-
2
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza G.L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3 (2003) 721-732
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
3
-
-
4644370374
-
Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications
-
Brahimi-Horn C., Mazure N., and Pouyssegur J. Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications. Cell Signal 17 (2005) 1-9
-
(2005)
Cell Signal
, vol.17
, pp. 1-9
-
-
Brahimi-Horn, C.1
Mazure, N.2
Pouyssegur, J.3
-
4
-
-
0142182783
-
The von Hippel-Lindau gene, kidney cancer, and oxygen sensing
-
Kaelin Jr. W.G. The von Hippel-Lindau gene, kidney cancer, and oxygen sensing. J Am Soc Nephrol 14 (2003) 2703-2711
-
(2003)
J Am Soc Nephrol
, vol.14
, pp. 2703-2711
-
-
Kaelin Jr., W.G.1
-
6
-
-
2942731503
-
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia
-
Nakayama K., Frew I.J., Hagensen M., Skals M., Habelhah H., Bhoumik A., et al. Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell 117 (2004) 941-952
-
(2004)
Cell
, vol.117
, pp. 941-952
-
-
Nakayama, K.1
Frew, I.J.2
Hagensen, M.3
Skals, M.4
Habelhah, H.5
Bhoumik, A.6
-
7
-
-
28544446058
-
Mitochondrial tumor suppressors: Genetic and Biochemical update
-
Gottlieb E., and Tomlinson I. Mitochondrial tumor suppressors: Genetic and Biochemical update. Nat Rev Cancer 5 (2005) 857-866
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 857-866
-
-
Gottlieb, E.1
Tomlinson, I.2
-
8
-
-
24744460523
-
Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF
-
Bilton R., Mazure N., Trottier E., Hattab M., Dery M.A., Richard D.E., et al. Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF. J Biol Chem 280 (2005) 31132-31140
-
(2005)
J Biol Chem
, vol.280
, pp. 31132-31140
-
-
Bilton, R.1
Mazure, N.2
Trottier, E.3
Hattab, M.4
Dery, M.A.5
Richard, D.E.6
-
10
-
-
33750622643
-
Redox regulation of the hypoxia-inducible factor
-
Pouysségur J., and Mechta-Grigoriou F. Redox regulation of the hypoxia-inducible factor. Biol Chem 387 (2006) 1337-1346
-
(2006)
Biol Chem
, vol.387
, pp. 1337-1346
-
-
Pouysségur, J.1
Mechta-Grigoriou, F.2
-
11
-
-
11244315697
-
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
-
Manalo D.J., Rowan A., Lavoie T., Natarajan L., Kelly B.D., Ye S.Q., et al. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105 (2005) 659-669
-
(2005)
Blood
, vol.105
, pp. 659-669
-
-
Manalo, D.J.1
Rowan, A.2
Lavoie, T.3
Natarajan, L.4
Kelly, B.D.5
Ye, S.Q.6
-
12
-
-
0037515549
-
MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300
-
Sang N., Stiehl D.P., Bohensky J., Leshchinsky I., Srinivas V., and Caro J. MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300. J Biol Chem 278 (2003) 14013-14019
-
(2003)
J Biol Chem
, vol.278
, pp. 14013-14019
-
-
Sang, N.1
Stiehl, D.P.2
Bohensky, J.3
Leshchinsky, I.4
Srinivas, V.5
Caro, J.6
-
13
-
-
10444223878
-
The hypoxia-inducible factor and tumor progression along the angiogenic pathway
-
Brahimi-Horn M.C., and Pouyssegur J. The hypoxia-inducible factor and tumor progression along the angiogenic pathway. Int Rev Cytol 242 (2005) 157-213
-
(2005)
Int Rev Cytol
, vol.242
, pp. 157-213
-
-
Brahimi-Horn, M.C.1
Pouyssegur, J.2
-
14
-
-
0037837724
-
Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex
-
Maynard M.A., Qi H., Chung J., Lee E.H., Kondo Y., Hara S., et al. Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex. J Biol Chem 278 (2003) 11032-11040
-
(2003)
J Biol Chem
, vol.278
, pp. 11032-11040
-
-
Maynard, M.A.1
Qi, H.2
Chung, J.3
Lee, E.H.4
Kondo, Y.5
Hara, S.6
-
15
-
-
0035969508
-
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
-
Makino Y., Cao R., Svensson K., Bertilsson G., Asman M., Tanaka H., et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 414 (2001) 550-554
-
(2001)
Nature
, vol.414
, pp. 550-554
-
-
Makino, Y.1
Cao, R.2
Svensson, K.3
Bertilsson, G.4
Asman, M.5
Tanaka, H.6
-
16
-
-
33646764243
-
Hypoxia-inducible factors, hypoxia, and tumor angiogenesis
-
Gruber M., and Simon M.C. Hypoxia-inducible factors, hypoxia, and tumor angiogenesis. Curr Opin Hematol 13 (2006) 169-174
-
(2006)
Curr Opin Hematol
, vol.13
, pp. 169-174
-
-
Gruber, M.1
Simon, M.C.2
-
17
-
-
0034671307
-
Hypoxia-inducible expression of tumor-associated carbonic anhydrases
-
Wykoff C.C., Beasley N.J., Watson P.H., Turner K.J., Pastorek J., Sibtain A., et al. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 60 (2000) 7075-7083
-
(2000)
Cancer Res
, vol.60
, pp. 7075-7083
-
-
Wykoff, C.C.1
Beasley, N.J.2
Watson, P.H.3
Turner, K.J.4
Pastorek, J.5
Sibtain, A.6
-
18
-
-
4644237401
-
Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors
-
Aprelikova O., Chandramouli G.V., Wood M., Vasselli J.R., Riss J., Maranchie J.K., et al. Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors. J Cell Biochem 92 (2004) 491-501
-
(2004)
J Cell Biochem
, vol.92
, pp. 491-501
-
-
Aprelikova, O.1
Chandramouli, G.V.2
Wood, M.3
Vasselli, J.R.4
Riss, J.5
Maranchie, J.K.6
-
19
-
-
33645735151
-
The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha
-
Dayan F., Roux D., Brahimi-Horn M.C., Pouyssegur J., and Mazure N.M. The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha. Cancer Res 66 (2006) 3688-3698
-
(2006)
Cancer Res
, vol.66
, pp. 3688-3698
-
-
Dayan, F.1
Roux, D.2
Brahimi-Horn, M.C.3
Pouyssegur, J.4
Mazure, N.M.5
-
20
-
-
0037335034
-
How the ubiquitin-proteasome system controls transcription
-
Muratani M., and Tansey W.P. How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol 4 (2003) 192-201
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 192-201
-
-
Muratani, M.1
Tansey, W.P.2
-
21
-
-
1642315195
-
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
-
Koivunen P., Hirsila M., Gunzler V., Kivirikko K.I., and Myllyharju J. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J Biol Chem 279 (2004) 9899-9904
-
(2004)
J Biol Chem
, vol.279
, pp. 9899-9904
-
-
Koivunen, P.1
Hirsila, M.2
Gunzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
22
-
-
5644240828
-
Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (HIF) in regulating HIF transcriptional target genes
-
Stolze I.P., Tian Y.M., Appelhoff R.J., Turley H., Wykoff C.C., Gleadle J.M., et al. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (HIF) in regulating HIF transcriptional target genes. J Biol Chem 279 (2004) 42719-42725
-
(2004)
J Biol Chem
, vol.279
, pp. 42719-42725
-
-
Stolze, I.P.1
Tian, Y.M.2
Appelhoff, R.J.3
Turley, H.4
Wykoff, C.C.5
Gleadle, J.M.6
-
23
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
Pouyssegur J., Dayan F., and Mazure N.M. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441 (2006) 437-443
-
(2006)
Nature
, vol.441
, pp. 437-443
-
-
Pouyssegur, J.1
Dayan, F.2
Mazure, N.M.3
-
24
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby R.A., and Gillies R.J. Why do cancers have high aerobic glycolysis?. Nat Rev Cancer 4 (2004) 891-899
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
25
-
-
33745149291
-
p53 regulates mitochondrial respiration
-
Matoba S., Kang J.G., Patino W.D., Wragg A., Boehm M., Gavrilova O., et al. p53 regulates mitochondrial respiration. Science 312 (2006) 1650-1653
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
-
26
-
-
33744783432
-
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
-
Fantin V.R., St-Pierre J., and Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 9 (2006) 425-434
-
(2006)
Cancer Cell
, vol.9
, pp. 425-434
-
-
Fantin, V.R.1
St-Pierre, J.2
Leder, P.3
-
27
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
-
Kim J.W., Tchernyshyov I., Semenza G.L., and Dang C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3 (2006) 177-185
-
(2006)
Cell Metab
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
28
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I., Cairns R.A., Fontana L., Lim A.L., and Denko N.C. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 3 (2006) 187-197
-
(2006)
Cell Metab
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
29
-
-
0040735606
-
The expanding family of eucaryotic Na(+)/H(+) exchangers
-
Counillon L., and Pouyssegur J. The expanding family of eucaryotic Na(+)/H(+) exchangers. J Biol Chem 275 (2000) 1-4
-
(2000)
J Biol Chem
, vol.275
, pp. 1-4
-
-
Counillon, L.1
Pouyssegur, J.2
-
30
-
-
2542601328
-
Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target
-
Potter C., and Harris A.L. Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target. Cell Cycle 3 (2004) 164-167
-
(2004)
Cell Cycle
, vol.3
, pp. 164-167
-
-
Potter, C.1
Harris, A.L.2
-
31
-
-
0035237389
-
-
Pouyssegur J, Franchi A, Pages G, pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth. In: Novartis Found Symp2001: John Wiley & Sons, Ltd. p. 186-96.
-
-
-
-
33
-
-
33646917296
-
The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha dependent mechansm
-
Ullah M.S., Davies A.J., and Halestrap A.P. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha dependent mechansm. J Biol Chem 281 (2006) 9030-9037
-
(2006)
J Biol Chem
, vol.281
, pp. 9030-9037
-
-
Ullah, M.S.1
Davies, A.J.2
Halestrap, A.P.3
-
34
-
-
25844528025
-
The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis
-
Cardone R.A., Casavola V., and Reshkin S.J. The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis. Nat Rev Cancer 5 (2005) 786-795
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 786-795
-
-
Cardone, R.A.1
Casavola, V.2
Reshkin, S.J.3
-
35
-
-
23144467910
-
An expanding role for mTOR in cancer
-
Guertin D.A., and Sabatini D.M. An expanding role for mTOR in cancer. Trends Mol Med 11 (2005) 353-361
-
(2005)
Trends Mol Med
, vol.11
, pp. 353-361
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
36
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
Brugarolas J., Lei K., Hurley R.L., Manning B.D., Reiling J.H., Hafen E., et al. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 18 (2004) 2893-2904
-
(2004)
Genes Dev
, vol.18
, pp. 2893-2904
-
-
Brugarolas, J.1
Lei, K.2
Hurley, R.L.3
Manning, B.D.4
Reiling, J.H.5
Hafen, E.6
-
37
-
-
0041920901
-
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
-
Brugarolas J.B., Vazquez F., Reddy A., Sellers W.R., and Kaelin Jr. W.G. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell 4 (2003) 147-158
-
(2003)
Cancer Cell
, vol.4
, pp. 147-158
-
-
Brugarolas, J.B.1
Vazquez, F.2
Reddy, A.3
Sellers, W.R.4
Kaelin Jr., W.G.5
-
38
-
-
12344287138
-
Transcriptional regulation of the vascular endothelial growth factor gene-a concert of activating factors
-
Pages G., and Pouyssegur J. Transcriptional regulation of the vascular endothelial growth factor gene-a concert of activating factors. Cardiovasc Res 65 (2005) 564-573
-
(2005)
Cardiovasc Res
, vol.65
, pp. 564-573
-
-
Pages, G.1
Pouyssegur, J.2
-
39
-
-
25444440875
-
The role of autophagy in cancer development and response to therapy
-
Kondo Y., Kanzawa T., Sawaya R., and Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5 (2005) 726-734
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 726-734
-
-
Kondo, Y.1
Kanzawa, T.2
Sawaya, R.3
Kondo, S.4
-
40
-
-
4944246547
-
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis
-
Greijer A.E., and van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 57 (2004) 1009-1014
-
(2004)
J Clin Pathol
, vol.57
, pp. 1009-1014
-
-
Greijer, A.E.1
van der Wall, E.2
-
41
-
-
3142588858
-
Lactate: mirror and motor of tumor malignancy
-
Walenta S., and Mueller-Klieser W.F. Lactate: mirror and motor of tumor malignancy. Semin Radiat Oncol 14 (2004) 267-274
-
(2004)
Semin Radiat Oncol
, vol.14
, pp. 267-274
-
-
Walenta, S.1
Mueller-Klieser, W.F.2
-
42
-
-
33645748171
-
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor
-
Esteban M.A., Tran M.G., Harten S.K., Hill P., Castellanos M.C., Chandra A., et al. Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Cancer Res 66 (2006) 3567-3575
-
(2006)
Cancer Res
, vol.66
, pp. 3567-3575
-
-
Esteban, M.A.1
Tran, M.G.2
Harten, S.K.3
Hill, P.4
Castellanos, M.C.5
Chandra, A.6
-
43
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
Ferrara N., and Kerbel R.S. Angiogenesis as a therapeutic target. Nature 438 (2005) 967-974
-
(2005)
Nature
, vol.438
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
44
-
-
33749362031
-
Inhibiting hypoxia-inducible factor 1 for cancer therapy
-
Melillo G. Inhibiting hypoxia-inducible factor 1 for cancer therapy. Mol Cancer Res 4 (2006) 601-605
-
(2006)
Mol Cancer Res
, vol.4
, pp. 601-605
-
-
Melillo, G.1
-
45
-
-
3843079885
-
An unexpected role for hypoxic response: oxygenation and inflammation
-
Peyssonaux C., and Johnson R.S. An unexpected role for hypoxic response: oxygenation and inflammation. Cell Cycle 3 (2004) 168-171
-
(2004)
Cell Cycle
, vol.3
, pp. 168-171
-
-
Peyssonaux, C.1
Johnson, R.S.2
-
46
-
-
0037478437
-
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
-
Pennacchietti S., Michieli P., Galluzzo M., Mazzone M., Giordano S., and Comoglio P.M. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 3 (2003) 347-361
-
(2003)
Cancer Cell
, vol.3
, pp. 347-361
-
-
Pennacchietti, S.1
Michieli, P.2
Galluzzo, M.3
Mazzone, M.4
Giordano, S.5
Comoglio, P.M.6
-
47
-
-
33745926802
-
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis
-
Tam B.Y., Wei K., Rudge J.S., Hoffman J., Holash J., Park S.K., et al. VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nat Med 12 (2006) 793-800
-
(2006)
Nat Med
, vol.12
, pp. 793-800
-
-
Tam, B.Y.1
Wei, K.2
Rudge, J.S.3
Hoffman, J.4
Holash, J.5
Park, S.K.6
-
49
-
-
4043119692
-
The HIF pathway as a therapeutic target
-
Hewitson K.S., and Schofield C.J. The HIF pathway as a therapeutic target. Drug Discov Today 9 (2004) 704-711
-
(2004)
Drug Discov Today
, vol.9
, pp. 704-711
-
-
Hewitson, K.S.1
Schofield, C.J.2
-
50
-
-
2642515744
-
HIF at the crossroads between ischemia and carcinogenesis
-
Paul S.A., Simons J.W., and Mabjeesh N.J. HIF at the crossroads between ischemia and carcinogenesis. J Cell Physiol 200 (2004) 20-30
-
(2004)
J Cell Physiol
, vol.200
, pp. 20-30
-
-
Paul, S.A.1
Simons, J.W.2
Mabjeesh, N.J.3
-
51
-
-
1242271198
-
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications
-
Rapisarda A., Uranchimeg B., Sordet O., Pommier Y., Shoemaker R.H., and Melillo G. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res 64 (2004) 1475-1482
-
(2004)
Cancer Res
, vol.64
, pp. 1475-1482
-
-
Rapisarda, A.1
Uranchimeg, B.2
Sordet, O.3
Pommier, Y.4
Shoemaker, R.H.5
Melillo, G.6
-
52
-
-
33749005405
-
Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors
-
Shaked Y., Ciarrocchi A., Franco M., Lee C.R., Man S., Cheung A.M., et al. Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 313 (2006) 1785-1787
-
(2006)
Science
, vol.313
, pp. 1785-1787
-
-
Shaked, Y.1
Ciarrocchi, A.2
Franco, M.3
Lee, C.R.4
Man, S.5
Cheung, A.M.6
-
53
-
-
23144456813
-
Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system
-
Sengupta S., Eavarone D., Capila I., Zhao G., Watson N., Kiziltepe T., et al. Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. Nature 436 (2005) 568-572
-
(2005)
Nature
, vol.436
, pp. 568-572
-
-
Sengupta, S.1
Eavarone, D.2
Capila, I.3
Zhao, G.4
Watson, N.5
Kiziltepe, T.6
|