Activation of the unfolded protein response is necessary and sufficient for reducing topoisomerase IIα protein levels and decreasing sensitivity to topoisomerase-targeted drugs

Molecular Pharmacology

Volumn 68, Issue 6, 2005, Pages 1699-1707

  Gray, Miranda D ^a   Mann, Melissa ^a   Nitiss, John L ^a   Hendershot, Linda M ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING) A; ETOPOSIDE;

ANIMAL CELL; ARTICLE; DRUG SENSITIVITY; DRUG TARGETING; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; STRESS;

ANIMALS; ANTIGENS, NEOPLASM; CELL LINE; DNA TOPOISOMERASES, TYPE II; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM; ETOPOSIDE; MOLECULAR CHAPERONES; PROTEIN FOLDING; STRESS;

EID: 27844568955     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.014753     Document Type: Article

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