-
1
-
-
4644370374
-
Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications
-
Brahimi-Horn C., et al. Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications. Cell. Signal. 17 (2005) 1-9
-
(2005)
Cell. Signal.
, vol.17
, pp. 1-9
-
-
Brahimi-Horn, C.1
-
2
-
-
0038037735
-
Regulation of angiogenesis by hypoxia: role of the HIF system
-
Pugh C.W., and Ratcliffe P.J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med. 9 (2003) 677-684
-
(2003)
Nat. Med.
, vol.9
, pp. 677-684
-
-
Pugh, C.W.1
Ratcliffe, P.J.2
-
3
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3 (2003) 721-732
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
4
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
Pouyssegur J., et al. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441 (2006) 437-443
-
(2006)
Nature
, vol.441
, pp. 437-443
-
-
Pouyssegur, J.1
-
6
-
-
18744375998
-
Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation
-
Jeong J.W., et al. Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Cell 111 (2002) 709-720
-
(2002)
Cell
, vol.111
, pp. 709-720
-
-
Jeong, J.W.1
-
7
-
-
0033837634
-
Regulation of gene expression by transcription factor acetylation
-
Bannister A.J., and Miska E.A. Regulation of gene expression by transcription factor acetylation. Cell. Mol. Life Sci. 57 (2000) 1184-1192
-
(2000)
Cell. Mol. Life Sci.
, vol.57
, pp. 1184-1192
-
-
Bannister, A.J.1
Miska, E.A.2
-
8
-
-
0041848257
-
Composition and function of the eukaryotic N-terminal acetyltransferase subunits
-
Polevoda B., and Sherman F. Composition and function of the eukaryotic N-terminal acetyltransferase subunits. Biochem. Biophys. Res. Commun. 308 (2003) 1-11
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.308
, pp. 1-11
-
-
Polevoda, B.1
Sherman, F.2
-
9
-
-
0023426588
-
The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus
-
Whiteway M., et al. The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus. Mol. Cell. Biol. 7 (1987) 3713-3722
-
(1987)
Mol. Cell. Biol.
, vol.7
, pp. 3713-3722
-
-
Whiteway, M.1
-
10
-
-
0022407123
-
The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways
-
Whiteway M., and Szostak J.W. The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways. Cell 43 (1985) 483-492
-
(1985)
Cell
, vol.43
, pp. 483-492
-
-
Whiteway, M.1
Szostak, J.W.2
-
11
-
-
0141640821
-
The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides
-
Gautschi M., et al. The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides. Mol. Cell. Biol. 23 (2003) 7403-7414
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 7403-7414
-
-
Gautschi, M.1
-
12
-
-
0034494265
-
Genetic manipulation indicates that ARD1 is an essential N(infinity)-acetyltransferase in Trypanosoma brucei
-
Ingram A.K., et al. Genetic manipulation indicates that ARD1 is an essential N(infinity)-acetyltransferase in Trypanosoma brucei. Mol. Biochem. Parasitol. 111 (2000) 309-317
-
(2000)
Mol. Biochem. Parasitol.
, vol.111
, pp. 309-317
-
-
Ingram, A.K.1
-
13
-
-
0344663967
-
Two putative acetyltransferases, san and deco, are required for establishing sister chromatid cohesion in Drosophila
-
Williams B.C., et al. Two putative acetyltransferases, san and deco, are required for establishing sister chromatid cohesion in Drosophila. Curr. Biol. 13 (2003) 2025-2036
-
(2003)
Curr. Biol.
, vol.13
, pp. 2025-2036
-
-
Williams, B.C.1
-
14
-
-
15944413192
-
Identification and characterization of the human ARD1-NATH protein acetyltransferase complex
-
Arnesen T., et al. Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. Biochem. J. 386 (2005) 433-443
-
(2005)
Biochem. J.
, vol.386
, pp. 433-443
-
-
Arnesen, T.1
-
15
-
-
33744971921
-
Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex
-
Arnesen T., et al. Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex. Oncogene 25 (2006) 4350-4360
-
(2006)
Oncogene
, vol.25
, pp. 4350-4360
-
-
Arnesen, T.1
-
16
-
-
20544431636
-
Analysis of ARD1 function in hypoxia response using retroviral RNA interference
-
Fisher T.S., et al. Analysis of ARD1 function in hypoxia response using retroviral RNA interference. J. Biol. Chem. 280 (2005) 17749-17757
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17749-17757
-
-
Fisher, T.S.1
-
17
-
-
33744979048
-
Characterization of hARD2, a processed hARD1 gene duplicate encoding a human protein N-alpha-acetyltransferase
-
Arnesen T., et al. Characterization of hARD2, a processed hARD1 gene duplicate encoding a human protein N-alpha-acetyltransferase. BMC Biochem. 7 (2006) 13
-
(2006)
BMC Biochem.
, vol.7
, pp. 13
-
-
Arnesen, T.1
-
18
-
-
0028222543
-
Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae
-
Tribioli C., et al. Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae. Hum. Mol. Genet. 3 (1994) 1061-1067
-
(1994)
Hum. Mol. Genet.
, vol.3
, pp. 1061-1067
-
-
Tribioli, C.1
-
19
-
-
29644438345
-
Characterization of ARD1 variants in mammalian cells
-
Kim S.H., et al. Characterization of ARD1 variants in mammalian cells. Biochem. Biophys. Res. Commun. 340 (2006) 422-427
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.340
, pp. 422-427
-
-
Kim, S.H.1
-
20
-
-
33746491112
-
Characterization of the native and fibrillar conformation of the human Nalpha-acetyltransferase ARD1
-
Sanchez-Puig N., and Fersht A.R. Characterization of the native and fibrillar conformation of the human Nalpha-acetyltransferase ARD1. Protein Sci. 15 (2006) 1968-1976
-
(2006)
Protein Sci.
, vol.15
, pp. 1968-1976
-
-
Sanchez-Puig, N.1
Fersht, A.R.2
-
21
-
-
24744460523
-
Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF
-
Bilton R., et al. Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF. J. Biol. Chem. 280 (2005) 31132-31140
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31132-31140
-
-
Bilton, R.1
-
22
-
-
0141925607
-
An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development
-
Sugiura N., et al. An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development. J. Biol. Chem. 278 (2003) 40113-40120
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 40113-40120
-
-
Sugiura, N.1
-
23
-
-
27744450043
-
Interaction between HIF-1alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1alpha
-
Arnesen T., et al. Interaction between HIF-1alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1alpha. FEBS Lett. 579 (2005) 6428-6432
-
(2005)
FEBS Lett.
, vol.579
, pp. 6428-6432
-
-
Arnesen, T.1
-
24
-
-
33645322383
-
Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1
-
Yoo Y.G., et al. Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1. EMBO J. 25 (2006) 1231-1241
-
(2006)
EMBO J.
, vol.25
, pp. 1231-1241
-
-
Yoo, Y.G.1
-
25
-
-
33746776975
-
Effect of connective tissue growth factor on hypoxia-inducible factor 1alpha degradation and tumor angiogenesis
-
Chang C.C., et al. Effect of connective tissue growth factor on hypoxia-inducible factor 1alpha degradation and tumor angiogenesis. J. Natl. Cancer Inst. 98 (2006) 984-995
-
(2006)
J. Natl. Cancer Inst.
, vol.98
, pp. 984-995
-
-
Chang, C.C.1
-
26
-
-
4944248618
-
Berberine inhibits HIF-1alpha expression via enhanced proteolysis
-
Lin S., et al. Berberine inhibits HIF-1alpha expression via enhanced proteolysis. Mol. Pharmacol. 66 (2004) 612-619
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 612-619
-
-
Lin, S.1
-
27
-
-
33749006252
-
Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1{alpha}
-
Qian D.Z., et al. Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1{alpha}. Cancer Res. 66 (2006) 8814-8821
-
(2006)
Cancer Res.
, vol.66
, pp. 8814-8821
-
-
Qian, D.Z.1
-
28
-
-
33744963443
-
Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha
-
Fath D.M., et al. Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha. J. Biol. Chem. 281 (2006) 13612-13619
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 13612-13619
-
-
Fath, D.M.1
-
29
-
-
33645236747
-
Purified recombinant hARD1 does not catalyse acetylation of Lys(532) of HIF-1alpha fragments in vitro
-
Murray-Rust T.A., et al. Purified recombinant hARD1 does not catalyse acetylation of Lys(532) of HIF-1alpha fragments in vitro. FEBS Lett. 580 (2006) 1911-1918
-
(2006)
FEBS Lett.
, vol.580
, pp. 1911-1918
-
-
Murray-Rust, T.A.1
-
30
-
-
0034663894
-
Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor protein
-
Tanimoto K., et al. Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J. 19 (2000) 4298-4309
-
(2000)
EMBO J.
, vol.19
, pp. 4298-4309
-
-
Tanimoto, K.1
-
31
-
-
27944445890
-
Differential responses of two degradation domains of HIF-1alpha to hypoxia and iron deficiency
-
Lee K.H., et al. Differential responses of two degradation domains of HIF-1alpha to hypoxia and iron deficiency. Biochimie 88 (2006) 163-169
-
(2006)
Biochimie
, vol.88
, pp. 163-169
-
-
Lee, K.H.1
-
32
-
-
0346059588
-
Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1alpha isoform: implications for tumor promotion
-
Chun Y.S., et al. Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1alpha isoform: implications for tumor promotion. Cancer Res. 63 (2003) 8700-8707
-
(2003)
Cancer Res.
, vol.63
, pp. 8700-8707
-
-
Chun, Y.S.1
-
33
-
-
85047699941
-
Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling
-
Deroanne C.F., et al. Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene 21 (2002) 427-436
-
(2002)
Oncogene
, vol.21
, pp. 427-436
-
-
Deroanne, C.F.1
-
34
-
-
0035048449
-
Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
-
Kim M.S., et al. Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat. Med. 7 (2001) 437-443
-
(2001)
Nat. Med.
, vol.7
, pp. 437-443
-
-
Kim, M.S.1
-
35
-
-
31544464120
-
Targeting tumor angiogenesis with histone deacetylase inhibitors: the hydroxamic acid derivative LBH589
-
Qian D.Z., et al. Targeting tumor angiogenesis with histone deacetylase inhibitors: the hydroxamic acid derivative LBH589. Clin. Cancer Res. 12 (2006) 634-642
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 634-642
-
-
Qian, D.Z.1
-
36
-
-
33748451151
-
Anticancer activities of histone deacetylase inhibitors
-
Bolden J.E., et al. Anticancer activities of histone deacetylase inhibitors. Nat. Rev. Drug Discov. 5 (2006) 769-784
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 769-784
-
-
Bolden, J.E.1
-
37
-
-
30344477367
-
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
-
Minucci S., and Pelicci P.G. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat. Rev. Cancer 6 (2006) 38-51
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 38-51
-
-
Minucci, S.1
Pelicci, P.G.2
-
38
-
-
0035887011
-
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon P.C., et al. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15 (2001) 2675-2686
-
(2001)
Genes Dev.
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
-
39
-
-
4744368147
-
Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity
-
Kato H., et al. Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. J. Biol. Chem. 279 (2004) 41966-41974
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 41966-41974
-
-
Kato, H.1
-
40
-
-
22844432021
-
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors
-
Bali P., et al. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J. Biol. Chem. 280 (2005) 26729-26734
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26729-26734
-
-
Bali, P.1
-
41
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
-
Isaacs J.S., et al. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. J. Biol. Chem. 277 (2002) 29936-29944
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
-
42
-
-
33644780111
-
Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1{alpha}
-
Kong X., et al. Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1{alpha}. Mol. Cell. Biol. 26 (2006) 2019-2028
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 2019-2028
-
-
Kong, X.1
-
43
-
-
27844514169
-
Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression
-
Kasper L.H., et al. Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J. 24 (2005) 3846-3858
-
(2005)
EMBO J.
, vol.24
, pp. 3846-3858
-
-
Kasper, L.H.1
-
44
-
-
0036673950
-
NATH, a novel gene overexpressed in papillary thyroid carcinomas
-
Fluge O., et al. NATH, a novel gene overexpressed in papillary thyroid carcinomas. Oncogene 21 (2002) 5056-5068
-
(2002)
Oncogene
, vol.21
, pp. 5056-5068
-
-
Fluge, O.1
-
45
-
-
0037024449
-
Serological identification and expression analysis of gastric cancer-associated genes
-
Line A., et al. Serological identification and expression analysis of gastric cancer-associated genes. Br. J. Cancer 86 (2002) 1824-1830
-
(2002)
Br. J. Cancer
, vol.86
, pp. 1824-1830
-
-
Line, A.1
-
46
-
-
27744441053
-
Expression of N-acetyl transferase human and human arrest defective 1 proteins in thyroid neoplasms
-
Arnesen T., et al. Expression of N-acetyl transferase human and human arrest defective 1 proteins in thyroid neoplasms. Thyroid 15 (2005) 1131-1136
-
(2005)
Thyroid
, vol.15
, pp. 1131-1136
-
-
Arnesen, T.1
-
47
-
-
0030954208
-
GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein
-
Neuwald A.F., and Landsman D. GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein. Trends Biochem. Sci. 22 (1997) 154-155
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 154-155
-
-
Neuwald, A.F.1
Landsman, D.2
-
48
-
-
0024461828
-
Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast
-
Mullen J.R., et al. Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. EMBO J. 8 (1989) 2067-2075
-
(1989)
EMBO J.
, vol.8
, pp. 2067-2075
-
-
Mullen, J.R.1
-
49
-
-
0026605888
-
ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity
-
Park E.C., and Szostak J.W. ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. EMBO J. 11 (1992) 2087-2093
-
(1992)
EMBO J.
, vol.11
, pp. 2087-2093
-
-
Park, E.C.1
Szostak, J.W.2
-
50
-
-
33645757829
-
Cloning and characterization of hNAT5/hSAN: An evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex
-
Arnesen T., et al. Cloning and characterization of hNAT5/hSAN: An evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex. Gene 371 (2006) 291-295
-
(2006)
Gene
, vol.371
, pp. 291-295
-
-
Arnesen, T.1
-
51
-
-
33751328013
-
HIF-1alpha & ARD1: enemies, friends or neither
-
Arnesen T. HIF-1alpha & ARD1: enemies, friends or neither. Nat. Rev. Cancer 6 (2006) 249
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 249
-
-
Arnesen, T.1
-
52
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
Ferrara N., and Kerbel R.S. Angiogenesis as a therapeutic target. Nature 438 (2005) 967-974
-
(2005)
Nature
, vol.438
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
53
-
-
0037334578
-
Angiogenesis in hematologic malignancies
-
Moehler T.M., et al. Angiogenesis in hematologic malignancies. Crit. Rev. Oncol. Hematol. 45 (2003) 227-244
-
(2003)
Crit. Rev. Oncol. Hematol.
, vol.45
, pp. 227-244
-
-
Moehler, T.M.1
|