
(1992)
Ann Neurol
, vol.32
, pp. 109-111
-
-
Kitayama, S.1
Shimada, S.2
Uhl, G.R.3
-
21
-
-
0020680904
-
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
-
Langston JW, Ballard P, Tetrud JW, Irwin I. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983;219:979-80.
-
(1983)
Science
, vol.219
, pp. 979-980
-
-
Langston, J.W.1
Ballard, P.2
Tetrud, J.W.3
Irwin, I.4
-
22
-
-
0033557640
-
Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons
-
Lotharius J, Dugan LL, O'Malley KL. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J Neurosci 1999;19:1284-93.
-
(1999)
J Neurosci
, vol.19
, pp. 1284-1293
-
-
Lotharius, J.1
Dugan, L.L.2
O'Malley, K.L.3
-
23
-
-
0021137683
-
Intraneuronal generation of a pyridinium metabolite may cause drug-induced Parkinsonism
-
Markey SP, Johannessen JN, Chiueh CC, Burns RS, Herkenham MA. Intraneuronal generation of a pyridinium metabolite may cause drug-induced Parkinsonism. Nature 1984;311:464-7.
-
(1984)
Nature
, vol.311
, pp. 464-467
-
-
Markey, S.P.1
Johannessen, J.N.2
Chiueh, C.C.3
Burns, R.S.4
Herkenham, M.A.5
-
24
-
-
0022388516
-
Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP
-
Melamed E, Rosenthal J, Cohen O, Globus M, Uzzan A. Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP. Eur J Pharmacol 1985;116:179-81.
-
(1985)
Eur J Pharmacol
, vol.116
, pp. 179-181
-
-
Melamed, E.1
Rosenthal, J.2
Cohen, O.3
Globus, M.4
Uzzan, A.5
-
25
-
-
0030929663
-
Immunochemical analysis of dopamine transporter protein in Parkinson's disease
-
Miller GW, Staley JK, Heilman CJ, Perez JT, Mash DC, Rye DB, Levey AI. Immunochemical analysis of dopamine transporter protein in Parkinson's disease. Ann Neurol 1997;41:530-9.
-
(1997)
Ann Neurol
, vol.41
, pp. 530-539
-
-
Miller, G.W.1
Staley, J.K.2
Heilman, C.J.3
Perez, J.T.4
Mash, D.C.5
Rye, D.B.6
Levey, A.I.7
-
28
-
-
0033934847
-
The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: The role of mitochondrial complex I and reactive oxygen species revisited
-
Nakamura K, Bindokas VP, Marks JD, Wright DA, Frim DM, Miller RJ, Kang UJ. The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited. Mol Pharmacol 2000;58:271-8.
-
(2000)
Mol Pharmacol
, vol.58
, pp. 271-278
-
-
Nakamura, K.1
Bindokas, V.P.2
Marks, J.D.3
Wright, D.A.4
Frim, D.M.5
Miller, R.J.6
Kang, U.J.7
-
30
-
-
0021810979
-
Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
-
Nicklas WJ, Vyas I, Heikkila RE. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci 1985;36:2503-8.
-
(1985)
Life Sci
, vol.36
, pp. 2503-2508
-
-
Nicklas, W.J.1
Vyas, I.2
Heikkila, R.E.3
-
31
-
-
0028276628
-
The light-addressable potentiometric sensor: Principles and biological applications
-
Owicki JC, Bousse LJ, Hafeman DG, Kirk GL, Olson JD, Wada HG, Parce JW. The light-addressable potentiometric sensor: principles and biological applications. Annu Rev Biophys Biomol Struct 1994;23:87-113.
-
(1994)
Annu Rev Biophys Biomol Struct
, vol.23
, pp. 87-113
-
-
Owicki, J.C.1
Bousse, L.J.2
Hafeman, D.G.3
Kirk, G.L.4
Olson, J.D.5
Wada, H.G.6
Parce, J.W.7
-
32
-
-
0027454020
-
Dopamine transporter expression confers cytotoxicity to low doses of the Parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium
-
Pifl C, Giros B, Caron MG. Dopamine transporter expression confers cytotoxicity to low doses of the Parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium. J Neurosci 1993;13:4246-53.
-
(1993)
J Neurosci
, vol.13
, pp. 4246-4253
-
-
Pifl, C.1
Giros, B.2
Caron, M.G.3
-
33
-
-
0026602988
-
Effects of excitotoxin exposure on metabolic rate of primary hippocampal cultures: Application of silicon microphysiometry to neurobiology
-
Raley-Susman KM, Miller KR, Owicki JC, Sapolsky RM. Effects of excitotoxin exposure on metabolic rate of primary hippocampal cultures: application of silicon microphysiometry to neurobiology. J Neurosci 1992;12:773-80.
-
(1992)
J Neurosci
, vol.12
, pp. 773-780
-
-
Raley-Susman, K.M.1
Miller, K.R.2
Owicki, J.C.3
Sapolsky, R.M.4
-
34
-
-
0022516015
-
Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic Parkinsonism
-
Ramsay RR, Salach JI, Dadgar J, Singer TP. Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic Parkinsonism. Biochem Biophys Res Commun 1986;135:269-75.
-
(1986)
Biochem Biophys Res Commun
, vol.135
, pp. 269-275
-
-
Ramsay, R.R.1
Salach, J.I.2
Dadgar, J.3
Singer, T.P.4
-
35
-
-
0026754078
-
Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: Relationship to the dopamine uptake system and inhibition of mitochondrial respiration
-
Saporito MS, Heikkila RE, Youngster SK, Nicklas WJ, Geller HM. Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration. J Pharmacol Exp Ther 1992;260:1400-9.
-
(1992)
J Pharmacol Exp Ther
, vol.260
, pp. 1400-1409
-
-
Saporito, M.S.1
Heikkila, R.E.2
Youngster, S.K.3
Nicklas, W.J.4
Geller, H.M.5
-
36
-
-
0003332720
-
An in vitro model of Parkinson's disease: Chronic complex I inhibition
-
Sherer TB, Betarbet R, Lund S, Kuwajima M, Greenamyre JT. An in vitro model of Parkinson's disease: chronic complex I inhibition. Soc Neurosci Abst 2000;26:241-80.
-
(2000)
Soc Neurosci Abst
, vol.26
, pp. 241-280
-
-
Sherer, T.B.1
Betarbet, R.2
Lund, S.3
Kuwajima, M.4
Greenamyre, J.T.5
-
37
-
-
0026532177
-
Dopamine transporter mRNA: Dense expression in ventral midbrain neurons
-
Shimada S, Kitayama S, Walther D, Uhl G. Dopamine transporter mRNA: dense expression in ventral midbrain neurons. Ann Neurol 1992;13:359-62.
-
(1992)
Ann Neurol
, vol.13
, pp. 359-362
-
-
Shimada, S.1
Kitayama, S.2
Walther, D.3
Uhl, G.4
-
38
-
-
0028129692
-
The reaction sites of rotenone and ubiquinone with mitochondrial NADH dehydrogenase
-
Singer TP, Ramsay RR. The reaction sites of rotenone and ubiquinone with mitochondrial NADH dehydrogenase. Biochim Biophys Acta 1994;118:192-202.
-
(1994)
Biochim Biophys Acta
, vol.118
, pp. 192-202
-
-
Singer, T.P.1
Ramsay, R.R.2
-
40
-
-
0033542739
-
+ inhibits proliferation of PC12 cells by a p21(WAF1/Cip1)-dependent pathway and induces cell death in cells lacking p21(WAF1/Cip1)
-
+ inhibits proliferation of PC12 cells by a p21(WAF1/Cip1)-dependent pathway and induces cell death in cells lacking p21(WAF1/Cip1). Exp Cell Res 1999;250:75-85.
-
(1999)
Exp Cell Res
, vol.250
, pp. 75-85
-
-
Soldner, F.1
Weller, M.2
Haid, S.3
Beinroth, S.4
Miller, S.W.5
Wullner, U.6
Davis, R.E.7
Dichgans, J.8
Klockgether, T.9
Schulz, J.B.10
-
41
-
-
0030865963
-
Cytotoxic effects of MPTP on SH-SY5Y human neuroblastoma cells
-
Song X, Perkins S, Jortner BS, Ehrich M. Cytotoxic effects of MPTP on SH-SY5Y human neuroblastoma cells. Neurotoxicology 1997;18:341-53.
-
(1997)
Neurotoxicology
, vol.18
, pp. 341-353
-
-
Song, X.1
Perkins, S.2
Jortner, B.S.3
Ehrich, M.4
-
42
-
-
0026719208
-
1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism
-
Storey E, Hyman BT, Jenkins B, Brouillet E, Miller JM, Rosen BR, Beal MF. 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism. J Neurochem 1992;58:1975-8.
-
(1992)
J Neurochem
, vol.58
, pp. 1975-1978
-
-
Storey, E.1
Hyman, B.T.2
Jenkins, B.3
Brouillet, E.4
Miller, J.M.5
Rosen, B.R.6
Beal, M.F.7
-
44
-
-
0031979752
-
Hypothesis: The role of dopaminergic transporters in selective vulnerability of cells in Parkinson's disease
-
Uhl GR. Hypothesis: the role of dopaminergic transporters in selective vulnerability of cells in Parkinson's disease. Ann Neurol 1998;43:555-60.
-
(1998)
Ann Neurol
, vol.43
, pp. 555-560
-
-
Uhl, G.R.1
-
45
-
-
0035894881
-
Caspase-9 activation results in downstream caspase-8 activation and Bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease
-
Viswanath V, Wu Y, Boonplueang R, Chen S, Stevenson FF, Yantiri F, Yang L, Beal MF, Anderson JK. Caspase-9 activation results in downstream caspase-8 activation and Bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease. J Neurosci 2001;21:9519-28.
-
(2001)
J Neurosci
, vol.21
, pp. 9519-9528
-
-
Viswanath, V.1
Wu, Y.2
Boonplueang, R.3
Chen, S.4
Stevenson, F.F.5
Yantiri, F.6
Yang, L.7
Beal, M.F.8
Anderson, J.K.9
-
46
-
-
0022503139
-
Studies on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Inhibition of NAD-linked substrate oxidation by its metabolite, 1-methyl-4-phenylpyridinium
-
Vyas I, Heikkila RE, Nicklas WJ. Studies on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: inhibition of NAD-linked substrate oxidation by its metabolite, 1-methyl-4-phenylpyridinium. J Neurochem 1986;46:1501-7.
-
(1986)
J Neurochem
, vol.46
, pp. 1501-1507
-
-
Vyas, I.1
Heikkila, R.E.2
Nicklas, W.J.3
-
47
-
-
0026752794
-
MK-801 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in primates
-
Zuddas A, Oberto G, Vaglini F, Fascetti F, Fornai F, Corsini GU. MK-801 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in primates. J Neurochem 1992;59:733-9.
-
(1992)
J Neurochem
, vol.59
, pp. 733-739
-
-
Zuddas, A.1
Oberto, G.2
Vaglini, F.3
Fascetti, F.4
Fornai, F.5
Corsini, G.U.6
|