Spatial mutation of the T cell immunological synapse

Current Opinion in Chemical Biology

Volumn 10, Issue 6, 2006, Pages 544-550

  Groves, Jay T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

BIOPHYSICS; CELL FUNCTION; CHEMICAL REACTION; EXPERIMENTATION; GENETICS; HUMAN; HYBRID; IMMUNOLOGY; INTRACELLULAR SPACE; METHODOLOGY; MOLECULAR DYNAMICS; MUTATION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE; T LYMPHOCYTE;

HUMANS; MUTATION; PROTEIN TRANSPORT; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 33751431986     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2006.10.021     Document Type: Review

References (35)

1. Friedl P., den Boer A.T., and Gunzer M. Tuning immune responses: diversity and adaptation of the immunological synapse. Nat Rev Immunol 5 (2005) 532-545
2. Cemerski S., and Shaw A. Immune synapses in T cell activation. Curr Opin Immunol 18 (2006) 298-304
3. Dustin M.L., Tseng S.Y., Varma R., and Campi G. T cell-dendritic cell immunological synapses. Curr Opin Immunol 18 (2006) 512-516
4. Monks C.R.F., Freiberg B.A., Kupfer H., Sciaky N., and Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395 (1998) 82-86
5. Grakoui A., Bromley S.K., Sumen C., Davis M.M., Shaw A.S., Allen P.M., and Dustin M.L. The immunological synapse: a molecular machine controlling T cell activation. Science 285 (1999) 221-227
6. Davis D.M., Chiu I., Fassett M., Cohen G.B., Mandelboim O., and Strominger J.L. The human natural killer cell immune synapse. Proc Natl Acad Sci USA 96 (1999) 15062-15067
7. Batista F.D., Iber D., and Neuberger M.S. B cells acquire antigen from target cells after synapse formation. Nature 411 (2001) 489-494
8. Fleire S.J., Goldman J.P., Carrasco Y.R., Weber M., Bray D., and Batista F.D. B cell ligand discrimination through a spreading and contracting response. Science 312 (2006) 738-741. This study reports dynamic observations of B cell synaptic patterns. Dynamic spreading and contraction of the B cell over the antigen-bearing membrane appears to be a mechanism of gathering antigen.
9. Carrasco Y.R., and Batista F.D. B cell recognition of membrane bound antigen: an exquisite way of sensing ligands. Curr Opin Immunol 18 (2006) 286-291
10. Campi G., Varma R., and Dustin M.L. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J Exp Med 202 (2005) 1031-1036. Some signaling characteristics originally attributed to the cSMAC may actually occur in these TCR microclusters instead.
11. Yokosuka T., Sakata-Sogawa K., Kobayashi W., Hiroshima M., Hashimoto-Tane A., Tokunaga M., Dustin M.L., and Saito T. Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nat Immunol 6 (2005) 1253-1262. Identification of TCR microclusters, remote from the cSMAC, as active sites of TCR signaling.
12. Donnadieu E., Revy P., and Trautmann A. Imaging T-cell antigen recognition and comparing immunological and neuronal synapses. Immunology 103 (2001) 417-425
13. McCann F.E., Vanherberghen B., Eleme K., Carlin L.M., Newsam R.J., Goulding D., and Davis D.M. The size of the synaptic cleft and distinct distributions of filamentous actin, ezrin, CD43, and CD45 at activating and inhibitory human NK cell immune synapses. J Immunol 170 (2003) 2862-2870
14. Shaw A.S., and Dustin M.L. Making the T cell receptor go the distance: review of a topographical view of T cell activation. Immunity 6 (1997) 361-369
15. Qi S.Y., Groves J.T., and Chakraborty A.K. Synaptic pattern formation during cellular recognition. Proc Natl Acad Sci USA 98 (2001) 6548-6553
16. Wild M.K., Cambiaggi A., Brown M.H., Davies E.A., Ohno H., Saito T., and van der Merwe P.A. Dependence of T cell antigen recognition on the dimensions on an accessory receptor-ligand complex. J Exp Med 190 (1999) 31-41
17. Choudhuri K., Wiseman D., Brown M.H., Gould K., and van der Merwe P.A. T-cell triggering is critically dependent on the dimensions of its peptide-MHC ligand. Nature 436 (2005) 578-582. Re-engineering the physical size of MHC alters TCR recognition in the context of the immunological synapse. These observations confirm that size-exclusion is likely to be one of the key mechanisms of pattern formation in the synapse.
18. Wülfing C., Tskvitaria-Fuller I., Burroughs N., Sjaastad M.D., Klem J., and Schatzle J.D. Interface accumulation of receptor/ligand couples in lymphocyte activation: methods, mechanisms, and significance. Immunol Rev 189 (2002) 64-83
19. Saito T., and Yokosuka T. Immunological synapse and microclusters: the site for recognition and activation of T cells. Curr Opin Immunol 18 (2006) 305-313. Review of TCR microclusters in the immunological synapse.
20. Singhvi R., Kumar A., Lopez G.P., Stephanopoulos G.N., Wang D.I., Whitesides G.M., and Ingber D.E. Engineering cell shape and function. Science 264 (1994) 696-698
21. Chen C.S., Mrksich M., Huang S., Whitesides G.M., and Ingber D.E. Geometric control of cell life and death. Science 276 (1997) 1425-1428
22. Healy K.E., Lom B., and Hockberger P.E. Spatial distribution of mammalian cells dictated by material surface chemistry. Biomaterials 43 (1994) 792-800
23. Doh J., and Irvine D.J. Immunological synapse arrays: patterned protein surfaces that modulate immunological synapse structure formation in T cells. Proc Natl Acad Sci USA 103 (2006) 5700-5705. T cell synapse repatterning based on static display of ligand patterns on surfaces.
24. Mossman K.D., Campi G., Groves J.T., and Dustin M.L. Altered TCR signaling from geometrically repatterned immunological synapses. Science 310 (2005) 1191-1193. This study demonstrates that physically altering the spatial pattern of TCR in the synapse changes signaling activity as observed by tyrosine phosphorylation and intracellular calcium levels.
25. Lee K.M., Chuang E., Griffin M., Khattri R., Hong D.K., Zhang W., Straus D., Samelson L.E., Thompson C.B., and Bluestone J.A. Molecular basis of T cell inactivation by CTLA-4. Science 282 (1998) 2263-2266
26. Doh J., and Irvine D.J. Photogenerated polyelectrolyte bilayers from an aqueous-processible photoresist for multicomponent protein patterning. J Am Chem Soc 126 (2004) 9170-9171. Polymer resist-based protein patterning strategy to co-pattern two T cell ligand mimics on a surface.
27. Li Q.-J., Dinner A.R., Qi S., Irvine D.J., Huppa J.B., Davis M.M., and Chakraborty A.K. CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nat Immunol 5 (2004) 791-799. Introduction of the heterodimer hypothesis in which both agonist and endogenous peptides participate in TCR signaling via coordinating CD4 interactions.
28. Krogsgaard M., Li Q.J., Sumen C., Huppa J.B., Huse M., and Davis M.M. Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature 434 (2005) 238-243. Experimental observation of agonist/endogenous peptide-MHC heterodimers during T cell activation.
29. Groves J.T., and Dustin M.L. Supported planar bilayers in studies of immune cell adhesion and communication. J Immunol Methods 278 (2003) 19-32
30. Sackmann E. Supported membranes: scientific and practical applications. Science 271 (1996) 43-48
31. Tanaka M., and Sackmann E. Polymer-supported membranes as models of the cell surface. Nature 437 (2005) 656-663. Review of supported membrane technology.
32. Salafsky J., Groves J.T., and Boxer S.G. Architecture and function of membrane proteins in planar supported bilayers: a study with photosynthetic reaction centers. Biochemistry 35 (1996) 14773-14781
33. Groves J.T., Ulman N., and Boxer S.G. Micropatterning fluid lipid bilayers on solid supports. Science 275 (1997) 651-653
34. Groves J.T., and Boxer S.G. Micropattern formation in supported lipid membranes. Acc Chem Res 35 (2002) 149-157
35. Irvine D.J., Purbhoo M.A., Krogsgaard M., and Davis M.M. Direct observation of ligand recognition by T cells. Nature 419 (2002) 845-849