Activation of nuclear factor-κB transcriptional activity in airway epithelial cells by thioredoxin but not by N-acetyl-cysteine and glutathione

American Journal of Respiratory Cell and Molecular Biology

Volumn 25, Issue 2, 2001, Pages 178-185

  Harper, R ^a   Wu, K ^a   Chang, M M J ^a   Yoneda, K ^a   Pan, R ^a   Reddy, S P M ^a   Wu, R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CELL IMMORTALIZATION; CELL LINE; CONCENTRATION (PARAMETERS); EPITHELIUM CELL; GENETIC REGULATION; GENETIC TRANSCRIPTION; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OXIDATION REDUCTION REACTION; PROTEIN LOCALIZATION; REPORTER GENE; THIOREDOXIN; TRANSACTIVATION; TUMOR NECROSIS FACTOR ALPHA;

EID: 0034864796     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.25.2.4471     Document Type: Article

References (47)

1. Interactions of oxygen radicals with airway epithelium
2. Free radicals in disease processes: A compilation of cause and consequence
3. NF-kappa B activation by ultraviolet light not dependent on a nuclear signal
4. Redox regulation of cellular signalling
5. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1
6. Radical ideas: Genetic responses to oxidative stress
7. Oxygen radicals and signaling
8. Antioxidant and redox regulation of gene transcription
9. Oxidants, antioxidants, and respiratory tract lining fluids
10. Multiple nuclear factors interact with the immunoglobulin enhancer sequences
11. Structure, regulation and function of NF-kappa B
12. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B
13. Tumor necrosis factor beta (TNF-beta) induces binding of the NF-kappa B transcription factor to a high-affinity kappa B element in the TNF-beta promoter
14. Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappa B: TNF alpha is not needed for induction of a biological effect via TNF receptors
15. NF-kappa B - Ten years after
16. The NF-kappa-B and I-kappa-B proteins - New discoveries and insights
17. Oxidoreductive regulation of nuclear factor kappa B: Involvement of a cellular reducing catalyst thioredoxin
18. Functions of glutathione and glutathione disulfide in immunology and immunopathology
19. Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type I by thiol redox control mechanism
20. Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B
21. Activation of NF-kappa B and elevation of MnSOD gene expression by thiol reducing agents in lung adenocarcinoma (A549) cells
22. Albumin-mediated regulation of cellular glutathione and nuclear factor kappa B activation
23. Clara cell specific protein (CC16) expression after acute lung inflammation induced by intratracheal lipopolysaccharide administration
24. Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution
25. Thioredoxin and glutaredoxin systems
26. Transcriptional regulation of glutaredoxin and thioredoxin pathways and related enzymes in response to oxidative stress
27. Effects of thioredoxin on activation of transcription factor NF-kappa B
28. Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus
29. A novel mechanism of retinoic acid-enhanced interleukin-8 gene expression in airway epithelium
30. Growth and differentiation of conducting airway epithelial cells in culture
31. Papilloma virus immortalized tracheal epithelial cells retain a well-differentiated phenotype
32. Expression of human squamous cell differentiation marker, SPR1, in tracheobronchial epithelium depends on JUN and TRE motifs
33. Thioredoxin gene expression is transcriptionally up-regulated by retinol in monkey conducting airway epithelial cells
34. Paclitaxel up-regulates interleukin-8 synthesis in human lung carcinoma through an NF-kappa B- and AP-l-dependent mechanism
35. Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (Re1A) and NF-IL-6
36. Novel mechanism of glucocorticoid-mediated gene repression: Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression
37. Molecular mechanism of interleukin-8 gene expression
38. Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity
39. Regulation of gene expression by reactive oxygen
40. Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62
41. N-terminal DNA-binding domains contribute to differential DNA-binding specificities of NF-kappa B p50 and p65
42. Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-kappa B in vitro
43. The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein
44. Generation of superoxide free radical during the autoxidation of thiols
45. Distinct roles of thioredoxin in the cytoplasm and in the nucleus - A two-step mechanism of redox regulation of transcription factor NF-kappa B
46. Nucleoredoxin, glutaredoxin, and thioredoxin differentially regulate NF-kappa B, AP-1, and CREB activation in HEK293 cells